Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

Authors: Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

Source: Molecular Neurodegeneration, Vol 20, Iss 1, Pp 1-23 (2025)

Subject Terms: HDAC7, TFEB, Astrocytes, Lysosomal biogenesis, Tau pathology, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/d69d504fdac046fb90f21578793b6eea

Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification

Authors: Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang

Source: Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)

Subject Terms: ROCK1, Lysosomal biogenesis, Lysosomal acidification, TFEB, Alzheimer’s disease, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/3ea5a9c842a046a092488d50aaae8355

Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation

Authors: Ashley N. Oliveira, Jonathan M. Memme, Jenna Wong, David A. Hood

Source: Skeletal Muscle, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Mitochondrial respiration, ROS emission, Sex differences, Lysosomal biogenesis, Mitophagy, Autophagy, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5040

Access URL: https://doaj.org/article/d319cf9a31ed44a9975624117faf7779

Altered endosomal-lysosomal biogenesis in melanoma

Authors: Giang T. Lam, Alexandra Sorvina, Carmela Martini, Sarita Prabhakaran, Ben S.-Y. Ung, Joanna Lazniewska, Courtney R. Moore, Andrew R. Beck, Ashley M. Hopkins, Ian R.D. Johnson, Maria C. Caruso, Shane M. Hickey, Robert D. Brooks, Louise Jackett, Litsa Karageorgos, Erwin J. Foster-Smith, Victoria Malone, Sonja Klebe, John J. O'Leary, Douglas A. Brooks, Jessica M. Logan

Source: Neoplasia: An International Journal for Oncology Research, Vol 43, Iss , Pp 100924- (2023)

Subject Terms: Melanoma pathogenesis, Endosomal-lysosomal biogenesis, Syntenin-1, Sortilin, IGF2R, Rab25, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558623000490; https://doaj.org/toc/1476-5586

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Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation

Authors: Ding, Xiao ^{a, b, ∗, 1}, Yang, Xu ^{a, c, 1}, Zhao, Yueqin ^{a, c}, Wang, Yinyuan ^{a, d}, Fei, Jimin ^e, Niu, Zhenpeng ^{a, f}, Dong, Xianxiang ^{a, c}, Wang, Xuenan ^{a, g}, Liu, Biao ^e, Li, Hongmei ^a, Hao, Xiaojiang ^{a, b, ∗∗}, Zhao, Yuhan ^{a, ∗∗∗}

Source: In Heliyon October 2022 8(10)

TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity

Authors: Zeyu Hu, Wanjing Xu, Jingjing Zhang, Yanling Tang, Hengrui Xing, Panpan Xu, Yue Ma, Qiang Niu

Source: Ecotoxicology and Environmental Safety, Vol 253, Iss , Pp 114674- (2023)

Subject Terms: Fluoride, Liver, Autophagy, Lysosomal degradation function, Lysosomal biogenesis, TFE3, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651323001781; https://doaj.org/toc/0147-6513

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ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes

Authors: Yosuke Suzuki, Daisuke Kami, Toshihiko Taya, Arata Sano, Takehiro Ogata, Satoaki Matoba, Satoshi Gojo

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: lysosome acidity, lysosomal biogenesis, bacterial degradation, mitochondrial biogenesis, sepsis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1089905/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/664f61c253ec4d179467d3a88f4bb16e

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity

Authors: Jingjing Zhang, Yanling Tang, Zeyu Hu, Wanjing Xu, Yue Ma, Panpan Xu, Hengrui Xing, Qiang Niu

Source: Ecotoxicology and Environmental Safety, Vol 250, Iss , Pp 114511- (2023)

Subject Terms: Fluoride, Developmental neurotoxicity, Lysosomal biogenesis, TRPML1/TFEB, Pyroptosis, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651323000155; https://doaj.org/toc/0147-6513

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Molecular mechanism of acetylsalicylic acid in improving learning and memory impairment in APP/PS1 transgenic mice by inhibiting the abnormal cell cycle re-entry of neurons

Authors: Pei-Pei Guan, Wei-Yan Ding, Pu Wang

Source: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Subject Terms: cell cycle re-entry, acetylsalicylic acid, apoptosis, lysosomal biogenesis, autophagy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.1006216/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/261ae2073b6c4d23aa7ca4b9a35f44f4

Structural and Comparative Analyses of Insects Suggest the Presence of an Ultra-Conserved Regulatory Element of the Genes Encoding Vacuolar-Type ATPase Subunits and Assembly Factors

Authors: Domenica Lovero, Damiano Porcelli, Luca Giordano, Claudio Lo Giudice, Ernesto Picardi, Graziano Pesole, Eugenia Pignataro, Antonio Palazzo, René Massimiliano Marsano

Source: Biology, Vol 12, Iss 8, p 1127 (2023)

Subject Terms: V-ATPase, lysosomal biogenesis, gene regulation, dCLEAR, evolution, cis-regulatory sequences, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/12/8/1127; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/0768520fc48a473f80dcdcd0cdb826fd

Effect of the Ketone Body, D-β-Hydroxybutyrate, on Sirtuin2-Mediated Regulation of Mitochondrial Quality Control and the Autophagy–Lysosomal Pathway

Authors: Juan Carlos Gómora-García, Teresa Montiel, Melanie Hüttenrauch, Ashley Salcido-Gómez, Lizbeth García-Velázquez, Yazmin Ramiro-Cortés, Juan Carlos Gomora, Susana Castro-Obregón, Lourdes Massieu

Source: Cells, Vol 12, Iss 3, p 486 (2023)

Subject Terms: autophagy, ketone bodies, lysosomal biogenesis, mitophagy, sirtuin2, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/3/486; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5119d52593034d85a04f9f118226e29b

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

Authors: Sujyoti Chandra, Avik Roy, Malabendu Jana, Kalipada Pahan

Source: Neurobiology of Disease, Vol 124, Iss , Pp 379-395 (2019)

Subject Terms: Lysosomal biogenesis, Cinnamic acid, PPARα, TFEB, Plaque clearance, 5XFAD model, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996118307058; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/a84218bfb264438796530b74e9ebaee7

Corrigendum: TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis

Authors: Xuejin Zhu, Yangjia Zhuo, Shulin Wu, Yanfei Chen, Jianheng Ye, Yulin Deng, Yuanfa Feng, Ren Liu, Shanghua Cai, Zhihao Zou, Bin Wang, Chin-Lee Wu, Guohua Zeng, Weide Zhong

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: TFEB, ABCA2, prostate cancer, tumor microenvironment, lysosomal biogenesis, biochemical recurrence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.750277/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6168d38d1abf40e3b94b5e45bebda40e

USP7 protects TFEB from proteasome-mediated degradation

Authors: Keshri, Swati ^{1, 2}, Vicinanza, Mariella ^{1, 2}, Takla, Michael ^{1, 2}, Rubinsztein, David C. ^{1, 2, 3, ∗}

Source: In Cell Reports 26 November 2024 43(11)

TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis

Authors: Xuejin Zhu, Yangjia Zhuo, Shulin Wu, Yanfei Chen, Jianheng Ye, Yulin Deng, Yuanfa Feng, Ren Liu, Shanghua Cai, Zhihao Zou, Bin Wang, Chin-Lee Wu, Guohua Zeng, Weide Zhong

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: TFEB, ABCA2, prostate cancer, tumor microenvironment, lysosomal biogenesis, biochemical recurrence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.632524/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/2a32b904db694b6f9534f87731b4a09e

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

Authors: Yunyun Fang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Jingjing Zhang, Junxi Lu, Jun Yin, Li Wei

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: non-alcoholic fatty liver disease, liraglutide, autophagy-lysosome, lysosomal biogenesis, TFEB, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.602574/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/df89ff16a924436296995c3a45650831

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

Authors: Chuanbin Yang, Zhou Zhu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Jian Xie, Yu Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Krishnamoorthi Senthilkumar, King-Ho Cheung, Ju-Xian Song, Hong-Jie Zhang, Min Li

Source: Redox Biology, Vol 32, Iss , Pp - (2020)

Subject Terms: p38 inhibitor, SB202190, SB203580, TFEB, TFE3, Autophagy and lysosomal biogenesis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231719311802; https://doaj.org/toc/2213-2317

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SERTAD1 Sensitizes Breast Cancer Cells to Doxorubicin and Promotes Lysosomal Protein Biosynthesis

Authors: Hai Anh Nguyen, Son Hai Vu, Samil Jung, Beom Suk Lee, Thi Ngoc Quynh Nguyen, Hyojeong Lee, Hye-gyeong Lee, Davaajargal Myagmarjav, Taeyeon Jo, Yeongseon Choi, Myeong-Sok Lee

Source: Biomedicines, Vol 10, Iss 5, p 1148 (2022)

Subject Terms: breast cancer, anti-cancer drugs, anoikis, autophagy, SERTAD1, lysosomal biogenesis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/5/1148; https://doaj.org/toc/2227-9059

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AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Authors: Ponarulselvam Sekar, Duen-Yi Huang, Shie-Liang Hsieh, Shwu-Fen Chang, Wan-Wan Lin

Source: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-15 (2018)

Subject Terms: P2X7, AMPK, Mitophagy, Lysosomal biogenesis, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12964-018-0293-3; https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/1d1dce88ee6e41619626b220c4183272

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

Authors: Gabriele Civiletto, Sukru Anil Dogan, Raffaele Cerutti, Gigliola Fagiolari, Maurizio Moggio, Costanza Lamperti, Cristiane Benincá, Carlo Viscomi, Massimo Zeviani

Source: EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-15 (2018)

Subject Terms: autophagy, lysosomal biogenesis, mitochondrial disease, mTORC1, rapamycin, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/4ceca83a73594e0b84ecb798f4bbcb33