Real-World Effectiveness of Frontline Treatments Among Patients with Chronic Lymphocytic Leukemia: Results from ConcertAI.

Authors: Roeker, Lindsey E.¹ (AUTHOR), Burke, John M.² (AUTHOR), Rhodes, Joanna M.³ (AUTHOR), Emechebe, Nnadozie⁴ (AUTHOR), Jawaid, Dureshahwar^4,5 (AUTHOR), Manzoor, Beenish S.^4,6 (AUTHOR) beenish.manzoor@abbvie.com, Jensen, Christopher E.^1,5 (AUTHOR), Ryland, Lindsay^2,4 (AUTHOR), Liu, Yangyang^3,4 (AUTHOR), Marx, Steve E.⁴ (AUTHOR), Sinai, Wendy^4,5 (AUTHOR), Roser, Jordan^4,6 (AUTHOR), Shadman, Mazyar⁶ (AUTHOR)

Source: Cancers. Mar2025, Vol. 17 Issue 5, p799. 15p.

Subject Terms: *CHRONIC lymphocytic leukemia treatment, *CHRONIC lymphocytic leukemia, *RESEARCH funding, *IMMUNOTHERAPY, *SCIENTIFIC observation, *TREATMENT effectiveness, *DECISION making in clinical medicine, *RETROSPECTIVE studies, *TREATMENT duration, *DESCRIPTIVE statistics, *CANCER chemotherapy, *ELECTRONIC health records, *RESEARCH methodology, *CANCER patient psychology, *OVERALL survival, *ADULTS

Geographic Terms: UNITED States

Prognostic and predictive impact of NOTCH1 mutation in chronic lymphocytic leukemia: a systematic review.

Authors: Guglielmana, Veronica^1,2,3 (AUTHOR), Rossi, Davide^3,4,5 (AUTHOR) davide.rossi@eoc.ch

Source: Leukemia & Lymphoma. Apr2025, Vol. 66 Issue 4, p584-593. 10p.

Subject Terms: *CHRONIC lymphocytic leukemia, *PROGNOSIS, *BCL-2 proteins, *BRUTON tyrosine kinase, *NOTCH genes, *CD20 antigen

Single-cell analysis of a bi-clonal chronic lymphocytic leukemia reveals two clones with distinct gene expression pattern.

Authors: Dampmann, Maria^1,2 (AUTHOR) maria.dampmann@uk-essen.de, Kibler, Artur^1,3 (AUTHOR), von Tresckow, Julia² (AUTHOR), Reinhardt, Hans Christian^2,4,5 (AUTHOR), Küppers, Ralf^1,5 (AUTHOR), Budeus, Bettina¹ (AUTHOR)

Source: Leukemia & Lymphoma. Apr2025, Vol. 66 Issue 4, p744-752. 9p.

Subject Terms: *CHRONIC lymphocytic leukemia, *GENE expression, *B cell receptors, *TRANSCRIPTOMES, *IMMUNOGLOBULIN genes, *CELL analysis

CINner: Modeling and simulation of chromosomal instability in cancer at single-cell resolution.

Authors: Dinh, Khanh N.^1,2 (AUTHOR) knd2127@columbia.edu, Vázquez-García, Ignacio^1,3,4,5 (AUTHOR) ivazquez-garcia@mgh.harvard.edu, Chan, Andrew⁶ (AUTHOR), Malhotra, Rhea^3,7 (AUTHOR), Weiner, Adam^3,8 (AUTHOR), McPherson, Andrew W.³ (AUTHOR), Tavaré, Simon^1,2 (AUTHOR) st3193@columbia.edu

Source: PLoS Computational Biology. 4/3/2025, Vol. 21 Issue 4, p1-33. 33p.

Subject Terms: *CHRONIC lymphocytic leukemia, *CELLULAR evolution, *TUMOR growth, *CANCER invasiveness, *GENETIC mutation, *TUMOR suppressor genes

Real-world outcomes after discontinuation of covalent BTK inhibitor-based therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

Authors: Jain, Nitin¹ (AUTHOR) njain@mdanderson.org, Eyre, Toby A.² (AUTHOR), Winfree, Katherine B.³ (AUTHOR), Bhandari, Naleen Raj³ (AUTHOR), Khanal, Manoj³ (AUTHOR), Sugihara, Tomoko⁴ (AUTHOR), Chen, Yongmei³ (AUTHOR), Abada, Paolo⁵ (AUTHOR), Patel, Krish⁶ (AUTHOR)

Source: Leukemia & Lymphoma. Mar2025, p1-13. 13p. 5 Illustrations.

Subject Terms: *CHRONIC lymphocytic leukemia, *OVERALL survival, *DATABASES, *BRUTON tyrosine kinase, *LYMPHOMAS

Assigning Transcriptomic Subtypes to Chronic Lymphocytic Leukemia Samples Using Nanopore RNA-Sequencing and Self-Organizing Maps.

Authors: Arakelyan, Arsen^1,2 (AUTHOR) aarakelyan@sci.am, Sirunyan, Tamara^1,2 (AUTHOR), Khachatryan, Gisane^1,2,3 (AUTHOR), Hakobyan, Siras^1,3,4 (AUTHOR), Minasyan, Arpine^1,5 (AUTHOR), Nikoghosyan, Maria^1,3 (AUTHOR), Hakobyan, Meline^1,2 (AUTHOR), Chavushyan, Andranik^1,3 (AUTHOR), Martirosyan, Gevorg^1,4 (AUTHOR), Hakobyan, Yervand^4,5 (AUTHOR), Binder, Hans^3,5 (AUTHOR)

Source: Cancers. Mar2025, Vol. 17 Issue 6, p964. 15p.

Subject Terms: *CHRONIC lymphocytic leukemia, *CLUSTER analysis (Statistics), *T cells, *RESEARCH funding, *POLYMERASE chain reaction, *CELL proliferation, *CELL cycle, *DESCRIPTIVE statistics, *RNA, *SUPPORT vector machines, *GENE expression profiling, *NANOTECHNOLOGY, *DNA repair, *MACHINE learning, *GENETIC techniques, *INFLAMMATION, *DATA analysis software, *SEQUENCE analysis, *ALGORITHMS, *PHENOTYPES, *REGRESSION analysis, *B cells

Updates on the Treatment of Richter's Syndrome, Including Novel Combination Approaches.

Authors: Jain, Tanim¹ (AUTHOR), Heyman, Benjamin² (AUTHOR) bheyman@health.ucsd.edu

Source: Cancers. Mar2025, Vol. 17 Issue 6, p943. 17p.

Subject Terms: *CHRONIC lymphocytic leukemia, *PREDICTIVE tests, *HEMATOPOIETIC stem cell transplantation, *IMMUNOTHERAPY, *POSITRON emission tomography computed tomography, *CELLULAR therapy, *CANCER chemotherapy, *IMMUNE checkpoint inhibitors, *RICHTER syndrome, *SENSITIVITY & specificity (Statistics), *DISEASE risk factors, *SYMPTOMS

Chronic Lymphocytic Leukemia: Investigation of Survival and Prognostic Factors with Drug-Related Remission.

Authors: Pektaş, Gökhan¹ (AUTHOR), Gönül, Ercan^1,2 (AUTHOR), Öncü, Şeyma^2,3 (AUTHOR), Becit Kızılkaya, Merve^3,4 (AUTHOR), Sadi, Gökhan^1,4 (AUTHOR), Pektaş, Mehmet Bilgehan² (AUTHOR) mbpektas@gmail.com

Source: Diagnostics (2075-4418). Mar2025, Vol. 15 Issue 6, p728. 17p.

Subject Terms: *CHRONIC lymphocytic leukemia, *STATISTICAL significance, *PROGNOSIS, *OVERALL survival, *LYMPHOCYTE count

Combinatory Flowcytometric Approach in Pediatric Acute Lymphoid Leukemia Identifies Surrogate Minimal Residual Disease Markers.

Authors: George, Noreen Grace¹ (AUTHOR), Rishi, Bhavika^1,2 (AUTHOR), Ray, Sanghmitra^2,3 (AUTHOR), Kaur, Manpreet^1,4 (AUTHOR), Kamal, Raj¹ (AUTHOR), Garg, Shikha^2,3 (AUTHOR), Mehndiratta, Sumit^2,3 (AUTHOR), Chopra, Nidhi^2,4 (AUTHOR), Zaman, Shamsuz⁴ (AUTHOR), Singh, Amitabh² (AUTHOR), Misra, Aroonima¹ (AUTHOR)

Source: Diagnostics (2075-4418). Mar2025, Vol. 15 Issue 6, p658. 12p.

Subject Terms: *LYMPHOCYTIC leukemia, *CLONE cells, *ACUTE leukemia, *TREATMENT effectiveness, *FLOW cytometry

Characterisation of Cytotoxicity-Related Receptors on γδ T Cells in Chronic Lymphocytic Leukaemia.

Authors: Zarobkiewicz, Michał¹ (AUTHOR) michal.zarobkiewicz@umlub.pl, Lehman, Natalia^1,2 (AUTHOR), Morawska-Michalska, Izabela¹ (AUTHOR), Michalski, Adam^1,2 (AUTHOR), Kowalska, Wioleta¹ (AUTHOR), Szymańska, Agata¹ (AUTHOR), Tomczak, Waldemar² (AUTHOR), Bojarska-Junak, Agnieszka¹ (AUTHOR)

Source: Cells (2073-4409). Mar2025, Vol. 14 Issue 6, p451. 13p.

Subject Terms: *CHRONIC leukemia, *LYMPHOCYTIC leukemia, *GENE expression, *B cells, *PROTEIN expression, *T cells

BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia.

Authors: Chong, Stephen Jun Fei^1,2,3 (AUTHOR), Lu, Junyan⁴ (AUTHOR), Valentin, Rebecca^1,5 (AUTHOR), Lehmberg, Timothy Z.¹ (AUTHOR), Eu, Jie Qing³ (AUTHOR), Wang, Jing¹ (AUTHOR), Zhu, Fen¹ (AUTHOR), Kong, Li Ren³ (AUTHOR), Fernandes, Stacey M.¹ (AUTHOR), Zhang, Jeremy¹ (AUTHOR), Herbaux, Charles¹ (AUTHOR), Goh, Boon Cher³ (AUTHOR), Brown, Jennifer R.¹ (AUTHOR), Niemann, Carsten U.⁵ (AUTHOR), Huber, Wolfgang⁶ (AUTHOR), Zenz, Thorsten⁷ (AUTHOR), Davids, Matthew S.¹ (AUTHOR) matthew_davids@dfci.harvard.edu

Source: Molecular Cancer. 3/3/2025, Vol. 24 Issue 1, p1-19. 19p.

Subject Terms: *MEDICAL sciences, *CHRONIC lymphocytic leukemia, *GENETIC markers, *BCL-2 proteins, *CYTOCHROME c, *EPIGENOMICS

Molecular Mechanisms in the Transformation from Indolent to Aggressive B Cell Malignancies.

Authors: Maher, Nawar¹ (AUTHOR), Mouhssine, Samir^1,2 (AUTHOR), Matti, Bassam Francis^2,3 (AUTHOR), Alwan, Alaa Fadhil^1,3 (AUTHOR), Gaidano, Gianluca^1,2 (AUTHOR) gianluca.gaidano@uniupo.it

Source: Cancers. Mar2025, Vol. 17 Issue 5, p907. 24p.

Subject Terms: *CHRONIC lymphocytic leukemia, *CANCER invasiveness, *NON-Hodgkin's lymphoma, *CELL proliferation, *CELLULAR signal transduction, *IMMUNE system, *GENES, *DNA repair, *B cell lymphoma, *GENETICS, *IMMUNITY, *BIOMARKERS

Targeting Tumor Microenvironment Interactions in Chronic Lymphocytic Leukemia Using Leukotriene Inhibitors.

Authors: Sadeghi, Laia¹ (AUTHOR) laia.sadeghi@ki.se, Merrien, Magali² (AUTHOR), Björkholm, Magnus³ (AUTHOR), Österborg, Anders^4,5 (AUTHOR), Sander, Birgitta^2,5 (AUTHOR), Claesson, Hans-Erik^1,3 (AUTHOR), Wright, Anthony P. H.^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p2209. 12p.

Subject Terms: *BRUTON tyrosine kinase, *CHRONIC lymphocytic leukemia, *MANTLE cell lymphoma, *STROMAL cells, *CELL adhesion

An Incidental Finding of Gain of a Diminished Chromosome 12 Centromere in an Individual with Lymphocytosis: A Case Report and Clinical Implications in Cytogenetic Testing.

Authors: Xia, Changqing¹ (AUTHOR), Cannatella, Jeffrey J.^1,2 (AUTHOR), Smith, Scott C.^1,2 (AUTHOR), Althof, Pamela A.^1,2 (AUTHOR), Koerselman, Haley¹ (AUTHOR), Hempel, Thomas¹ (AUTHOR), Jaworski, Erin E.¹ (AUTHOR), Winkler, Lisa M.¹ (AUTHOR), Spaulding, Joanna R.¹ (AUTHOR), Pickering, Diane¹ (AUTHOR), Khoury, Joseph D.¹ (AUTHOR), Tang, Zhenya¹ (AUTHOR) ztang@unmc.edu

Source: Diagnostics (2075-4418). Mar2025, Vol. 15 Issue 5, p618. 10p.

Subject Terms: *FLUORESCENCE in situ hybridization, *CHRONIC lymphocytic leukemia, *CENTROMERE, *CYTOGENETICS, *KARYOTYPES

Clinical trials in early-stage CLL: what has been learned and what's next?

Authors: Hoechstetter, Manuela A.¹ (AUTHOR) Manuela.Hoechstetter@med.uni-muenchen.de, Wendtner, Clemens-Martin¹ (AUTHOR)

Source: Leukemia & Lymphoma. Mar2025, Vol. 66 Issue 3, p378-388. 11p.

Subject Terms: *CHRONIC lymphocytic leukemia, *PROGNOSTIC models, *ASYMPTOMATIC patients, *OVERALL survival, *CLINICAL trials

Preferences for First-Line Chronic Lymphocytic Leukemia Treatments: Results From a Multinational Study on the Perspectives of Patients and Physicians.

Authors: Sile, Bersabeh (AUTHOR), Patel, Dipen (AUTHOR), Horchi, Dahbia (AUTHOR), Rault, Bleuenn (AUTHOR), Mulvihill, Emily (AUTHOR), Beusterien, Kathleen (AUTHOR), Stewart, Katherine (AUTHOR), Miranda, Paulo (AUTHOR), Guillaume, Xavier (AUTHOR)

Source: Patient Preference & Adherence. Mar2025, Vol. 18, p823-837. 15p.

Subject Terms: *CHRONIC lymphocytic leukemia, *TERMINATION of treatment, *PHYSICIANS' attitudes, *PATIENTS' attitudes, *PATIENT preferences

G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo.

Authors: Cassarino, María Chiara¹ (AUTHOR), Colado, Ana¹ (AUTHOR), Martinez, Valeria Sarapura¹ (AUTHOR), Martines, Claudio² (AUTHOR), Bonato, Alice² (AUTHOR), Bertini, Martin³ (AUTHOR), Pavlovksy, Miguel⁴ (AUTHOR), Custidiano, Rosario⁵ (AUTHOR), Bezares, Fernando Raimundo³ (AUTHOR), Morande, Pablo Elías¹ (AUTHOR), Vermeulen, Mónica¹ (AUTHOR), Gamberale, Romina¹ (AUTHOR), Giordano, Mirta¹ (AUTHOR), Efremov, Dimitar G^2,6 (AUTHOR), Borge, Mercedes¹ (AUTHOR) mercedesborge@hotmail.com

Source: Scientific Reports. 2/24/2025, Vol. 15 Issue 1, p1-11. 11p.

Subject Terms: *LYMPHOCYTIC leukemia, *CHRONIC leukemia, *MEDICAL sciences, *LYMPHOID tissue, *BONE marrow, *G protein coupled receptors

Resistance mechanisms and approach to chronic lymphocytic leukemia after BTK inhibitor therapy.

Authors: Gruessner, Christine¹ (AUTHOR), Wiestner, Adrian¹ (AUTHOR), Sun, Clare¹ (AUTHOR) clare.sun@nih.gov

Source: Leukemia & Lymphoma. Feb2025, p1-13. 13p. 4 Illustrations.

Subject Terms: *BRUTON tyrosine kinase, *CHRONIC lymphocytic leukemia, *PROTEIN-tyrosine kinases, *PROTEIN-tyrosine kinase inhibitors, *CELLULAR signal transduction

BTK Is the Target That Keeps on Giving: A Review of BTK-Degrader Drug Development, Clinical Data, and Future Directions in CLL.

Authors: Salvaris, Ross T.^1,2 (AUTHOR) ross.salvaris@monashhealth.org, Brennan, Jamie³ (AUTHOR) jamiegraybrennan@gmail.com, Lewis, Katharine L.^3,4 (AUTHOR) katharine.lewis@health.wa.gov.au

Source: Cancers. Feb2025, Vol. 17 Issue 3, p557. 15p.

Subject Terms: *CHRONIC lymphocytic leukemia, *DRUG toxicity, *CANCER relapse, *PROTEIN-tyrosine kinase inhibitors, *DRUG development, *GENETIC mutation, *SEQUENCE analysis

Distinct NF-kB Regulation Favors a Synergic Action of Pevonedistat and Laduviglusib in B-Chronic Lymphocytic Leukemia Cells Ex Vivo.

Authors: Arenas, Víctor¹ (AUTHOR) victor.arenas@idival.org, Castaño, Jose Luis¹ (AUTHOR) jose.castano@idival.org, Domínguez, Juan José² (AUTHOR) juanjose.dominguez@scsalud.es, Yáñez, Lucrecia² (AUTHOR) lucrecia.yanez@scsalud.es, Pipaón, Carlos¹ (AUTHOR) carlos.pipaon@scsalud.es

Source: Cancers. Feb2025, Vol. 17 Issue 3, p533. 18p.

Subject Terms: *THERAPEUTIC use of proteins, *CHRONIC lymphocytic leukemia, *NF-kappa B, *PROTEIN kinase inhibitors, *PROTEINS, *RESEARCH funding, *APOPTOSIS, *CELLULAR signal transduction, *IMMUNODIAGNOSIS, *MESSENGER RNA, *GENE expression profiling, *DRUG synergism, *CELL surface antigens