Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation

Authors: Xiao, Chengcheng ^{a, 1}, Wang, Yayun ^{b, 1}, Liu, Jingwei ^c, Li, Xin ^d, Wang, Peng ^a, Zhou, Junran ^e, Xiu, Hao ^f, Lu, Shun ^f, Zhu, Hai ^a, Wang, Renhe ^{f, ⁎}

Source: In Phytomedicine January 2025 136

Inhibitory mechanism of α-glucosidase by liquiritigenin and its combined effect with acarbose: Multi-spectroscopic analyses and molecular docking simulation

Authors: Zhou, Qin ^a, Wei, Yishi ^a, Liao, Yijing ^b, Hu, Xing ^a, Gong, Deming ^a, Zhang, Guowen ^{a, c, ⁎}

Source: In Food Bioscience January 2025 63

Effects of oral liquiritigenin inoculation on gut microbiota and gene expression in intestinal and extraintestinal tissues of mice

Authors: Zhaotaize Suo, Ying Yu, Fangyun Shi, Jijing Tian, Zhihui Hao, Jingren Zhang, Jun Zou

Source: Frontiers in Microbiomes, Vol 3 (2024)

Subject Terms: phytochemicals, flavonoid, liquiritigenin, gut microbiota, RNA-seq analysis, gene expression, Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/frmbi.2024.1380152/full; https://doaj.org/toc/2813-4338

Access URL: https://doaj.org/article/81ca17dde9bb4c8493d9936d65512831

The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin

Authors: Qingzhong Hua, Lu Ren

Source: Chinese Medicine, Vol 19, Iss 1, Pp 1-17 (2024)

Subject Terms: Liquiritigenin, SIRT1, Nrf2, Oxidative stress, Myofibroblast differentiation, Pulmonary fibrosis, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://doaj.org/toc/1749-8546

Access URL: https://doaj.org/article/570835e40ce444ee85d5ba2b785f59e1

Method Development and Validation in Food and Pharmaceutical Analysis

Contributors: Yoon, In-Soo, Cho, Hyun-Jong

Subject Terms: wild rice, antioxidant, macroporous resins, LC-MS/MS, phenolics, procyanidins, osimertinib, UPLC-TOF-MS, rat, pharmacokinetics, carbonyl derivatization, phenylhydrazine, phenylenediamine, hydroxylamine, water analysis, lipoxidation, lisdexamfetamine dimesylate, impurities, structural elucidation, forced degradation, HPLC validation, chemical constituent profiles of Sinisan, chinese medicine processing, chinese medicinal formula compatibility, Dendropanax morbifera leaf, xanthine oxidase, hyperuricemia, HPLC, advanced glycation end-products (AGEs), Nε-(carboxymethyl) lysine (CML), Nε-(carboxyethyl) lysine (CEL), antler velvet processing, UPLC-MS/MS, Cinnamomum yabunikkei leaf, elastase, Citrus junos Seib ex TANAKA, rhKGF-1, rhKGF-2, bioactivity, cell-based bioassay, method validation, CYP450 enzyme, cocktail probe drug, RT-PCR, galangin, affecting factors, amadori compound, furosine, Maillard reaction, velvet antler processing, Brazilian green propolis, phenolic acids, UPLC-ESI-QTOF-MS, quantitation, methodological verification, Glycyrrhizae Radix extract, glycyrrhizin, isoliquiritigenin, liquiritigenin, liquiritin, LC–MS/MS analysis, desoxo-narchinol A, Nardostachys jatamansi, bioavailability, silybin, silymarin product, comparative pharmacokinetics, ginsenosides, red ginseng extract, human, acanthus ilicifolius herb, phenylethanoid glycosides, C.tricuspidata Bureau, tyrosinase, dialyzable leukocyte extract, Transferon®, complex mixture of peptides, quality specifications, biological potency, development and validation, Dioscorea nipponica Makino, steroidal saponin, HPLC-UV, UPLC-QTOF/MS, validation, osteosarcoma, apoptosis, epinastine, comparison, SH-1242, 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone, HPLC-MS/MS, Research and information: general, Chemistry, Analytical chemistry

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Access URL: https://directory.doabooks.org/handle/20.500.12854/96768
https://mdpi.com/books/pdfview/book/6714

Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis

Authors: Yu Qiu, Yueyang Zhao, Zhimin Long, Aijia Song, Peng Huang, Kejian Wang, Ling Xu, David Paul Molloy, Guiqiong He

Source: Genes and Diseases, Vol 10, Iss 1, Pp 284-300 (2023)

Subject Terms: Apoptosis, Auto-lysosomal degradation, Liquiritigenin, Osteogenic differentiation, Osteoporosis, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304221000891; https://doaj.org/toc/2352-3042

Access URL: https://doaj.org/article/d5ec4adb654c40c1b38b85bf3031ea88

Combined computational approaches for developing new anti-Alzheimer drug candidates: 3D-QSAR, molecular docking and molecular dynamics studies of liquiritigenin derivatives

Authors: Nour, Hassan ^a, Daoui, Ossama ^b, Abchir, Oussama ^a, ElKhattabi, Souad ^b, Belaidi, Salah ^c, Chtita, Samir ^{a, ∗}

Source: In Heliyon December 2022 8(12)

Coumarin and Its Derivatives

Contributors: Matos, Maria João

Subject Terms: coumarin, hydroxyl-modified coumarin, photophysical, thermal and structural characterization, Glycyrrhiza uralensis, glycyrol, liquiritigenin, cholinesterases, human monoamine oxidases, kinetics, docking simulation, chalcone, neurodegenerative diseases, adenosine receptors, binding affinity, docking, 4-hydroxy-7-methoxycoumarin, macrophage, inflammation, NF-κB, MAPK, calanolides, pseudocalanolides, calanolide A, Calophyllum, Calophyllaceae, anti-HIV, reverse transcriptase, non-nucleoside reverse transcriptase inhibitors (NNRTIs), osthole, umbelliferone, esculin, 4-hydroxycoumarin, sorafenib, apoptosis, autophagy, Yin Chen Hao, constitutive androstane receptor, scoparone, coumarins, quorum sensing, QS inhibitors, plant-derived molecules, Chromobacterium violaceum, immunoproteasome, psoralen core, non-peptidic, electrophilic compounds, warhead scan, inflammatory bowel disease, isocoumarin, Crohn’s disease, ulcerative colitis, glutathione, oxidative stress, complementary therapies, intestinal inflammation, benzopyrones, five-membered aromatic heterocycles, furan, pyrrole, thiophene, selenophen, dihydrocoumarin-fused dihydropyranones, 3-aroylcoumarines, benzyl 2,3-butadienoate, 6’-(4-biphenyl)-β-iso-cinchonine, biological applications, drug discovery, fluorescent probes, warfarin, acenocoumarol, mechanical valve, time in therapeutic range, anticoagulation, Ruta chalepensis, Rutaceae, chalepin, chalepensin, bioactivity, biosynthesis, coumarin3-carboxamides, pyranocoumarins, anticancer activity, antibacterial activity, free radical polymerization, LED, photocomposites, direct laser write, analytical methods, model plant, natural genetic variation, natural products, simple coumarins, chalcocoumarin, MAO-B, molecular dynamics, in silico studies, dye-sensitized solar cells, coumarin dyes, thieno [3,2-b] thiophene, charge transfer, ethynylaryl, esculetin, antiplatelet activity, impedance aggregometry, COX, polyphenols, pyrazole, imidazole, thiazole, oxazole, triazole, thiadiazole, curcumin, curcumin–coumarin hybrids, neuroprotection, monoamine oxidase inhibition, cholinesterase inhibition, scavenging activity, Escherichia coli, biotransformation, ferulenol, structural annotation, in silico tools, Research and information: general, Biology, life sciences

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Access URL: https://directory.doabooks.org/handle/20.500.12854/77168
https://mdpi.com/books/pdfview/book/4786

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Authors: Yan-Zhen Li, Yuan-Jie Liu, Wei Zhang, Shi-Fang Luo, Xin Zhou, Gui-Qiong He

Source: Neural Regeneration Research, Vol 16, Iss 10, Pp 2078-2085 (2021)

Subject Terms: 17β-estradiol, amyloid β, dementia, estrogen receptor α, estrogen receptor β, glycogen synthase kinase-3β, liquiritigenin, menopause, neuron loss, tau, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=10;spage=2078;epage=2085;aulast=Li; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/cb7fc810c97a4a84843679a2b26ac4da

Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis

Authors: Marta Carnovali, Giuseppe Banfi, Massimo Mariotti

Source: Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 300-306 (2020)

Subject Terms: Zebrafish, Liquiritigenin, Osteoporosis, Bone metabolism, Scales, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861320300566; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/0c3734c9d68d41758b5e7556d8f10c6a

Liquiritigenin-Loaded Submicron Emulsion Protects Against Doxorubicin-Induced Cardiotoxicity via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activity

Authors: Shi C, Wu H, Xu K, Cai T, Qin K, Wu L, Cai B

Source: International Journal of Nanomedicine, Vol Volume 15, Pp 1101-1115 (2020)

Subject Terms: liquiritigenin, submicron emulsion, bioavailability, cardiotoxicity, protective efficacy, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/liquiritigenin-loaded-submicron-emulsion-protects-against-doxorubicin--peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/d66375e4fa2f4f6e863deffbbb900777

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

Authors: Mami Kato, Yasunori Takayama, Masataka Sunagawa

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: TMEM16A, TRP channel, flavonoid, Liquiritigenin, Estrogen, aglycone, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.628968/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/35178caf6dac4882870f72712da3e2f6

Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function

Authors: Meng Zhou, Yanpeng Dai, Yong Ma, Yi Yan, Min Hua, Qi Gao, Xue Geng, Qian Zhou

Source: Molecules, Vol 27, Iss 12, p 3823 (2022)

Subject Terms: liquiritigenin, NRF2, cisplatin, SIRT3, mitochondrial biogenesis, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/12/3823; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/dada9a16792c4d8498396c4c0419ee71

Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota

Authors: Adili Keranmu, Li-Bin Pan, Jie Fu, Pei Han, Hang Yu, Zheng-Wei Zhang, Hui Xu, Xin-Yu Yang, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Nian-Zeng Xing, Yan Wang

Source: Molecules, Vol 27, Iss 10, p 3057 (2022)

Subject Terms: liquiritigenin, gut microbiota, liver microsome, metabolites, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/10/3057; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c6f542fb96cb4798aecb11f33c89198e

Secondary metabolites from the roots of Astragalus maximus

Authors: J. Ghasemian-Yadegari, H. Nazemiyeh, S. Hamedeyazdan, F. Fathiazad

Source: Research Journal of Pharmacognosy, Vol 4, Iss 2, Pp 31-38 (2017)

Subject Terms: Astragalus maximus, cycloartane-type saponins, Flavonoids, isoquercitrin, liquiritigenin, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.rjpharmacognosy.ir/article_44251_656e27404a6fbdfca830555d83c3de50.pdf; https://doaj.org/toc/2345-4458; https://doaj.org/toc/2345-5977

Access URL: https://doaj.org/article/20270d0e316f422f8263241b9db1db71

Medicago truncatula ABCG10 is a transporter of 4-coumarate and liquiritigenin in the medicarpin biosynthetic pathway

Authors: Biała, Wanda, Banasiak, Joanna, Jarzyniak, Karolina, Pawela, Aleksandra, Jasiński, Michał

Source: Journal of Experimental Botany, 2017 Jan 01. 68(12), 3231-3241.

Access URL: https://www.jstor.org/stable/26392327

Stereospecific pharmacokinetic characterization of liquiritigenin in the rat

Authors: Samaa Alrushaid, Neal M Davies, Stephanie E Martinez, Casey L Sayre

Source: Research in Pharmaceutical Sciences, Vol 12, Iss 3, Pp 176-186 (2017)

Subject Terms: liquiritigenin, pharmacokinetics, stereospecific, flavonoid, chiral, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=3;spage=176;epage=186;aulast=Alrushaid; https://doaj.org/toc/1735-5362; https://doaj.org/toc/1735-9414

Access URL: https://doaj.org/article/f22579c79a70475f97fb685924cfb85e

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis

Authors: Geum Seok Jeong, Myung-Gyun Kang, Joon Yeop Lee, Sang Ryong Lee, Daeui Park, MyoungLae Cho, Hoon Kim

Source: Molecules, Vol 25, Iss 17, p 3896 (2020)

Subject Terms: Glycyrrhiza uralensis, glycyrol, liquiritigenin, cholinesterases, human monoamine oxidases, kinetics, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/17/3896; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/a12e1cde4d28456e89c9ec66cac6a238

Oral Administration of Liquiritigenin Confers Protection from Atopic Dermatitis through the Inhibition of T Cell Activation

Authors: Hyun-Su Lee, Eun-Nam Kim, Gil-Saeng Jeong

Source: Biomolecules, Vol 10, Iss 5, p 786 (2020)

Subject Terms: liquiritigenin, T cell activation, CD69, MAPK, atopic dermatitis, lymph nodes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/5/786; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/bad27e440b6b48c093e8313577d4fbdc

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models

Authors: Mahesh Ramalingam, Hyojung Kim, Yunjong Lee, Yun-Il Lee

Source: Frontiers in Aging Neuroscience, Vol 10 (2018)

Subject Terms: isoliquiritigenin, liquiritigenin, memory, Parkinson’s disease, Radix Glycyrrhizae, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnagi.2018.00348/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/3c0105014c3648c8b485599b9a907fea