Research Progress on Metabolism of Cereal Ferulic Acid Mediated by Gut Microbiota and Its Physiological Effects

Authors: LU Shiyi, CHENG Danyang, AN Mengda, LI Hongyan, WANG Jing

Source: Shipin Kexue, Vol 45, Iss 18, Pp 307-314 (2024)

Subject Terms: ferulic acid, existing forms, intestinal metabolism, metabolites, health effects, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-18-035.pdf; https://doaj.org/toc/1002-6630

Access URL: https://doaj.org/article/c224513a6a044057a647b97c0875afb7

Dysbiosis of intestinal microbiota and metabolism caused by acute patulin exposure in mice

Authors: Ting Zhang, Zimeng Guo, Jiayin Che, Min Yan, Jingyimei Liang, Furong Wang, Jinhong Hu, Wei Song, Yahong Yuan, Tianli Yue

Source: Food Frontiers, Vol 5, Iss 4, Pp 1819-1832 (2024)

Subject Terms: gut microbiota, intestinal metabolism, patulin, SCFAs, tryptophan metabolism, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://doaj.org/toc/2643-8429

Access URL: https://doaj.org/article/f4002b2432134f30b5420a055e0712af

Nanometabolomics elucidated oral Mo2C nanozyme-based therapy towards sleep deprivation-induced intestinal metabolic disorders via the regulation of ROS-related metabolism

Authors: Zhang, Dingkun ^{a, b}, Liu, Yumeng ^{a, b}, Dai, Yaru ^{a, b}, Zeng, Yu ^{a, b}, Sun, Tong ^c, Liang, Ge ^d, Zheng, Wen ^d, Gui, Luolan ^d, Li, Xin ^{a, b}, Hu, Xinyi ^{a, b}, Fan, Rong ^{e, f}, Lu, Yang ^{e, f}, Li, Tao ^g, Yang, Hao ^{a, b}, Cheng, Jingqiu ^{a, b}, Guan, Junwen ^{c, ⁎⁎}, Gong, Meng ^{a, b, ⁎}

Source: In Carbon February 2025 233

Flumethrin exposure perturbs gut microbiota structure and intestinal metabolism in honeybees (Apis mellifera)

Authors: Liu, Jianhui ^{a, b}, Shi, Jingliang ^c, Hu, Yueyang ^{a, b}, Su, Yuchen ^{a, b}, Zhang, Yonghong ^{a, b}, Wu, Xiaobo ^{a, b, ⁎}

Source: In Journal of Hazardous Materials 5 December 2024 480

Ginger polysaccharide alleviates the effects of acute exposure to carbonate in crucian carp (Carassius auratus) by regulating immunity, intestinal microbiota, and intestinal metabolism

Authors: Xianwei Meng, Liang Luo, Zhigang Zhao, Shihui Wang, Rui Zhang, Kun Guo

Source: Ecotoxicology and Environmental Safety, Vol 273, Iss , Pp 116127- (2024)

Subject Terms: Ginger polysaccharide, Carassius auratus, Carbonate alkalinity stress, Intestinal microbiota, Intestinal metabolism, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651324002021; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/a2339f69136545a29e7a9df462aabf25

Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to NutrientsSummary

Authors: Heather A. McCauley, Anne Marie Riedman, Jacob R. Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A. Lang, James M. Wells

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1293-1310 (2023)

Subject Terms: Enteroendocrine Cells, Intestinal Metabolism, Mitochondria, Intestinal Stem Cell, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X22002673; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/1572cbb0e6804874852f6a419b62b436

Composition and functional profiles of gut microbiota reflect the treatment stage, severity, and etiology of acute pancreatitis

Authors: Zhenjiang Wang, Mingyi Guo, Jing Li, Chuangming Jiang, Sen Yang, Shizhuo Zheng, Mingzhe Li, Xinbo Ai, Xiaohong Xu, Wenbo Zhang, Xingxiang He, Yinan Wang, Yuping Chen

Source: Microbiology Spectrum, Vol 11, Iss 5 (2023)

Subject Terms: acute pancreatitis, gut microbiota, metagenomic sequencing, intestinal metabolism, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/bac87a8cfdcd445e9eacbea38d0b38b3

In Vitro Stability and Pharmacokinetic Study of Pedunculoside and Its Beta-CD Polymer Inclusion Complex

Authors: Liang Wu, Danfeng Li, Peijing Wang, Linling Dong, Wang Zhang, Jianjun Xu, Xiaoliang Jin

Source: Pharmaceutics, Vol 16, Iss 5, p 591 (2024)

Subject Terms: pedunculoside, pedunculoside–βCDP, pharmacokinetic behavior, LC-MS/MS, method validation, intestinal metabolism, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/5/591; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/17a62663dfe347d9b94b647a0c7f9fe6

Regional Intestinal Drug Absorption

Contributors: Gonzalez-Alvarez, Maria Isabel, Dahan, Arik

Subject Terms: bioequivalence, Biopharmaceutics Classification System, in vitro, dissolution test, pravastatin, oral absorption, in silico modeling, GastroPlus, Phoenix WinNonlin, pharmacokinetics, clinical studies, ibuprofen, manometry, gastrointestinal, mechanistic modeling, PBPK, PBBM, disintegration, dissolution, enteric-coated, ICH, quality control, regional intestinal permeability, permeation enhancers, absorption-modifying excipients, oral peptide delivery, intestinal perfusion, pharmaceutical development, controlled release drug product, biopharmaceutics classification system, drug solubility, drug permeability, location-dependent absorption, segregated flow intestinal model (SFM), traditional model (TM), route-dependent intestinal metabolism, first-pass effect, drug-drug interactions, DDI, in vitro in vivo extrapolations, IVIVE, zero-order absorption, first-order absorption, combined zero- and first-order absorption, transit compartment absorption model, in situ perfusion, microdevices, shape, mucoadhesion, colon absorption, nutrient digestion, nutrient absorption, gastrointestinal hormone, postprandial glycaemia, energy intake, region of the gut, obesity, type 2 diabetes, Franz–PAMPA, BCS drugs, biomimetic membrane, Franz cell, passive drug transport, BCS class IV drugs, segmental-dependent intestinal permeability, intestinal absorption, oral drug delivery, biopharmaceutics, physiologically-based pharmacokinetic (PBPK) modeling, furosemide, intestinal permeability, human colon carcinoma cell layer (Caco-2), hierarchical support vector regression (HSVR), drug absorption, drug solubility/dissolution, regional/segmental-dependent permeability and absorption, Medicine and Nursing, Manufacturing industries

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/81051
https://mdpi.com/books/pdfview/book/5393

Significant alterations of intestinal symbiotic microbiota induced by intraperitoneal vaccination mediate changes in intestinal metabolism of NEW Genetically Improved Farmed Tilapia (NEW GIFT, Oreochromis niloticus)

Authors: Zhenbing Wu, Qianqian Zhang, Jicheng Yang, Jinyong Zhang, Jie Fu, Chenyuan Dang, Mansen Liu, Shuyi Wang, Yaoyao Lin, Jingwen Hao, Meiqi Weng, Derong Xie, Aihua Li

Source: Microbiome, Vol 10, Iss 1, Pp 1-18 (2022)

Subject Terms: Nile tilapia, Inactivated vaccination, Symbiotic microbiota, High-throughput sequencing, Intestinal metabolism, Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2049-2618

Access URL: https://doaj.org/article/572bbb24e9f0469389d057e7a474208a

Drug Metabolism/Transport and Pharmacokinetics

Contributors: Song, Im-Sook

Subject Terms: tofacitinib, dose-dependent pharmacokinetics, hepatic and intestinal first-pass effect, rats, catalposide, in vitro human metabolism, UDP-glucuronosyltransferase, sulfotransferase, carboxylesterase, celecoxib, drug–drug interaction, fluorescence, HPLC, metabolism, repaglinide, HSG4112, anti-obesity agent, stereoselectivity, pharmacokinetics, compound K, protopanaxadiol (PPD), biliary excretion, intestinal metabolism, Carthamus tinctorius extract, notoginseng total saponins, comparative pharmacokinetic study, large volume direct injection, compatibility mechanism, mertansine, human hepatocytes, cytochrome P450, UDP-glucuronosyltransferases, sodium-glucose cotransporter 2 (SGLT2) inhibitors, DWP16001, kidney distribution, inhibition mode, diabetes, transporter-enzyme interplay, influx transporter, efflux transporter, physiologically based pharmacokinetic model, cytochrome P450 enzymes, tiropramide, healthy Korean subjects, modeling, population pharmacokinetic, quercetin, breast cancer resistance protein, inhibitor, prazosin, sulfasalazine, kinetic analysis, food–drug interactions, Caco-2, EpiIntestinal, first-pass, P-gp, BCRP, drug transporter, CYP3A4, oral availability, automatization, drug absorption, drug dosing, head-and-neck cancer, real-time measurements, taxanes, tissue engineering, UHPLC-MS/MS, metformin, verapamil, drug interaction, organic cation transporter 2, renal excretion, acute renal failure, gentamicin, cisplatin, hepatic CYP3A1(23), creatinine clearance, renal clearance, nonrenal clearance, Medicine and Nursing, Manufacturing industries

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/77070
https://mdpi.com/books/pdfview/book/4688

Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System

Authors: Satoshi Kondo, Masateru Miyake

Source: Pharmaceutics, Vol 15, Iss 12, p 2732 (2023)

Subject Terms: intestinal absorption, intestinal metabolism, transport index (TI), prediction, Ussing chamber, metabolites formation index (MFI), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/12/2732; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/a0cd1fb03a7f462cb15a704bd86b429a

L-arginine as a novel target for clinical intervention in inflammatory bowel disease

Authors: Björn Nüse, Jochen Mattner

Source: Exploration of Immunology, Vol 1, Iss 2, Pp 80-89 (2021)

Subject Terms: arginase-1, l-arginine, inflammatory bowel disease, colitis, gut microbiota, intestinal metabolism, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.explorationpub.com/Journals/ei/Article/10038; https://doaj.org/toc/2768-6655

Access URL: https://doaj.org/article/795628a54bfe46eca020af5f2c59efd8

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

Authors: Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki

Source: BMC Biotechnology, Vol 20, Iss 1, Pp 1-10 (2020)

Subject Terms: Mammalian artificial chromosome, Chromosome transfer, Cytochrome P450, Intestinal metabolism, Caco-2 cell, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12896-020-00637-8; https://doaj.org/toc/1472-6750

Access URL: https://doaj.org/article/d02bc38d5e334fcda8409a89edc1ab1b

Effects of Maren Pills on the Intestinal Microflora and Short-Chain Fatty Acid Profile in Drug-Induced Slow Transit Constipation Model Rats

Authors: Yu Zhan, Yong Wen, Li-juan Du, Xiao-xiang Wang, Shi-yu Tang, Peng-fei Kong, Wei-guo Huang, Xue-gui Tang

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: slow transit constipation, Maren pills, gut microbiota, intestinal metabolism, 5-HT pathway, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.804723/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/a8563192913346eda33f1edaa7a42301

Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine

Contributors: Konvalinka, Jan [Academy of Sciences of the Czech Republic (ASCR), Prague (Czech Republic). Gilead Sciences and IOCB Research Centre. Inst. of Organic Chemistry and Biochemistry; Charles Univ., Prague (Czech Republic). Dept. of Biochemistry]

Source: Journal of Biological Chemistry; 290; 18

File Description: Medium: ED; Size: p. 11321-11336

Access URL: http://www.osti.gov/scitech/servlets/purl/1251224

Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation

Authors: Esther Mezhibovsky, Kim A. Knowles, Qiyue He, Ke Sui, Kevin M. Tveter, Rocio M. Duran, Diana E. Roopchand

Source: Frontiers in Nutrition, Vol 8 (2021)

Subject Terms: hepatic steatosis, energy expenditure, Akkermansia muciniphila, butyrate, intestinal metabolism, Western diet, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnut.2021.675267/full; https://doaj.org/toc/2296-861X

Access URL: https://doaj.org/article/8cf641094d81498f9823e669254cd222

Comparable Intestinal and Hepatic First-Pass Effect of YL-IPA08 on the Bioavailability and Effective Brain Exposure, a Rapid Anti-PTSD and Anti-Depression Compound

Authors: You Gao, Chunmiao Yang, Lingchao Wang, Yanan Xiang, Wenpeng Zhang, Yunfeng Li, Xiaomei Zhuang

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: YL-IPA08, pharmacokinetics, bioavailability, hepatic metabolism, intestinal metabolism, brain exposure, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.588127/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/558ecd5119e3476d9479e8a9141c78d2

The Intestinal and Biliary Metabolites of Ibuprofen in the Rat with Experimental Hyperglycemia

Authors: Hawsar Othman Mohammed, Attila Almási, Szilárd Molnár, Pál Perjési

Source: Molecules, Vol 27, Iss 13, p 4000 (2022)

Subject Terms: ibuprofen, streptozotocin, hyperglycemia, intestinal metabolism, hepatic metabolism, HPLC-MS, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/13/4000; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/985de48e183047cc9c48bfddf8dceb0c

Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue

Authors: Zoe Coombes, Katie Plant, Cristina Freire, Abdul W. Basit, Philip Butler, R. Steven Conlan, Deyarina Gonzalez

Source: Pharmaceutics, Vol 13, Iss 10, p 1707 (2021)

Subject Terms: progesterone, intestinal metabolism, liver metabolism, aldo keto reductase, AKR, aldehyde oxidase, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/10/1707; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/d119133376384a938c97f70eee5b6048