Hyperforin-induced gut microbiota metabolite carbocysteine protects against depressive-like behaviors in mice by modulating the colonic mucus barrier

Authors: Zhang, Zheng ^{a, b, ⁎}, Xing, Bo ^{a, b}, Liu, Xuhui ^{a, b}, Shi, Kaixuan ^{a, b}, Chen, Qingjie ^{c, ⁎⁎}

Source: In Journal of Affective Disorders 1 July 2025 380:620-630

Preventive effect of hyperforin on lipopolysaccharide-induced acute kidney injury and inflammation by repressing the NF-κB/miR-21 axis

Authors: Haozhe Fan, Xiao He, Hongjie Tong, Kun Chen

Source: Central European Journal of Immunology, Vol 49, Iss 2, Pp 169-186 (2024)

Subject Terms: sepsis, acute kidney injury, mir-21, hyperforin, apoptosis, Medicine

File Description: electronic resource

Relation: https://www.termedia.pl/Preventive-effect-of-hyperforin-on-lipopolysaccharide-induced-acute-kidney-injury-and-inflammation-by-repressing-the-NF-B-miR-21-axis,10,54276,1,1.html; https://doaj.org/toc/1426-3912; https://doaj.org/toc/1644-4124

Access URL: https://doaj.org/article/3ee38d0a63254f33893b79b2236c36c0

Antimicrobial and Antiherpetic Properties of Nanoencapsulated Hypericum perforatum Extract

Authors: Yoana Sotirova, Nadezhda Ivanova, Neli Ermenlieva, Neli Vilhelmova-Ilieva, Lora Simeonova, Miroslav Metodiev, Viliana Gugleva, Velichka Andonova

Source: Pharmaceuticals, Vol 18, Iss 3, p 366 (2025)

Subject Terms: antibacterial activity, antifungal activity, antimicrobial activity, antiviral activity, herpesvirus, hyperforin, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/18/3/366; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/3a0587d6e820461682327eed940e50fc

Hyperforin-mediated anticancer mechanisms in MDA-MB-231 cell line: insights into apoptotic mediator modulation and caspase activation

Authors: Muttiah Barathan, Ahmad Khusairy Zulpa, Kumutha Malar Vellasamy, Zaridatul Aini Ibrahim, See Mee Hoong, Vanitha Mariappan, Gopinath Venkatraman, Jamuna Vadivelu

Source: Journal of Taibah University for Science, Vol 17, Iss 1 (2023)

Subject Terms: Apoptosis, breast cancer, caspase, hyperforin, paclitaxel, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1658-3655

Access URL: https://doaj.org/article/56533d95ac5c4f95a34408c00f10b773

Tissue Regeneration and Remodeling in Rat Models after Application of Hypericum perforatum L. Extract-Loaded Bigels

Authors: Yoana Sotirova, Yoana Kiselova-Kaneva, Deyana Vankova, Oskan Tasinov, Diana Ivanova, Hristo Popov, Minka Hristova, Krastena Nikolova, Velichka Andonova

Source: Gels, Vol 10, Iss 5, p 341 (2024)

Subject Terms: hyperforin, inflammation, St. John’s wort, TNF-α, wound healing, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65

File Description: electronic resource

Relation: https://www.mdpi.com/2310-2861/10/5/341; https://doaj.org/toc/2310-2861

Access URL: https://doaj.org/article/152f188022374908a85c91317c897875

Paradox Role of Oxidative Stress in Cancer

Contributors: Domenicotti, Cinzia, Marengo, Barbara

Subject Terms: sonodynamic therapy, carbon doped titanium dioxide, sonosensitizers, ultrasound, cancer treatment, breast cancer treatment, radiotherapy, hematological malignancies, oxidative stress, lymphoma, leukemia, multiple myeloma, apoptosis, mitochondria, ultraviolet-C (UVC), withanolide, combined treatment, oral cancer, DNA damage, cancer therapy, immune system, Hypericum perforatum, hyperforin, reactive oxygen species, pH regulation, tumor prevention, tumor therapy, cancerogenesis, inflammatory signaling, natural compounds, pancreatic cancer, antitumor agents, coordination polymers, bioinorganic chemistry, cold atmospheric plasma, reactive oxygen and nitrogen species, nitrite, cancer stem cells, chemoresistance, glutathione, lipid peroxidation, ZEB-1, GPX4, ferroptosis, HO-1, Nrf2, cancer progression, patients, therapy, prognosis, biomarker, Eprenetapopt, Erastin, glutathione (GSH), SLC7A11, iron, NRF2, Medicine and Nursing, Oncology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/87477
https://mdpi.com/books/pdfview/book/5665

Hypericum perforatum: Traditional uses, clinical trials, and drug interactions

Authors: Seyedeh Zahra Nobakht, Maryam Akaberi, Amirhooshang Mohammadpour, Ali Tafazoli Moghadam, Ahmad Emami

Source: Iranian Journal of Basic Medical Sciences, Vol 25, Iss 9, Pp 1045-1058 (2022)

Subject Terms: clinical trials, hyperforin, hypericaceae, hypericin, hypericum perforatum, st. john’s wort, Medicine

File Description: electronic resource

Relation: https://ijbms.mums.ac.ir/article_20779_fcc3482524cc2535728514b73df242ba.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874

Access URL: https://doaj.org/article/a9fd0d3b96cc439798abfd0f7f40d6bb

Transplacental passage of hyperforin, hypericin, and valerenic acid

Authors: Deborah Spiess, Vanessa Fabienne Abegg, Antoine Chauveau, Joshua Rath, Andrea Treyer, Michael Reinehr, Sabrina Kuoni, Mouhssin Oufir, Olivier Potterat, Matthias Hamburger, Ana Paula Simões-Wüst

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: hyperforin, hypericin, valerenic acid, Hypericum perforatum, Valeriana officinalis, placental perfusion, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1123194/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1eefad6644e44b5a8fd8513a0ff5693e

Bigel formulations of St. John’s wort extract in wound healing: toxicological aspects

Authors: Yoana Sotirova, Deyana Vankova, Oskan Tasinov, Stefka Stoeva, Minka Hristova, Ivelin Iliev, Svetlana Georgieva, Yoana Kiselova-Kaneva, Velichka Andonova

Source: Biotechnology & Biotechnological Equipment, Vol 37, Iss 1 (2023)

Subject Terms: Bigels, hyperforin, QSAR, Hypericum perforatum, in vivo toxicity, wounds, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1310-2818; https://doaj.org/toc/1314-3530

Access URL: https://doaj.org/article/8d988ea9e82340fd8c0798c21b7e3707

Mitochondria in Health and Diseases

Contributors: Javadov, Sabzali, Kozlov, Andrey V., Camara, Amadou K.S.

Subject Terms: hypoglycemia, sodium dichloroacetate, pyruvate dehydrogenase kinase, pyruvate dehydrogenase, oxidative stress, neuron death, cholangiocellular carcinoma, mitochondria, energy metabolism, oxidative phosphorylation, 4-HNE, DRP1, ERK1/2, hippocampus, JNK, mitochondrial dynamics, PKA, protein phosphatases, TUNEL, DDE, high-fat diet, mitochondrial UCP2, ROS, antioxidant system, uncoupling protein, mitochondria: energy metabolism, lipid handling, fatty acid oxidation, potassium channel, reactive oxygen species, antioxidants, life span, aging, BKCa channels, pravastatin, gemfibrozil, liver, colon, mitochondrial function, cyclosporin A, mitochondria calcium buffering, mitochondria bioenergetics, mitochondria permeability transition pore, inorganic phosphate, hepatic fibrogenesis, HtrA2/Omi, reactive oxygen species stress, mitochondrial homeostasis, complex I (CI) deficiency, metabolome and proteome profiling, reactive oxygen species (ROS), respirasome assembly, electron tunneling (ET), perilipin 5, lipid droplet, H9c2 cardiomyoblasts, adenine nucleotide translocase, respiratory supercomplexes, ETC complexes, dentate granule cell, epilepsy, hyperforin, LONP1, neuroprotection, pilocarpine, seizure, siRNA, cardioprotection, mitochondrial permeability transition pores, mitochondrial connexin 43, cardiolipin, iron overload, hepcidin, transferrin, ferritin, ZIP, inflammation, mtDNA, mitochondrial dysfunction, muscle aging, physical performance, LHON, Siberian population, ancient mutation, specific genetic background, apoptosis, human amniotic membrane, mitochondrial cell death, BAX, BCL-2, tensile strength, mitochondrial gene expression, mtDNA transcription, mtRNA, post-transcriptional mtRNA processing, dsRNA, innate immunity, interferon response, amino acid neurotransmitter, cerebellar amino acid metabolism, hypoxia, 2-oxoglutarate dehydrogenase, tricarboxylic acid cycle, heart, cytoskeletal proteins, mitochondrial interactions, plectin, tubulin beta, signaling, GW9662, ischemia reperfusion injury, Langendorff, myocardial, pioglitazone, redox state, rosiglitazone, TZD, uncoupling, ADP/ATP carrier, KmADP, dextran, morphology, cardiomyocytes, telomere length, telomerase activity, development, regeneration, intranuclear mitochondria, healthy cells, electron and confocal microscopy, signaling pathways, ion homeostasis, human diseases, Medicine and Nursing

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/69023
https://mdpi.com/books/pdfview/book/2792

BIOLOGICAL ACTIVITY OF HYPERICUM PERFORATUM L. (HYPERICACEAE): A REVIEW

Authors: A. L. Budantsev, V. A. Prikhodko, I. V. Varganova, S. V. Okovityi

Source: Фармация и фармакология (Пятигорск), Vol 9, Iss 1, Pp 17-31 (2021)

Subject Terms: st. john's wort, antidepressant, neuroprotective, nootropic, anxiolytic, antibacterial, cytotoxic, hypoglycemic activity, hypericin, hyperforin, amentoflavone, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.pharmpharm.ru/jour/article/view/793; https://doaj.org/toc/2307-9266; https://doaj.org/toc/2413-2241

Access URL: https://doaj.org/article/4df3eb38159743baad69741a2b0c4706

Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice

Authors: Bartłomiej Pochwat, Paulina Misztak, Julia Masternak, Ewa Bączyńska, Krystian Bijata, Matylda Roszkowska, Monika Bijata, Jakub Włodarczyk, Małgorzata Szafarz, Elżbieta Wyska, Bożena Muszyńska, Agata Krakowska, Włodzimierz Opoka, Gabriel Nowak, Bernadeta Szewczyk

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: refractory depression, ketamine, hyperforin and lanicemine, zinc deficiency, chronic stress, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.933364/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b358d4e3043d414eb1864ae94ad23e41

Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties

Authors: Ala Mohagheghzadeh, Parmis Badr, Abdolali Mohagheghzadeh, Shiva Hemmati

Source: Pharmaceuticals, Vol 16, Iss 6, p 887 (2023)

Subject Terms: bile acid, bioactive compounds, cholesterol, p-coumaric acid, hypericin, hyperforin, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/6/887; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/c9dee431dd894365b4ec7763ecf32e2e

Bigel Formulations of Nanoencapsulated St. John’s Wort Extract—An Approach for Enhanced Wound Healing

Authors: Yoana Sotirova, Viliana Gugleva, Stanila Stoeva, Iliyan Kolev, Rositsa Nikolova, Maria Marudova, Krastena Nikolova, Yoana Kiselova-Kaneva, Minka Hristova, Velichka Andonova

Source: Gels, Vol 9, Iss 5, p 360 (2023)

Subject Terms: biphasic gels, hyperforin, Hypericum perforatum, nanostructured lipid carriers, wounds, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65

File Description: electronic resource

Relation: https://www.mdpi.com/2310-2861/9/5/360; https://doaj.org/toc/2310-2861

Access URL: https://doaj.org/article/8909c72938414b109efa34f924d59ce0

A comparison of artificial intelligence techniques for predicting hyperforin content in Hypericum perforatum L. in different ecological habitats

Authors: Maryam Saffariha, Ali Jahani, Reza Jahani

Source: Plant Direct, Vol 5, Iss 11, Pp n/a-n/a (2021)

Subject Terms: artificial intelligence, ecological modeling, graphical user interface, hyperforin, Hypericum perforatum, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/2475-4455

Access URL: https://doaj.org/article/29fb0757746e46b0a1e0bb712d1a880a

Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A–Producing γδ T Cells

Authors: Song Zhang, Jia Zhang, Juanjuan Yu, Xiaolu Chen, Fangyuan Zhang, Wei Wei, Lingyun Zhang, Wenmao Chen, Nengxing Lin, Yan Wu

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: IL-17A, psoriasis, hyperforin, γδT cells, Stat3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.635076/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/6d1a0d983c2f4913819e9e734b9a162c

Production of St. John's Wort Plants under Controlled Environment for Maximizing Biomass and Secondary Metabolites

Authors: Saxena, P. K.

Source: In Vitro Cellular & Developmental Biology. Plant, 2004 Jan 01. 40(1), 108-114.

Access URL: https://www.jstor.org/stable/4293703

Investigation of the effect of hyperforin and hypericin on inflammatory response in RAW 264.7 macrophages

Authors: Mehmet Berköz, Oruc Allahverdiyev, Metin Yıldırım

Source: Van Tıp Dergisi, Vol 25, Iss 2, Pp 124-131 (2018)

Subject Terms: hypericin, hyperforin, raw 264.7, nitric oxide, prostaglandin e2, Medicine

File Description: electronic resource

Relation: https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-07769; https://doaj.org/toc/2587-0351

Access URL: https://doaj.org/article/cb2ee95b85df44ed9389d130abde9dcd

Hyperforin Promotes Post-stroke Neuroangiogenesis via Astrocytic IL-6-Mediated Negative Immune Regulation in the Ischemic Brain

Authors: Hua Yao, Yujing Zhang, Huaqing Shu, Bing Xie, Yuanfa Tao, Yin Yuan, You Shang, Shiying Yuan, Jiancheng Zhang

Source: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Subject Terms: hyperforin, IL-6, immunity, ischemic stroke, neuroangiogenesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fncel.2019.00201/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/c23f761ba69146e0b63a6bdf4468ef04

Bioactive compounds from Hypericum humifusum and Hypericum perfoliatum: inhibition potential of polyphenols with acetylcholinesterase and key enzymes linked to type-2 diabetes

Authors: Afef Béjaoui, Issam Ben Salem, Nesrine Rokbeni, Yassine M’rabet, Mohamed Boussaid, Abdennacer Boulila

Source: Pharmaceutical Biology, Vol 55, Iss 1, Pp 906-911 (2017)

Subject Terms: hypericum species, hypericin, hyperforin, antioxidant, enzyme inhibitory, antimicrobial, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

Access URL: https://doaj.org/article/6b16f7fb13a94bfdbd4017e6fc4825cb