Preclinical Models of Hepatocellular Carcinoma: Current Utility, Limitations, and Challenges

Authors: Antonio Cigliano, Weiting Liao, Giovanni A. Deiana, Davide Rizzo, Xin Chen, Diego F. Calvisi

Source: Biomedicines, Vol 12, Iss 7, p 1624 (2024)

Subject Terms: liver cancer, genetically engineered mice, hydrodynamic gene delivery, organoids, signaling pathways, precision medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/7/1624; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b14a71e1dcc342b2839dfb7a55032f4d

Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy

Authors: Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

Source: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 903-913 (2023)

Subject Terms: MT: Delivery Strategies, hydrodynamic gene delivery, large animal, gene therapy, baboon, hemophilia, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123001336; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/d2e1e76ad0ef44c494e670b26a7f8fe2

Transcription Factor Binding Site in Promoter Determines the Pattern of Plasmid-Based Transgene Expression In Vivo

Authors: Chunbo Zhang, Dexi Liu

Source: Pharmaceutics, Vol 16, Iss 4, p 544 (2024)

Subject Terms: promoter, transcription factor binding site, gene expression regulation, gene therapy, nonviral vector, hydrodynamic gene delivery, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/4/544; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/eff0b28cc1a3471abf29524ce547dd8a

CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice

Authors: Mingzhi Ren, Jianfei Pan, Xueying Yu, Kaile Chang, Xiaopeng Yuan, Chunbo Zhang

Source: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-17 (2022)

Subject Terms: CTRP1, Hydrodynamic gene delivery, Glucose homeostasis, Fatty liver, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/64c58f7a54ac423b8e8723c399c2ba23

Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

Authors: Osamu Shibata, Kenya Kamimura, Yuto Tanaka, Kohei Ogawa, Takashi Owaki, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Shuji Terai

Source: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 342-352 (2022)

Subject Terms: delivery strategies, pancreatic cancer, animal model, gene delivery, hydrodynamic gene delivery, oncogene, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253122000683; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/06496c299510468bace0c2f71ac60a07

Enhancing the expression of a key mitochondrial enzyme at the inception of ischemia-reperfusion injury can boost recovery and halt the progression of acute kidney injury

Authors: Peter R. Corridon

Source: Frontiers in Physiology, Vol 14 (2023)

Subject Terms: IDH2 [isocitrate dehydrogenase 2 (NADP+) and mitochondrial], gene delivery, acute kidney injury, hydrodynamic injections, ischemia-reperfusion injury (I/R), hydrodynamic gene delivery, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1024238/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/599c7086c6c840ffb2be379435e0b8dc

Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats

Authors: Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

Source: Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 80-88 (2017)

Subject Terms: gene therapy, hydrodynamic gene delivery, non-viral vectors, pancreas, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253117302378; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/5e516df0cd104238ada376bb8d56549b

Site-Specific Impact of a Regional Hydrodynamic Injection: Computed Tomography Study during Hydrodynamic Injection Targeting the Swine Liver

Authors: Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Kenya Kamimura, Dexi Liu, Shuji Terai

Source: Pharmaceutics, Vol 7, Iss 3, Pp 334-343 (2015)

Subject Terms: hydrodynamic gene delivery, swine, computed tomography, interventional radiology, regional application, hemodynamics, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4923/7/3/334; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/6c09157b27fd4718a9b7d63bfd94a476

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

Authors: Daniella Kovacsics, author¹, Jayne Raper, author¹

Source: Journal of Visualized Experiments. (87)

Availability: http://www.jove.com/video/51481

Expression of Human Cytokines Dramatically Improves Reconstitution of Specific Human-Blood Lineage Cells in Humanized Mice

Authors: Chen, Qingfeng, Khoury, Maroun, Chen, Jianzhu, Eisen, Herman N.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Dec 01. 106(51), 21783-21788.

Access URL: https://www.jstor.org/stable/40536173

Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model

Authors: Hiroyuki Abe, Kenya Kamimura, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Riuko Ohashi, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

Source: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

Subject Terms: gene therapy, hydrodynamic gene delivery, liver cirrhosis, MMP13, nucleic acids delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253117300057; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/95f3eb7577674372b50386444c905a77

Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery

Authors: Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

Source: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

Subject Terms: gene therapy, hydrodynamic gene delivery, liver fibrosis, MMP13, nonviral gene delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225311730077X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/bd47aac2c9bc46bd8ee49e0bb643f102

Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver

Authors: Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

Source: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)

Subject Terms: gene therapy, human α-1 antitrypsin, hydrodynamic gene delivery, image-guided gene delivery, non-viral vector, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253116301846; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/2799f2c6b83d4b2f889d35e7c6afb7cf

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