Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer

Authors: Bhoomi Tarapara, Franky Shah

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-12 (2025)

Subject Terms: Hereditary breast and ovarian cancer, DNA damage repair, Peripheral blood, Real time PCR, BRCA1, BRCA2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/0c58748db1ce4868b4307a1e6a9c3a07

Pattern Anlysis of Risk-Reducing Strategies in Unaffected Korean BRCA1/2 Mutation Carriers

Authors: Dabin Kim, Jai Min Ryu, Sang-Ah Han, Zisun Kim, Sung-Won Kim

Source: Current Oncology, Vol 31, Iss 11, Pp 6767-6777 (2024)

Subject Terms: hereditary breast and ovarian cancer syndrome, BRCA1 gene, BRCA2 gene, prophylactic mastectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/31/11/499; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/153c231351304580b5ff1462c0c95298

Joint analysis of germline genetic data from over 29,000 cases with suspected hereditary breast and ovarian cancer (HBOC) as part of the NASGE initiative

Authors: Jan Henkel, Andreas Laner, Melanie Locher, Tobias Wohlfrom, Birgit Neitzel, Kerstin Becker, Teresa Neuhann, Angela Abicht, Verena Steinke-Lange, Barbara Klink, Birgit Eichhorn, Winfried Schmidt, Daniel Berner, Anna Teubert, Anne Holtorf, Sarah Heinrich, Gabriele Wildhardt, Martin Schulze, Laura von der Heyden, Konstanze Hörtnagel, Daniela Steinberger, Saskia Kleier, Peter Lorenz, Ralf Glaubitz, Saskia Biskup, Elke Holinski-Feder

Source: Breast, Vol 80, Iss , Pp 103887- (2025)

Subject Terms: Genetic testing, Hereditary breast and ovarian cancer syndrome, Gene panel testing, Genetic predisposition to disease, Neoplastic syndromes, Hereditary, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977625000165; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/fe72cde4a9a245eca1156db5b8eaf5bf

Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients with Gastric Cancer Associated with Hereditary Breast and Ovarian Cancer

Authors: Takuma Hayashi, Kenji Sano, Mako Okada, Manabu Muto, Ikuo Konishi

Source: Current Oncology, Vol 31, Iss 11, Pp 6723-6734 (2024)

Subject Terms: gastric cancer, Helicobacter pylori, BRCA1, BRCA2, hereditary breast and ovarian cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/31/11/496; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/3648020812d84c3f904ebf430bbe43af

Clinicopathological Characteristics of Multiple Primary Malignancies Involving Female Genital Tract at a Tertiary Cancer Institute of Northeast India

Authors: Eshwarya Jessy Kaur, Debabrata Barmon, Upasana Baruah, Dimpy Begum

Source: Journal of Mid-Life Health, Vol 15, Iss 3, Pp 161-166 (2024)

Subject Terms: hereditary breast and ovarian cancer, metachronous malignancy, multiple primary malignancies, synchronous malignancy, Gynecology and obstetrics, RG1-991, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/jmh.jmh_55_24; https://doaj.org/toc/0976-7800; https://doaj.org/toc/0976-7819

Access URL: https://doaj.org/article/575b42b2a3a74e66b9304657f74348e6

Clinical significance of germline breast cancer susceptibility gene (gBRCA) testing and olaparib as maintenance therapy for patients with pancreatic cancer

Authors: Yasuharu Kawamoto, Takuo Yamai, Kenji Ikezawa, Yusuke Seiki, Ko Watsuji, Takeru Hirao, Makiko Urabe, Yugo Kai, Ryoji Takada, Kaori Mukai, Tasuku Nakabori, Hiroyuki Uehara, Tazuko Inoue, Fumie Fujisawa, Kazuyoshi Ohkawa

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)

Subject Terms: BRACAnalysis, Family history, FOLFIRINOX, Hereditary Breast and Ovarian Cancer syndrome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/6292ec4d6d2d45238af47a573faf3db0

Systematic review of the molecular basis of hereditary breast and ovarian cancer syndrome in Brazil: the current scenario

Authors: Andreza Amália de Freitas Ribeiro, Nilson Moreira Cipriano Junior, Luciana Lara dos Santos

Source: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-15 (2024)

Subject Terms: HBOC in Brazil, Hereditary breast and ovarian cancer, BRCA mutations, Systematic review, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/45dc33f9888046afbe4c91434381fd32

Counselling Framework for Germline BRCA1/2 and PALB2 Carriers Considering Risk-Reducing Mastectomy

Authors: Stephanie M. Wong, Carla Apostolova, Elisheva Eisenberg, William D. Foulkes

Source: Current Oncology, Vol 31, Iss 1, Pp 350-365 (2024)

Subject Terms: breast neoplasms, BRCA1, BRCA2, hereditary breast and ovarian cancer syndrome, mastectomy, cancer prevention, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/31/1/23; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/4fef363ae06e4271a6274bf5562e7357

Direct letters to relatives at risk of hereditary cancer—study protocol for a multi-center randomized controlled trial of healthcare-assisted versus family-mediated risk disclosure at Swedish cancer genetics clinics (DIRECT-study)

Authors: Carolina Hawranek, Hans Ehrencrona, Anna Öfverholm, Barbro Numan Hellquist, Anna Rosén

Source: Trials, Vol 24, Iss 1, Pp 1-15 (2023)

Subject Terms: Hereditary breast and ovarian cancer, Genetic testing, Lynch syndrome, Randomized controlled trial, Cancer prevention, Risk disclosure, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/c171f9874944417da3b8bc5f1fd6b6d3

Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience

Authors: Aya Tanaka, Megumi Matsumoto, Mami Takao, Shoko Miura, Yuri Hasegawa, Ryota Otsubo, Hiroko Hayashi, Ichiro Isomoto, Kiyonori Miura, Takeshi Nagayasu

Source: Hereditary Cancer in Clinical Practice, Vol 21, Iss 1, Pp 1-7 (2023)

Subject Terms: Hereditary breast and Ovarian cancer, BRCA1, BRCA2, Contralateral risk-reducing mastectomy, Risk-reducing salpingo-oophorectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1897-4287

Access URL: https://doaj.org/article/6dec25dad03446f4a033d672480e2e19

Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies

Authors: Jocelyn N. Plowman, Evanjalina J. Matoy, Lavanya V. Uppala, Samantha B. Draves, Cynthia J. Watson, Bridget A. Sefranek, Mark L. Stacey, Samuel P. Anderson, Michael A. Belshan, Elizabeth E. Blue, Chad D. Huff, Yusi Fu, Holly A.F. Stessman

Source: HGG Advances, Vol 5, Iss 3, Pp 100306- (2024)

Subject Terms: Cancer, Hereditary cancer, Lynch Syndrome, Hereditary breast and ovarian cancer (HBOC) syndrome, Targeted sequencing, Variants of undetermined significance, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247724000459; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/c20ab52b19624c2ebea28cfd72751227

Outcomes and the effect of PGT-M in women with hormone-related hereditary tumor syndrome

Authors: Dingran Wang, Xueling Song, Xiaohui Zhu, Liying Yan, Xu Zhi, Jie Yan, Huamao Liang, Jie Qiao

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: PGT, hereditary tumor syndrome, fertility preservation, HBOC (hereditary breast and ovarian cancer), lynch syndrome (hereditary non-polyposis colorectal cancer), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1378019/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/7024532d3e364e098667f882914bf950

Effectiveness of evidence-based decision aids for women with pathogenic BRCA1 or BRCA2 variants in the german health care context: results from a randomized controlled trial

Authors: Sibylle Kautz-Freimuth, Marcus Redaèlli, Arim Shukri, Hannah Kentenich, Dusan Simic, Vanessa Mildenberger, Rita Schmutzler, Kerstin Rhiem, Stephanie Stock

Source: BMC Medical Informatics and Decision Making, Vol 23, Iss 1, Pp 1-13 (2023)

Subject Terms: BRCA1 and BRCA2 variants, Decision aids, Decisional conflict, Decision-making, Hereditary breast and ovarian cancer, Preventive options, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6947

Access URL: https://doaj.org/article/e1ceec0835e54963a8510a52e9bd5632

Recurrent genetic variants and prioritization of variants of uncertain clinical significance associated with hereditary breast and ovarian cancer in families from the Region of Murcia

Authors: Rosado-Jiménez Laura, Mestre-Terkemani Younes, García-Aliaga Ángeles, Marín-Vera Miguel, Macías-Cerrolaza José Antonio, Sarabia-Meseguer María Desamparados, García-Hernández María Rosario, Zafra-Poves Marta, Sánchez-Henarejos Pilar, Ayala de la Peña Francisco, Alonso-Romero José Luis, Noguera-Velasco José Antonio, Ruiz-Espejo Francisco

Source: Advances in Laboratory Medicine, Vol 4, Iss 3, Pp 279-287 (2023)

Subject Terms: founder effect, mutational spectrum, prioritization, hereditary breast and ovarian cancer, variants of uncertain clinical significance, recurrent pathogenic variants, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/2628-491X

Access URL: https://doaj.org/article/73c1acb0fdf04f06ba103102eb3131ee

Risk management actions following genetic testing in the Cancer Health Assessments Reaching Many (CHARM) Study: A prospective cohort study

Authors: Boya Guo, Sarah Knerr, Tia L. Kauffman, Kathleen F. Mittendorf, Erin Keast, Marian J. Gilmore, Heather Spencer Feigelson, Frances L. Lynch, Kristin R. Muessig, Sonia Okuyama, Jamilyn M. Zepp, David L. Veenstra, Li Hsu, Amanda I. Phipps, Sara Lindström, Michael C. Leo, Katrina A. B. Goddard, Benjamin S. Wilfond, Beth Devine, the CHARM Study team

Source: Cancer Medicine, Vol 12, Iss 18, Pp 19112-19125 (2023)

Subject Terms: genetic testing, genomic sequencing, health service utilization, hereditary breast and ovarian cancer, hereditary cancer, Lynch syndrome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/2d62d587cd2049a98961c4d161f97529

Clinical implications of incorporating genetic and non-genetic risk factors in CanRisk-based breast cancer risk prediction

Authors: Anja Tüchler, Antoine De Pauw, Corinna Ernst, Amélie Anota, Inge M.M. Lakeman, Julia Dick, Nienke van der Stoep, Christi J. van Asperen, Monika Maringa, Natalie Herold, Britta Blümcke, Robert Remy, Anke Westerhoff, Denise J. Stommel-Jenner, Eléonore Frouin, Lisa Richters, Lisa Golmard, Nadine Kütting, Chrystelle Colas, Barbara Wappenschmidt, Kerstin Rhiem, Peter Devilee, Dominique Stoppa-Lyonnet, Rita K. Schmutzler, Eric Hahnen

Source: Breast, Vol 73, Iss , Pp 103615- (2024)

Subject Terms: Breast cancer, Genetic testing, Hereditary breast and ovarian cancer syndrome, Cancer prevention, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977623007415; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/f91dd96772b24b38a3d25235b52f3750

CA125 Levels in BRCA mutation carriers – a retrospective single center cohort study

Authors: P Gebhart, CF Singer, D Gschwantler-Kaulich

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-8 (2023)

Subject Terms: CA-125 antigen, Genes, BRCA1, Genes, BRCA2, Hereditary breast and ovarian cancer syndrome, Early detection of cancer, Ovarian neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/c71e31f709d24116840b3efd1810fae1

Distress, anxiety, and depression in persons with hereditary cancer syndromes: Results from a nationwide cross‐sectional study in Germany

Authors: Anna Maria Kastner, Josefine Fischer‐Jacobs, Jan Brederecke, Andrea Hahne, Tanja Zimmermann

Source: Cancer Medicine, Vol 12, Iss 12, Pp 13701-13711 (2023)

Subject Terms: anxiety, colorectal neoplasms, depression, hereditary, hereditary breast and ovarian cancer syndrome, hereditary nonpolyposis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/8d1e37437034457db0e67604c0077263

Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays

Authors: Nicola Bassi, Henrikke Nilsen Hovland, Kashif Rasheed, Elisabeth Jarhelle, Nikara Pedersen, Eunice Kabanyana Mchaina, Sara Marie Engelsvold Bakkan, Nina Iversen, Hildegunn Høberg-Vetti, Bjørn Ivar Haukanes, Per Morten Knappskog, Ingvild Aukrust, Elisabet Ognedal, Marijke Van Ghelue

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)

Subject Terms: Hereditary breast and ovarian cancer, BRCA1, Functional assay, Homologous recombination repair, Transcriptional activation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/3cfc411134d040d8a50b6bbb38b22097

Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

Authors: Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki‐Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata

Source: Cancer Medicine, Vol 12, Iss 6, Pp 6594-6602 (2023)

Subject Terms: Fanconi anemia, hereditary breast and ovarian cancer, BRCA1, BRCA2, ALDH2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/48f4ba75ffe041cd97eccb6be34eeb79