Hepatic and extra-hepatic metabolism of propylene glycol ethers in the context of central nervous system toxicity

Authors: Werner, Sophie ^{a, b, c}, Pamies, David ^{c, d}, Zurich, Marie-Gabrielle ^{c, d}, Suter-Dick, Laura ^{a, c, ⁎}

Source: In Toxicology March 2025 512

Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver

Authors: Monika Gjorgjieva, Nicolas Calo, Cyril Sobolewski, Dorothea Portius, Jean-Luc Pitetti, Flavien Berthou, Anne-Sophie Ay, Marion Peyrou, Lucie Bourgoin, Christine Maeder, Margot Fournier, Marta Correia de Sousa, Etienne Delangre, Laurent Vinet, Xavier Montet, Christine Sempoux, Serge Nef, Michelangelo Foti

Source: JHEP Reports, Vol 7, Iss 4, Pp 101305- (2025)

Subject Terms: Hepatic metabolism, Hepatocarcinogenesis, Insulin receptor, IGF-1 receptor, Steatosis, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924003094; https://doaj.org/toc/2589-5559

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Post-COVID metabolic enzyme alterations in K18-hACE2 mice exacerbate alcohol-induced liver injury through transcriptional regulation

Authors: Park, SiYeong ^{a, 1}, Lee, Youn Woo ^{b, 1}, Choi, Seunghoon ^{c, d, 1}, Jo, Harin ^a, Kim, NaHyun ^a, Cho, Sumin ^a, Lee, Eunji ^a, Choi, Eun-Bin ^a, Park, Inyoung ^a, Jeon, Young ^a, Noh, Hyuna ^{c, d}, Seok, Sang-Hyuk ^e, Oh, Seung Hyun ^f, Choi, Yang-Kyu ^g, Kwon, Ho-Keun ^h, Seo, Jun-Young ⁱ, Nam, Ki Taek ^{j, k}, Park, Jun Won ^e, Choi, Kang-Seuk ^l, Lee, Ho-Young ^{b, ⁎⁎⁎}, Yun, Jun-Won ^{a, ⁎⁎}, Seong, Je Kyung ^{c, d, m, ⁎}

Source: In Free Radical Biology and Medicine 1 March 2025 229:1-12

Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum

Authors: Alica Fischle, Ulrich Schreiber, Viola Haupt, Felix Schimang, Lina Schürmann, Matthias Behrens, Florian Hübner, Melanie Esselen, Dmitrii V. Kalinin, Svetlana A. Kalinina

Source: Frontiers in Fungal Biology, Vol 5 (2024)

Subject Terms: semi-synthesis, regioisomerism, Stachybotrys, genotoxicity, biological activity, hepatic metabolism, Plant culture, SB1-1110

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Relation: https://www.frontiersin.org/articles/10.3389/ffunb.2024.1494795/full; https://doaj.org/toc/2673-6128

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Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice

Authors: Macêdo, Ana Paula Azevêdo ^a, de Sousa Neto, Ivo Vieira ^b, Antonio, Guilherme Correia Ferri ^a, Gaspar, Rafael Calais ^c, de Lima, Robson Damasceno ^a, Dias, Larissa Moreira ^a, Vieira, Renan Fudoli Lins ^a, Muñoz, Vitor Rosetto ^b, Brunelli, Diego Trevisan ^a, da Silva, Adelino Sanchez Ramos ^b, Cintra, Dennys Esper ^{d, e}, Ropelle, Eduardo Rochete ^{a, e}, Pauli, José Rodrigo ^{a, e, ⁎}

Source: In Nutrition May 2025 133

2-Monoacylglycerol Mimetic Liposomes to Promote Intestinal Lymphatic Transport for Improving Oral Bioavailability of Dihydroartemisinin

Authors: Zheng B, Pan F, Shi M, He C, He B, Wang R, Ren G, Yang S, Zhang S

Source: International Journal of Nanomedicine, Vol Volume 19, Pp 5273-5295 (2024)

Subject Terms: intestinal lymphatic transport, biomimetic liposomes, first-pass hepatic metabolism, oral delivery, dihydroartemisinin, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/2-monoacylglycerol-mimetic-liposomes-to-promote-intestinal-lymphatic-t-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/0cce6f13ccdc43e1955a2da0c5ae20e8

Evaluating Hepatotoxicity: A Comparative Analysis of New Generation versus Historical Antiretroviral Agents

Authors: Simona-Alina Abu-Awwad, Ahmed Abu-Awwad, Madalina-Ianca Suba, Voichita Elena Lazureanu, Andrei-Daniel Bolovan, Ovidiu Rosca, Mirela-Mădălina Turaiche, Adela-Teodora Benea, Bogdan Hogea

Source: Infectious Disease Reports, Vol 16, Iss 3, Pp 423-434 (2024)

Subject Terms: HIV, antiretroviral therapy, liver metabolic health, hepatic metabolism, liver function, latest-generation ARV therapies, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://www.mdpi.com/2036-7449/16/3/31; https://doaj.org/toc/2036-7449

Access URL: https://doaj.org/article/340bcb9e33454f18924381217b159977

Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles: an approach of overcoming olanzapine drawbacks

Authors: Hirlekar Rajashree, Momin Alfiha, Bhairy Srinivas

Source: European Pharmaceutical Journal, Vol 71, Iss 1, Pp 1-15 (2024)

Subject Terms: olanzapine, hepatic metabolism, solid lipid nanoparticles, dry adsorbed nanoparticles, lymphatic uptake, oral bioavailability, Therapeutics. Pharmacology, RM1-950

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Relation: https://doaj.org/toc/2453-6725

Access URL: https://doaj.org/article/f91d8674dca84f7a984ea67f74ac5207

Suppression of NNK Metabolism by Anthocyanin-Rich Haskap Berry Supplementation Through Modulation of P450 Enzymes

Authors: Madumani Amararathna, David W. Hoskin, Kerry B. Goralski, H. P. Vasantha Rupasinghe

Source: Pharmaceuticals, Vol 17, Iss 12, p 1615 (2024)

Subject Terms: blue honeysuckle, cytochrome P450, hepatic metabolism, carcinogen, lung cancer, smoking, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/12/1615; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/d32184864719432ab6c7c1a7d95ec63f

Hepatic Transcriptomics of Broilers with Low and High Feed Conversion in Response to Caloric Restriction

Authors: Adewunmi O. Omotoso, Henry Reyer, Michael Oster, Siriluck Ponsuksili, Barbara Metzler-Zebeli, Klaus Wimmers

Source: Metabolites, Vol 14, Iss 11, p 625 (2024)

Subject Terms: meat-type chicken, resource allocation, restrictive feeding, mRNA profiling, hepatic metabolism, Microbiology, QR1-502

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Relation: https://www.mdpi.com/2218-1989/14/11/625; https://doaj.org/toc/2218-1989

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Changes in growth performance, gene expressions related to protein absorption and hepatic metabolism of triploid crucian carp (Carassius carassius triploid) caused by dietary protein level

Authors: Li He, Yuyang Cai, Xiang Tang, Xinting Li, Shenping Cao, Linhan Xu, Yang Xiao, Dang Li, Gaode Zhong, Peng Zeng, Yanan Luo, Haoyang Wangchen, Zhimin He, Zhen Liu

Source: Aquaculture Reports, Vol 35, Iss , Pp 102023- (2024)

Subject Terms: Carassius carassius triploid, Dietary protein level, Growth performance, Protein absorption, Hepatic metabolism, Aquaculture. Fisheries. Angling, SH1-691

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Relation: http://www.sciencedirect.com/science/article/pii/S235251342400111X; https://doaj.org/toc/2352-5134

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Growth performance, plasma and hepatic biochemistry of jundiá Rhamdia quelen fed dephytinized rice bran protein concentrate

Authors: BRUNO B. LOUREIRO, TAIDA J. ADORIAN, DIRLEISE PIANESSO, PATRÍCIA I. MOMBACH, NAGLEZI M. LOVATTO, ANA B.B. BENDER, CAROLINE S. SPERONI, FERNANDA R.G. FERRIGOLO, LEILA P. DA SILVA

Source: Anais da Academia Brasileira de Ciências, Vol 96, Iss 1 (2024)

Subject Terms: hepatic metabolism, nutrient deposition, phytic acid, protein concentrate, rice bran, Science

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000101301&tlng=en; https://doaj.org/toc/1678-2690

Access URL: https://doaj.org/article/6c173b1c895d43b4be357ce8509105f6

Integrated liver proteomics and metabolomics identify metabolic pathways affected by pantothenic acid deficiency in Pekin ducks

Authors: Jing Tang, Yongbao Wu, Bo Zhang, Suyun Liang, Zhanbao Guo, Jian Hu, Zhengkui Zhou, Ming Xie, Shuisheng Hou

Source: Animal Nutrition, Vol 11, Iss , Pp 1-14 (2022)

Subject Terms: Pantothenic acid, Hepatic metabolism, Proteomics, Metabolomics, Hypoglycemia, Animal culture, SF1-1100

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405654522000713; https://doaj.org/toc/2405-6545

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Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Authors: Muluneh M. Fashe, Taryn A. Miner, John K. Fallon, Amanda P. Schauer, Craig Sykes, Philip C. Smith, Craig R. Lee

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: pregnancy, targeted proteomics, CYP3A4, CYP3A5, hepatic metabolism, pregnancy related hormones, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1218703/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/5bf5aea07c3d46e3afd836d8b7b04fe3

Exercise during weight loss improves hepatic mitophagy

Authors: Megan E. Rosa-Caldwell, Kaylee E. Poole, Andrew Seija, Matthew P. Harris, Nicholas P. Greene, Joshua S. Wooten

Source: Sports Medicine and Health Science, Vol 4, Iss 3, Pp 183-189 (2022)

Subject Terms: Autophagy, High-fat diet, Mitochondria, Hepatic metabolism, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666337622000221; https://doaj.org/toc/2666-3376

Access URL: https://doaj.org/article/ba6774127c994e41a7346b5549a669d3

Drug Absorption Studies: In Situ, In Vitro and In Silico Models

Contributors: Song, Im-Sook

Subject Terms: rebamipide, nanocrystals, oral mucositis, hydrogel, endocytosis, enoxaparin, lipid–polymer hybrid nanoparticles, oral, intestinal absorption, naftidrofuryl oxalate, solubility, permeability, dissolution profiles, pharmaceutical availability, BCS drug classification, non-sink condition, solubility–permeability interplay, unstirred water layer, poorly soluble drugs, solubilizer additive, phenylketonuria, l-phenylalanine ammonia-lyase, enzyme, kinetics, catabolism disorder, biomedical drug, P-glycoprotein, breast cancer resistance protein, LY335979, WK-X-34, in vivo–in vitro correlation, lipolysis-permeation, lipid-based drug delivery system, PermeaPad, cinnarizine, lipolysis, amorphous solid dispersion, candesartan Cilexetil, PVPK30, pH-modulation, spray drying, bioavailability, nasal administration, spray-drying, chitosan, microsphere, meloxicam, silymarin, D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS), liver distribution, acetaminophen-induced hepatotoxicity, extra virgin olive oil, secoiridoids, metabolism, phenolic compounds, intestinal permeability, drug-phytochemical interaction, hepatic metabolism, mixed inhibition, quercetin, repaglinide, Medicine and Nursing, Manufacturing industries

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/77071
https://mdpi.com/books/pdfview/book/4689

In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542

Authors: Hyunki Cho, Young Jun Kim, Jung-Woo Chae, Markus R. Meyer, Sang Kyum Kim, Chang Seon Ryu

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: GRL0617, cytochrome P450, hepatic metabolism, LC-QTOF, human liver microsome, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1067408/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/a2b93a4d00ac4808bedcdc6e0f3a4072

Contemplating cannabis? The complex relationship between cannabinoids and hepatic metabolism resulting in the potential for drug-drug interactions

Authors: Rosemary T. Smith, Staci A. Gruber

Source: Frontiers in Psychiatry, Vol 13 (2023)

Subject Terms: medical cannabis, cannabidiol (CBD), drug-drug interaction (DDI), CYP450, hepatic metabolism, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1055481/full; https://doaj.org/toc/1664-0640

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Nicotinamide Riboside and Phycocyanin Oligopeptides Affect Stress Susceptibility in Chronic Corticosterone-Exposed Rats

Authors: Cemal Orhan, Emre Sahin, Mehmet Tuzcu, Nurhan Sahin, Abdullah Celik, Sara Perez Ojalvo, Sarah Sylla, James R. Komorowski, Kazim Sahin

Source: Antioxidants, Vol 12, Iss 10, p 1849 (2023)

Subject Terms: corticosterone, phycocyanin, nicotinamide riboside, NAD, hepatic metabolism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/10/1849; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/779a156425834b9288a6ddee36a5c77d

Dietary Curcumin Supplementation Could Improve Muscle Quality, Antioxidant Enzyme Activities and the Gut Microbiota Structure of Pelodiscus sinensis

Authors: Jia-Yuan Jiang, Hua Wen, Ming Jiang, Juan Tian, Li-Xue Dong, Ze-Chao Shi, Tong Zhou, Xing Lu, Hong-Wei Liang

Source: Animals, Vol 13, Iss 16, p 2626 (2023)

Subject Terms: Pelodiscus sinensis, reptile, dietary curcumin, antioxidant, hepatic metabolism, gut microbiome, Veterinary medicine, SF600-1100, Zoology, QL1-991

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Relation: https://www.mdpi.com/2076-2615/13/16/2626; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/6c62fe4823ed416fbb9aaa9645618e8e