Drug Metabolism/Transport and Pharmacokinetics

Contributors: Song, Im-Sook

Subject Terms: tofacitinib, dose-dependent pharmacokinetics, hepatic and intestinal first-pass effect, rats, catalposide, in vitro human metabolism, UDP-glucuronosyltransferase, sulfotransferase, carboxylesterase, celecoxib, drug–drug interaction, fluorescence, HPLC, metabolism, repaglinide, HSG4112, anti-obesity agent, stereoselectivity, pharmacokinetics, compound K, protopanaxadiol (PPD), biliary excretion, intestinal metabolism, Carthamus tinctorius extract, notoginseng total saponins, comparative pharmacokinetic study, large volume direct injection, compatibility mechanism, mertansine, human hepatocytes, cytochrome P450, UDP-glucuronosyltransferases, sodium-glucose cotransporter 2 (SGLT2) inhibitors, DWP16001, kidney distribution, inhibition mode, diabetes, transporter-enzyme interplay, influx transporter, efflux transporter, physiologically based pharmacokinetic model, cytochrome P450 enzymes, tiropramide, healthy Korean subjects, modeling, population pharmacokinetic, quercetin, breast cancer resistance protein, inhibitor, prazosin, sulfasalazine, kinetic analysis, food–drug interactions, Caco-2, EpiIntestinal, first-pass, P-gp, BCRP, drug transporter, CYP3A4, oral availability, automatization, drug absorption, drug dosing, head-and-neck cancer, real-time measurements, taxanes, tissue engineering, UHPLC-MS/MS, metformin, verapamil, drug interaction, organic cation transporter 2, renal excretion, acute renal failure, gentamicin, cisplatin, hepatic CYP3A1(23), creatinine clearance, renal clearance, nonrenal clearance, Medicine and Nursing, Manufacturing industries

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Access URL: https://directory.doabooks.org/handle/20.500.12854/77070
https://mdpi.com/books/pdfview/book/4688

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism

Authors: Ji Sang Lee, So Hee Kim

Source: Pharmaceutics, Vol 11, Iss 7, p 318 (2019)

Subject Terms: tofacitinib, dose-dependent pharmacokinetics, hepatic and intestinal first-pass effect, rats, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/11/7/318; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/61ba7f25c1d54996b7a7649e0da676d0