Clinical Melanoma Diagnosis with Artificial Intelligence: Insights from a Prospective Multicenter Study

Authors: Heinlein, Lukas, Maron, Roman C., Hekler, Achim, Haggenmüller, Sarah, Wies, Christoph, Utikal, Jochen S., Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F., Sergon, Mildred, Hauschild, Axel, French, Lars E., Heinzerling, Lucie, Schlager, Justin G., Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J., Poch, Gabriela, Korsing, Sören, Berking, Carola, Heppt, Markus V., Erdmann, Michael, Haferkamp, Sebastian, Drexler, Konstantin, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Krieghoff-Henning, Eva, Brinker, Titus J.

Subject Terms: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Statistics - Applications

Access URL: http://arxiv.org/abs/2401.14193

Using Multiple Dermoscopic Photographs of One Lesion Improves Melanoma Classification via Deep Learning: A Prognostic Diagnostic Accuracy Study

Authors: Hekler, Achim, Maron, Roman C., Haggenmüller, Sarah, Schmitt, Max, Wies, Christoph, Utikal, Jochen S., Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F., Sergon, Mildred, Hauschild, Axel, French, Lars E., Heinzerling, Lucie, Schlager, Justin G., Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J., Poch, Gabriela, Korsing, Sören, Berking, Carola, Heppt, Markus V., Erdmann, Michael, Haferkamp, Sebastian, Drexler, Konstantin, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Kather, Jakob N., Krieghoff-Henning, Eva, Brinker, Titus J.

Subject Terms: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2306.02800

Optimized monitoring for immune checkpoint inhibitor induced myocarditis using high-sensitivity troponin-T

Authors: Tomsitz, Dirk ^a, Grabmaier, Ulrich ^b, Spiro, Judith ^c, Nicolai, Leo ^{b, d}, French, Lars E. ^{a, e}, Massberg, Steffen ^b, Heinzerling, Lucie ^{a, f, g, ⁎}

Source: In European Journal of Cancer 5 February 2025 216

First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma: A multicenter study from the prospective skin cancer registry ADOREG

Authors: Reinhard, Sören ^a, Utikal, Jochen Sven ^{b, c}, Zaremba, Anne ^d, Lodde, Georg ^d, von Wasielewski, Imke ^e, Klespe, Kai Christian ^e, Meier, Friedegund ^f, Haferkamp, Sebastian ^g, Kähler, Katharina C. ^h, Herbst, Rudolf ⁱ, Gebhardt, Christoffer ^j, Sindrilaru, Anca ^k, Dippel, Edgar ^l, Angela, Yenny ^m, Mohr, Peter ⁿ, Pfoehler, Claudia ^o, Forschner, Andrea ^p, Kaatz, Martin ^q, Schell, Beatrice ^r, Gesierich, Anja ^s, Loquai, Carmen ^t, Hassel, Jessica C. ^u, Ulrich, Jens ^v, Meiss, Frank ^w, Schley, Gaston ^x, Heinzerling, Lucie M. ^y, Sachse, Michael ^z, Welzel, Julia ^aa, Weishaupt, Carsten ^ab, Sunderkötter, Cord ^ac, Michl, Christiane ^ac, Lindhof, Harm-Henning ^ad, Kreuter, Alexander ^ae, Heppt, Markus V. ^af, Wenk, Saskia ^ag, Mauch, Cornelia ^ah, Berking, Carola ^af, Nedwed, Annekathrin Silvia ^ai, Gutzmer, Ralf ^m, Leiter, Ulrike ^p, Schadendorf, Dirk ^c, Ugurel, Selma ^c, Weichenthal, Michael ^h, Haist, Maximilian ^a, Fleischer, Maria Isabel ^a, Lang, Berenice ^a, Grabbe, Stephan ^a, Stege, Henner ^{a, ⁎}

Source: In European Journal of Cancer 2 May 2025 220

Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy – A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg

Authors: Kött, Julian, Zell, Tim, Zimmermann, Noah, Rünger, Alessandra, Smit, Daniel J., Abeck, Finn, Geidel, Glenn, Hansen-Abeck, Inga, Heidrich, Isabel, Weichenthal, Michael, Ugurel, Selma, Leiter, Ulrike, Berking, Carola, Gutzmer, Ralf, Schadendorf, Dirk, Zimmer, Lisa, Livingstone, Elisabeth, Wasielewski, Imke von, Mohr, Peter, Meier, Friedegund, Haferkamp, Sebastian, Drexler, Konstantin, Herbst, Rudolf, Kellner, Ivonne, Utikal, Jochen, Wohlfeil, Sebastian A., Pföhler, Claudia, Adam, Leonie, Terheyden, Patrick, Ulrich, Jens, Meiss, Frank, Möbes, Monica, Welzel, Julia, Schilling, Bastian, Ziller, Fabian, Kaatz, Martin, Kreuter, Alexander, Sindrilaru, Anca, Dippel, Edgar, Sachse, Michael, Weishaupt, Carsten, Hüning, Svea, Heinzerling, Lucie, Loquai, Carmen, Schley, Gaston, Gambichler, Thilo, Löffler, Harald, Grabbe, Stephan, Schultz, Erwin, Devereux, Nina, Hassel, Jesscia C., Simon, Jan-Ch., Raap, Ulrike, Assaf, Chalid, Klemke, Claus-Detlev, Sunderkötter, Cord, Hofmann, Silke C., Wenk, Saskia, Tronnier, Michael, Thies, Silke, Heppt, Markus V., Eggermont, Alexander, Schulze, Hans-Joachim, Zouboulis, Christos C., Tüting, Thomas, Bauer, Alexander T., Schneider, Stefan W., Gebhardt, Christoffer

Source: In European Journal of Cancer January 2025 214

A phase 2 open-label study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1): Final long-term analysis of groups 1, 2, and 3, and primary analysis of fixed-dose treatment group 6

Authors: Hughes, Brett G.M., Guminski, Alexander, Bowyer, Samantha, Migden, Michael R., Schmults, Chrysalyne D., Khushalani, Nikhil I., Chang, Anne Lynn S., Grob, Jean-Jacques, Lewis, Karl D., Ansstas, George, Day, Fiona, Ladwa, Rahul, Stein, Brian N., Muñoz Couselo, Eva, Meier, Friedegund, Hauschild, Axel, Schadendorf, Dirk, Basset-Seguin, Nicole, Modi, Badri, Dalac-Rat, Sophie, Dunn, Lara A., Flatz, Lukas, Mortier, Laurent, Guégan, Sarah, Heinzerling, Lucie M., Mehnert, Janice M., Trabelsi, Sabiha, Soria-Rivas, Ainara, Stratigos, Alexander J., Ulrich, Claas, Wong, Deborah J., Beylot-Barry, Marie, Bossi, Paolo, Bugés Sánchez, Cristina, Chandra, Sunandana, Robert, Caroline, Russell, Jeffery S., Silk, Ann W., Booth, Jocelyn, Yoo, Suk-Young, Seebach, Frank, Lowy, Israel, Fury, Matthew G., Rischin, Danny

Source: In Journal of the American Academy of Dermatology January 2025 92(1):68-77

Clinical and pathological characterization of tebentafusp-associated skin toxicity: A cohort study with 33 patients

Authors: Tomsitz, Dirk, Kerl, Katrin, French, Lars Einar, Heinzerling, Lucie

Source: In Journal of the American Academy of Dermatology December 2024 91(6):1136-1142

Checkpoint inhibitor–induced lichen planus differs from spontaneous lichen planus on the clinical, histological, and gene expression level

Authors: Meier-Schiesser, Barbara, Zecha, Christine, Zierold, Sarah, Kolm, Isabel, Röckel, Magdalena, Fröhlich, Waltraud, Mittag, Nora, Schmitt, Christina, Kumbrink, Joerg, Hassel, Jessica C., Berking, Carola, Nashan, Dorothee, French, Lars Einar, Vera-González, Julio, Dummer, Reinhard, Kerl-French, Katrin, Heinzerling, Lucie

Source: In JAAD International June 2024 15:157-164

Second-line therapies for steroid-refractory immune-related adverse events in patients treated with immune checkpoint inhibitors

Authors: Ruf, Theresa, Kramer, Rafaela, Forschner, Andrea, Leiter, Ulrike, Meier, Friedegund, Reinhardt, Lydia, Dücker, Pia, Ertl, Carolin, Tomsitz, Dirk, Tietze, Julia K., Gutzmer, Ralf, Dabrowski, Evelyn, Zimmer, Lisa, Gesierich, Anja, Zierold, Sarah, French, Lars E., Eigentler, Thomas, Amaral, Teresa, Heinzerling, Lucie

Source: In European Journal of Cancer May 2024 203

The side effect registry immuno-oncology (SERIO) – A tool for systematic analysis of immunotherapy-induced side effects

Authors: Ertl, Carolin, Ruf, Theresa, Mentzer, Dirk, Kong, Mingzi, Kramer, Rafaela, Bergwelt-Baildon, Michael von, Subklewe, Marion, Tomsitz, Dirk, Ascierto, Paolo A., Dummer, Reinhard, Gogas, Helen, Lebbé, Celeste, Long, Georgina V., McArthur, Grant, Neilan, Tomas G., Ribas, Antoni, Robert, Caroline, Schadendorf, Dirk, Zimmer, Lisa, Eigentler, Thomas, Grabbe, Stephan, Forschner, Andrea, Kähler, Katharina C., Milani, Valeria, Pföhler, Claudia, Hassel, Jessica, Gutzmer, Ralf, Loquai, Carmen, Routy, Bertrand, Furness, Andrew J.S., Blank, Christian, Wolchok, Jedd D., French, Lars E., Hauschild, Axel, Heinzerling, Lucie

Source: In European Journal of Cancer March 2024 199

Immune checkpoint inhibition in patients with NRAS mutated and NRAS wild type melanoma: a multicenter Dermatologic Cooperative Oncology Group study on 637 patients from the prospective skin cancer registry ADOREG

Authors: Zaremba, Anne, Mohr, Peter, Gutzmer, Ralf, Meier, Friedegund, Pföhler, Claudia, Weichenthal, Michael, Terheyden, Patrick, Forschner, Andrea, Leiter, Ulrike, Ulrich, Jens, Utikal, Jochen, Welzel, Julia, Kaatz, Martin, Gebhardt, Christoffer, Herbst, Rudolf, Sindrilaru, Anca, Dippel, Edgar, Sachse, Michael, Meiss, Frank, Heinzerling, Lucie, Haferkamp, Sebastian, Weishaupt, Carsten, Löffler, Harald, Kreft, Sophia, Griewank, Klaus, Livingstone, Elisabeth, Schadendorf, Dirk, Ugurel, Selma, Zimmer, Lisa

Source: European journal of cancer. 188:140-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192375890.0x000001&indx=1&recIds=ETOCvdc_100192375890.0x000001

Real‐world outcomes using PD‐1 antibodies and BRAF + MEK inhibitors for adjuvant melanoma treatment from 39 skin cancer centers in Germany, Austria and Switzerland

Authors: Schumann, Katharina, Mauch, Cornelia, Klespe, Kai‐Christian, Loquai, Carmen, Nikfarjam, Ulrike, Schlaak, Max, Akçetin, Larissa, Kölblinger, Peter, Hoellwerth, Magdalena, Meissner, Markus, Mengi, Guelcin, Braun, Andreas Dominik, Mengoni, Miriam, Dummer, Reinhard, Mangana, Joanna, Sindrilaru, Mihaela‐Anca, Radmann, Dan, Hafner, Christine, Freund, Johann, Rappersberger, Klemens, Weihsengruber, Felix, Meiss, Frank, Reinhardt, Lydia, Meier, Friedegund, Rainer, Barbara, Richtig, Erika, Ressler, Julia Maria, Höller, Christoph, Eigentler, Thomas, Amaral, Teresa, Peitsch, Wiebke K., Hillen, Uwe, Harth, Wolfgang, Ziller, Fabian, Schatton, Kerstin, Gambichler, Thilo, Susok, Laura, Maul, Lara Valeska, Läubli, Heinz, Debus, Dirk, Weishaupt, Carsten, Börger, Sevil, Sievers, Katharina, Haferkamp, Sebastian, Zenderowski, Veronika, Nguyen, Van Anh, Wanner, Marina, Gutzmer, Ralf, Terheyden, Patrick, Kähler, Katharina, Emmert, Steffen, Thiem, Alexander, Sachse, Michael, Gercken‐Riedel, Silke, Kaune, Kjell Matthias, Thoms, Kai‐Martin, Heinzerling, Lucie, Heppt, Markus Vincent, Tratzmiller, Sabine, Hoetzenecker, Wolfram, Öllinger, Angela, Steiner, Andreas, Peinhaupt, Tobias, Podda, Maurizio, Schmid, Sabine, Wollina, Uwe, Biedermann, Tilo, Posch, Christian

Source: Journal of the European Academy of Dermatology and Venereology. 37(5):894-906

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182173690.0x000001&indx=1&recIds=ETOCvdc_100182173690.0x000001

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial

Authors: van Akkooi, Alexander, van Houdt, Winan, Wilhelm, Tabea, Farmer, Kimberley, Ulrich, Claas, Gambichler, Thilo, Bluhm, Leonie, Schinagl, Heidemarie, Kellner, Ivonne, Herbst, Rudolf, Meiß, Frank, Rafei-Shamsabadi, David, Sell, Sabine, Kaatz, Martin, Wulfken, Lena, Hartmann, Martin, Kähler, Katharina, Ziemer, Mirjana, Simon, Jan, Terheyden, Patrick, Thaci, Diamant, Loquai, Carmen, Mitzel-Rink, Heidrun, Grabbe, Stephan, Stege, Henner, Gaiser, Maria, Utikal, Jochen, Berking, Carola, Heinzerling, Lucie, Schlaak, Max, Tomsitz, Dirk, Dyballa, Jörg, Magnolo, Nina, Weishaupt, Carsten, Berneburg, Mark, Garbe, Claus, Flatz, Lukas, Gesierich, Anja, Schilling, Bastian, Becker, Jürgen C, Ugurel, Selma, Leiter, Ulrike, Meier, Friedegund, Gutzmer, Ralf, Haferkamp, Sebastian, Zimmer, Lisa, Livingstone, Elisabeth, Eigentler, Thomas K, Hauschild, Axel, Kiecker, Felix, Hassel, Jessica C, Mohr, Peter, Fluck, Michael, Thomas, Ioannis, Garzarolli, Marlene, Grimmelmann, Imke, Drexler, Konstantin, Spillner, Alexandra N, Eckhardt, Sebastian, Schadendorf, Dirk ^*

Source: In The Lancet 2-8 September 2023 402(10404):798-808

Practical guidelines for the management of adverse events of the T cell engager bispecific tebentafusp

Authors: Hassel, Jessica C., Berking, Carola, Forschner, Andrea, Gebhardt, Christoffer, Heinzerling, Lucie, Meier, Friedegund, Ochsenreither, Sebastian, Siveke, Jens, Hauschild, Axel, Schadendorf, Dirk

Source: In European Journal of Cancer September 2023 191

Stereotactic radiosurgery and combined immune checkpoint therapy with ipilimumab and nivolumab in patients with melanoma brain metastases: A retrospective monocentric toxicity analysis

Authors: Bodensohn, Raphael, Werner, Simone, Reis, Jonas, Pazos Escudero, Montserrat, Kaempfel, Anna-Lena, Hadi, Indrawati, Forbrig, Robert, Manapov, Farkhad, Corradini, Stefanie, Belka, Claus, Theurich, Sebastian, Heinzerling, Lucie, Schlaak, Max, Niyazi, Maximilian

Source: In Clinical and Translational Radiation Oncology March 2023 39

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Authors: Nuñez, Nicolas Gonzalo, Berner, Fiamma, Friebel, Ekaterina, Unger, Susanne, Wyss, Nina, Gomez, Julia Martinez, Purde, Mette-Triin, Niederer, Rebekka, Porsch, Maximilian, Lichtensteiger, Christa, Kramer, Rafaela, Erdmann, Michael, Schmitt, Christina, Heinzerling, Lucie, Abdou, Marie-Therese, Karbach, Julia, Schadendorf, Dirk, Zimmer, Lisa, Ugurel, Selma, Klümper, Niklas, Hölzel, Michael, Power, Laura, Kreutmair, Stefanie, Capone, Mariaelena, Madonna, Gabriele, Cevhertas, Lacin, Heider, Anja, Amaral, Teresa, Hasan Ali, Omar, Bomze, David, Dimitriou, Florentia, Diem, Stefan, Ascierto, Paolo Antonio, Dummer, Reinhard, Jäger, Elke, Driessen, Christoph, Levesque, Mitchell Paul, van de Veen, Willem, Joerger, Markus, Früh, Martin, Becher, Burkhard, Flatz, Lukas

Source: In Med 10 February 2023 4(2):113-129

Characterization of the impact of immune checkpoint inhibitors on platelet activation and aggregation

Authors: Schlüter, Julian, Cunningham, Sarah, Zimmermann, Robert, Achenbach, Susanne, Kramer, Rafaela, Erdmann, Michael, Beckmann, Malte, Heinzerling, Lucie, Hackstein, Holger

Source: In Immunobiology January 2023 228(1)

Global Circumferential and Radial Strain Among Patients With Immune Checkpoint Inhibitor Myocarditis

Authors: Quinaglia, Thiago, Gongora, Carlos, Awadalla, Magid, Hassan, Malek Z.O., Zafar, Amna, Drobni, Zsofia D., Mahmood, Syed S., Zhang, Lili, Coelho-Filho, Otavio R., Suero-Abreu, Giselle A., Rizvi, Muhammad A., Sahni, Gagan, Mandawat, Anant, Zatarain-Nicolás, Eduardo, Mahmoudi, Michael, Sullivan, Ryan, Ganatra, Sarju, Heinzerling, Lucie M., Thuny, Franck, Ederhy, Stephane, Gilman, Hannah K., Sama, Supraja, Nikolaidou, Sofia, Mansilla, Ana González, Calles, Antonio, Cabral, Marcella, Fernández-Avilés, Francisco, Gavira, Juan José, González, Nahikari Salterain, García de Yébenes Castro, Manuel, Barac, Ana, Afilalo, Jonathan, Zlotoff, Daniel A., Zubiri, Leyre, Reynolds, Kerry L., Devereux, Richard, Hung, Judy, Picard, Michael H., Yang, Eric H., Gupta, Dipti, Michel, Caroline, Lyon, Alexander R., Chen, Carol L., Nohria, Anju, Fradley, Michael G., Thavendiranathan, Paaladinesh, Neilan, Tomas G.

Source: In JACC: Cardiovascular Imaging November 2022 15(11):1883-1896

Persistent immune-related adverse events after cessation of checkpoint inhibitor therapy: Prevalence and impact on patients' health-related quality of life

Authors: Schulz, Thomas U., Zierold, Sarah, Sachse, Michael M., Pesch, Giulia, Tomsitz, Dirk, Schilbach, Katharina, Kähler, Katharina C., French, Lars E., Heinzerling, Lucie

Source: In European Journal of Cancer November 2022 176:88-99

Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study

Authors: Müller-Jensen, Leonie, Zierold, Sarah, Versluis, Judith M., Boehmerle, Wolfgang, Huehnchen, Petra, Endres, Matthias, Mohr, Raphael, Compter, Annette, Blank, Christian U., Hagenacker, Tim, Meier, Friedegund, Reinhardt, Lydia, Gesierich, Anja, Salzmann, Martin, Hassel, Jessica C., Ugurel, Selma, Zimmer, Lisa, Banks, Patricia, Spain, Lavinia, Soon, Jennifer A., Enokida, Tomohiro, Tahara, Makoto, Kähler, Katharina C., Seggewiss-Bernhardt, Ruth, Harvey, Catriona, Long, Georgina V., Schöberl, Florian, von Baumgarten, Louisa, Hundsberger, Thomas, Schlaak, Max, French, Lars E., Knauss, Samuel, Heinzerling, Lucie M.

Source: In European Journal of Cancer November 2022 175:224-235