Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Authors: Zhexi Chi, Bo Lu, Rongjun Liu, Chen Pan, Bo Meng, Xiuzhong Xing, Hui Yuan, Xuewei Wu, Yushan Chen, Yuxuan Ren, Wenwei Wu, Mengmeng Miao, Junping Chen, Xiaowei Chen

Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-19 (2025)

Subject Terms: Neuropathic pain, HDAC6, ACY-1215, STAT3, CCL7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/c0c455153b3d4fa0bfdf69b0c3188cd6

VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway

Authors: Honglan Sun, Chao Yang, Xiaoyunqing Yin, Shizhao Chen, Yuqi Huang, Huifang Kuang, Wen Luo

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: Oral submucosal fibrosis, Von Hippel-Lindau, HDAC6, Ubiquitination, NF-κB, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3c6efdce85084097a2a4378a6e0b05dc

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain

Authors: Geurs, Silke ^{a, b}, Staessens, Eleni ^{b, c, d}, Bredael, Kato ^a, Borghgraef, Stefaan ^a, De Ridder, Jordy ^a, Persoons, Leentje ^e, De Jonghe, Steven ^f, Schols, Dominique ^f, Mann, Mandeep K. ^g, Harding, Rachel J. ^{g, h, i}, Franceus, Jorick ^j, Desmet, Tom ^j, Van Hecke, Kristof ^k, Clarisse, Dorien ^{b, c, d, ⁎⁎}, De Bosscher, Karolien ^{b, c, d, ⁎⁎⁎}, D'hooghe, Matthias ^{a, d, ⁎}

Source: In European Journal of Medicinal Chemistry 5 March 2025 285

Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer

Authors: Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

Source: Experimental Hematology & Oncology, Vol 14, Iss 1, Pp 1-22 (2025)

Subject Terms: Head and neck cancer, Radioresistance, Combination therapy, HDAC6 inhibition, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/a0d365f982b84ddebba9a121e4b36186

Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects

Authors: Kiara E. Bornes, Marcus A. Moody, Thomas M. Huckaba, Megan C. Benz, Emily C. McConnell, Maryam Foroozesh, Van H. Barnes, Bridgette M. Collins‐Burow, Matthew E. Burow, Terry J. Watt, Tasha B. Toro

Source: FEBS Open Bio, Vol 15, Iss 1, Pp 94-107 (2025)

Subject Terms: HDAC6, HDAC8, HDACi, immunofluorescence, RNA‐seq, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/2b0a8d5f4aa142abbad2c69f8adc7808

DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer

Authors: Jiayu Zhang, Yingxi Zhao, Ruijuan Liang, Xue Zhou, Zhonghua Wang, Cheng Yang, Lingyue Gao, Yonghao Zheng, Hui Shao, Yang Su, Wei Cui, Lina Jia, Jingyu Yang, Chunfu Wu, Lihui Wang

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 12, Pp 5219-5234 (2024)

Subject Terms: DNMT3A, NSCLC, Synthetic lethal, HDAC6, HIF-1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524003459; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/660e52e83f18407ba42ee029cc5ee060

HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease

Authors: Khang-Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In-Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee, Dong-Young Choi, Simmyung Yook

Source: Redox Biology, Vol 79, Iss , Pp 103457- (2025)

Subject Terms: HDAC6 inhibitor, CAY10603, Parkinson's disease, Lactoferrin, PLGA nanoparticle, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221323172400435X; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/31b1be9379a74c7c8c5a1efd31c40186

MicroRNA-mediated epigenetic regulation of HDAC8 and HDAC6: Functional significance in cervical cancer

Authors: Debasmita Naik, Arunasree M. Kalle

Source: Non-coding RNA Research, Vol 9, Iss 3, Pp 732-743 (2024)

Subject Terms: HDAC8, HDAC6, MiRNA, MiR-324–3p, MiR-497–3p, Cervical cancer, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468054024000301; https://doaj.org/toc/2468-0540

Access URL: https://doaj.org/article/0bad0d41f1d3492fbedfcc02058dd15e

Inhibiting histone deacetylase 6 suppresses the proliferation of microvascular endothelial cells by epigenetically activating miR-375-3p, potentially contributing to bone loss during mechanical unloading

Authors: Liqun Xu, Lijun Zhang, Gaozhi Li, Xiaoyan Zhang, Quan Sun, Zebing Hu, Xinsheng Cao, Yixuan Wang, Fei Shi, Shu Zhang

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: Mechanical unloading, Bone loss, HDAC6, miR-375-3p, LRP5, Cell proliferation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/cd8749fa61694f23a28f0c2de45b1d90

Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro

Authors: Yi-Ting Yang, Bin Yan, Li-Na Guo, Miao Liu, Yu-Hua Li, Zhi-Yu Shao, Hua Diao, Su-Ying Liu, He-Guo Yu

Source: Asian Journal of Andrology, Vol 26, Iss 5, Pp 490-499 (2024)

Subject Terms: asthenozoospermia, hdac6, icsi, scriptaid, sperm motility, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/aja202416; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262

Access URL: https://doaj.org/article/e6e26ac01c9e45d9817757f657aa6304

SARS-CoV-2 nucleocapsid protein promotes self-deacetylation by inducing HDAC6 to facilitate viral replication

Authors: Arpita Mukherjee, Mahadeb Lo, Pritam Chandra, Ratul Datta Chaudhuri, Papiya De, Shanta Dutta, Mamta Chawla-Sarkar

Source: Virology Journal, Vol 21, Iss 1, Pp 1-16 (2024)

Subject Terms: Deacetylation, Stress granules (SGs), SARS-CoV-2, HDAC6, G3BP1, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/e7f6f012a3e441fa92f012147b900a1c

Repurposing of known drugs from multiple libraries to identify novel and potential selective inhibitors of HDAC6 via in silico approach and molecular modeling

Authors: Mert, Naz Mina, Erdogan, Buse, Yelekçi, Kemal ^⁎

Source: In Heliyon 15 August 2024 10(15)

Targeting the HDAC6/Hint2/MICU1 axis to ameliorate acute liver failure via inhibiting NETosis

Authors: Guo, Jin, Shi, Chunxia, Wang, Yukun, Zhang, Danmei, Zhang, Qingqi, Zhang, Xiaoya, Wang, Luwen, Gong, Zuojiong ^⁎

Source: In Life Sciences 1 April 2025 366-367

The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model

Authors: Bian, Yuting, Fukui, Yusuke, Ota-Elliott, Ricardo Satoshi, Hu, Xinran, Sun, Hongming, Bian, Zhihong, Zhai, Yun, Yu, Haibo, Hu, Xiao, An, Hangping, Liu, Hongzhi, Morihara, Ryuta, Ishiura, Hiroyuki, Yamashita, Toru ^⁎

Source: In Neuroscience Research April 2025 213:128-137

Inhibition of HDAC6 elicits anticancer effects on head and neck cancer cells through Sp1/SOD3/MKP1 signaling axis to downregulate ERK phosphorylation

Authors: Kausar, Rukhsana ^a, Nguyen, Nga Thi Thanh ^b, Le, Truc Phan Hoang ^b, Kim, Jae Hyung ^c, Lee, Sang Yoon ^{a, b, ⁎}

Source: In Cellular Signalling March 2025 127

HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy

Authors: Kim, Jun-Sik ^{a, 1}, Jun, Jae Hyun ^{a, b, 1}, Lee, Jeongmi ^a, Park, Sunyoung ^a, Kim, Eunae ^a, Hwang, Su Jung ^a, Moon, Heesu ^c, Baek, Seung Hyun ^a, Kim, Hark Kyun ^a, Park, Jinsu ^a, Cho, Yoonsuk ^a, Han, Jihoon ^a, Kim, Chanhee ^a, Kim, Jongho ^a, Yang, Hyun-Mo ^d, Lee, Changsik ^d, Chung, Yeonseok ^c, Lee, Hyo-Jong ^a, Jo, Dong-Gyu ^{a, e, f, g, ⁎}

Source: In Metabolism March 2025 164

Pharmacologically induced proteolysis of histone deacetylase-6 attenuates influenza virus replication despite limited anti-tumor effects

Authors: Jungwirth, Johannes ^{a, b, 1}, Mieland, Andreas O. ^{b, 1}, Piée-Staffa, Andrea ^b, Heimburg, Tino ^c, Brenner, Walburgis ^d, Ehrhardt, Christina ^a, Sippl, Wolfgang ^{c, ⁎}, Henke, Andreas ^{a, ⁎, 2}, Krämer, Oliver H. ^{b, ⁎, 2}

Source: In Life Sciences 15 February 2025 363

MAP3K4 signaling regulates HDAC6 and TRAF4 coexpression and stabilization in trophoblast stem cells

Authors: Nelson, Hannah A., Mullins, Nathan A., Abell, Amy N. ^∗

Source: In Journal of Biological Chemistry February 2025 301(2)

N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression

Authors: Yalan Rui, Haisheng Zhang, Kangning Yu, Shiyao Qiao, Chenglin Gao, Xiansong Wang, Weifeng Yang, Gholamreza Asadikaram, Zigang Li, Kun Zhang, Jianxin Peng, Jiexin Li, Junming He, Hongsheng Wang

Source: Advanced Science, Vol 12, Iss 2, Pp n/a-n/a (2025)

Subject Terms: acetylated α‐tubulin, cilia length, HDAC6, m6A, cervical cancer, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/8e049956b8a34461b344cfa64e5da80f

The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia

Authors: Minjia Chen, Xiuqin Cao, Ronghui Zheng, Haixia Chen, Ruixia He, Hao Zhou, Zhiwei Yang

Source: Virulence, Vol 15, Iss 1 (2024)

Subject Terms: Histone deacetylase 6 (HDAC6), autophagy, Legionella pneumophila, autophagyolysosomal pathway, macrophages, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608

Access URL: https://doaj.org/article/836e92e4e3044338bd85972e29f1eab1