Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway

Authors: Liang Xiao, Zhang Jie, Luo Ya

Source: Open Life Sciences, Vol 19, Iss 1, Pp 441-51 (2024)

Subject Terms: hcn1, ikkβ, myocardial infarction, nf-κb, pdtc, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2391-5412

Access URL: https://doaj.org/article/768550a9596441a1879c4e2bdc7b4673

Characterization of the phenotype and functional alternations of three HCN1 variants in Chinese epilepsy patients

Authors: Han, Ziyao, Xie, Lingling, Liu, Xiaorui, Yang, Jiaxin, Luo, Hanyu, Ding, Ran, Chen, Hengsheng, Cheng, Li, Fang, Zhixu ^⁎, Jiang, Li ^⁎

Source: In Epilepsy Research March 2025 211

Potassium channels in animal models of post-traumatic stress disorder: mechanistic and therapeutic implications

Authors: Ravi Philip Rajkumar

Source: Frontiers in Cellular Neuroscience, Vol 18 (2024)

Subject Terms: post-traumatic stress disorder, potassium channels, HCN1, KCNQ, GIRK, amygdala, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2024.1441514/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/49a1efa203f3423c9c3a0f99b313dc42

Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel

Authors: Xiao-Dan Luo, Tao Xiang, Si-Jun Li, Mei-Gang Ma, Mei-Ling Chen, Yuan Wu

Source: Neural Regeneration Research, Vol 18, Iss 3, Pp 594-602 (2023)

Subject Terms: (rs)-3, 5-dihydroxyphenylglycine, ca1 region, excitability, h89, hcn1 channel, ly367385, mglur1, pentylenetetrazole, status epilepticus, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=3;spage=594;epage=602;aulast=Luo; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/e5bd288114d140089f4e0cf4ff79911c

Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain

Authors: Rebecca L. Joyce, Gareth R. Tibbs, J. David Warren, Christopher J. Costa, Kelly Aromolaran, R. Lea Sanford, Olaf S. Andersen, Zhucui Li, Guoan Zhang, Dianna E. Willis, Peter A. Goldstein

Source: Neurobiology of Pain, Vol 14, Iss , Pp 100141- (2023)

Subject Terms: Anti-hyperalgesia, Alkylphenol, HCN1, Ion channel, Spared nerve injury, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452073X23000284; https://doaj.org/toc/2452-073X

Access URL: https://doaj.org/article/32cd11e9aa564ac7b45c089bb33d5df1

Contribution of HCN1 variant to sinus bradycardia: A case report

Authors: Hangang Yu, Bryan Gall, Mackenzie Newman, Quincy Hathaway, Kathleen Brundage, Amanda Ammer, Peter Mathers, David Siderovski, Robert W. Hull

Source: Journal of Arrhythmia, Vol 37, Iss 5, Pp 1337-1347 (2021)

Subject Terms: HCN1, HCN4, hyperpolarization‐activated ion channel, missense mutation, sinus bradycardia, whole‐exome sequencing, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1880-4276; https://doaj.org/toc/1883-2148

Access URL: https://doaj.org/article/26f6371bfc3741e1ae40323dccd1bb70

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

Authors: Andrea Merseburg, Jacquelin Kasemir, Eric W Buss, Felix Leroy, Tobias Bock, Alessandro Porro, Anastasia Barnett, Simon E Tröder, Birgit Engeland, Malte Stockebrand, Anna Moroni, Steven A Siegelbaum, Dirk Isbrandt, Bina Santoro

Source: eLife, Vol 11 (2022)

Subject Terms: HCN1, ion channels, epileptic encephalopathy, lamotrigine, phenytoin, Dravet syndrome, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/70826; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/8b585477e0574545a68c918c60be4371

Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Authors: Changning Xie, Fangyun Liu, Hailan He, Fang He, Leilei Mao, Xiaole Wang, Fei Yin, Jing Peng

Source: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Subject Terms: epilepsy, intellectual disorders, patch clamp, neuronal excitability, HCN1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.870182/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/569c21a43f96427b849efdf657844807

Impaired Color Recognition in HCN1 Epilepsy: A Single Case Report

Authors: Chaseley E. Mckenzie, Chen-Jui Ho, Ian C. Forster, Ming S. Soh, A. Marie Phillips, Ying-Chao Chang, Ingrid E. Scheffer, Christopher A. Reid, Meng-Han Tsai

Source: Frontiers in Neurology, Vol 13 (2022)

Subject Terms: HCN1, epilepsy, developmental and epileptic encephalopathy, color vision, missense, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.834252/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/33a3627bc73b425e920ad245f5a1fbc4

The Effect of SIRT3/Ac-SOD2 Mediated Oxidative Stress and HCN1 Channel Activity on Anesthesia/Surgery Induced Anxiety-Like Behavior in Mice

Authors: Hui-Hui Miao, Qiang Liu, Ning Wang, Yan-Ping Liu, Chen Chen, Hai-Bi Wang, Hui Huang, Wei-Feng Wu, Jia-Tao Lin, Yong-Kang Qiu, Chuan-Wu Zhang, Cheng-Hua Zhou, Yu-Qing Wu

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: anxiety, anesthesia/surgery, SIRT3, SOD2, HCN1, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.783931/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/e05d9c0f67164e299b46d7c42c98d6e0

Genetic epilepsy with febrile seizures plus (GEFS+)

Authors: A. A. Sharkov

Source: Эпилепсия и пароксизмальные состояния, Vol 12, Iss 1S (2020)

Subject Terms: genetic epilepsy with febrile seizures plus, gefs+, scn1b, scn1a, gabrg2, gabrd, scn9a, stx1b, hcn1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.epilepsia.su/jour/article/view/549; https://doaj.org/toc/2077-8333; https://doaj.org/toc/2311-4088

Access URL: https://doaj.org/article/9d356ce0c46e4ba0b0f319b3b36ea294

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability

Authors: Mattia Bonzanni, Jacopo C. DiFrancesco, Raffaella Milanesi, Giulia Campostrini, Barbara Castellotti, Annalisa Bucchi, Mirko Baruscotti, Carlo Ferrarese, Silvana Franceschetti, Laura Canafoglia, Francesca Ragona, Elena Freri, Angelo Labate, Antonio Gambardella, Cinzia Costa, Ilaria Rivolta, Cinzia Gellera, Tiziana Granata, Andrea Barbuti, Dario DiFrancesco

Source: Neurobiology of Disease, Vol 118, Iss , Pp 55-63 (2018)

Subject Terms: HCN1, Genetic generalized epilepsy, Electrophysiology, Membrane excitability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996118301918; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/d23258a9e43a4f519934f140b2c934bc

Using a Multiplex Nucleic Acid in situ Hybridization Technique to Determine HCN4 mRNA Expression in the Adult Rodent Brain

Authors: Julia Oyrer, Lauren E. Bleakley, Kay L. Richards, Snezana Maljevic, A. Marie Phillips, Steven Petrou, Cameron J. Nowell, Christopher A. Reid

Source: Frontiers in Molecular Neuroscience, Vol 12 (2019)

Subject Terms: HCN4 channels, HCN1 channel, HCN2, multiplex nucleic acid in situ hybridization, Ih, quantifcation workflow, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2019.00211/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/df2a283ccc4545638ae1422d408b2153

Constitutive Genetic Deletion of Hcn1 Increases Alcohol Preference during Adolescence

Authors: Michael C. Salling, Neil L. Harrison

Source: Brain Sciences, Vol 10, Iss 11, p 763 (2020)

Subject Terms: Hcn1, alcohol, prefrontal cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/10/11/763; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/e32ddf3c754241b58f8569c56028a6ed

Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility

Authors: Felix Mader, Steffen Müller, Ludwig Krause, Armin Springer, Karoline Kernig, Chris Protzel, Katrin Porath, Simone Rackow, Tristan Wittstock, Marcus Frank, Oliver W. Hakenberg, Rüdiger Köhling, Timo Kirschstein

Source: Frontiers in Physiology, Vol 9 (2018)

Subject Terms: ZD7288, 18β-glycyrrhetic acid, HCN1 knockout, electron microscopy, organ bath, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2018.00753/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/f5aa014fb8a645ac9ce88eb51f549bd8

Synaptic Ultrastructure Might Be Involved in HCN1-Related BDNF mRNA in Withdrawal-Anxiety After Ethanol Dependence

Authors: Lanwei Hou, Yujuan Guo, Bo Lian, Yanyu Wang, Changjiang Li, Gang Wang, Qi Li, Jinjing Pang, Hongwei Sun, Lin Sun

Source: Frontiers in Psychiatry, Vol 9 (2018)

Subject Terms: ethanol withdrawal, anxiety, BDNF, HCN1, synaptic ultrastructure, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fpsyt.2018.00215/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/7ccedb5d896249ab80e2b86f056d5ea8

Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy

Authors: A. Marie Phillips, Taehwan Kim, Ernesto Vargas, Steven Petrou, Christopher A. Reid

Source: Neurobiology of Disease, Vol 64, Iss , Pp 30-35 (2014)

Subject Terms: Absence epilepsy, Co-morbidity, Memory, Ih, HCN1, CA1 pyramidal, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996113003513; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/e512b50ad5a649ca9027f56b17ef6764

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

Authors: Wendy K. Chung, Minyoung Shin, Thomas C. Jaramillo, Rudolph L. Leibel, Charles A. LeDuc, Stuart G. Fischer, Efthia Tzilianos, Ayman A. Gheith, Alan S. Lewis, Dane M. Chetkovich

Source: Neurobiology of Disease, Vol 33, Iss 3, Pp 499-508 (2009)

Subject Terms: Hyperpolarization-activated cyclic nucleotide-gated channels, Seizure, Ethosuximide, Ataxia, HCN2, HCN1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996108003082; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/48c1e721331045fa8ebf02b07eeda6e1

Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy

Authors: Bin Tang, Thomas Sander, Kimberley B. Craven, Anne Hempelmann, Andrew Escayg

Source: Neurobiology of Disease, Vol 29, Iss 1, Pp 59-70 (2008)

Subject Terms: Hyperpolarization-activated cyclic nucleotide-gated channel, HCN1, HCN2, Idiopathic generalized epilepsy, IGE, Mutation analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996107001854; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/aadb22e2a36f4c7e923538cbf4c390fb

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