Isolation and structure of broad SIV-neutralizing antibodies reveal a proximal helical MPER epitope recognized by a rhesus multi-donor class

Authors: Gorman, Jason ^{1, 2, ∗}, Du, Renguang ¹, Lai, Yen-Ting ¹, Ahmadi, Mohammed S. ¹, King, Hannah A.D. ¹, Song, Kaimei ¹, Manalang, Kimberly ¹, Gonelli, Christopher A. ¹, Schramm, Chaim A. ¹, Cheng, Cheng ¹, Nguyen, Richard ¹, Ambrozak, David ¹, Druz, Aliaksandr ¹, Shen, Chen-Hsiang ¹, Yang, Yongping ¹, Douek, Daniel C. ¹, Kwong, Peter D. ^{1, 3}, Roederer, Mario ¹, Mason, Rosemarie D. ^{1, 4, ∗∗}

Source: In Cell Reports 28 January 2025 44(1)

HIV-1 envelope facilitates the development of protease inhibitor resistance through acquiring mutations associated with viral entry and immune escape

Authors: Ntombikhona F. Maphumulo, Michele L. Gordon

Source: Frontiers in Microbiology, Vol 15 (2024)

Subject Terms: HIV-1, envelope, gag, PR, gp120, gp41, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1388729/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/6392b1d9f07a40f68a2d38153a61a996

ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41

Authors: Ruiying Liang, Dou Dou, Chunying Wang, Shanshan Huo, Yang Wu, Juan Wang, Zhengsen Yu, Shuomin Zhang, Jingjing Xu, Yue Liu, Peng Liu, Shibo Jiang, Fei Yu

Source: Current Research in Microbial Sciences, Vol 7, Iss , Pp 100260- (2024)

Subject Terms: HIV-1, gp41, Small molecule, Inhibitors, Broad-spectrum, Microbiology, QR1-502, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666517424000427; https://doaj.org/toc/2666-5174

Access URL: https://doaj.org/article/659dfb7a923d454ab407fdf71482f9c0

Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation

Authors: Lujia Sun, Bo Chen, Xianbo Liu, Yun Zhu, Guangxu Zhang, Xiaoxing Liang, Lixiao Xing, Wei Xu, Shibo Jiang, Xinling Wang

Source: Current Research in Microbial Sciences, Vol 7, Iss , Pp 100263- (2024)

Subject Terms: HIV-1, Alpaca, Nanobody, gp41 NHR, Broadly neutralizing antibody, Microbiology, QR1-502, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666517424000452; https://doaj.org/toc/2666-5174

Access URL: https://doaj.org/article/b1599c8680fd4699ba607c86828fa3e0

HIV Transmembrane Glycoprotein Conserved Domains and Genetic Markers Across HIV-1 and HIV-2 Variants

Authors: Ana Valadés-Alcaraz, Roberto Reinosa, África Holguín

Source: Frontiers in Microbiology, Vol 13 (2022)

Subject Terms: HIV, transmembrane glycoprotein gp41, transmembrane glycoprotein gp36, conservation, variants, antibody binding domains, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.855232/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/edbc3452f4b54d18bb244d63af2363be

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1

Authors: Grant Klug, Frances M. Cole, Mark D. Hicar, Connie Watt, Tami Peters, Seth H. Pincus

Source: Vaccines, Vol 11, Iss 4, p 829 (2023)

Subject Terms: HIV envelope, gp41, immunoconjugate, immunotoxin, CD4, cytotoxicity, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/11/4/829; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/fa48a71784544d62adac48bf26e89b67

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Authors: Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang

Source: Viruses, Vol 15, Iss 5, p 1038 (2023)

Subject Terms: HIV-1, gp41, CCR5, entry inhibitors, multitarget-directed ligands, coiled coil, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/5/1038; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/1981d0a939a446fcaadeed1571df4444

Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41

Authors: Alexandra Maslennikova, Natalia Kruglova, Svetlana Kalinichenko, Dmitriy Komkov, Mikhail Shepelev, Dmitriy Golubev, Andrei Siniavin, Andrei Vzorov, Alexander Filatov, Dmitriy Mazurov

Source: mBio, Vol 13, Iss 1 (2022)

Subject Terms: CRISPR/Cas9, knock-in, GPI proteins, CD52, gp41, fusion inhibitors, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/4e7712bc7f5f432a8319b1abf985f3ac

Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges

Authors: Samir K. Lakhashe, Mario Amacker, Dinesh Hariraju, Hemant K. Vyas, Kyle S. Morrison, Joshua A. Weiner, Margaret E. Ackerman, Vicky Roy, Galit Alter, Guido Ferrari, David C. Montefiori, Georgia D. Tomaras, Sheetal Sawant, Nicole L. Yates, Chris Gast, Sylvain Fleury, Ruth M. Ruprecht

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: HIV-1 gp41, virosomes, virosomal vaccine, intramuscular prime/intranasal boost vaccination, Indian-origin rhesus macaque model, SHIV, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.788619/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e308409b63fc452c868c82580e8c0050

Characterization of resistance to a potent d-peptide HIV entry inhibitor

Authors: Amanda R. Smith, Matthew T. Weinstock, Amanda E. Siglin, Frank G. Whitby, J. Nicholas Francis, Christopher P. Hill, Debra M. Eckert, Michael J. Root, Michael S. Kay

Source: Retrovirology, Vol 16, Iss 1, Pp 1-12 (2019)

Subject Terms: HIV entry inhibition, d-peptide, PIE12-trimer, gp120, gp41, Viral resistance mutation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12977-019-0489-7; https://doaj.org/toc/1742-4690

Access URL: https://doaj.org/article/afdf95a93d6b45de92747e1a8e5821fd

Targeting a Conserved Lysine in the Hydrophobic Pocket of HIV-1 gp41 Improves Small Molecule Antiviral Activity

Authors: Li He, Guangyan Zhou, Vladimir Sofiyev, Eddie Garcia, Newton Nguyen, Kathy H. Li, Miriam Gochin

Source: Viruses, Vol 14, Iss 12, p 2703 (2022)

Subject Terms: HIV-1, gp41, covalent inhibitor, fusion inhibitor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/12/2703; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/5065a82cb7664402b470a0fa6f5244e5

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Authors: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn

Source: eLife, Vol 10 (2021)

Subject Terms: HIV-1, gp41, membrane fusion, LN01, 4E10, 2H10, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/65005; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/c1f8eb01d322414cb7d10e348e2d38dc

Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV‐1 Env Clustering

Authors: Jon Ander Nieto‐Garai, Aroa Arboleya, Sara Otaegi, Jakub Chojnacki, Josefina Casas, Gemma Fabriàs, F‐Xabier Contreras, Hans‐Georg Kräusslich, Maier Lorizate

Source: Advanced Science, Vol 8, Iss 3, Pp n/a-n/a (2021)

Subject Terms: cholesterol, Env clustering, gp41 cytoplasmic tails, HIV‐1, protein–lipid interactions, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/6f4e93d03c3e45a59350ab5ec6a29292

The Protective HIV-1 Envelope gp41 Antigen P1 Acts as a Mucosal Adjuvant Stimulating the Innate Immunity

Authors: Lin Xu, Daniela Tudor, Morgane Bomsel

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: adjuvant, intra-nasal vaccination route, IgA, mucosa, Th2-cytokine thymic stromal lymphopoietin, HIV-1 gp41, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.599278/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/28d218a2dba24d668ba7f50ad29ac6de

Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1

Authors: Jing Pu, Yu Dai, Qian Wang, Lu Lu, Junqi Zhang, Wei Xu, Lan Xie, Shengqi Wang, Fei Yu, Xiaoyang He, Shibo Jiang

Source: Frontiers in Pharmacology, Vol 11 (2021)

Subject Terms: HIV-1, entry inhibitor, inactivator, gp120, gp41, Six-helix bundle, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.613361/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/2b5ec25dc5794553a8b715a38d17d7d5

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Authors: Maxence Duchemin, Daniela Tudor, Andréa Cottignies-Calamarte, Morgane Bomsel

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: IgA, HIV-1 envelope gp41, phagocytosis, ADCP, FcαRI/CD89, neutrophils, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01141/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b4449858b4d648e7acda37c0f93cc5ce

The Glu143 Residue Might Play a Significant Role in T20 Peptide Binding to HIV-1 Receptor gp41: An In Silico Study

Authors: Ahmed L. Alaofi

Source: Molecules, Vol 27, Iss 12, p 3936 (2022)

Subject Terms: enfuvirtide, gp41, HIV-1 receptor, molecular dynamics simulations, principal component analysis, free energy landscape, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/12/3936; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/95cb1731f7c94072898c6dd8a3b7537e

Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent

Authors: Blandine Noailly, Melyssa Yaugel-Novoa, Justine Werquin, Fabienne Jospin, Daniel Drocourt, Thomas Bourlet, Nicolas Rochereau, Stéphane Paul

Source: Vaccines, Vol 10, Iss 6, p 903 (2022)

Subject Terms: HIV, broadly neutralizing antibodies, gp41, gp120, ADCC, neutralization, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/10/6/903; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/4f3e8a4b09654c6ba1400f3a1405b1c8

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Authors: Huan Liu, Xiaojie Su, Lulu Si, Lu Lu, Shibo Jiang

Source: Protein & Cell, Vol 9, Iss 7, Pp 596-615 (2018)

Subject Terms: HIV-1, gp41, MPER, vaccine, neutralizing antibodies, ADCC, Cytology, QH573-671, Animal biochemistry, QP501-801

File Description: electronic resource

Relation: http://link.springer.com/article/10.1007/s13238-018-0534-7; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

Access URL: https://doaj.org/article/a4f2f5ae76264e20872fca7a114deedb

A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile

Authors: Wei Xu, Zhe Cong, Qianyu Duan, Qian Wang, Shan Su, Rui Wang, Lu Lu, Jing Xue, Shibo Jiang

Source: Pharmaceuticals, Vol 15, Iss 4, p 424 (2022)

Subject Terms: HIV-1, gp41, fusion inhibitor, human serum albumin, long-acting inhibitor, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/4/424; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/e9009bf34b2a42ca90c37ccd5b087fb0