Solvent-Free Green Synthesis of New Isoquinazoline Derivatives Using Three Component Reactions of Isothiocyanates.

Authors: Jamnani, Mohammad Taghi Bagherian¹ (AUTHOR), Hajinasiri, Rahimeh¹ (AUTHOR) rahimeh.hajinasiri@iau.ac.ir, Ghafuri, Hossein² (AUTHOR), Hossaini, Zinatossadat¹ (AUTHOR)

Source: Polycyclic Aromatic Compounds. 2024, Vol. 44 Issue 9, p6000-6013. 14p.

Subject Terms: *SUSTAINABLE chemistry, *GLYCOSIDASE inhibitors, *REDUCTION potential, *ANTIVIRAL agents, *ISOTHIOCYANATES, *ISOQUINOLINE

N-2 Alkylated analogues of aza-galactofagomine as potential inhibitors of β-glucosidase.

Alternate Title: АЛКИЛОВАНИ АНАЛОЗИ АЗА-ГАЛАКТОФАГОМИНА КАО ПОТЕНЦИЈАЛНИ ИНХИБИТОРИ БЕТА-ГЛУКОЗИДАЗА

Authors: ĐURKOVIĆ, FILIP¹, ZLATOVIĆ, MARIO¹, SLADIĆ, DUŠAN¹, NOVAKOVIĆ, IRENA², BIHELOVIĆ, FILIP¹ filip@chem.bg.ac.rs, FERJANČIĆ, ZORANA¹ zferjan@chem.bg.ac.rs

Source: Journal of the Serbian Chemical Society. 2024, Vol. 89 Issue 10, p1255-1267. 13p.

Subject Terms: *GAUCHER'S disease, *GLYCOSIDASE inhibitors, *CHEMICAL synthesis, *IMINOSUGARS, *ACID analysis

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae).

Authors: Feunaing, Romeo Toko¹ (AUTHOR), Tamfu, Alfred Ngenge^2,3,4,5 (AUTHOR) macntamfu@yahoo.co.uk, Gbaweng, Abel Joel Yaya¹ (AUTHOR), Kucukaydin, Selcuk^3,4 (AUTHOR), Tchamgoue, Joseph^6,7 (AUTHOR), Lannang, Alain Meli² (AUTHOR), Lenta, Bruno Ndjakou⁶ (AUTHOR), Kouam, Simeon Fogue⁶ (AUTHOR), Duru, Mehmet Emin⁴ (AUTHOR), Anouar, El Hassane⁸ (AUTHOR), Talla, Emmanuel^1,2 (AUTHOR), Dinica, Rodica Mihaela⁵ (AUTHOR) macntamfu@yahoo.co.uk

Source: Molecules. Jun2024, Vol. 29 Issue 11, p2456. 19p.

Subject Terms: *MOLECULAR docking, *GLYCOSIDASE inhibitors, *TERMINALIA, *COMBRETACEAE, *ELLAGIC acid, *SHIKIMIC acid, *ACETYLCHOLINESTERASE, *ALPHA-glucosidases

N -Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments.

Authors: Moreń, Monika¹ (AUTHOR), Pereira Lourenço, Ana Laura^2,3 (AUTHOR), Cerdà-Cuéllar, Marta^2,3 (AUTHOR), Kochanowski, Karl^2,3 (AUTHOR), Jørgensen, Kåre B.¹ (AUTHOR), Sydnes, Magne O.^1,4 (AUTHOR), López, Óscar⁵ (AUTHOR) osc-lopez@us.es, Lindbäck, Emil¹ (AUTHOR) emil.lindback@uis.no

Source: Synthesis. Feb2025, Vol. 57 Issue 3, p684-694. 11p.

Subject Terms: *GLYCOSIDASE inhibitors, *LACTAM derivatives

Stereoselective Synthetic Routes to Iminosugars: A Divergent Approach Utilizing a Common Multifunctional Chiral Scaffold.

Authors: Pashikanti, Srinath¹ (AUTHOR), Datta, Apurba² (AUTHOR) adutta@ku.edu

Source: Synthesis. Jan2025, Vol. 57 Issue 1, p138-146. 9p.

Subject Terms: *GLYCOSIDASE inhibitors, *IMINOSUGARS, *PIPERIDINE, *MOIETIES (Chemistry)

Chia (Salvia hispanica L.), a Pre-Hispanic Food in the Treatment of Diabetes Mellitus: Hypoglycemic, Antioxidant, Anti-Inflammatory, and Inhibitory Properties of α-Glucosidase and α-Amylase, and in the Prevention of Cardiovascular Disease.

Authors: Tavera-Hernández, Rosario¹ (AUTHOR) rosario.tavera@gmail.com, Jiménez-Estrada, Manuel¹ (AUTHOR) manueljemex@gmail.com, Alvarado-Sansininea, J. Javier² (AUTHOR) javier33@comunidad.unam.mx, Huerta-Reyes, Maira³ (AUTHOR) chilanguisima@yahoo.com

Source: Molecules. Dec2023, Vol. 28 Issue 24, p8069. 19p.

Subject Terms: *GLYCOSIDASE inhibitors, *ANTIOXIDANTS, *CHIA, *DIABETES, *CARDIOVASCULAR diseases, *AMYLASES, *OMEGA-3 fatty acids, *PREVENTIVE medicine

Geographic Terms: CENTRAL America, MEXICO

Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1 H)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3 H)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents

Authors: El-Sayed, Nahed Nasser Eid¹ (AUTHOR) nahed.elsayed@edaegypt.gov.eg, Al-Otaibi, Taghreed M.² (AUTHOR) chemst222@gmail.com, Barakat, Assem² (AUTHOR) ambarakat@ksu.edu.sa, Almarhoon, Zainab M.² (AUTHOR) mzaben@ksu.edu.sa, Hassan, Mohd. Zaheen³ (AUTHOR) zaheen@kku.edu.sa, Al-Zaben, Maha I.² (AUTHOR), Krayem, Najeh⁴ (AUTHOR) krayemnajeh@yahoo.fr, Masand, Vijay H.⁵ (AUTHOR) vijamasand@gmail.com, Ben Bacha, Abir⁶ (AUTHOR) aalghanouchi@ksu.edu.sa

Source: Pharmaceuticals (14248247). Oct2023, Vol. 16 Issue 10, p1392. 58p.

Subject Terms: *BIOSYNTHESIS, *GLYCOSIDASE inhibitors, *KINASE inhibitors, *CYCLOOXYGENASE 2, *ALPHA-glucosidases, *ENZYME inhibitors, *PHARMACEUTICAL chemistry, *COLON cancer

A Microfluidic Countercurrent Reactor for Accelerating Enzymatic Reactions.

Authors: Juang, Duane S.¹ (AUTHOR), Huo, Yi‐Ren¹ (AUTHOR), Tseng, Hsin‐Kai¹ (AUTHOR), Chen, Chih‐Chen² (AUTHOR), Hsu, Chia‐Hsien^2,3 (AUTHOR), Lin, Chun‐Cheng^1,4 (AUTHOR) cclin66@mx.nthu.edu.tw

Source: ChemCatChem. 9/8/2023, Vol. 15 Issue 17, p1-8. 8p.

Subject Terms: *HORSERADISH peroxidase, *GLYCOSIDASE inhibitors, *ENZYME inhibitors, *ENZYMES, *CATALYSTS, *CATALYST poisoning

Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies.

Authors: Emadi, Mehdi¹ (AUTHOR), Mosavizadeh-Marvest, Fahimeh² (AUTHOR), Asadipour, Ali² (AUTHOR), Pourshojaei, Yaghoub^2,3 (AUTHOR) pourshojaei@yahoo.com, Hosseini, Samanesadat⁴ (AUTHOR), Mojtabavi, Somayeh⁵ (AUTHOR), Faramarzi, Mohammad Ali⁵ (AUTHOR), Larijani, Bagher⁶ (AUTHOR), Mohammadi-Khanaposhtani, Maryam⁷ (AUTHOR), Mahdavi, Mohammad⁶ (AUTHOR) momahdavi@tums.ac.ir

Source: BMC Chemistry. 6/15/2023, p1-14. 14p.

Subject Terms: *GLYCOSIDASE inhibitors, *KINASE inhibitors, *BINDING sites, *MOLECULAR hybridization, *ACETAMIDE derivatives, *BINDING energy, *ACARBOSE

Novel N′-substituted benzylidene benzohydrazides linked to 1,2,3-triazoles: potent α-glucosidase inhibitors.

Authors: Saeedi, Mina^1,2 (AUTHOR), Hariri, Roshanak³ (AUTHOR), Iraji, Aida^4,5 (AUTHOR), Ahmadi, Ali³ (AUTHOR), Mojtabavi, Somayeh⁶ (AUTHOR), Golshani, Shiva⁶ (AUTHOR), Faramarzi, Mohammad Ali⁶ (AUTHOR), Akbarzadeh, Tahmineh^2,3 (AUTHOR) akbarzad@tums.ac.ir

Source: Scientific Reports. 6/2/2023, Vol. 13 Issue 1, p1-15. 15p.

Subject Terms: *GLYCOSIDASE inhibitors, *FLUORESCENCE quenching, *MOLECULAR docking, *CHEMICAL synthesis, *BINDING constant, *MASS spectrometry

Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis.

Authors: Chen, Jing¹ (AUTHOR) chenjing010@126.com, Huang, Qi² (AUTHOR) liqilingssz@163.com, He, Zhuobin² (AUTHOR), Tan, Guoying² (AUTHOR), Zou, Yuansheng² (AUTHOR), Xie, Juying¹ (AUTHOR) xjy597189746@163.com, Qian, Zhengming^1,2 (AUTHOR) xjy597189746@163.com

Source: Molecules. May2023, Vol. 28 Issue 10, p4170. 14p.

Subject Terms: *XANTHINE oxidase, *GLYCOSIDASE inhibitors, *ENZYME inhibitors, *PHENOL oxidase, *HIGH performance liquid chromatography, *ULTRAFILTRATION, *BIOACTIVE compounds, *JAPANESE knotweed

Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity.

Authors: Aroua, Lotfi M.^1,2,3 (AUTHOR) lm.aroua@qu.edu.sa, Alosaimi, Abdulelah H.¹ (AUTHOR), Alminderej, Fahad M.¹ (AUTHOR), Messaoudi, Sabri^1,3 (AUTHOR), Mohammed, Hamdoon A.^4,5 (AUTHOR) lm.aroua@qu.edu.sa, Almahmoud, Suliman A.⁴ (AUTHOR), Chigurupati, Sridevi^4,6 (AUTHOR), Albadri, Abuzar E. A. E.¹ (AUTHOR), Mekni, Nejib H.^2,7 (AUTHOR)

Source: Pharmaceutics. Feb2023, Vol. 15 Issue 2, p457. 22p.

Subject Terms: *GLYCOSIDASE inhibitors, *MOLECULAR docking, *UREA derivatives, *BENZIMIDAZOLE derivatives, *ALPHA-glucosidases, *ANTIOXIDANTS, *AMYLASES, *ISOCYANATES, *ACARBOSE

FUNGAL POLYSACCHARIDES AND THEIR HYPOGLYCEMIC POTENTIAL TO ACT AS AN ADJUVANT IN THE TREATMENT OF DIABETES MELLITUS.

Alternate Title: Polissacarídeos fúngicos e seu potencial hipoglicemiante para atuar como adjuvante no tratamento do diabetes mellitus.

Authors: Figueroa, Gabriel Macêdo¹, Costa, Danilo Nascimento², dos Anjos Miranda, Alana Caise³, Valasques Júnior, Gildomar Lima⁴, Santana Mendes, Tátilla Putumujú⁵, Pires Cedro, Pâmala Évelin⁵ pamalaevelinpires@hotmail.com

Source: Evidência. jan-jun2023, Vol. 23 Issue 1, p47-62. 15p.

Subject Terms: *DIABETES, *GLYCOSIDASE inhibitors, *POLYSACCHARIDES, *DIGESTIVE enzymes, *GUT microbiome, *CELLULAR signal transduction

α-Glucosidase immobilization on the metal–organic framework composite membrane for enzyme inhibitor screening.

Authors: Wen, Ning¹ (AUTHOR), Wan, Guang-Zhen¹ (AUTHOR), Sun, Ke² (AUTHOR), Hu, Fang-Di¹ (AUTHOR) hufd@lzu.edu.cn, Chen, Juan¹ (AUTHOR) chenjuan@lzu.edu.cn

Source: New Journal of Chemistry. 7/7/2024, Vol. 48 Issue 25, p11496-11505. 10p.

Subject Terms: *GLYCOSIDASE inhibitors, *ENZYME inhibitors, *COMPOSITE membranes (Chemistry), *METAL-organic frameworks, *CAPILLARY electrophoresis, *X-ray photoelectron spectroscopy, *CHINESE medicine, *IMMOBILIZED enzymes

Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors.

Authors: Moheb, Mahshid¹ (AUTHOR), Iraji, Aida^2,3 (AUTHOR), Dastyafteh, Navid⁴ (AUTHOR), Khalili Ghomi, Minoo⁴ (AUTHOR), Noori, Milad⁴ (AUTHOR), Mojtabavi, Somayeh⁵ (AUTHOR), Faramarzi, Mohammad Ali⁵ (AUTHOR), Rasekh, Fatemeh⁶ (AUTHOR), Larijani, Bagher¹ (AUTHOR), Zomorodian, Kamiar⁷ (AUTHOR), Sadat-Ebrahimi, Seyed Esmaeil¹ (AUTHOR) sesebrahimi@yahoo.com, Mahdavi, Mohammad⁴ (AUTHOR) momahdavi@sina.tums.ac.ir

Source: BMC Chemistry. 11/15/2022, Vol. 16 Issue 1, p1-12. 12p.

Subject Terms: *GLYCOSIDASE inhibitors, *GLYCEMIC control, *MOLECULAR docking, *DIABETES, *ACARBOSE, *INSULIN

Amylase-producing marine actinobacterium of Micromonospora sp. and their potential antibacterial effects against oral pathogens.

Authors: Pradeep, Rajasri¹ (AUTHOR), Sivaperumal, Pitchiah² (AUTHOR), Roy, Anitha¹ (AUTHOR)

Source: Journal of Advanced Pharmaceutical Technology & Research. 2022 Suppl 1, Vol. 13, p76-79. 4p.

Subject Terms: *AMYLASES, *GLYCOSIDASE inhibitors, *ENDANGERED species, *ENZYME inhibitors, *ANTIBACTERIAL agents, *MICROBIAL growth, *SEDIMENT sampling, *ANTI-infective agents

Geographic Terms: INDIA

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study.

Authors: Ullah, Hayat¹ (AUTHOR) ayaanwazir366@gmail.com, Khan, Shoaib² (AUTHOR), Rahim, Fazal² (AUTHOR) ayaanwazir366@gmail.com, Taha, Muhammad³ (AUTHOR), Iqbal, Rashid⁴ (AUTHOR), Sarfraz, Maliha⁵ (AUTHOR), Shah, Syed Adnan Ali^6,7 (AUTHOR), Sajid, Muhammad⁸ (AUTHOR), Awad, Mohamed F.⁹ (AUTHOR), Omran, Awatif¹⁰ (AUTHOR), Albalawi, Marzough Aziz¹¹ (AUTHOR), Abdelaziz, Mahmoud A.¹² (AUTHOR), Al Areefy, Azza^13,14 (AUTHOR), Jafri, Ibrahim¹⁵ (AUTHOR)

Source: Molecules. Oct2022, Vol. 27 Issue 20, p6921-N.PAG. 22p.

Subject Terms: *MOLECULAR docking, *GLYCOSIDASE inhibitors, *STRUCTURE-activity relationships, *ALPHA-glucosidases, *METABOLIC disorders, *DRUG standards, *DIABETES

Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.

Authors: Liu, Yang¹ (AUTHOR), Zhou, Xue¹ (AUTHOR), Zhou, Dan¹ (AUTHOR), Jian, Yongxing¹ (AUTHOR), Jia, Jingfu² (AUTHOR) jeffjia2012@live.cn, Ge, Fahuan¹ (AUTHOR) jeffjia2012@live.cn

Source: Molecules. 9/15/2022, Vol. 27 Issue 18, p5742-N.PAG. 10p.

Subject Terms: *GLYCOSIDASE inhibitors, *WHITE mulberry, *STARCH metabolism, *MOLECULAR docking, *ENZYME metabolism, *MULBERRY, *HYDROPHOBIC interactions

Geographic Terms: CHINA

Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents.

Authors: Lafosse, Marine¹ (AUTHOR) marine.lafosse@orange.fr, Liang, Yan² (AUTHOR) yolandaly168@outlook.com, Schneider, Jérémy P.² (AUTHOR) jeremy.schneider@live.fr, Cartier, Elise¹ (AUTHOR) elise.cartier@cea.fr, Bodlenner, Anne² (AUTHOR) annebod@unistra.fr, Compain, Philippe² (AUTHOR) annebod@unistra.fr, Heck, Marie-Pierre¹ (AUTHOR) annebod@unistra.fr

Source: Molecules. Aug2022, Vol. 27 Issue 15, p4772-4772. 16p.

Subject Terms: *ORGANIC chemistry, *GLYCOSIDASE inhibitors, *ANIONS, *IMINOSUGARS

Potential of Rhinachanthus nasutus (L.) Kurz Leaves Extract as an Antioxidant and Inhibitor of a-Glucosidase Activity.

Authors: Irawan, Candra^1,2, Elya, Berna¹ berna.elya@farmasi.ui.ac.id, Hanafi, Muhammad³, Saputri, Fadlina Chany¹

Source: Pharmacognosy Journal. Jul/Aug2022, Vol. 14 Issue 4, p373-378. 6p.

Subject Terms: *ANTIOXIDANTS, *GLYCOSIDASE inhibitors, *ALPHA-glucosidases, *OXIDANT status, *EXTRACTS