Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs

Authors: Chie Furihata, Takayoshi Suzuki

Source: Genes and Environment, Vol 46, Iss 1, Pp 1-14 (2024)

Subject Terms: Toxicogenomics, Genotoxic marker genes, Open TG-GATEs, Genotoxic carcinogen, Non-genotoxic carcinogen, Non-carcinogen, Ecology, QH540-549.5, Genetics, QH426-470

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Relation: https://doaj.org/toc/1880-7062

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Differentially expressed and alternately spliced genes as a novel tool for genotoxicity: a computerized study in ATT-myc transgenic mice for the recognition of genotoxic and non-genotoxic chemical

Authors: Mansour A. Alghamdi, Eman M. El Nashar, Mahmoud Elalfy, Norah S. Al-Zahrani, Mohammed A. Alshehri, Mohammad El-Nablaway, Khulood M. Al-Khater, Rashid A. Aldahhan, Eman G. El-Hadidy, Fathy Sleem, Ahmed Aljazzar, Jürgen Borlak, Mona Elhadidy

Source: Frontiers in Genetics, Vol 16 (2025)

Subject Terms: gene expression pathways, exon array, att-myc model, HCC, genotoxic, non-genotoxic, Genetics, QH426-470

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Relation: https://www.frontiersin.org/articles/10.3389/fgene.2025.1505379/full; https://doaj.org/toc/1664-8021

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AI/ML modeling to enhance the capability of in vitro and in vivo tests in predicting human carcinogenicity

Authors: Tevosyan, Ani ^{a, b}, Yeghiazaryan, Hrach ^b, Tadevosyan, Gohar ^a, Apresyan, Lilit ^a, Atoyan, Vahe ^b, Misakyan, Anna ^a, Navoyan, Zaven ^b, Stopper, Helga ^c, Babayan, Nelly ^{a, d}, Khondkaryan, Lusine ^{a, ⁎}

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis April 2025 903

Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC

Authors: Dakshinya M, Anitha P, A.S. Smiline Girija, Paramasivam A, Vijayashree Priyadharsini J

Source: Journal of Oral Biology and Craniofacial Research, Vol 15, Iss 1, Pp 48-56 (2025)

Subject Terms: Microbiome, Head and neck cancer, Carcinoma, Genotoxic, Diagnosis, Prognosis, Dentistry, RK1-715

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Relation: http://www.sciencedirect.com/science/article/pii/S221242682400174X; https://doaj.org/toc/2212-4268

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Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury

Authors: Bettina Budeus, Chiara Kroepel, Lisa Marie Stasch, Diana Klein

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Lung organoid, iPSC, Lung injury, Disease modeling, Genotoxic stress, Single cell RNAseq, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

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Assessment of Acrocentric Chromosome Association/Satellite Associations in the Human Health Conditions and Exposure to Genotoxic Agents: A Comprehensive Review

Authors: Ravindra M. Samarth, Devojit Kumar Sarma, Vaishali Yadav, Meenakshi Samartha, Kailash Manda

Source: Journal of Radiation and Cancer Research, Vol 15, Iss 4, Pp 189-199 (2024)

Subject Terms: acrocentric chromosome associations, genotoxic exposure, human diseases, radiation, satellite associations, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://journals.lww.com/jrcr/fulltext/2024/15040/assessment_of_acrocentric_chromosome.2.aspx; https://doaj.org/toc/2588-9273; https://doaj.org/toc/2468-9203

Access URL: https://doaj.org/article/a447e9b6714a42c5941d256590ae7849

Photocatalytic efficacy of pyrite in the degradation of antiretroviral drugs: Biomphalaria glabrata as a bioindicator of toxic and genotoxic effects

Authors: Fernanda Sobreira Silva, Maíra de Vasconcelos Lima, Dewson Rocha Pereira, Ana Maria Mendonça de Albuquerque Melo, Jorge Vinícius Fernandes Lima Cavalcanti, Ramón Raudel Peña Garcia, Alex Leandro Andrade de Lucena, Joan Manuel Rodríguez-Díaz, Fernanda Araújo Honorato, Daniella Carla Napoleão

Source: Emerging Contaminants, Vol 11, Iss 1, Pp 100416- (2025)

Subject Terms: AOP, Genotoxic effects, Lamivudine, Photo-fenton heterogeneous, Zidovudine, Environmental pollution, TD172-193.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405665024001173; https://doaj.org/toc/2405-6650

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Overexpression of MRE11 from the moss Physcomitrium patens enhances resistance to genotoxic DNA strand breaks by stimulating homologous recombination

Authors: Arup Das, Sudipta Ray

Source: Plant Stress, Vol 15, Iss , Pp 100786- (2025)

Subject Terms: Physcomitrium patens, MRE11, DNA repair, Homology-directed repair, Genotoxic stress, Plant ecology, QK900-989

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Relation: http://www.sciencedirect.com/science/article/pii/S2667064X2500051X; https://doaj.org/toc/2667-064X

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Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: 'A review'

Authors: Ghanya Al-Naqeb, Aliki Kalmpourtzidou, Francesca Giampieri, Rachele De Giuseppe, Hellas Cena

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: plant extracts, genotoxic, non-genotoxic, antigenotoxic, phytochemicals, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1448731/full; https://doaj.org/toc/1663-9812

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Genotoxic and Cytotoxic Activities of Cornhusk Extract of Zea mays and Leaf Extract of Sacharum officinarum

Authors: Emem Eyo Akpan, Martin Osita Anagboso, Imoh Imeh Johnny, Nwakaego Omonigho Ebong, Jude Efiom Okokon

Source: Biology, Medicine & Natural Product Chemistry, Vol 13, Iss 2, Pp 531-540 (2024)

Subject Terms: allium cepa, cytotoxic, genotoxic, medicinal plants, zea mays husk, sacharum officinarum, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://sciencebiology.org/index.php/BIOMEDICH/article/view/560; https://doaj.org/toc/2089-6514; https://doaj.org/toc/2540-9328

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Argonaute 2 regulates nuclear DNA damage, repair, and phenotypes in Arabidopsis under genotoxic stress

Authors: Kim, Jin-Hong ^{a, b, ⁎}, Dubey, Shubham Kumar ^{a, b}, Ryu, Tae Ho ^c, Lee, Seung Sik ^{a, b}, Chung, Byung Yeoup ^a

Source: In Plant Physiology and Biochemistry March 2025 220

Editorial: Reducing animal use in carcinogenicity testing

Authors: Jan Willem Van der Laan, Joseph Manuppello

Source: Frontiers in Toxicology, Vol 6 (2024)

Subject Terms: regulatory toxicology, carcinogenicity testing, 3Rs, Non-genotoxic risk assessment, alternative methods, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1538905/full; https://doaj.org/toc/2673-3080

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Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method

Authors: Ning Wang

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: neodymium nitrate, alkaline comet assay, P53 signaling pathway, genotoxic biomarkers, Benchmark Dose method, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1484111/full; https://doaj.org/toc/1663-9812

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Cilostazol geno-protective effects mitigate carbamazepine-induced genotoxicity in human cultured blood lymphocytes

Authors: Enaam M. Al Momany, Abeer M. Rababa’h, Karem H. Alzoubi, Omar F. Khabour

Source: Toxicology Reports, Vol 13, Iss , Pp 101814- (2024)

Subject Terms: Carbamazepine, Cilostazol, Sister chromatid exchange, Cell kinetic assays, Genotoxic, Cytotoxic, Toxicology. Poisons, RA1190-1270

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Relation: http://www.sciencedirect.com/science/article/pii/S2214750024001975; https://doaj.org/toc/2214-7500

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In silico approximation to aflatoxin B1 metabolism and sensitivity in commercial poultry species based on empirical mathematical equations

Authors: Hansen W. Murcia, Gonzalo Diaz, Rubén Darío Acosta

Source: Toxicology Reports, Vol 13, Iss , Pp 101752- (2024)

Subject Terms: Xenobiotic metabolism simulation, in silico simulation, Aflatoxin B1 metabolism, Cytotoxic pathway, Genotoxic pathway, Toxicology. Poisons, RA1190-1270

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Relation: http://www.sciencedirect.com/science/article/pii/S2214750024001355; https://doaj.org/toc/2214-7500

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Trace-level quantification of NDMA in levosulpuride active pharmaceutical ingredient and tablet formulation Using UFLC-MS/MS

Authors: Hemanth Vikram P․R, Gunjan Kumar, Rajashree Deka, Umme Hani, Nazima Haider, Sirajunisa Talath, Adil Farooq Wali, Dilipkumar Reddy Kandula, Narasimha M. Beeraka, Sinchana B Gopalaiah, Devi Sri Chiriki, Namitha Bannimath, Pramod Kumar, Bannimath Gurupadayya

Source: Talanta Open, Vol 10, Iss , Pp 100375- (2024)

Subject Terms: Levosulpuride, Genotoxic, NDMA, Nitrosamine impurities, Greenness assessment, Analytical chemistry, QD71-142

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Relation: http://www.sciencedirect.com/science/article/pii/S2666831924000894; https://doaj.org/toc/2666-8319

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Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

Authors: Yong Joo Park, Ha Ryong Kim, Jun Woo Kim, Jong-Hyun Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Kyu Hyuck Chung

Source: Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117222- (2024)

Subject Terms: PHMG-p, Lung cancer, Adverse outcome pathway, Non-genotoxic, Carcinogenicity assessment, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

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Relation: http://www.sciencedirect.com/science/article/pii/S0147651324012983; https://doaj.org/toc/0147-6513

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Developing a solid-phase extraction method based on a novel polymer-silica composite for analysis of sulfonate genotoxic impurities in drugs

Authors: Zhou, Wen ^a, Zhu, Fucheng ^b, Li, Yuanlin ^a, Liu, Chen ^a, Xu, Jie ^c, Liu, Houmei ^{a, ⁎}

Source: In Microchemical Journal May 2025 212

Determination of potential genotoxic impurities in labetalol hydrochloride by HPLC-MS/MS method

Authors: Jiarui HAN, Yanmei XU, Lijuan HAO, Yanxia GAO

Source: Journal of Hebei University of Science and Technology, Vol 45, Iss 3, Pp 277-282 (2024)

Subject Terms: chemical analysis, labetalol hydrochloride, hplc-ms/ms, genotoxic impurity, n-nitroso-laelalol, Technology

File Description: electronic resource

Relation: https://xuebao.hebust.edu.cn/hbkjdx/article/pdf/b202403006?st=article_issue; https://doaj.org/toc/1008-1542

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Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

Authors: Lim, Hui Kheng ^{a, ⁎}, Hughes, Christopher Owen ^a, Landry, Timothy ^c, Tan, Choon Wee Joseph ^a, Ayehunie, Seyoum ^c, Smith, Benjamin Paul Chapman ^{a, b}

Source: In NAM Journal 2025 1