Epithelial-to-mesenchymal transition drives cancer genomic instability

Authors: Julienne L. Carstens, Sara Lovisa

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-5 (2025)

Subject Terms: EMT, Epithelial-to-mesenchymal transition, Genomic instability, Cell plasticity, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

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Advances in tumor subclone formation and mechanisms of growth and invasion

Authors: Yuhong Zhang, Weidong Wang

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-12 (2025)

Subject Terms: Tumor subclones, Clonal evolution, Genomic instability, Intratumoral heterogeneity, Phylogenetic analysis, Multi-omics integration, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/5ed8b587901e48aaad8022fa894d48bc

Palmitoylation-related gene expression and its prognostic value in ovarian cancer: insights into immune infiltration and therapeutic potential

Authors: Shaoying Zeng, Lijian Zeng, Xiaoying Xie, Liang Peng

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Palmitoylation, OV, Immune Infiltration, Prognostic model, Immunotherapy, Genomic instability, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/e4f1e3ead03c426b80025ba97a5f5b9e

Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib

Authors: Alan Barnicle, Isabelle Ray-Coquard, Etienne Rouleau, Karen Cadoo, Fiona Simpkins, Carol Aghajanian, Alexandra Leary, Andrés Poveda, Stephanie Lheureux, Eric Pujade-Lauraine, Benoit You, Jonathan Ledermann, Ursula Matulonis, Charlie Gourley, Kirsten M. Timms, Zhongwu Lai, Darren R. Hodgson, Cathy E. Elks, Simon Dearden, Coumaran Egile, Pierre Lao-Sirieix, Elizabeth A. Harrington, Jessica S. Brown

Source: Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)

Subject Terms: Ovarian cancer, Genomic instability, Translational research, Olaparib, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/2cc22ceb55de4044a920709aead2f670

Evaluation of Micronucleus in Buccal Mucosa Samples as a Potential Biomarker for Early Diagnosis of Parkinson’s Disease: A Cross-sectional Study

Authors: Disha K Davis, Rajila Hannah Sugirthabai Rajendran

Source: Journal of Clinical and Diagnostic Research, Vol 19, Iss 5, Pp AC01-AC03 (2025)

Subject Terms: genomic instability, micronuclei, neurodegenerative disease, non invasive indicator, Medicine

File Description: electronic resource

Relation: https://jcdr.net/articles/PDF/20924/78282_CE[Ra1]_F(SHU)_QC(PS_OM)_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X

Access URL: https://doaj.org/article/a7e0bff4bd534a74bfbd497f7802c692

SETD2 loss of function is a recurrent event in advanced‐phase chronic myeloid leukemia and contributes to genomic instability

Authors: Manuela Mancini, Sara De Santis, Cecilia Monaldi, Fausto Castagnetti, Miriam Iezza, Alessandra Iurlo, Daniele Cattaneo, Sara Galimberti, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Maura Rossi, Claudio Agostinelli, Manja Meggendorfer, Torsten Haferlach, Michele Cavo, Gabriele Gugliotta, Simona Soverini

Source: Clinical and Translational Medicine, Vol 15, Iss 4, Pp n/a-n/a (2025)

Subject Terms: Aurora kinase A, genomic instability, H3K36me3, MDM2, SETD2, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/fa2226c511bf4bcf901ad8a25d9c6de8

UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models

Authors: Huadong Xu, Fan Wu, Chuyan Zhang, Chan Ding, Shuqian Chen, Lingfang Feng, Junfei Chen, Zhaoqiang Jiang, Yongxin Li, Jianlin Lou

Source: Ecotoxicology and Environmental Safety, Vol 293, Iss , Pp 118047- (2025)

Subject Terms: Hexavalent chromium, UBA52, RDNA copy number, Genomic instability, DNA damage, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325003835; https://doaj.org/toc/0147-6513

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Genetic impact of copy number variations on congenital heart defects: Current insights and future directions

Authors: Nandini Krishnamurthy, Devi Krishna, Sanjana, Jebaraj Rathinasamy, Ashok Kumar, Andrea Mary Francis

Source: Global Medical Genetics, Vol 12, Iss 1, Pp 100008- (2025)

Subject Terms: Copy number variation, Genomic instability, Multiplex ligation-dependent probe amplification (MLPA), Chromosomal microarray analysis (CMA), Whole exome sequencing (WES), CNV-specific sequencing (CNV-seq), Genetics, QH426-470, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2699940424000080; https://doaj.org/toc/2699-9404

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Analysis for type of 53BP1 nuclear expression by immunofluorescence as an indicator of genomic instability in oropharyngeal squamous epithelial lesions

Authors: Hideaki Nishi, Katsuya Matsuda, Mariko Terakado, Hisayoshi Kondo, Yoshihiko Kumai, Masahiro Nakashima

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Oropharyngeal squamous cell carcinoma, 53BP1, HPV, Genomic instability, p16INK4a, p53, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

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A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background

Authors: Aravindan Narayanan, Ankita S. More, Muskan Talreja, Avinash M. Mali, Sannannagari Boya Vinay, Sharmila A. Bapat

Source: Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-14 (2024)

Subject Terms: ITGB8, p53, Aneuploidy, Genomic instability, Prosurvival mechanisms, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://doaj.org/toc/1757-2215

Access URL: https://doaj.org/article/56158b10f58e42828dccd1ff13c34b74

Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production

Authors: Chloë Deelkens, Elly De Vlieghere, Mario Van Poucke, Masaki Kinoshita, Jeffrey Aalders, Lieven Thorrez, Bert Devriendt, Ann Van Soom, Luc Peelman, Björn Menten, Catharina De Schauwer, Jolanda van Hengel

Source: Future Foods, Vol 11, Iss , Pp 100555- (2025)

Subject Terms: Bovine embryonic stem cells, Aneuploidy, Cellular agriculture, Genomic instability, Food safety, Cultured meat, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666833525000188; https://doaj.org/toc/2666-8335

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DNA damage induced by parasitic infections in humans and animals

Authors: Rajković, Milan ^{a, ⁎, 1, 2}, Deksne, Gunita ^{b, c}, Živković, Lada ^d, Leonova, Elina ^e, Spremo-Potparević, Biljana ^d, Sjakste, Nikolajs ^e

Source: In Comparative Immunology, Microbiology and Infectious Diseases May 2025 119

LIN28B enhances the chemosensitivity of colon cancer cells via inducing genomic instability by upsetting the balance between the production and removal of reactive oxygen species

Authors: Wang, Tianzhen ^{a, b, 1}, Weng, Mingjiao ^{a, b, c, 1}, Li, Kai ^{d, 1}, Li, Guoli ^{e, 1}, Hu, Shijie ^{a, b}, Hu, Ziyi ^{a, b}, Li, Yanping ^{a, b}, Li, Muhan ^{a, b}, Wu, Di ^f, Liang, Zhigang ^{c, ⁎}, Yu, Fei ^{g, ⁎⁎}, Wang, Guangyu ^{h, ⁎⁎⁎}, Li, Xiaobo ^{a, b, ⁎⁎⁎⁎}

Source: In Cancer Letters 28 April 2025 616

Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

Authors: Musiani, Daniele ¹, Yücel, Hatice ¹, Vallette, Marie ¹, Angrisani, Annapaola ², El Botty, Rania ³, Ouine, Bérengère ⁴, Schintu, Niccolo ¹, Adams, Caroline ¹, Chevalier, Manon ¹, Heloise, Derrien ³, El Marjou, Ahmed ⁴, Nemazanyy, Ivan ⁵, Regairaz, Marie ^{1, 6}, Marangoni, Elisabetta ³, Fachinetti, Daniele ², Ceccaldi, Raphael ^{1, 7, ∗}

Source: In Molecular Cell 20 March 2025 85(6):1072-1084

A predictive chromatin architecture nexus regulates transcription and DNA damage repair

Authors: Bhat, Audesh ^{1, ∗}, Bhan, Sonali ¹, Kabiraj, Aindrila ^{2, 3}, Pandita, Raj K. ⁴, Ramos, Keneth S. ⁴, Nandi, Sandhik ^{2, 3}, Sopori, Shreya ¹, Sarkar, Parthas S. ⁵, Dhar, Arti ⁶, Pandita, Shruti ⁷, Kumar, Rakesh ⁸, Das, Chandrima ^{2, 3, ∗}, Tainer, John A. ⁹, Pandita, Tej K. ^{4, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

p53-mediated regulation of LINE1 retrotransposon-derived R-loops

Authors: Paul, Pratyashaa, Kumar, Arun, Parida, Ankita Subhadarsani, De, Astik Kumar, Bhadke, Gauri, Khatua, Satyajeet, Tiwari, Bhavana ^∗

Source: In Journal of Biological Chemistry March 2025 301(3)

Mechanisms underlining R-loop biology and implications for human disease

Authors: Junzhe Liu, Fengze Li, Yulong Cao, Yonghui Lv, Kunjian Lei, Zewei Tu, Chuandong Gong, Haiyan Wang, Feng Liu, Kai Huang

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: R-loop, replication-transcription collision, genomic instability, neurodegenerative disorders, gene regulation, cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1537731/full; https://doaj.org/toc/2296-634X

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Editorial: Exploring genomic instability of cancers: applications in diagnosis and treatment

Authors: Dong Zhang, Shiaw-Yih Lin, Marietta Lee

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: genomic instability, cancer, hypoxia, lung adenocarcinoma, PARP inhbitors, tumor immunity, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1528281/full; https://doaj.org/toc/2296-634X

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Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability

Authors: Ryosuke Seino, Haruka Kubo, Kai Nishikubo, Hisanori Fukunaga

Source: Environment International, Vol 196, Iss , Pp 109315- (2025)

Subject Terms: DNA copy number variation, Genomic instability, Hereditary effect, mitochondrial DNA, Radiation, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412025000662; https://doaj.org/toc/0160-4120

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True cancer stem cells exhibit relative degrees of dormancy and genomic stability

Authors: Sanford H. Barsky, Krista Mcphail, Justin Wang, Jordan Dillard, Crystal J. Beard, Yin Ye

Source: Neoplasia: An International Journal for Oncology Research, Vol 60, Iss , Pp 101127- (2025)

Subject Terms: Cancer stem cells, Array CGH, Genomic instability, Gene amplifications, Gene deletions, Particle uptake, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558625000065; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/a9790275e4b84dd68a4cbae257ce3dd5