Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer

Authors: Xinyue Du, Weijie Luo, Hongwu Li, Qi Gu, Ping Huang, Cheng Wang, Na Li, Fanglan Liu, Chunhua Xia

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-24 (2025)

Subject Terms: CircRNAs, NSCLC, Gemcitabine resistance, MiR-582-5p, FGF9, WNT canonical and non-canonical signaling pathways, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/a49fab04da2946f6bbee8d7e0131cca1

FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma

Authors: Tung-Wei Hsu, Wan-Yu Wang, Hsin-An Chen, Tzu-Hsuan Wang, Chih-Ming Su, Po-Hsiang Liao, Alvin Chen, Kuei-Yen Tsai, George Kokotos, Cheng-Chin Kuo, Ching-Feng Chiu, Yen-Hao Su

Source: Cancer & Metabolism, Vol 13, Iss 1, Pp 1-19 (2025)

Subject Terms: FOXO3a, Gemcitabine resistance, Lactate dehydrogenase A, microRNA-4259, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/e90834b85d624c83af4da9bf7e89ba1c

The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer

Authors: Saimeng Shi, Longyun Ye, Kaizhou Jin, Xianjun Yu, Duancheng Guo, Weiding Wu

Source: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3634-3650 (2024)

Subject Terms: Pancreatic cancer, Gemcitabine resistance, Complement C3a, C3aR antagonist, Neoadjuvant therapy, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037024003118; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/977c18f132574aa0a690046006ab5d02

Niraparib perturbs autophagosome-lysosome fusion in pancreatic ductal adenocarcinoma and exhibits anticancer potential against gemcitabine-resistant PDAC

Authors: Zehui Yao, Huihui Zhang, Kewei Huang, Guizhong Huang, Pu Xi, Lingmin Jiang, Dailei Qin, Fan Chen, Shengping Li, Ran Wei

Source: Translational Oncology, Vol 51, Iss , Pp 102206- (2025)

Subject Terms: Pancreatic ductal adenocarcinoma, Niraparib, Autophagy, Gemcitabine-resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324003334; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/4e28507e61c146ef892fb3f7b592ebc3

Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress

Authors: Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang, Bai Cui, Quentin Liu, Fei Peng

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: Olanzapine, Chronic stress, Norepinephrine, CLOCK transcription, Gemcitabine resistance, Cancer stemness, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/74d58abd76404a50b913a8ffc5f166a8

Pentose phosphate recycling driven by Gli1 contributes to chemotherapy resistance in cancer cells

Authors: Hu, Qiangsheng ^{a, b, 1}, Jiang, Cong ^{b, 1}, Qin, Yi ^{a, c, d, e, f, 1}, Li, Borui ^{a, c, d, e, f, 1}, Wang, Jingyi ^{g, 1}, Wang, Ting ^{a, c, d, e, f}, Ji, Shunrong ^{a, c, d, e, f}, Ye, Zeng ^{a, c, d, e, f}, Dang, Qing ^{a, c, d, e, f}, Liu, Mingyang ^{h, ⁎}, Yu, Xianjun ^{a, c, d, e, f, ⁎⁎}, Xu, Xiaowu ^{a, c, d, e, f, ⁎⁎⁎}

Source: In Cancer Letters 28 May 2025 618

Flurbiprofen inhibits cAMP transport by MRP4/ABCC4 increasing the potency of gemcitabine treatment in PDAC cell models

Authors: Cerviño, Ramiro Héctor ^a, Gómez, Natalia ^a, Sahores, Ana ^a, Gouts, Agustín ^a, González, Betina ^a, Shayo, Carina ^b, Davio, Carlos ^a, Yaneff, Agustín ^{a, ⁎}

Source: In International Journal of Biological Macromolecules November 2024 280 Part 4

EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer

Authors: Zhe Yang, Feiran Chen, Dafu Wei, Fengping Chen, Haixing Jiang, Shanyu Qin

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: EGR1, Pancreatic cancer, Gemcitabine resistance, MDR1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/4c81a417e8b64efda039a816b13e56ae

Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress

Authors: Chunhua She, Chao Wu, Weihua Guo, Yongjie Xie, Shouyi Li, Weishuai Liu, Chao Xu, Hui Li, Pei Cao, Yanfang Yang, Xiuchao Wang, Antao Chang, Yukuan Feng, Jihui Hao

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-22 (2023)

Subject Terms: RUNX1, Gemcitabine resistance, ER stress, BiP, PDAC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/35cb9655f284424ab326102f407ef4cd

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma

Authors: Danqi Fu, Jingrui Yan, Zhaoyu Zhang, Yang Liu, Xiaoqing Ma, Jinsheng Ding, Shengyu Yang, Ran Zhao, Antao Chang, Chuntao Gao, Jing Liu, Tiansuo Zhao, Xiuchao Wang, Chongbiao Huang, Song Gao, Ying Ma, Bo Tang, Yukuan Feng, Hongwei Wang, Jihui Hao

Source: Cancer Biology & Medicine, Vol 20, Iss 8, Pp 599-626 (2023)

Subject Terms: gemcitabine resistance, pancreatic ductal adenocarcinoma, phospholipase d1, nucleophosmin 1, crispra library, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.cancerbiomed.org/content/20/8/599; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/a41f4acb910649a6b6434c404baaece3

Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance

Authors: Shengwei Jiang, Tingwei Deng, Huan Cheng, Weihan Liu, Dan Shi, Jiahui Yuan, Zhiwei He, Weiwei Wang, Boning Chen, Li Ma, Xianbin Zhang, Peng Gong

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)

Subject Terms: Gemcitabine resistance, Organoids, Macrophages, Cancer stem cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/9cf65e547cb34fb6ad5877d93a595764

m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway

Authors: Kai Lin, Endi Zhou, Ting Shi, Siqing Zhang, Jinfan Zhang, Ziruo Zheng, Yuetian Pan, Wentao Gao, Yabin Yu

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)

Subject Terms: FTO, N6-methyladenosine, Pancreatic carcinoma, Proliferation, Gemcitabine resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/d556c8e2e35c4b8aa19b1183d4681c03

Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling

Authors: He Hui, Guo Jiaqi, Hu Yunxiang, Zhang Han, Li Xinyang, Zhang Jian, Jin Shi

Source: Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1404-1414 (2023)

Subject Terms: saikosaponin D, gemcitabine resistance, intrahepatic cholangiocarcinoma, ADRB2, glycolysis, Biochemistry, QD415-436, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/6c5364d3579c479e8fc1e59bb4c58a5c

Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer

Authors: Yuan Li, Caiming Xu, Haiyong Han, Silvia Pascual-Sabater, Cristina Fillat, Ajay Goel

Source: Pharmaceuticals, Vol 17, Iss 7, p 911 (2024)

Subject Terms: pancreatic ductal adenocarcinoma, aronia berry extracts, gemcitabine resistance, MYD88, anticancer effect, chemoprevention, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/7/911; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/0e8279bd7feb45949c5d6c11840368a6

Knockdown of TGF-β in Pancreatic Cancer Helps Ameliorate Gemcitabine Resistance

Authors: Xinxing Wang, Wei Su, Chuan Qin, Ruxin Gao, Shuai Shao, Xianwen Xu, Zhenhai Zhang, Junlin Gao

Source: Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 269 (2024)

Subject Terms: tgf-β, pancreatic cancer, gemcitabine resistance, emt, m2-type polarization, Biochemistry, QD415-436, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.imrpress.com/journal/FBL/29/7/10.31083/j.fbl2907269; https://doaj.org/toc/2768-6701

Access URL: https://doaj.org/article/e0a7d2a44e484fdf9d8c9e0bc10a6c85

Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer

Authors: Renfa Liu, Huanyu Yang, Shuai Qu, Peipei Yang, Xin Zhi, Yunxue Xu, Zhifei Dai, Linxue Qian

Source: Aggregate, Vol 5, Iss 1, Pp n/a-n/a (2024)

Subject Terms: antimicrobial peptide, gemcitabine resistance, intratumoral microbiota, pancreatic ductal adenocarcinoma, photodynamic antibacterial therapy, Chemistry, QD1-999, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2692-4560

Access URL: https://doaj.org/article/7d64088f939b4e4aa4a3e7ab2a186800

Characterization and treatment of gemcitabine‐ and cisplatin‐resistant bladder cancer cells with a pan‐RAS inhibitor

Authors: Hirofumi Yoshino, Seiya Yokoyama, Motoki Tamai, Shunsuke Okamura, Sayaka Iizasa, Takashi Sakaguchi, Yoichi Osako, Satoru Inoguchi, Ryosuke Matsushita, Yasutoshi Yamada, Masayuki Nakagawa, Shuichi Tatarano, Akihide Tanimoto, Hideki Enokida

Source: FEBS Open Bio, Vol 13, Iss 6, Pp 1056-1066 (2023)

Subject Terms: bladder cancer, cisplatin resistance, gemcitabine resistance, pan‐RAS inhibitor, RAS, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/720e8450134c49778a8939c7650a0022

DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling

Authors: Huang Hui, Li Xia, Zhang Xianlin, Li Zhiqiang, Han Duo, Gao Wenzhe, Liu Ling, Peng Cheng, Zhu Hongwei, Yu Xiao

Source: Acta Biochimica et Biophysica Sinica, Vol 54, Pp 1775-1788 (2022)

Subject Terms: pancreatic cancer, lncRNA DSCR9, miR-21-5p, BTG2, proliferation, gemcitabine resistance, Biochemistry, QD415-436, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/e6ed761a23af4a1aa061c61ea15b2e6b

RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway

Authors: Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi

Source: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-15 (2022)

Subject Terms: RRP9, IGF2BP1, AKT, Apoptosis, DNA damage, Gemcitabine resistance, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/0cae5c3a03ed45fc8cffb88dd87561d9

Long non‐coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2‐mediated epigenetic modification

Authors: Yi Yu, Yu‐Feng Zou, Run‐Qi Hong, Wen‐Jie Chen, Liang Chen, Wen‐Qi Chen, Hui‐Peng Wang, Yuan Yu

Source: Kaohsiung Journal of Medical Sciences, Vol 38, Iss 10, Pp 981-991 (2022)

Subject Terms: EZH2, gemcitabine resistance, lncRNA SNHG16, pancreatic cancer, Smad4, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1607-551X; https://doaj.org/toc/2410-8650

Access URL: https://doaj.org/article/8e18f71a194d4ed1a132f5e5acb58da2