IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

Authors: Wallet, Pierre¹, Benaoudia, Sacha¹, Mosnier, Amandine¹, Lagrange, Brice¹, Martin, Amandine¹, Lindgren, Helena², Golovliov, Igor², Michal, Fanny¹, Basso, Pauline³, Djebali, Sophia¹, Provost, Angelina¹, Allatif, Omran¹, Meunier, Etienne⁴, Broz, Petr⁵, Yamamoto, Masahiro⁶, Py, Bénédicte F.¹, Faudry, Eric³, Sjöstedt, Anders², Henry, Thomas¹ thomas.henry@inserm.fr

Source: PLoS Pathogens. 10/3/2017, Vol. 13 Issue 10, p1-26. 26p.

Subject Terms: *FRANCISELLA novicida, *INTERFERON gamma, *INFLAMMASOMES, *ANTIBACTERIAL agents, *INTERFERON inducers

Shared features of cryptic plasmids from environmental and pathogenic Francisella species.

Authors: Challacombe, Jean F.¹ jchalla@lanl.gov, Pillai, Segaran², Kuske, Cheryl R.¹

Source: PLoS ONE. 8/24/2017, Vol. 12 Issue 8, p1-19. 19p.

Subject Terms: *FRANCISELLA novicida, *PATHOGENIC microorganisms, *BRACKISH waters, *PLASMIDS, *COOLING systems

Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida.

Authors: Dean, Scott N^1,2 (AUTHOR), van Hoek, Monique L^1,2 (AUTHOR) mvanhoek@gmu.edu

Source: Virulence. 2015, Vol. 6 Issue 5, p487-503. 17p.

Subject Terms: *FRANCISELLA novicida, *GRAM-negative bacteria, *BIOTERRORISM research, *MICROBIAL virulence, *MAPROTILINE, *THERAPEUTICS

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Authors: Meunier, Etienne¹, Wallet, Pierre², Dreier, Roland F¹, Costanzo, Stéphanie², Anton, Leonie¹, Rühl, Sebastian¹, Dussurgey, Sébastien³, Dick, Mathias S¹, Kistner, Anne¹, Rigard, Mélanie², Degrandi, Daniel⁴, Pfeffer, Klaus⁴, Yamamoto, Masahiro⁵, Henry, Thomas², Broz, Petr¹

Source: Nature Immunology. May2015, Vol. 16 Issue 5, p476-484. 9p. 8 Graphs.

Subject Terms: *FRANCISELLA novicida, *GUANYLATE cyclase, *CYTOSOL, *CYTOKINES, *DNA viruses, *BACTERIOLYSIS

Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates.

Authors: Chu, Ping¹, Cunningham, Aimee L.¹, Yu, Jieh-Juen¹, Nguyen, Jesse Q.¹, Barker, Jeffrey R.¹, Lyons, C. Rick², Wilder, Julie³, Valderas, Michelle³, Sherwood, Robert L.³, Arulanandam, Bernard P.¹, Klose, Karl E.¹ Karl.Klose@utsa.edu

Source: PLoS Pathogens. Oct2014, Vol. 10 Issue 10, p1-10. 10p.

Subject Terms: *TULAREMIA, *FRANCISELLA novicida, *BACTERIAL vaccines, *MICROBIAL virulence, *LABORATORY rats, *PRIMATES as laboratory animals, *THERAPEUTICS

Francisella novicida Pathogenicity Island Encoded Proteins Were Secreted during Infection of Macrophage-Like Cells.

Authors: Hare, Rebekah F.¹, Hueffer, Karsten² khueffer@alaska.edu

Source: PLoS ONE. Aug2014, Vol. 9 Issue 8, p1-16. 16p.

Subject Terms: *FRANCISELLA novicida, *PATHOGENIC bacteria, *MACROPHAGES, *INTRACELLULAR pathogens, *IMMUNE response, *PLASMIDS

Francisella novicida infection in a patient with pulmonary infection and pancreatitis in Italy

Authors: Sara Rigamonti, Emanuela Olivieri, Nadia Vicari, Erika Scaltriti, Moira Bazzucchi, Claudio Marco Lodola, Arianna Torri, Vittorio Sambri, Carlo Biagetti, Paola Prati

Source: IDCases, Vol 37, Iss , Pp e02038- (2024)

Subject Terms: Francisella novicida, Pneumonia, Italy, WGS, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214250924001148; https://doaj.org/toc/2214-2509

Access URL: https://doaj.org/article/38813efa01a0402cae09e389af7d6f0f

Chitinases Are Negative Regulators of Francisella novicida Biofilms.

Authors: Chung, Myung-Chul¹ mchung3@gmu.edu, Dean, Scott¹, Marakasova, Ekaterina S.¹, Nwabueze, Albert O.¹, van Hoek, Monique L.¹

Source: PLoS ONE. Mar2014, Vol. 9 Issue 3, p1-12. 12p.

Subject Terms: *CHITINASE, *FRANCISELLA novicida, *BACTERIA & the environment, *BACTERIAL cell surfaces, *BIOTIC communities, *MICROBIAL ecology

Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.

Authors: Jones, Crystal L.^1,2,3, Sampson, Timothy R.^1,2,3, Nakaya, Helder I.^2,3, Pulendran, Bali^2,3,4, Weiss, David S.^2,3,5

Source: Cellular Microbiology. Oct2012, Vol. 14 Issue 10, p1531-1543. 13p. 7 Graphs.

Subject Terms: *LIPOPROTEINS, *FRANCISELLA novicida, *BACTERIA, *NATURAL immunity, *IMMUNE recognition, *TOLL-like receptors, *INFLAMMATION, *PATHOGENIC microorganisms

Genetic diversity within the genus Francisella as revealed by comparative analyses of the genomes of two North American isolates from environmental sources.

Authors: Siddaramappa, Shivakumara¹, Challacombe, Jean F.^1,2, Petersen, Jeannine M., Pillai, Segaran³, Kuske, Cheryl R.¹ kuske@lanl.gov

Source: BMC Genomics. 2012, Vol. 13 Issue 1, p422-438. 17p. 4 Diagrams, 3 Charts, 1 Graph.

Subject Terms: *FRANCISELLA tularensis, *FRANCISELLA novicida, *PATHOGENIC microorganisms, *TULAREMIA, *BIOLOGICAL evolution

The first case of Francisella novicida infection in Taiwan: bacteraemic pneumonia in a haemodialysis adult

Authors: Hao-En Jan, Chin-Shiang Tsai, Nan-Yao Lee, Pei-Fang Tsai, Li-Rong Wang, Po-Lin Chen, Wen-Chien Ko

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 310-313 (2022)

Subject Terms: francisella novicida, bacteraemia, pneumonia, 16s ribosomal rna, taiwan, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/cd271f5e47ac4c21aa543204d1aeb490

Glycosylation of a Capsule-Like Complex (CLC) by Francisella novicida Is Required for Virulence and Partial Protective Immunity in Mice

Contributors: Inzana, Thomas [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States). Center for Molecular Medicine and Infectous Diseases, Dept. of Biomedical Sciences and Pathobiology; Virginia Technical Carilion School of Medicine, Roanoke, VA (United States). Dept. of Biomedical Sciences]

Source: Frontiers in Microbiology; 8

File Description: Medium: ED; Size: Article No. 935

Access URL: http://www.osti.gov/scitech/servlets/purl/1389272

Teaching old drugs new tricks: Addressing resistance in Francisella.

Authors: Feldmann, Erik A¹ (AUTHOR), Cavanagh, John¹ (AUTHOR) jcavana@ncsu.edu

Source: Virulence. 2015, Vol. 6 Issue 5, p414-416. 3p.

Subject Terms: *MULTIDRUG resistance in bacteria, *FRANCISELLA novicida, *FRANCISELLA tularensis, *TULAREMIA, *MICROBIAL virulence, *DRUG efficacy, *THERAPEUTICS

Single and multiplexed gene repression in solventogenic Clostridium via Cas12a-based CRISPR interference.

Authors: Joseph, Rochelle Carla, Sandoval, Nicholas R.

Source: Synthetic & Systems Biotechnology; Mar2023, Vol. 8 Issue 1, p148-156, 9p

Subject Terms: GENE expression, CLOSTRIDIUM, CRISPRS, FEEDSTOCK, FRANCISELLA novicida, GENOME editing

Expansion of the prime editing modality with Cas9 from Francisella novicida

Authors: Yeounsun Oh, Wi-jae Lee, Junho K. Hur, Woo Jeung Song, Youngjeon Lee, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Bong-Seok Song, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung, Seung Hwan Lee

Source: Genome Biology, Vol 23, Iss 1, Pp 1-12 (2022)

Subject Terms: Prime editing, Target expansion, CRISPR-Cas9, Ortholog, Francisella novicida, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/478d21aa92f94a34b52403f151d6642d

Turning up Francisella pathogenesis: The LPS thermostat.

Authors: Powell, Daniel A.¹ (AUTHOR), Li, Yanyan² (AUTHOR), Ernst, Robert K.¹ (AUTHOR) rkernst@umaryland.edu

Source: Virulence. 11/15/2012, Vol. 3 Issue 7, p594-595. 3p.

Subject Terms: *FRANCISELLA novicida, *FATTY acid synthesis, *ACYLATION, *INTRACELLULAR pathogens, *ENZYMES

RtxA like protein contributes to infection of Francisella novicida in silkworm and human macrophage THP-1.

Authors: Saha, Shib Shankar^1,2, Uda, Akihiko³, Watanabe, Kenta¹, Shimizu, Takashi¹, Watarai, Masahisa¹ watarai@yamaguchi-u.ac.jp

Source: Microbial Pathogenesis. Oct2018, Vol. 123, p74-81. 8p.

Subject Terms: *FRANCISELLA novicida, *SILKWORMS, *MACROPHAGES, *TULAREMIA, *ZOONOSES

Silkworm model for Francisella novicida infection.

Authors: Saha, Shib Shankar^1,2, Suzuki, Jin¹, Uda, Akihiko³, Watanabe, Kenta¹, Shimizu, Takashi¹, Watarai, Masahisa¹ watarai@yamaguchi-u.ac.jp

Source: Microbial Pathogenesis. Dec2017, Vol. 113, p94-101. 8p.

Subject Terms: *FRANCISELLA novicida, *SILKWORM diseases, *VIRULENCE of bacteria, *HEMOLYMPH infections, *BACTERIAL mutation

Effects of lipid A acyltransferases on the pathogenesis of F. novicida.

Authors: Yun, Jian^1,2,3, Wang, Xiaoyuan², Zhang, Liang⁴ zhangl@jiangnan.edu.cn, Li, Yanyan^1,2 yanyanli1123@hotmail.com

Source: Microbial Pathogenesis. Aug2017, Vol. 109, p313-318. 6p.

Subject Terms: *FRANCISELLA novicida, *ACYLTRANSFERASE genetics, *DNA mutational analysis, *CELL-mediated cytotoxicity, *MICROBIAL virulence genetics

Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA.

Authors: Alcón, Pablo¹, Montoya, Guillermo¹, Stella, Stefano¹

Source: Acta Crystallographica: Section F, Structural Biology Communications. Jul2017, Vol. 73 Issue 7, p409-415. 6p.

Subject Terms: *FRANCISELLA novicida, *ENDONUCLEASES, *CRISPRS