Efficacy and safety of triplet regimen capecitabine, oxaliplatin, and irinotecan (XELOXIRI) as first-line chemotherapy for advanced pancreatic cancer

Authors: Bi-Yang Cao, Qi Cao, Xiao-Ting Ma, Kai Ou, Wen-Wei Yang, Le-Tian Zhang, Jing-Yu Lu, Zhi-Chao Jiang, Wen Zhang, Jie Zhang, Qi Wang, Li-Zhen Gao, Lin Yang

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-9 (2025)

Subject Terms: Pancreatic cancer, Chemotherapy, XELOXIRI, First-line, Treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/0f311c2e95454dabb038499f854b4661

Microbiological Characteristics of Community-Acquired Pneumonia in Children in Northern Vietnam

Authors: Tung Anh DINH DUONG, Thi Oanh DAM

Source: International Journal of Biomedicine, Vol 15, Iss 1, Pp 183-187 (2025)

Subject Terms: community-acquired pneumonia, first-line antibiotics, antibiotic resistance, multidrug resistance, Medicine

File Description: electronic resource

Relation: http://www.ijbm.org/articles/i57/ijbm_15(1)_oa22.pdf; https://doaj.org/toc/2158-0510; https://doaj.org/toc/2158-0529

Access URL: https://doaj.org/article/875680b912884ca4ba96992f4e6cc5b7

The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma

Authors: Kazuhiro Shiraishi, Mao Okada, Shun Yamamoto, Yuki Matsubara, Toshiki Masuishi, Keitaro Shimozaki, Yoshiyuki Yamamoto, Suguru Hirose, Keiji Sugiyama, Mitsuhiro Furuta, Nozomu Machida, Naoki Takahashi, Takako Yoshii, Yosuke Kito, Takao Tsuzuki, Shogen Boku, Kenji Tsuchihashi, Akinori Sugaya, Toshizo Takayama, Azusa Komori, Seiichiro Mitani, Toshihiko Matsumoto, Takashi Nishimura, Kenro Hirata

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: Esophageal cancer, Chemotherapy, FOLFOX, First-line, Later-line, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1dd8d7761f5c4a22aee0a617b2f90010

Cost-effectiveness analysis of nimotuzumab combined with gemcitabine for K-Ras wild type locally advanced or metastatic pancreatic cancer in China

Authors: Rong Long, Hao Guo, Kun Chen

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: K-Ras wild type, Locally advanced or metastatic pancreatic cancer, Nimotuzumab, Gemcitabine, Cost-effectiveness, First-line treatment, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9f472f9a4b074ff5ae8d95d9ac1c8e58

Niraparib as First-Line Maintenance Therapy in Patients with Stage III Ovarian Cancer and No Visible Residual Disease: AR1ZE Real-World Study

Authors: Dana M. Chase, Maya Hanna, Jonathan T. Lim, Tirza Areli Calderón Boyle, Mark Guinter, Madeline Richey, Khilna Patel, Jeanne M. Schilder, Jean A. Hurteau, Amanda K. Golembesky

Source: Oncology and Therapy, Vol 13, Iss 1, Pp 253-262 (2025)

Subject Terms: Electronic health records, First-line maintenance therapy, Niraparib, Ovarian cancer, Real-world, Time to next treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2366-1070; https://doaj.org/toc/2366-1089

Access URL: https://doaj.org/article/326b6380ea1f410aabfcd207103001ec

Efficacy and safety of first-line nivolumab plus ipilimumab treatment in elderly patients (aged ≥ 75 years) with non-small cell lung cancer

Authors: Satoshi Endo, Hisao Imai, Atsuto Mouri, Kasumi Tsukamoto, Kenji Masaki, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Ou Yamaguchi, Junichi Nakagawa, Kyoichi Kaira, Kunihiko Kobayashi, Hiroshi Kagamu

Source: Journal of Cancer Research and Clinical Oncology, Vol 151, Iss 1, Pp 1-12 (2025)

Subject Terms: Advanced non-small cell lung cancer, Elderly patients, First-line treatment, Immune checkpoint inhibitor, Ipilimumab, Nivolumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/f7bc7fcf21d84df6988693fe3e7e0492

Analysis of ICIs alone or in combination rechallenged outcomes after progression from first-line ICIs plus chemotherapy in patients with advanced non-small cell lung cancer

Authors: Guisen Yin, Xin Liu, Xiangtao Yu, Song Tan, Fen Liu

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: Immune checkpoint inhibitors, Chemotherapy, First line, Non-small cell lung cancer, Progression, Survival, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/edd64bc2c51946fb9a0ebcb6f306f12d

Cost-effectiveness of the addition of sintilimab as a first-line therapy for locally advanced or metastatic oesophageal squamous cell carcinoma: a Chinese healthcare system perspective

Authors: Cuicui Yu, Yingqi Wu, Yadi Geng, Hui Yan, Pengli Zhu, Peng Ji, Fei Wu, Lijuan Ning, Yubin Feng, Aizong Shen

Source: Health Economics Review, Vol 15, Iss 1, Pp 1-10 (2025)

Subject Terms: Cost-effectiveness analysis, ORIENT-15 trial, Oesophageal squamous cell carcinoma, Sintilimab, First-line treatment, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-1991

Access URL: https://doaj.org/article/156f10955a0a4ba08446702343cede9b

Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients

Authors: Juan Wei, WeiFeng Xiang, HangPing Wei, XiaoYan Hu, YiFang Lu, XiaoFang Dong

Source: BMC Gastroenterology, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: Nutrition risk index, Prognostic nutritional index, Skeletal muscle index, Early myelosuppression, First-line chemotherapy, Stage IV gastric cancer, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1471-230X

Access URL: https://doaj.org/article/f783ff7936d74d04ad67724c3b2ee840

Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study

Authors: Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

Source: BMC Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Gastric cancer, First-line treatment, Immune checkpoint inhibitor, Retrospective study, Multi-omics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/dd359a9927634ddaa34770f2f12d6e5f

Longitudinal Assessment of FT3 to FT4 Conversion Ratio in Predicting the Efficacy of First-Line Pembrolizumab-Based Therapy in Advanced Non-Small Cell Lung Cancer: A Propensity-Score Matching Analysis of Data from the National Drug Monitoring Agency

Authors: Fabrizio Nelli, Enzo Maria Ruggeri, Marta Schirripa, Antonella Virtuoso, Diana Giannarelli, Armando Raso, Daniele Remotti, Agnese Fabbri

Source: Current Oncology, Vol 31, Iss 12, Pp 7647-7662 (2024)

Subject Terms: non-small-cell lung cancer, fT3/fT4, immune checkpoint blockade, pembrolizumab, chemotherapy, first-line therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/31/12/564; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/051c535457564fb39eb6ff36bbb82b3d

The prognostic impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on patients with small cell lung cancer receiving first-line platinum-based chemotherapy: a systematic review and meta-analysis

Authors: Yuansheng Zhao, Yongsheng Wang, Yongquan Jiang, Jiandong Yang, Yuefen Zhang

Source: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Small cell lung cancer, First-line platinum-based chemotherapy, Prognosis, Meta-analysis, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/05f5ecd9376f46798d0fe271f978ca98

Onset and predictors of first-line antiretroviral therapy treatment failure among children in Ethiopia: a systematic review and meta-analysis

Authors: Molla Yigzaw Birhanu, Getamesay Molla Bekele, Bekalu Endalew, Simegn Alemu, Cheru Tesema Lashargie, Dereje Ayalew Birhanu, Assefa Mulualem, Selamawit Shita Jemberie

Source: BMC Pediatrics, Vol 24, Iss 1, Pp 1-13 (2024)

Subject Terms: First-line ART failure, Onset, Predictors, Children, Ethiopia, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2431

Access URL: https://doaj.org/article/b551c06d35994322b9a2268750f8e661

First-line chemotherapy with tislelizumab for patients with extensive-stage small cell lung cancer: a cost-effectiveness analysis

Authors: Rong Long, Fangping Chen

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Extensive-stage small-cell lung cancer (ES-SCLC), Markov model, Cost-effectiveness, Quality-Adjusted life years (QALYs), Tislelizumab, First-line, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cf9c84c724224b2c80ad5afde7ef19dd

First-line treatment of EGFR-mutated non-small cell lung cancer with brain metastases: a systematic review and meta-analysis

Authors: Jietao Ma, Xiaoxue Pang, Shuling Zhang, Letian Huang, Li Sun, Chengbo Han

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: EGFR-TKIs, Non-small cell lung cancer, Brain metastases, First-line therapy, Overall survival, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8ebe442c00564a6bbb358712a3a844c2

Priority Setting in Norwegian Municipal and Health Care Services: A Thematic Analysis of Public Consultation Documents

Authors: Marius L. Torjusen, Eli Feiring, Mathias Barra, Nina Køpke Vøllestad, Carl Tollef Solberg

Source: Tidsskrift for Omsorgsforskning, Vol 10, Iss 2, Pp 124-137 (2024)

Subject Terms: Primary care, first-line care, long-term care, regional services, nursing, coping, Nursing, RT1-120

File Description: electronic resource

Relation: https://doaj.org/toc/2387-5976; https://doaj.org/toc/2387-5984

Access URL: https://doaj.org/article/26ce57d5e01943cea8b2d5639d42aa16

Women’s health and psychological well-being in the return-to-work process after long-term sick leave for common mental disorders: women’s and first-line managers’ perspectives

Authors: Åsa Hedlund, Marja-Leena Kristofferzon, Eva Boman, Karen Nieuwenhuijsen, Annika Nilsson

Source: BMC Public Health, Vol 24, Iss 1, Pp 1-14 (2024)

Subject Terms: Common mental disorders, First-line managers, Health, Psychological well-being, Return to work, Women, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2458

Access URL: https://doaj.org/article/4065d1e250824e82b1df878933fdd129

Cost-effectiveness analysis of pembrolizumab combined with gemcitabine and cisplatin for the first-line treatment for advanced cholangiocarcinoma

Authors: Wei Wang, Lijun Xu, Peilin Li, Yongsheng Li, Jing Wu, Jihua Wang, Shanshan Zhao, Guangbing Li, Shifeng Xu, Huaiguang Chen, Yuanwen Zheng

Source: Heliyon, Vol 11, Iss 6, Pp e42553- (2025)

Subject Terms: Cost-effectiveness, Pembrolizumab, Gemcitabine and cisplatin, First-line, Advanced cholangiocarcinoma, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844025009338; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/da7b7bbb8da54f03afae95cb06fded15

Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data

Authors: Zhihao Li, Daniel Aliseda, Owen Jones, Luckshi Rajendran, Christian Magyar, Robert Grant, Grainne M. O’Kane, Anna Saborowski, Gonzalo Sapisochin, Arndt Vogel

Source: JHEP Reports, Vol 7, Iss 3, Pp 101290- (2025)

Subject Terms: Biliary tract cancers, Cholangiocarcinoma, Systemic therapy, First-line therapy, Immunotherapy, Systematic review, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924002945; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/11cfa34c53c04099a5e94bc256c9fd92

Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer?

Authors: Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

Source: European Thyroid Journal, Vol 14, Iss 1 (2025)

Subject Terms: advanced thyroid cancer, differentiated thyroid cancer, tyrosine kinase inhibitors, selective kinase inhibitors, first-line treatment, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0332.xml; https://doaj.org/toc/2235-0802

Access URL: https://doaj.org/article/6ca4162ffd8144aa8c59b32653513d9f