Tackling the Moving Mutant Target: Taxifolin Derivatives as Novel Putative E571K Exportin-1 Inhibitors for KRAS-mutant Lung Adenocarcinoma

Authors: Adigun, Temidayo, Alejolowo, Omokolade, Sulaiman, Faoziyat, Oluwadare, Itunu Ayomikun, Ogunro, Olalekan Bukunmi, Akinduko, Ayokunmi, Evbuomwan, Ikponmwosa, Agunlejika, Adebimpe, Nwonuma, Charles, Rotimi, Damilare

Source: 2024 International Conference on Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG) Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG), 2024 International Conference on. :1-15 Apr, 2024

Relation: 2024 International Conference on Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG)

Association of non–gain-of-function alterations in exportin-1 with improved overall survival in colorectal cancer

Authors: Stecko, Hunter ^{a, b}, Tsilimigras, Diamantis ^a, Iyer, Sidharth ^{a, b}, Daw, Jad ^b, Zhu, Hua ^a, Huang, Emily ^a, Kalady, Matthew ^a, Pawlik, Timothy M. ^{a, ⁎}

Source: In Journal of Gastrointestinal Surgery April 2025 29(4)

Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment

Authors: Kereshmeh Tasbihi, Heiko Bruns

Source: Cells, Vol 14, Iss 6, p 430 (2025)

Subject Terms: Selinexor, XPOVIO, XPO1, Exportin-1, nuclear export, multiple myeloma, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/6/430; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/52124205c2794d52a0146760fbb907fa

Therapeutic targeting of exportin-1 beyond nuclear export

Authors: Chen, Yi Fan ^{1, 2, ⁎}, Adams, Drew J. ^{1, 2, ⁎}

Source: In Trends in Pharmacological Sciences January 2025 46(1):20-31

Anticancer Drugs 2021

Contributors: Meegan, Mary J, O’Boyle, Niamh M

Subject Terms: thymidylate synthase, cytotoxicity, 1,2,3-triazole, 1,3,4-oxadiazole, 5-fluoruracil, pemetrexed, docking, 3,4′-bis-guanidino, 3-amino-4′-guanidino, diphenyl ether, phenyl pyridyl ether, intramolecular hydrogen bond, cancer cell viability, HL-60, BRAF, apoptosis, thieno[2,3-d][1,2,3]triazine, acetamide, H1299, HER2, EGFR, Bcl-2 inhibitors, Indole-based analogues, benzimidazole, MTT cytotoxic assay, cell cycle analysis, DNA fragmentation, ELISA, solid/lipid nanoparticles, phenstatin, letrozole, tubulin polymerisation inhibitor, aromatase inhibitor, breast cancer, hybrid molecule, dual-targeting molecule, designed multiple ligand, NaMSA, cyclophosphamide, histopathology, testis, urinary bladder, anticancer agents, enantioselective synthesis, gastric adenocarcinoma, tryptophanol, concentration-guided dosing, model informed dosing, physiologically based pharmacokinetics, sorafenib, tyrosil-DNA-phosphodiesterase 1, adamantane, resin acid, TDP1, cytotoxic agents, apoptosis induction, HT-29 cells, MDA-MB-231 cells, mechanism prediction, STAT inhibitors, miR-21, hydrazide derivatives, nitrogen scaffolds, mitoxantrone, cardiotoxicity, inflammation, oxidative stress, age, cumulative dose, Trk, NTRK, tissue-agnostic, larotrectinib, entrectinib, Trk fusion, protein kinase inhibitors, USFDA, cancer, patent review, generic product, doxazosin, MD simulations, combretastatin A-4, cytotoxic activity, hybrid compounds, indazole, mucin, MUC1, MUC16, immunotherapy, cancer vaccine, CAR (chimeric antigen receptor), ADC (antibody-drug conjugate), thiourea, interleukin-6, trypan blue assay, chalcones, exportin-1, covalent binding, CovDock, anticancer activity, xanthone, in vitro, in vivo, isolation, synthesis, heterocyclic compound, benzenesulfonamides, imidazoles, alkylated, colony formation, tumor spheroids, HDAC inhibitors, chalcone, dual inhibitors, carvedilol, kidney, toxicity, 7-deaza-4′-thioadenosine derivatives, multi-kinase inhibitor, anticancer, nucleoside, Imiquimod, drug efflux, multidrug resistance, Toll-Like Receptor, Research and information: general, Chemistry

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/84569
https://mdpi.com/books/pdfview/book/5551

Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study

Authors: Marie Maerevoet, Josee M. Zijlstra, George Follows, Rene-Olivier Casasnovas, J. S. P. Vermaat, Nagesh Kalakonda, Andre Goy, Sylvain Choquet, Eric Van Den Neste, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P. Vassilakopoulos, Priyanka Samal, Matthew Ku, Xiwen Ma, Kelly Corona, Kamal Chamoun, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Miguel Canales

Source: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)

Subject Terms: Selinexor, Exportin-1, SINE compounds, DLBCL, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/a32f7416ac1d4ff49db82a15d0e6860f

Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma

Authors: Maria V. Mateos, Maria Gavriatopoulou, Thierry Facon, Holger W. Auner, Xavier Leleu, Roman Hájek, Meletios A. Dimopoulos, Sosana Delimpasi, Maryana Simonova, Ivan Špička, Ludĕk Pour, Iryna Kriachok, Halyna Pylypenko, Vadim Doronin, Ganna Usenko, Reuben Benjamin, Tuphan K. Dolai, Dinesh K. Sinha, Christopher P. Venner, Mamta Garg, Don A. Stevens, Hang Quach, Sundar Jagannath, Philippe Moreau, Moshe Levy, Ashraf Z. Badros, Larry D. Anderson, Nizar J. Bahlis, Michele Cavo, Yi Chai, Jacqueline Jeha, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Paul G. Richardson, Sebastian Grosicki

Source: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)

Subject Terms: Selinexor, Exportin-1, Multiple myeloma, SINE compound, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/20b9da9076424d1f8dc1d21eef7bc3c4

Selinexor and COVID-19: The Neglected Warden

Authors: Gomaa Mostafa-Hedeab, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Nermeen N. Welson, Gaber El-Saber Batiha, Carlos Adam Conte-Junior

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: SARS-CoV-2, COVID-19, Selinexor, nuclear exportin-1, inflammation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.884228/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/d18a56cda00d4a0cb58010ef689a1841

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB

Authors: Basia Galinski, Marcus Luxemburg, Yosef Landesman, Bruce Pawel, Katherine J. Johnson, Stephen R. Master, Kevin W. Freeman, David M. Loeb, Jean M. Hébert, Daniel A. Weiser

Source: Translational Oncology, Vol 14, Iss 8, Pp 101114- (2021)

Subject Terms: Neuroblastoma, Exportin-1, Selinexor, Bortezomib, IkB, NF-kB, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523321001066; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/df22e3a1000a4cbeba345adf608973b1

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

Authors: Marta Gargantilla, José López-Fernández, Maria-Jose Camarasa, Leentje Persoons, Dirk Daelemans, Eva-Maria Priego, María-Jesús Pérez-Pérez

Source: Pharmaceuticals, Vol 14, Iss 11, p 1131 (2021)

Subject Terms: chalcones, exportin-1, covalent binding, CovDock, anticancer activity, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/11/1131; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/95c424c0932d4672ab5e9ae929d2cd2a

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

Authors: Eline Boons, Els Vanstreels, Maarten Jacquemyn, Tatiane C. Nogueira, Jasper E. Neggers, Thomas Vercruysse, Joost van den Oord, Sharon Tamir, Sharon Shacham, Yosef Landesman, Robert Snoeck, Christophe Pannecouque, Graciela Andrei, Dirk Daelemans

Source: EBioMedicine, Vol 2, Iss 9, Pp 1102-1113 (2015)

Subject Terms: Exportin-1, CRM1, XPO1, Small-molecule inhibitors, HIV, AIDS-related lymphoma, Primary effusion lymphoma, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396415300931; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/032494f4bfb3424aa0ed97a02a53817f

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Authors: Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg

Source: Cells, Vol 8, Iss 10, p 1181 (2019)

Subject Terms: ddx3x, nuclear export, exportin-1, crm1, nes, antiviral immunity, parainfluenza virus, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/8/10/1181; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/3ad28a06abdf4916a62a2e524aadf905

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

Authors: Ho Yee Joyce Fung, Szu-Chin Fu, Yuh Min Chook

Source: eLife, Vol 6 (2017)

Subject Terms: Exportin-1, XPO1, nuclear transport, NES, nuclear export signal, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/23961; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/efb896d9a336473ebac1e4763f220ba6

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

Authors: Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook

Source: eLife, Vol 4 (2015)

Subject Terms: nuclear transport, exportin-1, CRM1, nuclear export signal, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/10034; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/50e3f5cb3a1f4f2187bd39729518a95e

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