First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing properties

Authors: Tulapurkar, Mohan E. ^{1, ∗∗∗}, Shirey, Kari Ann ², Lugkey, Katerina ^{1, 3}, Luo, Wendy ⁴, Lal, Ritu ⁴, Galan, Adam ⁴, Mahmoud, Omar ¹, McClean, Nathaniel ⁵, Thangaraju, Kiruphagaran ⁶, Cericola, Daniel ³, Lewis, Daniel ³, Murphy, William A. ³, Fletcher, Steven ³, MacKerell, Alexander D., Jr ³, Vogel, Stefanie N. ², Shapiro, Paul ^{3, ∗∗}, Hasday, Jeffrey D. ^{1, 3, ∗}

Source: In The Journal of Pharmacology and Experimental Therapeutics March 2025 392(3)

Focal adhesion kinase mediates microvascular leakage and endothelial barrier dysfunction in ischemia-reperfusion injury

Authors: Patrick, Rebecca ¹, Pando, Briana D. ¹, Yang, Clement, Aponte, Alexandra, Wang, Fang, Ewing, Tom, Ma, Yonggang, Yuan, Sarah Y., Wu, Mack H. ^⁎

Source: In Microvascular Research May 2025 159

Extracellular purines in lung endothelial permeability and pulmonary diseases

Authors: Evgenia Gerasimovskaya, Rahul S. Patil, Adrian Davies, McKenzie E. Maloney, Liselle Simon, Basmah Mohamed, Mary Cherian-Shaw, Alexander D. Verin

Source: Frontiers in Physiology, Vol 15 (2024)

Subject Terms: extracellular purines, purinergic receptors, endothelial cells, endothelial barrier function, vasa vasorum, angiogenesis, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2024.1450673/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/42e1427200574c2595c2de227c691497

S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function

Authors: Zhang, Jing ^{a, b}, Chen, Shuhua ^c, Xiang, Hong ^d, Xiao, Jie ^e, Zhao, Shaoli ^f, Shu, Zhihao ^{a, b}, Chai, Yanfei ^{a, b}, Ouyang, Jie ^{a, b}, Liu, Huiqin ^{a, b}, Wang, Xueweng ^{a, b}, Quan, Qisheng ^{a, b}, Fan, Jianing ^{a, b}, Gao, Peng ^{a, b}, Chen, Alex F. ^g, Lu, Hongwei ^{a, b, d, ⁎}

Source: In Life Sciences 1 September 2023 328

Pulmonary arterial hypertension drugs can partially restore altered angiogenic capacities in bmpr2‐silenced human lung microvascular endothelial cells

Authors: Birger Tielemans, Allard Wagenaar, Catharina Belge, Marion Delcroix, Rozenn Quarck

Source: Pulmonary Circulation, Vol 13, Iss 4, Pp n/a-n/a (2023)

Subject Terms: endothelial barrier function, endothelial bmpr2 silencing, in vitro angiogenesis, PAH drugs, pulmonary hypertension, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/2045-8940

Access URL: https://doaj.org/article/23afff6146db47438078aef8446412ab

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury

Authors: Alejandro E. Garcia-Flores, Christine M. Gross, Evgeny A. Zemskov, Qing Lu, Kim Tieu, Ting Wang, Stephen M. Black

Source: Frontiers in Physiology, Vol 13 (2022)

Subject Terms: mechanical stress, SOX-18, claudin-5, ALI, endothelial barrier function, tight junctions, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.1066515/full; https://doaj.org/toc/1664-042X

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S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway

Authors: Kayo Kunimura, Satomi Miki, Miyuki Takashima, Jun-ichiro Suzuki

Source: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-14 (2021)

Subject Terms: Vascular endothelial barrier function, Adherens junction, Tight junction, Actin remodeling, S-1-propenylcysteine, Aged garlic extract, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/37d809f4e5b74f42a149e70474f2c517

5-methoxytryptophan: an arsenal against vascular injury and inflammation

Authors: Kenneth K. Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee, Jun-Yang Liou

Source: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-8 (2020)

Subject Terms: 5-methoxytryptophan, Tryptophan hydroxylase-1, Hydroxyindole O-methyltransferase, Intimal hyperplasia, Endothelial barrier function, Smooth muscle cell migration and proliferation, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-020-00671-w; https://doaj.org/toc/1423-0127

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Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond

Authors: Peter M. Benz, Timo Frömel, Hebatullah Laban, Joana Zink, Lea Ulrich, Dieter Groneberg, Reinier A. Boon, Philip Poley, Thomas Renne, Cor de Wit, Ingrid Fleming

Source: Cells, Vol 12, Iss 13, p 1740 (2023)

Subject Terms: Ena/VASP proteins, actin dynamics, receptor trafficking, endothelial barrier function, angiogenesis, leukocyte infiltration and polarization, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/13/1740; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/193cde973e1b481c8141e87267bdcd12

Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability

Authors: Olga Rafikova, Joel James, Cody A. Eccles, Sergey Kurdyukov, Maki Niihori, Mathews Valuparampil Varghese, Ruslan Rafikov

Source: Biology of Sex Differences, Vol 11, Iss 1, Pp 1-9 (2020)

Subject Terms: Pulmonary hypertension, Heme signaling, Lung permeability, Sex difference, Endothelial barrier function, Medicine, Physiology, QP1-981

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13293-020-00289-5; https://doaj.org/toc/2042-6410

Access URL: https://doaj.org/article/291f43c415554f9aabf17c80db58e337

Protective effect of dexmedetomidine on endothelial barrier function in rats with sepsis

Authors: SHE Han, FANG He, LI Tao, LIU Liangming, HU Yi

Source: Di-san junyi daxue xuebao, Vol 42, Iss 4, Pp 334-341 (2020)

Subject Terms: dexmedetomidine, sepsis, endothelial barrier function, zonula occludes-1, pulmonary vein endothelial, cells, rats, Medicine (General), R5-920

File Description: electronic resource

Relation: http://aammt.tmmu.edu.cn/Upload/rhtml/201909226.htm; https://doaj.org/toc/1000-5404

Access URL: https://doaj.org/article/9fc04d5576074b6890d58babc23cf9b2

SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity

Authors: Somasundaram Raghavan, Divya Borsandra Kenchappa, M. Dennis Leo

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Subject Terms: endothelial barrier function, SARS-CoV-2, angiotensin converting enzyme-2, spike, junctional proteins, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.687783/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/d40e108100544eabb0fd16ce309d83f1

Protective Effects of Dexmedetomidine on the Vascular Endothelial Barrier Function by Inhibiting Mitochondrial Fission via ER/Mitochondria Contact

Authors: Han She, Yu Zhu, Haoyue Deng, Lei Kuang, He Fang, Zisen Zhang, Chenyang Duan, Jiaqing Ye, Jie Zhang, Liangming Liu, Yi Hu, Tao Li

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: sepsis, Drp1, ER-MITO contact, dexmedetomidine, vascular endothelial barrier function, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.636327/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/ed033b26efc14b368c2ea5066c4aaec1

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

Authors: Jingyan Han, Robert M. Weisbrod, Di Shao, Yosuke Watanabe, Xiaoyan Yin, Markus M. Bachschmid, Francesca Seta, Yvonne M.W. Janssen-Heininger, Reiko Matsui, Mengwei Zang, Naomi M. Hamburg, Richard A. Cohen

Source: Redox Biology, Vol 9, Iss C, Pp 306-319 (2016)

Subject Terms: Protein S-glutathionylation, Glutaredoxin-1, Actin cytoskeleton, Small Rho GTPase Rac1, Endothelial barrier function, ApoE-deficient mice, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231716301422; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/ee6d870c9a0647c6b1c280a5ee1e2a98

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

Authors: Istvan Czikora, Abdel A. Alli, Supriya Sridhar, Michael A. Matthay, Helena Pillich, Martina Hudel, Besim Berisha, Boris Gorshkov, Maritza J. Romero, Joyce Gonzales, Guangyu Wu, Yuqing Huo, Yunchao Su, Alexander D. Verin, David Fulton, Trinad Chakraborty, Douglas C. Eaton, Rudolf Lucas

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: epithelial sodium channel, non-selective cation channel, TNF, pneumonia, pneumolysin, endothelial barrier function, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00842/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e00463dfbf08482284ebe0f2bdc7fe4c

Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells

Authors: Tom Skaria, Gabriele Schoedon

Source: Journal of Inflammation, Vol 14, Iss 1, Pp 1-2 (2017)

Subject Terms: Inflammation, Wnt5A, Endothelial barrier function, Ryk, IL-4, Wnt inhibitory factor-1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12950-017-0163-6; https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/ec3cd12c8d60461e95efb3673d3bb426

Chronic ingestion of alcohol modulates expression of ubiquitin editing enzyme A20 in lung macrophages

Authors: Huang Quan-Yong, Chen Yu-Chuan, Liu Shui-Ping

Source: Multidisciplinary Respiratory Medicine, Vol 6, Iss 6, Pp 364-370 (2011)

Subject Terms: Alcohol, endothelial barrier function, lung, macrophage, ubiquitin, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://www.mrmjournal.com/content/6/6/364; https://doaj.org/toc/2049-6958

Access URL: https://doaj.org/article/9b9d11d3fcce4a968ffb183d4a1f79f1

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