EmbB and EmbC regulate the sensitivity of Mycobacterium abscessus to echinomycin

Authors: Jing He, Yamin Gao, Jingyun Wang, H. M. Adnan Hameed, Shuai Wang, Cuiting Fang, Xirong Tian, Jingran Zhang, Xingli Han, Yanan Ju, Yaoju Tan, Junying Ma, Jianhua Ju, Jinxing Hu, Jianxiong Liu, Tianyu Zhang

Source: mLife, Vol 3, Iss 3, Pp 459-470 (2024)

Subject Terms: echinomycin, EmbB, EmbC, functional compensation, Mycobacterium abscessus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2770-100X

Access URL: https://doaj.org/article/923780d5ac9241eb8a63a45d3cc8cfd2

HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect.

Authors: Yushi Yao^1,2 yaoy15@mcmaster.ca, Lei Wang³, Jihao Zhou², Xinyou Zhang² zhangxinyou0518@sina.com, Yao, Yushi^4,5 (AUTHOR), Wang, Lei⁶ (AUTHOR), Zhou, Jihao⁵ (AUTHOR), Zhang, Xinyou⁵ (AUTHOR)

Source: Journal of Translational Medicine. 2/10/2017, Vol. 15, p1-11. 11p.

Subject Terms: *ECHINOMYCIN, *GRAFT versus host disease, *LEUKEMIA, *STEM cell transplantation, *HYPOXEMIA, *THERAPEUTICS

Effects of the hypoxia-inducible factor-1 inhibitor echinomycin on vascular endothelial growth factor production and apoptosis in human ectopic endometriotic stromal cells.

Authors: Tsuzuki, Tomoko¹ (AUTHOR), Okada, Hidetaka¹ (AUTHOR) hokada@hirakata.kmu.ac.jp, Shindoh, Hisayuu¹ (AUTHOR), Shimoi, Kayo¹ (AUTHOR), Nishigaki, Akemi¹ (AUTHOR), Kanzaki, Hideharu¹ (AUTHOR)

Source: Gynecological Endocrinology. Apr2016, Vol. 32 Issue 4, p323-328. 6p.

Subject Terms: *ECHINOMYCIN, *APOPTOSIS, *VASCULAR endothelial growth factors, *STROMAL cells, *ENDOMETRIOSIS, *HYPOXIA-inducible factor 1, *PATHOLOGICAL physiology, *CELL proliferation

Echinomycin did not affect the safety of fracture healing: an experimental pilot study on a murine femur fracture model.

Authors: Jentzsch, Thorsten¹ thorsten.jentzsch@gmail.com, Zimmermann, Stefan M.¹, Nicholls, Flora², Cinelli, Paolo¹, Simmen, Hans-Peter¹, Werner, Clément M. L.¹

Source: Patient Safety in Surgery. 2/16/2016, Vol. 10, p1-6. 6p.

Subject Terms: *ECHINOMYCIN, *FRACTURE healing, *FEMUR injuries, *PATIENT safety, *SURGERY safety measures

Echinomycin as a promising therapeutic agent against KSHV-related malignancies

Authors: Jungang Chen, Zhen Lin, Jiao Song, Karlie Plaisance-Bonstaff, Jennifer James, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin

Source: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-6 (2023)

Subject Terms: KSHV, HHV-8, Myc, HIF1α, Echinomycin, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/098a23d60fc34c0796bc153ec9d81876

The Involvement of Hypoxia in the Response of Neuroblastoma Cells to the Exposure of Atorvastatin

Authors: Ana Salomé Correia, Lara Marques, Nuno Vale

Source: Current Issues in Molecular Biology, Vol 45, Iss 4, Pp 3333-3346 (2023)

Subject Terms: drug repurposing, atorvastatin, neuroblastoma cells, hypoxia-inducible factor-1, echinomycin, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/45/4/218; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/bd6f3061cbda4348bd403d29f4d397fe

Nonribosomal antibacterial peptides isolated from Streptomyces agglomeratus 5-1-3 in the Qinghai-Tibet Plateau

Authors: Kan Jiang, Ximing Chen, Wei Zhang, Yehong Guo, Guangxiu Liu

Source: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-9 (2023)

Subject Terms: S. agglomeratus 5-1-3, Antibacterial, Echinomycin, Nonribosomal peptides, MRSA, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/51d439dbfcf54b9aa74de366aef64faa

In Vitro Characterization of Echinomycin Biosynthesis: Formation and Hydroxylation of L-Tryptophanyl-S-Enzyme and Oxidation of (2S,3S) β-Hydroxytryptophan.

Authors: Zhang, Chen¹, Kong, Lingxin¹, Liu, Qian¹, Lei, Xuan¹, Zhu, Tao¹, Yin, Jun¹, Lin, Birun², Deng, Zixin¹, You, Delin¹ dlyou@sjtu.edu.cn

Source: PLoS ONE. Feb2013, Vol. 8 Issue 2, p1-13. 13p.

Subject Terms: *ECHINOMYCIN, *BIOSYNTHESIS, *HYDROXYLATION, *OXIDATION, *HYDROXYTRYPTOPHAN, *CARBOXYLIC acids, *HYDROXYQUINOLINE, *ANTINEOPLASTIC agents

REVIEW ON LITERATURE STUDY OF QUINOXALINE.

Authors: R. G., Ingle¹, R. P., Marathe¹

Source: Pharmacophore. Mar/Apr2012, Vol. 3 Issue 2, p109-116. 8p.

Subject Terms: *QUINOXALINES, *ECHINOMYCIN, *ANTI-infective agents, *HETEROCYCLIC compounds, *ATOMS, *HYDRAZONES, *TRIOSTINS

Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition

Authors: Maria Rita Garcia, Paula B. Andrade, Florence Lefranc, Nelson G. M. Gomes

Source: Marine Drugs, Vol 22, Iss 4, p 143 (2024)

Subject Terms: caulerpin, discorhabdin, dolastatin-15, echinomycin, epolactaene, fascaplysin, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/22/4/143; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/1444664d339a441fabe60262b67a24d0

The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin

Authors: Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu, Yan Liu

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)

Subject Terms: HIF1α, PDGFRα, PDGF-D, Glioblastoma, Echinomycin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/5f16d70476f349bdb968538fc330e371

Exploring the Role of Drug Repurposing in Bridging the Hypoxia–Depression Connection

Authors: Ana Salomé Correia, Lara Marques, Armando Cardoso, Nuno Vale

Source: Membranes, Vol 13, Iss 9, p 800 (2023)

Subject Terms: drug repurposing, hypoxia-inducible factor-1, serotonin receptors, cobalt chloride, Echinomycin, Chemical technology, TP1-1185, Chemical engineering, TP155-156

File Description: electronic resource

Relation: https://www.mdpi.com/2077-0375/13/9/800; https://doaj.org/toc/2077-0375

Access URL: https://doaj.org/article/4fa4be9fae8242ac8edc787b473b7a62

Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes

Authors: Jun-yi Zhu, Xiaohu Huang, Yulong Fu, Yin Wang, Pan Zheng, Yang Liu, Zhe Han

Source: Disease Models & Mechanisms, Vol 15, Iss 2 (2022)

Subject Terms: drosophila, mouse xenografts, leukemia, oncogenic ras, echinomycin, hypoxia pathway, hif1a, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/15/2/dmm048953; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/5d25a49f49b6465a86a66f4465f680cd

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis.

Authors: Al-Mestarihi, Ahmad H.¹, Villamizar, Germán², Fernández, Javier², Zolova, Olga E.³, Lombó, Felipe², Garneau-Tsodikova, Sylvie¹, sylviegtsodikova@uky.edu

Source: Journal of the American Chemical Society; 12/10/2014, Vol. 136 Issue 49, p17350-17354, 5p

Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis.

Authors: Hotta, Kinya^1,2, Keegan, Ronan M.³, Ranganathan, Soumya¹, Fang, Minyi¹, Bibby, Jaclyn^4,5, Winn, Martyn D.⁶, Sato, Michio⁷, Lian, Mingzhu¹, Watanabe, Kenji⁷, Rigden, Daniel J.⁴, Kim, Chu‐Young¹ chuyoung@nus.edu.sg

Source: Angewandte Chemie International Edition. Jan2014, Vol. 53 Issue 3, p824-828. 5p.

Subject Terms: *THIOACETALS, *ECHINOMYCIN, *BIOSYNTHESIS, *DEPSIPEPTIDES, *TRIOSTINS, *ANTIBIOTICS

Echinomycin biosynthesis.

Authors: Sato, Michio¹, Nakazawa, Takehito¹, Tsunematsu, Yuta¹, Hotta, Kinya², Watanabe, Kenji¹ kenji55@u-shizuoka-ken.ac.jp

Source: Current Opinion in Chemical Biology. Aug2013, Vol. 17 Issue 4, p537-545. 9p.

Subject Terms: *ECHINOMYCIN, *BIOSYNTHESIS, *ORGANIC synthesis, *ESCHERICHIA coli, *IN vitro studies, *THIOESTERASE

Echinomycin in the prevention of heterotopic ossification – An experimental antibiotic agent shows promising results in a murine model

Authors: Zimmermann, S.M.¹ st.zimmermann@gmx.ch, Würgler-Hauri, C.C.², Wanner, G.A.¹, Simmen, H.P.¹, Werner, C.M.L.¹

Source: Injury. Apr2013, Vol. 44 Issue 4, p570-575. 6p.

Subject Terms: *ECHINOMYCIN, *OSSIFICATION, *ANTIBIOTICS, *LABORATORY mice, *TRAUMA surgery, *POSTOPERATIVE pain, *CELLULAR signal transduction

Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A.

Authors: Espinosa, Avelina¹ aespinosa@rwu.edu, Socha, Aaron, Ryke, Erica¹, Rowley, David²

Source: Parasitology Research. Dec2012, Vol. 111 Issue 6, p2473-2477. 5p.

Subject Terms: *ACTINOMYCETALES, *ECHINOMYCIN, *TIRANDAMYCIN, *ENTAMOEBA histolytica, *AMEBIASIS treatment, *METRONIDAZOLE

SEARCH FOR ANTIMICROBIAL AGENTS: QUINOXALINE AS A PROMISING TARGET.

Authors: R. G., Ingle¹ rgingle86@gmail.com, S. J., Wadher¹

Source: Indian Drugs. Jul2017, Vol. 54 Issue 7, p5-9. 5p.

Subject Terms: *QUINOXALINES, *ANTI-infective agents, *ECHINOMYCIN, *QUINOXALINE compounds, *ESCHERICHIA coli

New route for the synthesis of N-alkyl-2-(phenylsulfonyl)anilines.

Authors: Hossan, Aisha

Source: Chemistry of Heterocyclic Compounds; Aug2016, Vol. 52 Issue 8, p570-573, 4p, 5 Diagrams

Subject Terms: PYRIDINIUM compounds, NUCLEOPHILES, PYRIDINE synthesis, ECHINOMYCIN, AMINOBUTYRIC acid