Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Authors: Anna Janaszak-Jasiecka, Agata Płoska, Joanna M. Wierońska, Lawrence W. Dobrucki, Leszek Kalinowski

Source: Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-28 (2023)

Subject Terms: Cardiovascular disease, Endothelial dysfunction, eNOS uncoupling, Oxidative/nitroxidative stress, Peroxynitrite, Nitric oxide, Cytology, QH573-671

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Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/1481216e256249e1bb3534beb15178fa

Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches

Contributors: Jeon, Byeong Hwa

Subject Terms: endothelial cells, oxidative stress, inflammageing, endothelial dysfunction, aldehyde dehydrogenase-2, cardiovascular disease, neurovascular disease, vascular inflammation, APE1/Ref-1, cardiovascular diseases, subcellular localization, serological biomarkers, atherosclerosis, aerobic exercise, PCSK9, LOX-1, insulin resistance, macrophage polarity, serum γ-glutamyltransferase, essential hypertension, cardiovascular risk factors, angiogenesis, nargenicin A1, compound 9, VEGF, VEGFR2, HIF-1α, electronegative low-density lipoprotein, LDL(–), L5 LDL, oxidized LDL, oxLDL, ADMA, arginine, arginine paradox, BH4, blood pressure, COVID-19, dietary supplements, endothelium, eNOS uncoupling, heart failure, hypertension, L-arginine, myocardial infarction, NADPH, nitric oxide, peripheral artery disease, ApoE knockout mouse, atorvastatin, VCAM-1, galectin-3, neutrophil/lymphocyte ratio, electronegative LDL, LDL(−), lectin-like oxLDL receptor-1, dyslipidemia, chronic venous insufficiency, prolyl oligopeptidase (POP), inflammation, endothelial disfunction, lung disease, endothelial to mesenchymal transition, pulmonary hypertension, pulmonary fibrosis, metformin, diabetes, CV risk, hyperglycemia, glycated lipoproteins, glycated LDL, glycated HDL, endothelial cell dysfunction, molecular mechanisms, epigenetic factors, therapeutic approaches, vasoactive factors, EndoMT, TGF-β, epigenetics, endothelial cell, glycolysis, metabolism, pathological angiogenesis, tumor microenvironment, MRI (magnetic resonance imaging), high-fat diets, plaque burden, low-level laser therapy, phototherapy, vascular disease, healing, ischemia, vascular calcification, chronic kidney disease, CKD, uremic toxins, hyperphosphatemia, vascular smooth muscle cells, VSMCs, macrophages, Technology: general issues, Biotechnology

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Access URL: https://directory.doabooks.org/handle/20.500.12854/81021
https://mdpi.com/books/pdfview/book/5363

Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function

Authors: Fanglin Niu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Hua Guan, Yang Li, Yan Zhang, Yirong Li, Junle Yang, Lu Qian, Wenzhen Shi, Xiaobin Fan, Jinli Li, Lele Shi, Yi Yu, Yuyan Xiong

Source: Redox Biology, Vol 65, Iss , Pp 102824- (2023)

Subject Terms: Vascular aging, Endothelial cell senescence, Endothelial dysfunction, eNOS uncoupling, Signaling, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231723002252; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/31b02edb888542e48dce51b2150f217d

C2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα–Signaling Pathway

Authors: Paola Di Pietro, Angela Carmelita Abate, Valeria Prete, Antonio Damato, Eleonora Venturini, Maria Rosaria Rusciano, Carmine Izzo, Valeria Visco, Michele Ciccarelli, Carmine Vecchione, Albino Carrizzo

Source: Antioxidants, Vol 13, Iss 1, p 101 (2024)

Subject Terms: C2CD4B, endothelial dysfunction, oxidative stress, eNOS uncoupling, diabetes, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.mdpi.com/2076-3921/13/1/101; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/107669eeaec54670bf28ca645932f61c

Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication

Authors: Kai Huang, Yusi Wu, Yixuan Zhang, Ji Youn Youn, Hua Cai

Source: Redox Biology, Vol 58, Iss , Pp 102521- (2022)

Subject Terms: Folic acid (FA), Nifedipine, Angiotensin II (Ang II), Abdominal aortic aneurysm (AAA), Apolipoprotein E null mice (apoE mice), Endothelial nitric oxide synthase (eNOS) uncoupling, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231722002932; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/be41969ff1984369abe38048395f7aa2

Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms

Authors: Yixuan Zhang, Kin Lung Siu, Qiang Li, Kimberly Howard-Quijano, Jennifer Scovotti, Aman Mahajan, Hua Cai

Source: Redox Biology, Vol 56, Iss , Pp 102444- (2022)

Subject Terms: Aortic aneurysm, Thoracic aortic aneurysm (TAA), Abdominal aortic aneurysm (AAA), Tetrahydrobiopterin (H4B), eNOS uncoupling, Human patients, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231722002166; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/dc1a9b0c07ef49d39d7a042e70431baf

(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway

Authors: Zhang Z, Zhang D

Source: Diabetes, Metabolic Syndrome and Obesity, Vol Volume 13, Pp 2495-2504 (2020)

Subject Terms: (-)-epigallocatechin-3-gallate, enos uncoupling, endothelial dysfunction, apoptosis, human umbilical vein endothelial cells, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: https://www.dovepress.com/--epigallocatechin-3-gallate-inhibits-enos-uncoupling-and-alleviates-h-peer-reviewed-article-DMSO; https://doaj.org/toc/1178-7007

Access URL: https://doaj.org/article/612eaa89c4ea46038200e1a7a29290a0

The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury

Authors: Hui Wang, Xutong Sun, Qing Lu, Evgeny A. Zemskov, Manivannan Yegambaram, Xiaomin Wu, Ting Wang, Haiyang Tang, Stephen M. Black

Source: Redox Biology, Vol 41, Iss , Pp 101878- (2021)

Subject Terms: ALI, eNOS uncoupling, Mitochondrial ROS, Inflammasome activation, RhoA, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231721000264; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/a51b4ad97d1e40a384a80d88f1dcf05f

Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

Authors: Kai Huang, Yongchen Wang, Kin Lung Siu, Yixuan Zhang, Hua Cai

Source: Redox Biology, Vol 38, Iss , Pp 101757- (2021)

Subject Terms: NADPH oxidase (NOX), NOX isoform 4 (NOX4), Reactive oxygen species (ROS), eNOS uncoupling/recoupling, Thoracic aortic aneurysm (TAA), Marfan syndrome (MFS), Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231720309629; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/e4069fca322c4aed93885cc9e87cd688

Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases

Authors: Abdullah Shaito, Karl Aramouni, Roland Assaf, Astrid Parenti, Alexander Orekhov, Ahmed El Yazbi, Gianfranco Pintus, Ali H. Eid

Source: Frontiers in Bioscience-Landmark, Vol 27, Iss 3, p 105 (2022)

Subject Terms: endothelial cell dysfunction, oxidative stress, reactive oxygen species (ros), cardiovascular diseases (cvds), nitric oxide, enos uncoupling, inflammation, mitochondrial dysfunction, Biochemistry, QD415-436, Biology (General), QH301-705.5

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Relation: https://www.imrpress.com/journal/FBL/27/3/10.31083/j.fbl2703105; https://doaj.org/toc/2768-6701

Access URL: https://doaj.org/article/cee2664cd0104e22bfc3a7909d4a2c1a

Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine

Authors: Xinya Xie, Zihui Zhang, Xinfeng Wang, Zhenyu Luo, Baochang Lai, Lei Xiao, Nanping Wang

Source: Molecular Medicine, Vol 24, Iss 1, Pp 1-10 (2018)

Subject Terms: Stachydrine, GTPCH1, DHFR, eNOS uncoupling, Vasorelaxation, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s10020-018-0010-0; https://doaj.org/toc/1076-1551; https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/9df8d8883e5c42e4b258793799f56293

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Authors: Anna Janaszak-Jasiecka, Anna Siekierzycka, Agata Płoska, Iwona T. Dobrucki, Leszek Kalinowski

Source: Biomolecules, Vol 11, Iss 7, p 982 (2021)

Subject Terms: nitric oxide, eNOS, eNOS uncoupling, tetrahydrobiopterin, ADMA, hypoxia, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/7/982; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/434dd0de9be64ad3add08ce61a333483

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