Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

Authors: Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xiao

Source: Neural Regeneration Research, Vol 20, Iss 5, Pp 1455-1466 (2025)

Subject Terms: apoptosis, atf4, autophagy, c/ebp homologous protein, cerebral ischemia/reperfusion injury, eif2α, endoplasmic reticulum stress, perk, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/NRR.NRR-D-23-00794; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

Access URL: https://doaj.org/article/12ea9f85432e4cc79213ac7b026c522e

Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics

Authors: Yueh Chien, You‐Ren Wu, Chih‐Ying Chen, Yi‐Ping Yang, Lo‐Jei Ching, Bo‐Xuan Wang, Wei‐Chao Chang, I‐Hsun Chiang, Pong Su, Shih‐Yu Chen, Wen‐Chang Lin, I‐Chieh Wang, Tai‐Chi Lin, Shih‐Jen Chen, Shih‐Hwa Chiou

Source: Advanced Science, Vol 12, Iss 1, Pp n/a-n/a (2025)

Subject Terms: chronic ER stress‐associated apoptosis, eIF2α signaling, genetically engineered mice, retinoschisin 1 (RS1), single‐cell RNA‐sequencing, spatiotemporal transcriptomics, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/0f320ead8a3f411d8476882cca194be4

Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis

Authors: Michela Luciano, Helene Sieberer, Peter W. Krenn, Hieu-Hoa Dang, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X. Weichenberger, Anna Eglseer, Michael S. Unger, Ancuela Andosch, Philip Steiner, Daniel Neureiter, Renate Bauer, Laura Hummer, Suzana Tesanovic, Stephanie Binder, Dominik P. Elmer, Helen Strandt, Susanne Schaller, Dirk Strunk, Lisa Pleyer, Richard Greil, Stephan Winkler, Tanja N. Hartmann, Dirk Schmidt-Arras, Christian G. Huber, Fritz Aberger, Jutta Horejs-Hoeck

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)

Subject Terms: Acute myeloid leukemia, Apoptosis, eIF2α, NLRP3, PERK, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/4d77e7ab0fdf4883bc818ffc7dd4f0d8

eEF2K regulates pain through translational control of BDNF

Authors: Smith, Patrick R. ¹, Garcia, Guadalupe ¹, Meyer, Angela R. ¹, Ryazanov, Alexey G. ², Ma, Tao ^{3, 4}, Loerch, Sarah ^{5, 6}, Campbell, Zachary T. ^{1, 7, ∗}

Source: In Molecular Cell 20 February 2025 85(4):756-769

Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway

Authors: Wang, Xiaoyun ^{a, b}, Dai, Chaochao ^a, Cheng, Wen ^c, Wang, Jianli ^d, Cui, Xiaopei ^{a, e}, Pan, Guopin ^f, Chen, Ye ^g, Han, Yu ^h, Guo, Xiaosun ^b, Jiang, Fan ^{a, ⁎}

Source: In International Immunopharmacology 6 February 2025 147

Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress

Authors: Le, Hien Thi ¹, Kim, Yong Hwan ², Kim, Mi-Jeong ¹, Hyun, Seung Hwa ¹, Kim, Hyeeun ¹, Chung, Su Wol ¹, Joe, Yeonsoo ³, Chung, Hun Taeg ³, Shin, Dong-Myung ², Back, Sung Hoon ^{1, 4, ⁎}

Source: In Molecules and Cells March 2025

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies

Authors: HE Mengke, XU Zizhen, LI Junmin

Source: Zhongliu Fangzhi Yanjiu, Vol 51, Iss 2, Pp 140-146 (2024)

Subject Terms: endoplasmic reticulum stress, unfolded protein response, perk, eif2α, atf4, chop, hematological malignancies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1000-8578

Access URL: https://doaj.org/article/b5d1e4b0e9314a66a38b40821038baf8

Potential Alzheimer’s early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology

Authors: Charles H. Wallace, Giovanni Oliveros, Lei Xie, Peter Serrano, Patricia Rockwell, Maria Figueiredo-Pereira

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Polypharmacology, Drug repurposing, Alzheimer’s, Potassium channel activator, eIF2α activator, EGR2, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f53658ccfa664502aadb3542cf8eca21

Activation of Endoplasmic Reticulum Stress Response by Applying of Nanosecond Pulsed Electric Fields for Medical Application

Authors: Furumoto, Yuji, Sato, Daiki, Teranishi, Kenji, Shimomura, Naoyuki, Hamada, Yoshimasa, Miyake, Masato, Oyadomari, Seiichi

Source: 2018 IEEE International Power Modulator and High Voltage Conference (IPMHVC) Power Modulator and High Voltage Conference (IPMHVC), 2018 IEEE International. :456-460 Jun, 2018

Relation: 2018 IEEE International Power Modulator and High Voltage Conference (IPMHVC)

The Antihypertensive Guanabenz Exacerbates Integrated Stress Response and Disrupts the Brain Circadian Clock

Authors: Hao Lin, Muhammad Naveed, Aidan Hansen, Tracy G. Anthony, Ruifeng Cao

Source: Clocks & Sleep, Vol 5, Iss 4, Pp 639-650 (2023)

Subject Terms: circadian rhythm, guanabenz, integrated stress response, eIF2α, SCN, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2624-5175/5/4/43; https://doaj.org/toc/2624-5175

Access URL: https://doaj.org/article/776965c8f16e4b568b2a3785d7c49928

An initial characterisation of the Unfolded Protein Response pathway in haematopoietic canine cancer cell lines – a necessary step for the future development of new therapies in dogs with neoplasia

Authors: Hernández-Suárez Beatriz, Gillespie David A., Obmińska-Mrukowicz Bożena, Pawlak Aleksandra

Source: Journal of Veterinary Research, Vol 67, Iss 3, Pp 447-458 (2023)

Subject Terms: canine cancer, eukaryotic translation initiation factor 2α (eif2α), ccaat/enhancer binding protein homologous protein (chop), protein kinase rna-like endoplasmic reticulum kinase (perk), Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/2450-8608

Access URL: https://doaj.org/article/9183972e09044830ae5bff155fd057b7

Glyphosate treatment mediates the accumulation of small discrete 5′ and 3′-terminal fragments of 18S rRNA in plant cells

Authors: A. V. Zhigailov, A. S. Nizkorodova, K. O. Sharipov, N. S. Polimbetova, B. K. Iskakov

Source: Вавиловский журнал генетики и селекции, Vol 27, Iss 2, Pp 93-98 (2023)

Subject Terms: wheat embryos, 18s rrna, discrete fragmentation, 40s ribosomal subunits, glyphosate, eif2α phosphorylation, stress, starvation, Genetics, QH426-470

File Description: electronic resource

Relation: https://vavilov.elpub.ru/jour/article/view/3673; https://doaj.org/toc/2500-3259

Access URL: https://doaj.org/article/29b99a12341e4fc6928644876a17148a

LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma

Authors: Xiaoting Liang, Jieyu Liu, Xingyuan Liu, Yi Jin, Minna Xu, Zhenyu Han, Ke Wang, Chunting Zhang, Fei Zou, Liang Zhou

Source: Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-24 (2023)

Subject Terms: LINP1, Unfolded protein response, eIF2α, Apoptosis, Cutaneous squamous cell carcinoma, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/3f1658e79cc647dd887a571d5e773995

Activity of the Di-Substituted Urea-Derived Compound I-17 in Leishmania In Vitro Infections

Authors: José Vitorino dos Santos, Jorge Mansur Medina, Karina Luiza Dias Teixeira, Daniel Marcos Julio Agostinho, Michael Chorev, Aurora Diotallevi, Luca Galluzzi, Bertal Huseyin Aktas, Ulisses Gazos Lopes

Source: Pathogens, Vol 13, Iss 2, p 104 (2024)

Subject Terms: Leishmaniasis, eIF2α, translation initiation, eIF2α kinase activators, di-substituted urea-derivatives, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/13/2/104; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/2035ec88eb354ef3ae0e4943654bd9ab

Pifithrin-µ Induces Stress Granule Formation, Regulates Cell Survival, and Rewires Cellular Signaling

Authors: Hicham Mahboubi, Henry Yu, Michael Malca, David McCusty, Ursula Stochaj

Source: Cells, Vol 13, Iss 11, p 885 (2024)

Subject Terms: pifithrin-µ, stress granules, eIF2α phosphorylation, 5′-AMP-activated protein kinase (AMPK), protein kinase Akt, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/11/885; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/38efb2799ad94a1b9439a52eb39eb2d8

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Authors: Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux

Source: Autophagy Reports, Vol 1, Iss 1, Pp 119-142 (2022)

Subject Terms: atf4, eif2α, leucine, lysine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2769-4127

Access URL: https://doaj.org/article/be1aa155eac94e5eaacf0757451823ad

AGAP1-associated endolysosomal trafficking abnormalities link gene–environment interactions in neurodevelopmental disorders

Authors: Sara A. Lewis, Somayeh Bakhtiari, Jacob Forstrom, Allan Bayat, Frédéric Bilan, Gwenaël Le Guyader, Ebba Alkhunaizi, Hilary Vernon, Sergio R. Padilla-Lopez, Michael C. Kruer

Source: Disease Models & Mechanisms, Vol 16, Iss 9 (2023)

Subject Terms: drosophila, agap1, synaptic morphology, endolysosome, autophagy, eif2α, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/16/9/dmm049838; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/b5bc83387ee645bd900fb0386a2ee975

Investigation about effects on endoplasmic reticulum stress responses by applying nanosecond pulsed electric fields

Authors: Hirai, Hiroto, Miyake, Masato, Nagano, Akihiko, Teranishi, Kenji, Shimomura, Naoyuki, Oyadomari, Seiichi

Source: 2014 IEEE International Power Modulator and High Voltage Conference (IPMHVC) Power Modulator and High Voltage Conference (IPMHVC), 2014 IEEE International. :419-422 Jun, 2014

Relation: 2014 IEEE International Power Modulator and High Voltage Conference (IPMHVC)

Translational Control of Alphavirus–Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response

Authors: Iván Ventoso, Juan José Berlanga, René Toribio, Irene Díaz-López

Source: Viruses, Vol 16, Iss 2, p 205 (2024)

Subject Terms: alphaviruses, translation initiation, eIF2α phosphorylation, RNA structure, antiviral response, interferon, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/2/205; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/64ce61ae77b24334bf92562a54bb12e1

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

Authors: Hang Ruan, Brian J. Leibowitz, Yingpeng Peng, Lin Shen, Lujia Chen, Charlie Kuang, Robert E. Schoen, Xinghua Lu, Lin Zhang, Jian Yu

Source: Molecular Biomedicine, Vol 3, Iss 1, Pp 1-16 (2022)

Subject Terms: Mutant KRAS, Myc, eIF2α, Colorectal cancer, Everolimus, Bortezomib, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2662-8651

Access URL: https://doaj.org/article/897eff7e4d3547fe9e1e5347bbb62633