Visible-light-promoted radical cyclisation of unactivated alkenes in benzimidazoles: synthesis of difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles

Authors: Yujun Pang, Jinglan Yan, Nawaf Al-Maharik, Qian Zhang, Zeguo Fang, Dong Li

Source: Beilstein Journal of Organic Chemistry, Vol 21, Iss 1, Pp 234-241 (2025)

Subject Terms: cyclization, difluoromethylation, hypervalent iodine, polycyclic imidazole, visible light, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Visible-light induced photocatalyst-free difluoromethylation of quinoxalinones with difluorosulfones

Authors: Linlin Shi, Tiantian Li, Wenjing Zhang, Weinan Hu, Xinju Zhu, Yixin Lu, Guang-Jian Mei

Source: Green Synthesis and Catalysis, Vol 5, Iss 4, Pp 277-281 (2024)

Subject Terms: Quinoxalinones, Difluoromethylation, Visible-light induced, Photocatalyst-free, Difluorosulfones, Chemical technology, TP1-1185, Biochemistry, QD415-436

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Relation: http://www.sciencedirect.com/science/article/pii/S266655492300073X; https://doaj.org/toc/2666-5549

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Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks

Authors: Zhang Dongxu

Source: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1741-1754 (2023)

Subject Terms: acylhydrazones, difluoromethylation, dihydropyridazine, fluorinated building blocks, hydrazones, imidazolidines, pyrazoles, pyrazolidines, pyrazolines, trifluoromethylation, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs

Authors: Thanh Tung Truong, John Nielsen

Source: Vietnam Journal of Science, Technology and Engineering, Vol 66, Iss 1 (2024)

Subject Terms: C-H activation, difluoromethylation, drug synthesis, quinoline, Science

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Relation: https://vietnamscience.vjst.vn/index.php/vjste/article/view/1185; https://doaj.org/toc/2525-2461; https://doaj.org/toc/2615-9937

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1,6-Nucleophilic Di- and Trifluoromethylation of para-Quinone Methides with Me3SiCF2H/Me3SiCF3 Facilitated by CsF/18-Crown-6

Authors: Dingben Chen, Ling Huang, Mingyu Liang, Xiaojing Chen, Dongdong Cao, Pan Xiao, Chuanfa Ni, Jinbo Hu

Source: Molecules, Vol 29, Iss 12, p 2905 (2024)

Subject Terms: difluoromethylation, trifluoromethylation, Me3SiCF2H/Me3SiCF3, 1,6-nucleophilic addition, CsF/18-crown-6, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/29/12/2905; https://doaj.org/toc/1420-3049

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N-Difluoromethylindazoles

Authors: Kirill I. Petko, Andrey A. Filatov

Source: Журнал органічної та фармацевтичної хімії, Vol 20, Iss 3, Pp 3-11 (2022)

Subject Terms: indazoles, n-difluoromethylation, isomer separation, Chemistry, QD1-999

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Relation: http://ophcj.nuph.edu.ua/article/view/265823; https://doaj.org/toc/2308-8303; https://doaj.org/toc/2518-1548

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Cathodic generation of reactive (phenylthio)difluoromethyl species and its reactions: mechanistic aspects and synthetic applications

Authors: Sadanobu Iwase, Shinsuke Inagi, Toshio Fuchigami

Source: Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 872-880 (2022)

Subject Terms: bis(phenylthio)difluoromethane, cathodic reduction, deuteration, o-phthalonitrile mediator, (phenylthio)difluoromethylation, (phenylthio)difluoromethyl radical, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)

Authors: Louise Ruyet, Tatiana Besset

Source: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1051-1065 (2020)

Subject Terms: copper, difluoromethylation, fluorinated reagents, fluorine chemistry, synthetic methodologies, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Pd-catalyzed C[sbnd]H (phenylsulfonyl)difluoromethylation of electron-rich heteroarenes

Authors: Liu, Zi-En ^{⁎, 1}, Lin, Tao ¹, Zhao, Yue, Cao, Jun

Source: In Tetrahedron Letters 15 March 2025 158

Nickel-catalyzed decarboxylative difluoromethylation and alkylation of alkenes

Authors: Ai, Zhenkang ¹, Chen, Hui ¹, Liao, Xuebin ^⁎

Source: In Chinese Chemical Letters March 2025 36(3)

Chemical tagging of chlorinated phenols for their facile detection and analysis by NMR spectroscopy

Contributors: Leif, Roald [Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)]

Source: Analytical and Bioanalytical Chemistry; 407; 13

File Description: Medium: ED; Size: p. 3539-3543

Access URL: http://www.osti.gov/scitech/servlets/purl/1182243

Facile Entry to Pharmaceutically Important 3-Difluoromethyl-quinoxalin-2-ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-ones

Authors: Kai-Zhong Fu, Xu-Xin Chen, Ya-Shi Zhao, Yuan-Qing Gu, Guo-Kai Liu

Source: Pharmaceuticals, Vol 15, Iss 12, p 1552 (2022)

Subject Terms: 3-CF2H-quinoxaline-2-ones, difluoromethylation, S-(difluoromethyl)sulfonium salt, fluorine-containing pharmaceuticals, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/15/12/1552; https://doaj.org/toc/1424-8247

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Reagent-Controlled Highly Stereoselective Difluoromethylation: Efficient Access to Chiral α-Difluoromethylamines from Ketimines

Authors: Qinghe Liu, Taige Kong, Chuanfa Ni, Jinbo Hu

Source: Molecules, Vol 27, Iss 20, p 7076 (2022)

Subject Terms: difluoromethylation, sulfoximine, nucleophilic addition, ketimine, fluorine, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/27/20/7076; https://doaj.org/toc/1420-3049

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(Sila)Difluoromethylation of Fluorenyllithium with CF3H and CF3TMS

Authors: Kenichi Maruyama, Daichi Saito, Koichi Mikami

Source: SynOpen, Vol 02, Iss 03, Pp 0234-0239 (2018)

Subject Terms: fluoroform, ruppert–prakash reagent, bioisostere, fluorene, difluoromethylation, difluoromethyl, difluoromethylene, difluorocarbene, Chemistry, QD1-999

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Relation: https://doaj.org/toc/2509-9396

Access URL: https://doaj.org/article/7d6b2898eae74a98ac8b767765656c3b

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Authors: Grégory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric R. Leroux

Source: Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2476-2536 (2013)

Subject Terms: catalysis, cross-coupling, difluoromethylation, fluorine, monofluoromethylation, organo-fluorine, transition metal, trifluoromethylation, trifluoromethylthiolation, Science, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/6def11311af04040bd27eb9d55d2f703

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Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals

Authors: Bing Gao, Chuanfa Ni, Jinbo Hu

Source: CHIMIA, Vol 68, Iss 6 (2014)

Subject Terms: Arenes, Difluoromethylation, Difluoromethylene, Cross-coupling, Transition metal, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.chimia.ch/chimia/article/view/5584; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424

Access URL: https://doaj.org/article/a4105dfe01f34b6ea698888e051af42f

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