Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development

Authors: Hesselman, Maria C. ¹, Zeeb, Marius ^{1, 2}, Rusert, Peter ¹, Pasin, Chloé ^{1, 2}, Mamrosh, Jennifer ³, Kariuki, Samuel ^{4, 5}, Pichler, Ian ¹, Sickmann, Michèle ¹, Kaufmann, Masako M. ¹, Schmidt, Daniel ¹, Friedrich, Nikolas ¹, Metzner, Karin J. ^{1, 2}, Rindler, Audrey ^{1, 2}, Kuster, Herbert ^{1, 2}, Adams, Craig ⁵, Thebus, Ruwayhida ⁵, Huber, Michael ¹, Yerly, Sabine ⁶, Leuzinger, Karoline ⁷, Perreau, Matthieu ⁸, Koller, Roger ⁹, Dollenmaier, Günter ¹⁰, Frigerio, Simona ¹¹, Westfall, Dylan H. ¹², Deng, Wenjie ¹², deCamp, Allan C. ¹³, Juraska, Michal ¹³, Edupuganti, Srilatha ¹⁴, Mgodi, Nyaradzo ^{15, 16}, Murrell, Hugh ⁵, Garrett, Nigel ^{17, 20}, Wagh, Kshitij ³, Mullins, James I. ¹², Williamson, Carolyn ^{5, 20}, Moore, Penny L. ^{18, 19, 20}, Günthard, Huldrych F. ^{1, 2}, Kouyos, Roger D. ^{1, 2}, Trkola, Alexandra ^{1, 21, ∗}

Source: In Cell Host & Microbe 12 February 2025 33(2):279-293

Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial

Authors: Kalichman, Artur, Edlefsen, Paul, Enama, Mary, Hural, John, Holt, Renee, Dunbar, Debora, Crawford, Dave, Maki, Ian, Johannessen, Jan, Estep, Scharla, Grigoriev, Yevgeny, Madenwald, Tamra, Hansen, Marianne, Holman, Drienna, Fair, Ramey, Meyer, Genevieve, Luke-Kilolam, Anya, Miner, Maurine D., deCamp, Allan, Grunenberg, Nicole, De Rosa, Stephen C., Fiore-Gartland, Andrew, Bar, Katherine, Spearman, Paul, Allen, Mary, Yu, Pei-Chun, Manso, Bryce, Frahm, Nicole, Kalams, Spyros, Baden, Lindsey, Keefer, Michael C., Scott, Hyman M., Novak, Richard, Van Tieu, Hong, Tomaras, Georgia D., Kublin, James G., McElrath, M. Juliana, Corey, Lawrence, Frank, Ian

Source: In eBioMedicine February 2024 100

Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition

Authors: Seaton, Kelly E., Huang, Yunda, Karuna, Shelly, Heptinstall, Jack R., Brackett, Caroline, Chiong, Kelvin, Zhang, Lily, Yates, Nicole L., Sampson, Mark, Rudnicki, Erika, Juraska, Michal, deCamp, Allan C., Edlefsen, Paul T., Mullins, James I., Williamson, Carolyn, Rossenkhan, Raabya, Giorgi, Elena E., Kenny, Avi, Angier, Heather, Randhawa, April, Weiner, Joshua A., Rojas, Michelle, Sarzotti-Kelsoe, Marcella, Zhang, Lu, Sawant, Sheetal, Ackerman, Margaret E., McDermott, Adrian B., Mascola, John R., Hural, John, McElrath, M. Julianna, Andrew, Philip, Hidalgo, Jose A., Clark, Jesse, Laher, Fatima, Orrell, Catherine, Frank, Ian, Gonzales, Pedro, Edupuganti, Srilatha, Mgodi, Nyaradzo, Corey, Lawrence, Morris, Lynn, Montefiori, David, Cohen, Myron S., Gilbert, Peter B., Tomaras, Georgia D.

Source: In eBioMedicine July 2023 93

A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses.

Authors: Shen, Xiaoying, Korber, Bette, Spreng, Rachel L., Sawant, Sheetal S., deCamp, Allan, McMillan, Arthur S., Mathura, Ryan, Zolla-Pazner, Susan, Pinter, Abraham, Parks, Robert, Bowman, Cindy, Sutherland, Laura, Scearce, Richard, Yates, Nicole L., Montefiori, David C., Haynes, Barton F., Tomaras, Georgia D.

Source: Vaccines; Feb2025, Vol. 13 Issue 2, p133, 25p

Subject Terms: COMBINED vaccines, SCAFFOLD proteins, VACCINE effectiveness, ANTIBODY formation, VACCINE trials

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

Authors: Huang, Deli, Abbott, Robert K., Havenar-Daughton, Colin, Skog, Patrick D., Al-Kolla, Rita, Groschel, Bettina, Blane, Tanya R., Menis, Sergey, Tran, Jenny Tuyet, Thinnes, Theresa C., Volpi, Sabrina A., Liguori, Alessia, Schiffner, Torben, Villegas, Sophia M., Kalyuzhniy, Oleksandr, Pintea, Mark, Voss, James E., Phelps, Nicole, Tingle, Ryan, Rodriguez, Alberto R., Martin, Greg, Kupryianov, Sergey, deCamp, Allan, Schief, William R., Nemazee, David, Crotty, Shane

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Sep . 117(37), 22920-22931.

Access URL: https://www.jstor.org/stable/26969222

Pharmacokinetics and predicted neutralisation coverage of VRC01 in HIV-uninfected participants of the Antibody Mediated Prevention (AMP) trials

Authors: Huang, Yunda, Naidoo, Logashvari, Zhang, Lily, Carpp, Lindsay N., Rudnicki, Erika, Randhawa, April, Gonzales, Pedro, McDermott, Adrian, Ledgerwood, Julie, Lorenzo, Margarita M.Gomez, Burns, David, DeCamp, Allan, Juraska, Michal, Mascola, John, Edupuganti, Srilatha, Mgodi, Nyaradzo, Cohen, Myron, Corey, Lawrence, Andrew, Philip, Karuna, Shelly, Gilbert, Peter B., Mngadi, Kathryn, Lazarus, Erica

Source: In EBioMedicine February 2021 64

Protein Dose-Sparing Effect of AS01B Adjuvant in a Randomized Preventive HIV Vaccine Trial of ALVAC-HIV (vCP2438) and Adjuvanted Bivalent Subtype C gp120.

Authors: Chirenje, Zvavahera Mike, Laher, Fatima, Dintwe, One, Muyoyeta, Monde, deCamp, Allan C, He, Zonglin, Grunenberg, Nicole, Omar, Faatima Laher, Seaton, Kelly E, Polakowski, Laura, Davis, Amanda S Woodward, Maganga, Lucas, Baden, Lindsey R, Mayer, Kenneth, Kalams, Spyros, Keefer, Michael, Edupuganti, Srilatha, Rodriguez, Benigno, Frank, Ian, Scott, Hyman

Source: Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe405-e415, 11p

Subject Terms: CLINICAL trial registries, HIV-1 glycoprotein 120, VACCINE trials, HIV, AIDS vaccines

Safety and Immunogenicity of a DNA Vaccine With Subtype C gp120 Protein Adjuvanted With MF59 or AS01 B : A Phase 1/2a HIV-1 Vaccine Trial.

Authors: Garrett, Nigel, Dintwe, One, Monaco, Cynthia L., Jones, Megan, Seaton, Kelly E., Church, E. Chandler, Grunenberg, Nicole, Hutter, Julia, deCamp, Allan, Huang, Yunda, Lu, Huiyin, Mann, Philipp, Robinson, Samuel T., Heptinstall, Jack, Jensen, Ryan L., Pantaleo, Giuseppe, Ding, Song, Koutsoukos, Marguerite, Hosseinipour, Mina C., Van Der Meeren, Olivier

Source: JAIDS: Journal of Acquired Immune Deficiency Syndromes; Aug2024, Vol. 96 Issue 4, p350-360, 11p

Histo–Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy

Authors: Lee, Benjamin, Dickson, Dorothy M., deCamp, Allan C., Colgate, E. Ross, Diehl, Sean A., Uddin, Muhammad Ikhtear, Sharmin, Salma, Islam, Shahidul, Bhuiyan, Taufiqur Rahman, Alam, Masud, Nayak, Uma, Mychaleckyj, Josyf C., Taniuchi, Mami, Petri, William A., Haque, Rashidul, Qadri, Firdausi, Kirkpatrick, Beth D.

Source: The Journal of Infectious Diseases, 2018 May 01. 217(9), 1399-1407.

Access URL: https://www.jstor.org/stable/26494868

Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial

Authors: Fong, Youyi, Shen, Xiaoying, Ashley, Vicki C., Deal, Aaron, Seaton, Kelly E., Yu, Chenchen, Grant, Shannon P., Ferrari, Guido, deCamp, Allan C., Bailer, Robert T., Koup, Richard A., Montefiori, David, Haynes, Barton F., Sarzotti-Kelsoe, Marcella, Graham, Barney S., Carpp, Lindsay N., Hammer, Scott M., Sobieszczyk, Magda, Karuna, Shelly, Swann, Edith, DeJesus, Edwin, Mulligan, Mark, Frank, Ian, Buchbinder, Susan, Novak, Richard M., McElrath, M. Juliana, Kalams, Spyros, Keefer, Michael, Frahm, Nicole A., Janes, Holly E., Gilbert, Peter B., Tomaras, Georgia D.

Source: The Journal of Infectious Diseases, 2018 Apr . 217(8), 1280-1288.

Access URL: https://www.jstor.org/stable/26494492

Oral Preexposure Prophylaxis Uptake and Discontinuation in the HIV Vaccine Trials Network 704/HIV Prevention Trials Network 085 Study: Implications for Biomedical Human Immunodeficiency Virus Prevention Trials.

Authors: Cantos, Valeria D, Neradilek, Moni, Huang, Yunda, Roxby, Alison C, Gillespie, Kevin, deCamp, Allan C, Karuna, Shelly T, Edupuganti, Srilatha, Gallardo-Cartagena, Jorge, Sanchez, Jorge, Rio, Carlos del, Veloso, Valdilea, Cohen, Myron S, Donnell, Deborah J, Corey, Lawrence, Kelley, Colleen F

Source: Open Forum Infectious Diseases; Jul2024, Vol. 11 Issue 7, p1-8, 8p

Subject Terms: HIV, VACCINE trials, AIDS vaccines, HIV prevention, HIV antibodies

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV.

Authors: Mayer, Bryan T., Zhang, Lily, deCamp, Allan C., Yu, Chenchen, Sato, Alicia, Angier, Heather, Seaton, Kelly E., Yates, Nicole, Ledgerwood, Julie E., Mayer, Kenneth, Caskey, Marina, Nussenzweig, Michel, Stephenson, Kathryn, Julg, Boris, Barouch, Dan H., Sobieszczyk, Magdalena E., Edupuganti, Srilatha, Kelley, Colleen F., McElrath, M. Juliana, Gelderblom, Huub C.

Source: Pharmaceutics; May2024, Vol. 16 Issue 5, p594, 21p

Subject Terms: MONOCLONAL antibodies, CLINICAL trials, PHARMACOKINETICS, MAXIMUM likelihood statistics, HIV, HIV antibodies

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention.

Authors: Mayer, Bryan T.¹ (AUTHOR), deCamp, Allan C.¹ (AUTHOR), Huang, Yunda^1,2,3 (AUTHOR), Schiffer, Joshua T.^1,4,5 (AUTHOR), Gottardo, Raphael¹ (AUTHOR), Gilbert, Peter B.^1,6 (AUTHOR), Reeves, Daniel B.¹ (AUTHOR) dreeves@fredhutch.org

Source: PLoS Computational Biology. 4/6/2022, Vol. 18 Issue 4, p1-20. 20p. 3 Charts, 4 Graphs.

Subject Terms: *HIV antibodies, *HIV prevention, *BISPECIFIC antibodies, *HIV infections, *HIV-positive persons

Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV 144 HIV Vaccine Efficacy Trial

Authors: RV305 Study Team, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Excler, Jean-Louis, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Premsri, Nakorn, Kunasol, Prayura, Karasavvas, Nicos, Schuetz, Alexandra, Ngauy, Viseth, Sinangil, Faruk, Dawson, Peter, deCamp, Allan C., Phogat, Sanjay, Garunathan, Sanjay, Tartaglia, James, DiazGranados, Carlos, Ratto-Kim, Silvia, Pegu, Poonam, Eller, Michael, Karnasuta, Chitraporn, Montefiori, David C., Sawant, Sheetal, Vandergrift, Nathan, Wills, Saintedym, Tomaras, Georgia D., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Vasan, Sandhya, O'Connell, Robert J.

Source: The Journal of Infectious Diseases, 2017 Apr . 215(8), 1255-1263.

Access URL: http://www.jstor.org/stable/26166999

Selection of HIV vaccine candidates for concurrent testing in an efficacy trial

Authors: Huang, Ying, DiazGranados, Carlos, Janes, Holly, Huang, Yunda, deCamp, Allan C, Metch, Barbara, Grant, Shannon, Sanchez, Brittany, Phogat, Sanjay, Koutsoukos, Marguerite, Kanesa-Thasan, Niranjan, Bourguignon, Patricia, Collard, Alix, Buchbinder, Susan, Tomaras, Georgia D, McElrath, Julie, Gray, Glenda, Kublin, James G, Corey, Lawrence, Gilbert, Peter B

Source: In Current Opinion in Virology April 2016 17:57-65

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.

Authors: deCamp, Allan C., Corcoran, Martin M., Fulp, William J., Willis, Jordan R., Cottrell, Christopher A., Bader, Daniel L. V., Kalyuzhniy, Oleksandr, Leggat, David J., Cohen, Kristen W., Hyrien, Ollivier, Menis, Sergey, Finak, Greg, Ballweber-Fleming, Lamar, Srikanth, Abhinaya, Plyler, Jason R., Rahaman, Farhad, Lombardo, Angela, Philiponis, Vincent, Whaley, Rachael E., Seese, Aaron

Source: NPJ Vaccines; 3/11/2024, Vol. 9 Issue 1, p1-13, 13p

Subject Terms: IMMUNOGLOBULIN genes, IMMUNOGLOBULIN heavy chains, HUMAN genes, B cells, VACCINE development

Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.

Authors: Magaret, Craig A., Li, Li, deCamp, Allan C., Rolland, Morgane, Juraska, Michal, Williamson, Brian D., Ludwig, James, Molitor, Cindy, Benkeser, David, Luedtke, Alex, Simpkins, Brian, Heng, Fei, Sun, Yanqing, Carpp, Lindsay N., Bai, Hongjun, Dearlove, Bethany L., Giorgi, Elena E., Jongeneelen, Mandy, Brandenburg, Boerries, McCallum, Matthew

Source: Nature Communications; 3/11/2024, Vol. 15 Issue 1, p1-22, 22p

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Authors: Jardine, Joseph G., Kulp, Daniel W., Havenar-Daughton, Colin, Sarkar, Anita, Briney, Bryan, Sok, Devin, Sesterhenn, Fabian, Ereño-Orbea, June, Kalyuzhniy, Oleksandr, Deresa, Isaiah, Hu, Xiaozhen, Spencer, Skye, Jones, Meaghan, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, deCamp, Allan C., Julien, Jean-Philippe, Wilson, Ian A., Burton, Dennis R., Crotty, Shane, Schief, William R.

Source: Science, 2016 Mar . 351(6280), 1458-1463.

Access URL: http://www.jstor.org/stable/24742668

Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

Authors: Zolla-Pazner, Susan, Edlefsen, Paul T., Rolland, Morgane, Kong, Xiang-Peng, deCamp, Allan, Gottardo, Raphael, Williams, Constance, Tovanabutra, Sodsai, Sharpe-Cohen, Sandra, Mullins, James I., deSouza, Mark S., Karasavvas, Nicos, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, O'Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Gilbert, Peter

Source: In EBioMedicine November 2014 1(1):37-45

Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features.

Authors: Juraska, Michal¹, mjuraska@fredhutch.org, Hongjun Bai^2,3, deCamp, Allan C.¹, Li Li, Craig A. Magaret¹, Gillespie, Kevin¹, Carppa, Lindsay N.¹, Giorgi, Elena E.¹, Ludwig, James¹, Molitor, Cindy¹, Hudson, Aaron¹, Williamson, Brian D.^1,4, Espy, Nicole⁵, Simpkins, Brian⁶, Rudnicki, Erika¹, Shao, Danica¹, Rossenkhan, Raabya¹, Edlefsen, Paul T.¹, Westfall, Dylan H.⁷, Wenjie Deng⁷, Chen, Lennie⁷

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/23/2024, Vol. 121 Issue 4, p1-12, 51p