Full-length inhibitor protein is the most effective to perturb human dUTPase activity

Authors: Bianka Kőhegyi, Zoé S. Tóth, Enikő Gál, Máté Laczkovich, András Benedek, Beáta G. Vértessy, Kinga Nyíri

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Subject Terms: dUTPase, Proteinaceous inhibitor, Peptide inhibitor, Structure based design, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9dcadde637e2431db76cc70b1db870b6

Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase)

Authors: Ravdna Sarre, Olena Dobrovolska, Patrik Lundström, Diana Turcu, Tatiana Agback, Øyvind Halskau, Johan Isaksson

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Human dUTPase, Protein dynamics, Multidimensional NMR, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d639c9eb1b8947979994794f2b3ad784

Structure-guided discovery of novel dUTPase inhibitors with anti-Nocardia activity by computational design

Authors: Zhi-Zheng Wang, Jun Weng, Jing Qi, Xin-Xin Fu, Ban-Bin Xing, Yang Hu, Chun-Hsiang Huang, Chin-Yu Chen, Zigong Wei

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Subject Terms: Computer-aided drug design, antibiotics, Nocardia, dUTPase, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/ac18eb85d6d44145bd23eadfbdec9365

Structural definition of pseudorabies virus dUTPase reveals a novel folding dimer in the herpesvirus family

Authors: Li, Jiachen ^{a, 1}, Ma, Sen ^{a, 1}, Yang, Runze ^{a, 1}, Xu, Jinrui ^{b, ⁎}, Wang, Yaxin ^{a, ⁎}, Ye, Sheng ^{a, ⁎}

Source: In International Journal of Biological Macromolecules November 2024 280 Part 1

Enzyme kinetics of deoxyuridine triphosphatase from Western corn rootworm

Authors: Carlos Riera-Ruiz, Hideaki Moriyama

Source: BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)

Subject Terms: Western corn rootworm, Diabrotica virgifera virgifera, 5ʹ-triphosphate nucleotidohydrolase (dUTPase), dUTP, Thymidylate synthase, dUMP, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/d56d0d84c665427a99ed1d2f0a5a2e35

The Bacteriophage–Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases

Authors: Carla Sanz-Frasquet, J. Rafael Ciges-Tomas, Christian Alite, José R. Penadés, Alberto Marina

Source: Microbiology Spectrum, Vol 11, Iss 1 (2023)

Subject Terms: dUTPase, inhibition, Stl repressor, crystal structure, protein-protein interaction, Dut-Stl complex, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/60c9cda5c2a44f358c3cb9422d2d1a47

Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1

Authors: Farzana Shahin, Sohail Raza, Xi Chen, Changmin Hu, Yingyu Chen, Huanchun Chen, Aizhen Guo

Source: Animals, Vol 13, Iss 16, p 2607 (2023)

Subject Terms: BoHV-1, dUTPase, polyclonal antiserum, cloned, localized, UL50, Veterinary medicine, SF600-1100, Zoology, QL1-991

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2615/13/16/2607; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/07db5e41f602411191de60ff02def2bc

Evaluation of critical design parameters for RT‐qPCR‐based analysis of multiple dUTPase isoform genes in mice

Authors: Gergely A. Rácz, Nikolett Nagy, Zoltán Gál, Tímea Pintér, László Hiripi, Beáta G. Vértessy

Source: FEBS Open Bio, Vol 9, Iss 6, Pp 1153-1170 (2019)

Subject Terms: dUTPase, isoform‐specific expression levels, mitochondrial dUTPase isoform, mouse organs, nuclear dUTPase isoform, RT‐qPCR optimization, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/edbe50a9b8c541b39a20d41ed983e06f

Screening and Identification of a Novel Anti-tuberculosis Compound That Targets Deoxyuridine 5′-Triphosphate Nucleotidohydrolase

Authors: Yu Zhang, Hongjuan Zhang, Ying Chen, Luyao Qiao, Yanxing Han, Yuan Lin, Shuyi Si, Jian-Dong Jiang

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: anti-tuberculosis, dUTPase, high-throughput screening, inhibitor, molecular docking, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.757914/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/047eaedec5814ec0a5ccb93c0f47e3fc

Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus

Authors: Catherine P. Chia, Noriko Inoguchi, Kyle C. Varon, Bradley M. Bartholomai, Hideaki Moriyama

Source: BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020)

Subject Terms: dUTPase, Dictyostelium discoideum, GFP, Mitochondrial targeting sequence, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/df9a4b5d5c6146b0995cdef6d2fe27a9

Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis

Authors: Md. Shahanoor Alam, Hideaki Moriyama, Midori Matsumoto

Source: BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)

Subject Terms: dUTPase, Planarian, Regeneration, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13104-019-4191-6; https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/f87ecb62a6ee453297d0ed85c0286b80

Viral dUTPases: Modulators of Innate Immunity

Authors: Maria Eugenia Ariza, Brandon Cox, Britney Martinez, Irene Mena-Palomo, Gloria Jeronimo Zarate, Marshall Vance Williams

Source: Biomolecules, Vol 12, Iss 2, p 227 (2022)

Subject Terms: deoxyuridine triphosphate nucleotidohydrolase, dUTPase, double-stranded DNA viruses, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/2/227; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/afee06217dcd45cba75451ef668743e1

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L. Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang

Source: Viruses, Vol 13, Iss 11, p 2175 (2021)

Subject Terms: African swine fever virus, African swine fever, dUTPase, epitope, therapeutic drug, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/11/2175; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/7bf9166b19c249e1966f43b0568de2ef

Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target

Authors: Changyao Li, Yan Chai, Hao Song, Changjiang Weng, Jianxun Qi, Yeping Sun, George F. Gao

Source: mBio, Vol 10, Iss 5 (2019)

Subject Terms: African swine fever virus, dUTPase, E165R, crystal structure, drug target, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/6b523e27dad8474bacd1723466769527

Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome

Authors: Qiwen Dong, Kyle R. Smith, Darby G. Oldenburg, Maxwell Shapiro, William R. Schutt, Laraib Malik, Joshua B. Plummer, Yunxiang Mu, Thomas MacCarthy, Douglas W. White, Kevin M. McBride, Laurie T. Krug

Source: mBio, Vol 9, Iss 5 (2018)

Subject Terms: DNA replication, dUTPase, gammaherpesvirus, genomic stability, herpesviruses, latency, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/e0bb07380d1b4f38bdcc807e729ffc60

QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities

Authors: Marilia N. N. Lima, Cleber C. Melo-Filho, Gustavo C. Cassiano, Bruno J. Neves, Vinicius M. Alves, Rodolpho C. Braga, Pedro V. L. Cravo, Eugene N. Muratov, Juliana Calit, Daniel Y. Bargieri, Fabio T. M. Costa, Carolina H. Andrade

Source: Frontiers in Pharmacology, Vol 9 (2018)

Subject Terms: malaria, virtual screening, QSAR, Plasmodium falciparum, dUTPase, transmission blocker, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2018.00146/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/ac9c9c7c94494efd9ede6cf618ca1df8

HDX and Native Mass Spectrometry Reveals the Different Structural Basis for Interaction of the Staphylococcal Pathogenicity Island Repressor Stl with Dimeric and Trimeric Phage dUTPases

Authors: Kinga Nyíri, Matthew J. Harris, Judit Matejka, Olivér Ozohanics, Károly Vékey, Antoni J. Borysik, Beáta G. Vértessy

Source: Biomolecules, Vol 9, Iss 9, p 488 (2019)

Subject Terms: dUTPase, inhibition, interaction surface, Stl staphylococcal repressor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/9/9/488; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/fae8e4d82df44a7293d592ac40230cae

The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition

Authors: András Benedek, Fanni Temesváry-Kis, Tamjidmaa Khatanbaatar, Ibolya Leveles, Éva Viola Surányi, Judit Eszter Szabó, Lívius Wunderlich, Beáta G. Vértessy

Source: Biomolecules, Vol 9, Iss 6, p 221 (2019)

Subject Terms: dUTPase, trimer, inhibition, StlSaPIbov1, crystal structure, C-terminal arm, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/9/6/221; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/2b4ea6bfeee54474b913a3344fc8e3cd

CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

Authors: Hajnalka Laura Pálinkás, Gergely Attila Rácz, Zoltán Gál, Orsolya Ivett Hoffmann, Gergely Tihanyi, Gergely Róna, Elen Gócza, László Hiripi, Beáta G. Vértessy

Source: Biomolecules, Vol 9, Iss 4, p 136 (2019)

Subject Terms: dUTPase, CRISPR/Cas9-mediated knock-out, blastocyst outgrowth, embryonic development, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/9/4/136; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/21208895c4914bc08d0e99ddbb79ab79

Life without dUTPase

Authors: Csaba Kerepesi, Judit E Szabó, Veronika Papp-Kádár, Orsolya Dobay, Dóra Szabó, Vince Grolmusz, Beata G Vertessy

Source: Frontiers in Microbiology, Vol 7 (2016)

Subject Terms: Bacteria, DNA Repair, Uracil, horizontal gene transfer, UNG, dUTPase, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01768/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/b4111ab7d87c4acd8bd6d46aac9a70d8