Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-endo cyclization

Authors: Asahi Kanno, Ryo Tanifuji, Satoshi Yoshida, Sota Sato, Saori Maki-Yonekura, Kiyofumi Takaba, Jungmin Kang, Kensuke Tono, Koji Yonekura, Hiroki Oguri

Source: Beilstein Journal of Organic Chemistry, Vol 21, Iss 1, Pp 226-233 (2025)

Subject Terms: cascade reactions, copper-catalyzed three-component coupling, gold-mediated 6-endo hydroamination, tandem cyclizations, tetrahydroisoquinoline alkaloids, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Nitrogen-Centered Radicals in Visible-Light-Promoted Reactions

Authors: Monica F. Boselli, Fabrizio Medici, Francesca Franco

Source: SynOpen, Vol 08, Iss 04, Pp 273-299 (2024)

Subject Terms: nitrogen radicals, photoredox catalysis, visible-light-driven reactions, amidyl radicals, cyclizations, addition to π systems, hydrogen atom transfer, Chemistry, QD1-999

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Relation: https://doaj.org/toc/2509-9396

Access URL: https://doaj.org/article/48b0b7e08bf943f890795eef2f8cef5f

From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti‐Liver Fibrosis Potential

Authors: Kai Guo, Xue Tang, Yan‐Chun Liu, Hui‐Zhen Cheng, Huan Liu, Yu‐Zhou Fan, Xiao‐Yu Qi, Rui Xu, Juan‐Juan Kang, De‐Sen Li, Guo‐Dong Wang, Jonathan Gershenzon, Yan Liu, Sheng‐Hong Li

Source: Advanced Science, Vol 12, Iss 9, Pp n/a-n/a (2025)

Subject Terms: anti‐liver fibrosis, Capsella bursa‑pastoris, cyclizations, sesterterpene synthase, sesterterpenes, Science

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Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/3042ef7dbbd84f2084a83eabb56a8025

Domino reactions of chromones with activated carbonyl compounds

Authors: Peter Langer

Source: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1256-1269 (2024)

Subject Terms: cyclizations, 1,3-dicarbonyl compounds, domino reactions, heterocycles, regioselectivity, silyl enol ethers, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

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Pyridoxal and Salicylaldehyde Derivatives: Synthesis, Characterization, and Antifungal Potential Against Opportunistic Yeast Pathogens

Authors: Jairo Camacho, Carlos A. Bejarano, John E. Diaz, Yerly Vargas-Casanova, Silvia Katherine Carvajal, Valentina Diaz Santoyo, Claudia M. Parra-Giraldo, Alix E. Loaiza

Source: Molecules, Vol 30, Iss 5, p 1165 (2025)

Subject Terms: pyridoxal, salicylaldehyde, radical cyclizations, click chemistry, antifungal activity, C. albicans, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/30/5/1165; https://doaj.org/toc/1420-3049

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Synthesis of 2,2,5-Trisubstituted Tetrahydrofurans by Ferrocenium-Catalyzed Dehydrative Diol Cyclization Reactions

Authors: Cody D. Amann, Khushboo, Eike B. Bauer

Source: Inorganics, Vol 13, Iss 2, p 59 (2025)

Subject Terms: diol cyclizations, trisubstituted tetrahydrofurans, iron catalysis, ferrocenium catalysis, Inorganic chemistry, QD146-197

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Relation: https://www.mdpi.com/2304-6740/13/2/59; https://doaj.org/toc/2304-6740

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Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles

Contributors: Starosotnikov, Alexey M., Bastrakov, Maxim A., Dalinger, Igor L.

Subject Terms: C–H functionalization, cyclization, indazole products, transition metals catalysis, nitro compounds, Azolo[1,5-a]pyrimidines, CK2 inhibition, antitumor activity, multicomponent reaction, amides, BF3·Et2O, debenzylation, nitrogen heterocycles, 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate, anthranilamide, ethyl levulinate, Amberlyst® 15, Brønsted acid, cascade reaction, mechanochemistry, quinazolinone, ball mill, azirines, pyrrolines, cycloaddition, annulation, copper catalysis, nitro group, nitropyridines, bis-(het)aryl ethenes, nucleophilic substitution, thiols, UV–Vis spectroscopy, alkoxides, aziridination, manganese, iminoiodinane, energetic materials, tetrazine, hydroxytetrazole, oxadiazole, sulfonylureas, DPP-IV inhibitors, diabetes mellitus, peptidomimetics, alkynes, enediynes, heterocycles, benzo[b]thiophene, Bergman cyclization, Nicholas reaction, Sonogashira coupling, benzenesulfonamides, antifolates, folic acids, synthesis, applications, drugs, aziridine, non-activated, nucleophilic, ring-opening, regioselectivity, pyrrole, domino reaction, 1H-indole synthesis, aza–Michael reaction, SNAr reaction, heteroaromatization, 4-hydroxy-2-pyrone, 4-pyridone, aminoenone, trifluoromethylated heterocycles, regioselective reactions, oxidative cyclization, manganese(IV) oxide, 1,2,4-triazine, phenols, cross-coupling, spiropyrrolidine derivatives, antimicrobial, antioxidant, antidiabetic, ADME, molecular docking and dynamic simulation, sulfur–nitrogen heterocycles, benzo[1,2-d:4,5-d’]bis([1,2,3]thiadiazole), aromatic nucleophilic substitution, Suzuki and Stille cross-coupling reactions, X-ray analysis, estradiol, benzisoxazole, hybrid, cancer selectivity, apoptosis induction, carborane, tetrazole, HEMDs, DFT, single crystal X-ray diffraction, electrochemistry, imidazoles, vinyl azides, click chemistry, mechanochemical synthesis, 1,2,3-triazole, cycloaddition reaction, Rufinamide synthesis, solvent-free, C-glycosyl compound, amidrazone, IEDDA, pyridine, aminofurazans, fused furazans, perchlorates, energetic compound, impact sensitivity, thermal decomposition, combustion, burning rate, 1,2,3-triazoles, nucleobases, Lewis acid, molecular docking, donor–acceptor cyclopropanes, primary amines, pyrrolidin-2-ones, benz[g]indolizidines, acetylenes, amino acids, C-H activation, catalysis, isoquinolones, active methylene thioamides, Michael addition, dithiomalondianilide, cyanoacetic esters, [1,2]dithiolo[3,4-b]pyridines, herbicide safeners, azomethine ylide, pyrrolidine, spiro-compound, imidazole, medicinal chemistry, drug discovery, Minisci reaction, heterogeneous photocatalysis, N-hydroxyphthalimide, titanium dioxide, green chemistry, visible light photocatalysis, 2-hydroxyphenyl group, hydrogen bond, ESIPT, luminescence, [1,2,4]triazolo[4,3-c]quinazolines, fluorescence, solvatochromism, pH-sensor, multicomponent domino cyclizations, ethyl trifluoropyruvate, methyl ketones, amino alcohols, γ-lactams, tetrahydropyrrolo[2,1-b]oxazolones, tetrahydropyrrolo[2,1-b]oxazinones, alkaloid, Maillard reaction, crystallization-induced diastereomer transformation, glutamine, hydroxy amino acid, diketopiperazine, thiourea dioxide, TDO, pyridazine, pyrimidine, pyrazine, organophosphorus compounds, dipyrroloquinoxaline, bathochromic shift, substituent effect, energy gap, N-trifluoromethyl group, imidates, iminonitriles, nitrostyrenes, 2-aminopyridine, N-heterocycles, 1,3,4-oxadiazole, D-ribose, L-amino acid, pyrrole-2-carbaldehyde, iodine effect, antibacterial activity, sustainable synthesis, aromatic N-heterocycles, solid acids, nanoparticles, microwaves, ultrasounds, visible light activation, high hydrostatic pressure, biomass, 1,3-diynamides, ynamides, homogeneous catalysis, annulation reactions, cycloaddition cascade reactions, helical twisted frontier molecular orbitals (Hel-FMO), Hexa-dehydro-Diels–Alder (HDDA) reaction, quinolines, indoles, carbazoles, N-heterocyclic-based dyes, photosensitizers, photodynamic therapy, Research and information: general, Thermodynamics and heat

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Access URL: https://directory.doabooks.org/handle/20.500.12854/152739
https://mdpi.com/books/pdfview/book/9882

Anion–π catalysis on carbon allotropes

Authors: M. Ángeles Gutiérrez López, Mei-Ling Tan, Giacomo Renno, Augustina Jozeliūnaitė, J. Jonathan Nué-Martinez, Javier Lopez-Andarias, Naomi Sakai, Stefan Matile

Source: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1881-1894 (2023)

Subject Terms: anion–π interactions, autocatalysis, catalysis, carbon nanotubes, diels–alder reactions, electric-field-induced catalysis, electromicrofluidics, enolate addition, ether cyclizations, fullerenes, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/eafc07211bd44098804d87ded7bcb476

Multiple Isocyanide insertions promoted by protic and Lewis acids

Authors: John Kornfeind, Fraser F. Fleming

Source: Tetrahedron Chem, Vol 9, Iss , Pp 100056- (2024)

Subject Terms: Isocyanide, Insertions, Cyclizations, Lewis acids, Cascades, Organic chemistry, QD241-441

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Relation: http://www.sciencedirect.com/science/article/pii/S2666951X23000220; https://doaj.org/toc/2666-951X

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Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives

Authors: Nitesh K. Nandwana, Om P. S. Patel, Manish K. Mehra, Anil Kumar, Joseph M. Salvino

Source: Molecules, Vol 29, Iss 10, p 2353 (2024)

Subject Terms: quinazoline heterocycles, transition metal-catalyzed synthesis, C-H activation, cascade reactions, intramolecular dehydrative/dehydrogenative cyclizations, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/29/10/2353; https://doaj.org/toc/1420-3049

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Synthesis and Reactivity of Electron-Deficient 3-Vinylchromones

Authors: Vyacheslav Y. Sosnovskikh

Source: SynOpen, Vol 05, Iss 03, Pp 255-277 (2021)

Subject Terms: 3-vinylchromones, nucleophilic reactions, ambiphilic cyclizations­, cycloaddition reactions, heterocycles, Chemistry, QD1-999

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Relation: https://doaj.org/toc/2509-9396

Access URL: https://doaj.org/article/4587ceb0ffa346c5a11548fc5d765a7f

S,N-Heteropentacenes – Syntheses of Electron-Rich Anellated Pentacycles

Authors: Henning R. V. Berens, Thomas J. J. Müller

Source: Organic Materials, Vol 03, Iss 02, Pp 155-167 (2021)

Subject Terms: heteroacenes, cross-coupling, condensations, cyclizations, modular syntheses, optoelectronics, energy conversion, materials, Chemistry, QD1-999

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Relation: https://doaj.org/toc/2625-1825

Access URL: https://doaj.org/article/727c61ec7b024ae3bbd1ec794f4407af

Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles

Authors: Marina V. Goryaeva, Olesya A. Fefelova, Yanina V. Burgart, Marina A. Ezhikova, Mikhail I. Kodess, Pavel A. Slepukhin, Vasily S. Gaviko, Victor I. Saloutin

Source: Molecules, Vol 28, Iss 4, p 1983 (2023)

Subject Terms: multicomponent domino cyclizations, ethyl trifluoropyruvate, methyl ketones, amino alcohols, γ-lactams, tetrahydropyrrolo[2,1-b]oxazolones, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/28/4/1983; https://doaj.org/toc/1420-3049

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Silver-Catalyzed Cascade Cyclization of Amino-NH-1,2,3-Triazoles with 2-Alkynylbenzaldehydes: An Access to Pentacyclic Fused Triazoles

Authors: Shuitao Zhang, Jianxin Li, Tiebo Xiao, Baomin Yang, Yubo Jiang

Source: Molecules, Vol 27, Iss 21, p 7567 (2022)

Subject Terms: cascade, cyclizations, fused 1,2,3-triazoles, isoquinoline, quinazoline, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/27/21/7567; https://doaj.org/toc/1420-3049

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Lewis Acid-Catalyzed 2,3-Dihydrofuran Acetal Ring-Opening Benzannulations toward Functionalized 1-Hydroxycarbazoles

Authors: Shaoren Yuan, Gabriel Guerra Faura, Hailey E. Areheart, Natalie E. Peulen, Stefan France

Source: Molecules, Vol 27, Iss 23, p 8344 (2022)

Subject Terms: benzannulation, carbazoles, dihydrofuran acetals, ring-opening cyclizations, synthetic methods, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/27/23/8344; https://doaj.org/toc/1420-3049

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Catalytic Reductive Amination of Aldehydes and Ketones With Nitro Compounds: New Light on an Old Reaction

Authors: Alexey Yu. Sukhorukov

Source: Frontiers in Chemistry, Vol 8 (2020)

Subject Terms: nitro compounds, reductive amination, secondary amines, heterogeneous catalysis, cyclizations, nitrogen heterocycles, Chemistry, QD1-999

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Relation: https://www.frontiersin.org/article/10.3389/fchem.2020.00215/full; https://doaj.org/toc/2296-2646

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Antimicrobial and anticancer evaluation of a novel synthetic tetracyclic system obtained by Dimroth rearrangement

Authors: Gomha Sobhi M., Abbas Ikhlass M., Elneairy Mohamed A.A., Elaasser Mahmoud M., Mabrouk Bazada K.A.

Source: Journal of the Serbian Chemical Society, Vol 80, Iss 10, Pp 1251-1264 (2015)

Subject Terms: hydrazones, oxidative cyclizations, thienopyridines, reaction mechanism, Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/0352-5139; https://doaj.org/toc/1820-7421

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Synthesis of Nitrogen Heterocycles Using Samarium(II) Iodide

Authors: Shicheng Shi, Michal Szostak

Source: Molecules, Vol 22, Iss 11, p 2018 (2017)

Subject Terms: samarium iodide, nitrogen heterocycles, nitrogen, radicals, reductive coupling, SmI2, radical cyclizations, samarium diiodide, umpolung cyclizations, aminoketyl radicals, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/22/11/2018; https://doaj.org/toc/1420-3049

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TARGET-ORIENTED SYNTHESIS OF SOME TERPENOIDS OF MARINE ORIGIN

Authors: Nicon Ungur

Source: Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 6, Iss 2, Pp 30-35 (2011)

Subject Terms: marine natural products, terpenoids, glycerol, scalaranes, cheilanthanes, sesterterpenoids, cyclizations, superacids, rearrangements, synthesis, Chemistry, QD1-999, General. Including alchemy, QD1-65

File Description: electronic resource

Relation: http://www.cjm.asm.md/sites/default/files/article_files/Ungur%20008%20.pdf; https://doaj.org/toc/1857-1727; https://doaj.org/toc/2345-1688

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Solvent- and ligand-induced switch of selectivity in gold(I)-catalyzed tandem reactions of 3-propargylindoles

Authors: Estela Álvarez, Delia Miguel, Patricia García-García, Manuel A. Fernández-Rodríguez, Félix Rodríguez, Roberto Sanz

Source: Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 786-793 (2011)

Subject Terms: catalysis, gold, indoles, Nazarov cyclizations, selectivity, Science, Organic chemistry, QD241-441

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Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/282d09694b2f4fe1b5ad2a177641ca58