SYNTHESIS, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF STEROIDAL cytotoxic AGENTS.

Authors: Lohe, Radhika G.¹, Mahajan, Vijay², Jagdale, Deepali M.¹ jagdaledeepali5680@gmail.com

Source: Indian Drugs. Jan2025, Vol. 62 Issue 1, p18-27. 10p.

Subject Terms: *HEDGEHOG signaling proteins, *CHALCONES, *MOLECULAR docking, *NEOVASCULARIZATION inhibitors, *CYTOTOXINS, *CHALCONE

Chiral Sodium Glycerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones.

Authors: Ghigo, Giovanni¹ (AUTHOR) giovanni.ghigo@unito.it, Rivella, Julia¹ (AUTHOR), Robiolio Bose, Alessio¹ (AUTHOR), Dughera, Stefano¹ (AUTHOR) giovanni.ghigo@unito.it

Source: Molecules. Oct2024, Vol. 29 Issue 19, p4763. 7p.

Subject Terms: *MICHAEL reaction, *CHALCONES, *CATALYSTS, *SODIUM

Medicinally Privileged Natural Chalcones: Abundance, Mechanisms of Action, and Clinical Trials.

Authors: Villa, Sophia M.¹ (AUTHOR) sophia_villa@hms.harvard.edu, Heckman, Justin² (AUTHOR) justin.heckman01@utrgv.edu, Bandyopadhyay, Debasish^3,4 (AUTHOR) debasish.bandyopadhyay@utrgv.edu

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9623. 22p.

Subject Terms: *CHALCONES, *BIODEGRADATION, *PLANT metabolites, *DEMYELINATION, *VIRUS diseases, *CHALCONE

Access to Functionalized 2-Phenyl-4-(Indol-3-yl)-4H-Chromenes via Coupling of 2-Hydroxychalcones and Indole in PEG-400/H2O under Catalyst-free Conditions.

Authors: Roy, S.¹ sushmitar93@gmail.com

Source: Journal of Scientific Research. 2024, Vol. 16 Issue 3, p857-872. 16p.

Subject Terms: *HETEROCYCLIC compounds, *CHALCONES, *INDOLE compounds, *BENZENE, *SIMPLICITY

Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells.

Authors: Letulle, Cécile^1,2 (AUTHOR) cecile.letulle@etu.univ-lehavre.fr, Toublet, François-Xavier¹ (AUTHOR) francois-xavier.toublet@unilim.fr, Pinon, Aline¹ (AUTHOR) aline.pinon@unilim.fr, Hba, Soufyane^1,3 (AUTHOR) hbasoufyane@gmail.com, Laurent, Aurélie¹ (AUTHOR) aurelie.laurent@unilim.fr, Sol, Vincent¹ (AUTHOR) vincent.sol@unilim.fr, Fagnère, Catherine¹ (AUTHOR) catherine.fagnere@unilim.fr, Rioux, Benjamin¹ (AUTHOR) benjamin.rioux@cma-nouvelleaquitaine.fr, Allais, Florent⁴ (AUTHOR) florent.allais@agroparistech.fr, Michallet, Sophie⁵ (AUTHOR) sophie.michallet@univ-grenoble-alpes.fr, Lafanechère, Laurence⁵ (AUTHOR) laurence.lafanechere@univ-grenoble-alpes.fr, Limami, Youness^3,6 (AUTHOR) mouniaoudghiri@gmail.com, Oudghiri, Mounia³ (AUTHOR), Othman, Mohamed² (AUTHOR) adam.daich@univ-lehavre.fr, Daïch, Adam² (AUTHOR), Liagre, Bertrand¹ (AUTHOR) bertrand.liagre@unilim.fr, Lawson, Ata Martin² (AUTHOR) ata-fmartin.lawson@univ-lehavre.fr, Pouget, Christelle¹ (AUTHOR) ata-fmartin.lawson@univ-lehavre.fr

Source: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1207. 24p.

Subject Terms: *PROSTATE cancer, *CHALCONES, *CHROMONES, *CANCER cells, *COLORECTAL cancer, *CHALCONE

(E)-2-Benzylidenecyclanones: Part XIX. Reaction of (E)-2-(4′-X-Benzylidene)-1-tetralones with Cellular Thiols: Comparison of Thiol Reactivities of Open-Chain Chalcones and Their Six- and Seven-Membered Cyclic Analogs.

Authors: Kenari, Fatemeh¹ (AUTHOR) kenari.fatemeh@gmail.com, Pintér, Zoltán¹ (AUTHOR) pinter.zoltan@pte.hu, Molnár, Szilárd^1,2 (AUTHOR) molnar.szilard@pte.hu, Borges, Igor D.³ (AUTHOR) i.dalarmelino@gmail.com, Camargo, Ademir J.³ (AUTHOR) ajc@ueg.br, Napolitano, Hamilton B.³ (AUTHOR) hamilton@ueg.br, Perjési, Pál^1,3 (AUTHOR) pal.perjesi@gytk.pte.hu

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7773. 18p.

Subject Terms: *CHALCONES, *FRONTIER orbitals, *LIQUID chromatography-mass spectrometry, *CHALCONE, *CYTOTOXINS, *THIOLS, *LIQUID chromatography

Chalcones—Features, Identification Techniques, Attributes, and Application in Agriculture.

Authors: Dziągwa-Becker, Magdalena¹ (AUTHOR) m.dziagwa@iung.wroclaw.pl, Oleszek, Marta² (AUTHOR) moleszek@iung.pulawy.pl, Zielińska, Sylwia³ (AUTHOR) sylwia.zielinska@umw.edu.pl, Oleszek, Wiesław² (AUTHOR) wieslaw.oleszek@iung.pulawy.pl

Source: Molecules. May2024, Vol. 29 Issue 10, p2247. 11p.

Subject Terms: *CHALCONES, *CHALCONE, *AGRICULTURE, *PESTICIDES, *CHEMICAL reduction, *NATURAL resources, *AGRICULTURAL industries, *HERBICIDE resistance

The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework.

Authors: Stalinskaya, Alena L.¹ (AUTHOR), Dengis, Natalia A.² (AUTHOR), Vlasenko, Vasily S.² (AUTHOR), Kulakov, Ivan V.¹ (AUTHOR) i.v.kulakov@utmn.ru

Source: Chemistry of Heterocyclic Compounds. Feb2024, Vol. 60 Issue 1/2, p41-47. 7p.

Subject Terms: *AROMATIC aldehydes, *CHALCONES, *ACETIC acid, *HYDRAZINES, *PYRIDINE, *HYDRAZINE, *HYDRAZINE derivatives

DOCKING, ANTI-BREAST CANCER AND ANTIOXIDANT STUDY OF SOME NEW SULFISOXAZOLE BASED ON CARBOHYDRATE.

Authors: Alhaideri, Mohammed Ridha A.¹ redhaabod@gmail.com, Zimam, Ezzat H.¹

Source: Acta Chemica Iaşi. 2024, Vol. 32 Issue 1, p33-54. 22p.

Subject Terms: *ACETIC anhydride, *CHALCONES, *BREAST cancer, *ALDEHYDES, *CARBOHYDRATES, *CHALCONE

Solvent-free synthesis and in vitro cytotoxicity of fluorinated chalcones against HepG2 cells.

Authors: Van Thi Bich Pham¹, Hien Van Nguyen¹, Ha Quoc An Than², Trung Thanh Pham³, Hao Minh Hoang³ haohm@hcmute.edu.vn

Source: ARKIVOC: Online Journal of Organic Chemistry. 2024, Vol. 2024, p1-13. 13p.

Subject Terms: *CONDENSATION reactions, *CHALCONES, *CYTOTOXINS, *ORGANIC compounds, *ANTINEOPLASTIC agents

Assessing the Antiangiogenic Effects of Chalcones and Their Derivatives.

Authors: Burmaoglu, Serdar¹ (AUTHOR) sboglu@atauni.edu.tr, Gobek, Arzu¹ (AUTHOR), Anil, Derya Aktas² (AUTHOR), Alagoz, Mehmet Abdullah³ (AUTHOR), Guner, Adem⁴ (AUTHOR), Güler, Cem⁵ (AUTHOR), Hepokur, Ceylan⁶ (AUTHOR), Karabay Yavasoglu, N. Ulku⁵ (AUTHOR), Algul, Oztekin^7,8 (AUTHOR) oztekinalgul@mersin.edu.tr

Source: Polycyclic Aromatic Compounds. 2024, Vol. 44 Issue 1, p51-66. 16p.

Subject Terms: *CHALCONES, *CHALCONE, *NEOVASCULARIZATION inhibitors, *BINDING sites, *MOLECULAR docking, *ANTINEOPLASTIC agents

A novel naphthylchalcone ([E]‐4‐(3‐[naphthalen‐2‐yl]‐3‐oxoprop‐1‐en‐1‐yl) induces intrinsic and extrinsic apoptosis in human acute leukemia cell lines.

Authors: Jacques, Amanda V.^1,2 (AUTHOR), Stefanes, Natália M.^1,2 (AUTHOR), Walter, Laura O.^1,2 (AUTHOR), Syracuse, Stephanie M.² (AUTHOR), Bigolin, Alisson^1,2 (AUTHOR), Chiaradia‐Delatorre, Louise D.³ (AUTHOR), de Souza, Luiz F. S.^3,4 (AUTHOR), de Moraes, Ana C. R.^1,2 (AUTHOR), Nunes, Ricardo J.^3,4 (AUTHOR), Santos‐Silva, Maria C.^1,2 (AUTHOR) maria.claudia.silva@ufsc.br

Source: Fundamental & Clinical Pharmacology. Feb2025, Vol. 39 Issue 1, p1-20. 20p.

Subject Terms: *ACUTE leukemia, *CHALCONES, *CYTOTOXINS, *CASPASES regulation, *NAPHTHYL compounds, *APOPTOSIS

Visible-Light-Driven Metal-Free and Photocatalyst-Free Intra-molecular Cyclization of Chalcones to Access Phenanthrenes.

Authors: Yi, Miaoyan^1,2 (AUTHOR), Zhang, Chen¹ (AUTHOR), Liao, Saihu² (AUTHOR), Sun, Bing¹ (AUTHOR) bing.sun@whut.edu.cn

Source: Synlett. Feb2025, Vol. 36 Issue 3, p274-278. 5p.

Subject Terms: *CHALCONES, *RING formation (Chemistry), *PHENANTHRENE, *PHOTOCATALYSIS, *FLUORESCENCE

Water extract of red mud (WERM): an effective alternative sustainable basic medium for H2O2-promoted epoxidation of chalcones and hydration of nitriles.

Authors: Patra, Snigdha Rani¹ (AUTHOR), Tanwer, Yogesh Bhaskar Singh¹ (AUTHOR), Das, Debjit² (AUTHOR) debjitofchem@gmail.com, Bhunia, Sabyasachi¹ (AUTHOR) sabyasachi.bhunia@cuj.ac.in

Source: Research on Chemical Intermediates. Dec2023, Vol. 49 Issue 12, p5395-5405. 11p.

Subject Terms: *CHALCONES, *EPOXIDATION, *NITRILES, *HYDRATION, *MUD, *AMIDES, *CHALCONE

CHALCONE: A PRIVILEGE SCAFFOLD IN SYNTHETIC CHEMISTRY.

Authors: Shejol, Vinayak¹, Singh, Namrata¹

Source: Advances in Pharmacology & Toxicology. Dec2023, Vol. 24 Issue 2, p17-28. 12p.

Subject Terms: *CHALCONES, *FLAVONOIDS, *THERMODYNAMICS, *ANTIOXIDANTS, *CHEMICAL industry, *PHARMACOLOGY

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles.

Authors: Hba, Soufyane^1,2 (AUTHOR) hbasoufyane@gmail.com, Ghaddar, Suzan² (AUTHOR) aline.pinon@unilim.fr, Wahnou, Hicham¹ (AUTHOR) hwwahnou@gmail.com, Pinon, Aline² (AUTHOR) christelle.pouget@unilim.fr, El Kebbaj, Riad³ (AUTHOR) elkebbajriad@gmail.com, Pouget, Christelle² (AUTHOR) vincent.sol@unilim.fr, Sol, Vincent² (AUTHOR), Liagre, Bertrand² (AUTHOR) bertrand.liagre@unilim.fr, Oudghiri, Mounia¹ (AUTHOR) mounia.oudghiri@univh2c.ma, Limami, Youness^1,3 (AUTHOR) bertrand.liagre@unilim.fr

Source: Pharmaceutics. Dec2023, Vol. 15 Issue 12, p2718. 20p.

Subject Terms: *COLON cancer, *CHALCONES, *CHALCONE, *DRUG delivery systems, *NANOPARTICLES

Synthesis of Chalcones: An Improved High-Yield and Substituent-Independent Protocol for an Old Structure.

Authors: Donaire-Arias, Ana¹ (AUTHOR) anaariasd@iqs.url.edu, Poulsen, Martin L.¹ (AUTHOR), Ramón-Costa, Jaime¹ (AUTHOR), Montagut, Ana Maria¹ (AUTHOR), Estrada-Tejedor, Roger¹ (AUTHOR), Borrell, José I.¹ (AUTHOR) j.i.borrell@iqs.url.edu

Source: Molecules. Nov2023, Vol. 28 Issue 22, p7576. 11p.

Subject Terms: *CHALCONES, *WITTIG reaction, *ALDOL condensation, *ELIMINATION reactions, *COLUMN chromatography, *SILICA gel, *CHALCONE

Natural Chalcones for the Management of Obesity Disease.

Authors: Maisto, Maria¹ (AUTHOR) adua.marzocchi@unina.it, Marzocchi, Adua¹ (AUTHOR), Keivani, Niloufar¹ (AUTHOR), Piccolo, Vincenzo¹ (AUTHOR), Summa, Vincenzo¹ (AUTHOR), Tenore, Gian Carlo¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15929. 20p.

Subject Terms: *CHALCONES, *CHALCONE, *DISEASE management, *APPETITE depressants, *AVIAN influenza, *TYPE 2 diabetes, *LIPASE inhibitors, *PEPTIDE receptors

Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization.

Authors: Moreira, Joana^1,2 (AUTHOR) joana.m26@hotmail.com, Loureiro, Joana B.³ (AUTHOR) up201407524@ff.up.pt, Correia, Danilo¹ (AUTHOR) danilocorreia54@gmail.com, Palmeira, Andreia^1,2 (AUTHOR) apalmeira@ff.up.pt, Pinto, Madalena M.^1,2 (AUTHOR) madalena@ff.up.pt, Saraiva, Lucília³ (AUTHOR) lucilia.saraiva@ff.up.pt, Cidade, Honorina^1,2 (AUTHOR) lucilia.saraiva@ff.up.pt

Source: Pharmaceuticals (14248247). Oct2023, Vol. 16 Issue 10, p1354. 32p.

Subject Terms: *STRUCTURE-activity relationships, *CHALCONES, *ANTINEOPLASTIC agents, *CHALCONE, *BCL-2 proteins, *MOLECULAR dynamics

Design, Synthesis, and Evaluation of Novel Indole Hybrid Chalcones and Their Antiproliferative and Antioxidant Activity.

Authors: Kudličková, Zuzana¹ (AUTHOR) maria.vilkova@upjs.sk, Michalková, Radka² (AUTHOR) radka.michalkova@upjs.sk, Salayová, Aneta³ (AUTHOR) aneta.salayova@uvlf.sk, Ksiažek, Marián³ (AUTHOR) marian.ksiazek@student.uvlf.sk, Vilková, Mária¹ (AUTHOR), Bekešová, Slávka⁴ (AUTHOR) slavka.bekesova@thermofisher.com, Mojžiš, Ján² (AUTHOR) zuzana.kudlickova@upjs.sk

Source: Molecules. Sep2023, Vol. 28 Issue 18, p6583. 21p.

Subject Terms: *CHALCONE, *CHALCONES, *INDOLE, *CELL lines, *CATECHOL