Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation

Authors: Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)

Subject Terms: Hematological cancer, Molecular glue, IMIDs, Cereblon, Rational drug design, Neosubstrate, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/53485170677d439b9bf56471960e9a2e

Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells

Authors: Anita G. Kansy, Ramy Ashry, Al‐Hassan M. Mustafa, Abdallah M. Alfayomy, Markus P. Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H. Krämer

Source: Molecular Oncology, Vol 18, Iss 8, Pp 1958-1965 (2024)

Subject Terms: ATR, cereblon, DNA replication stress, leukemia, PROTAC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/3c603aa7f4ed49c783038eaa1696cb4c

Molecular World Today and Tomorrow: Recent Trends in Biological Sciences 2.0

Contributors: Zaman, Wajid

Subject Terms: climate change, crops, genetic improvement, HLH, PRE, fast-growth, shoot elongation, moso bamboo, transcription factor, flowering, AT-hook gene family, Juglans regia, hypocotyl, Phylogenetics, root-lesion nematode, genome, ultra-low DNA input, contigs, sequencing, BUSCO, diploid, TCP transcription factor, nodulation, nitrate concentration, anthocyanin biosynthesis, purple tomato, HY5, MBW, PIFs, phytochemicals, flavonoids, metastasis prevention, signaling pathways, sirtuins, SIRT6, gene expression, aging, inflammation, metabolism, aging pathomechanism, physical activity, proteomics, coconut cultivars, solid endosperm, maturation stages, carbohydrate and lipid metabolisms, TMT-SPS-MS3, cornea, mesenchymal stem cells, exosomes, corneal diseases, corneal regeneration, lenalidomide, pomalidomide, cereblon, bioinformatics, zinc finger, microarray, RNA-seq, teratogen, transcriptome, graph, analgesia, alloknesis, antinociception, interleukin-31 (IL-31), interleukin receptor A (IL-31RA), IL-31 receptor A-deficient (IL-31RAKI) mice, itch, pain, metabarcoding, bacterioplankton community, 16S rRNA, Candidatus Pelagibacter, Pseudoalteromonas, Vibrio, pathogenic bacteria, autophagy, nitrogen starvation, whole-genome bisulfite sequencing (WGBS), hormone, maize haploid, chromosome doubling, paclitaxel, caffeine–taurine, colchicine, anticancer, 5-fluorouracil, SSB, anticancer drug, single-stranded DNA-binding protein, SsbA, crystal structure, docking, conformational change, DNA extraction, complex samples, next-generation sequencing, metagenomics, microbiome, bioreactor, cucurbits, ethylene, omics, sex differentiation, female development, Primulina eburnea, MYB transcription factor, gene family, drought stress, genes, genomic resources, sea urchin, Computer science

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/137786
https://mdpi.com/books/pdfview/book/9021

CRBN deletion enhances mitochondrial metabolism by stimulating mitochondrial calcium accumulation in non-small cell lung cancer

Authors: Shin, Seungheon ^a, Cho, Steve K. ^{a, b, ⁎}

Source: In Life Sciences 1 March 2025 364

Effect of iberdomide on cutaneous manifestations in systemic lupus erythematosus: A randomized phase 2 clinical trial

Authors: Werth, Victoria P. ^{a, ∗}, Merrill, Joan T. ^b, Furie, Richard ^c, Dörner, Thomas ^d, van Vollenhoven, Ronald ^e, Lipsky, Peter ^f, Weiswasser, Michael ^g, Korish, Shimon ^g, Schafer, Peter H. ^g, Stern, Mark ^g, Li, Stan ^g, Delev, Nikolay ^g

Source: In Journal of the American Academy of Dermatology March 2025 92(3):435-443

An engineered cereblon optimized for high-throughput screening and molecular glue discovery

Authors: Bailey, Henry J. ^{1, 5, 11}, Eisert, Jonathan ^{2, 11}, Kazi, Rubina ¹, Gerhartz, Jan ³, Pieńkowska, Dominika Ewa ³, Dressel, Ina ³, Vollrath, Joshua ^{1, 4, 5}, Kondratov, Ivan ^{6, 7, 8}, Matviyuk, Tetiana ⁶, Tolmachova, Nataliya ⁶, Shah, Varun Jayeshkumar ¹, Giuliani, Giulio ¹, Mosler, Thorsten ¹, Geiger, Thomas M. ³, Esteves, Ana M. ⁹, Santos, Sandra P. ⁹, Sousa, Raquel L. ⁹, Bandeiras, Tiago M. ⁹, Leibrock, Eva-Maria ², Bauer, Ulrike ², Leuthner, Birgitta ², Langer, Julian D. ^{5, 10}, Wegener, Ansgar A. ², Nowak, Radosław P. ³, Sorrell, Fiona J. ^{2, ∗}, Dikic, Ivan ^{1, 5, 12, ∗∗}

Source: In Cell Chemical Biology 20 February 2025 32(2):363-376

Routes to molecular glue degrader discovery

Authors: Liu, Yanfen ^{1, ⁎}, Bai, Jieyun ¹, Li, Dong ¹, Cang, Yong ^{1, ⁎}

Source: In Trends in Biochemical Sciences February 2025 50(2):134-142

Machine learning proteochemometric models for Cereblon glue activity predictions

Authors: Francis J. Prael, III, Jiayi Cox, Noé Sturm, Peter Kutchukian, William C. Forrester, Gregory Michaud, Jutta Blank, Lingling Shen, Raquel Rodríguez-Pérez

Source: Artificial Intelligence in the Life Sciences, Vol 6, Iss , Pp 100100- (2024)

Subject Terms: Machine learning, Glues, Targeted protein degradation, Cereblon, Proteochemometric models, Chemogenomics, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667318524000072; https://doaj.org/toc/2667-3185

Access URL: https://doaj.org/article/55a983e8b68c47b29a24a8f5a592f2c3

Cereblon mediates macrophage differentiation and microglial phagocytosis by regulating calpain protease activity

Authors: Zhou, Liang ^{⁎, 1}, Sun, Qing, Cao, Dan

Source: In Biomedicine & Pharmacotherapy November 2024 180

Cereblon deficiency ameliorates carbon tetrachloride-induced acute hepatotoxicity in HepG2 cells by suppressing MAPK-mediated apoptosis

Authors: Seo Young Choi, Parkyong Song, Ji Sun Hwang, You Kyeong Lee, Mi Song Shin, Hong-Joo Son, Yu-Jin Kim, Wanil Kim, Kwang Min Lee

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: inflammation, carbon tetrachloride, pro-inflammatory cytokines, hepatotoxicity, cereblon, MAP kinase, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457636/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d176183ba4bd4329b1786d78855201eb

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

Authors: Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán

Source: EMBO Molecular Medicine, Vol 16, Iss 4, Pp 755-783 (2024)

Subject Terms: Cannabinoid, Cereblon, Hippocampus, Memory, Rimonabant, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/5c7b69f9446144719e20ce1f4a631547

The cyclimids: Degron-inspired cereblon binders for targeted protein degradation

Authors: Ichikawa, Saki ^{1, 5, 9}, Payne, N. Connor ^{1, 2, 9}, Xu, Wenqing ¹, Chang, Chia-Fu ^{1, 6}, Vallavoju, Nandini ¹, Frome, Spencer ^{1, 7}, Flaxman, Hope A. ^{1, 8}, Mazitschek, Ralph ^{2, 3, 4, ∗}, Woo, Christina M. ^{1, 4, 10, ∗∗}

Source: In Cell Chemical Biology 20 June 2024 31(6):1162-1175

Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode

Authors: Shevalev, Robert ^a, Bischof, Luca ^b, Sapegin, Alexander ^a, Bunev, Alexander ^c, Olga, Grigor'eva ^c, Kantin, Grigory ^a, Kalinin, Stanislav ^{a, ⁎}, Hartmann, Marcus D. ^{b, ⁎⁎}

Source: In European Journal of Medicinal Chemistry 15 April 2024 270

The Relationship Between the Expression of CRBN in Peripheral Blood and the Severity and Prognosis of Adult Sepsis

Authors: Kuang Z, Gu Q

Source: International Journal of General Medicine, Vol Volume 16, Pp 5215-5223 (2023)

Subject Terms: sepsis, cereblon protein, prognosis, severity, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/the-relationship-between-the-expression-of-crbn-in-peripheral-blood-an-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074

Access URL: https://doaj.org/article/0022f8bcc5914f8aa5fe44669bdbbfaa

Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo

Authors: Yang, Hua ^{a, 1}, Qin, Jinling ^{a, 1}, Pei, Yuanyuan ^{a, 1}, Guan, Sumeng ^a, Zhao, Mei ^a, Wang, Yingge ^a, Yao, Yongfang ^a, Duan, Yongtao ^{b, ∗∗}, Sun, Moran ^{a, ∗}

Source: In European Journal of Medicinal Chemistry 5 February 2024 265

IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors

Authors: Yu Wang, Shunsuke Shimosaki, Emi Ikebe, Hidekatsu Iha, Jun-ichi Yamamoto, Nichole Fife, Tomonaga Ichikawa, Mitsuo Hori, Masao Ogata, Yoshiyuki Tsukamoto, Naoki Hijiya, Masatsugu Moriyama, Shotaro Hagiwara, Shuichi Kusano, Masumichi Saito, Kamruddin Ahmed, Akira Nishizono, Hiroshi Handa, Kazuhiro Morishita

Source: Frontiers in Oncology, Vol 13 (2024)

Subject Terms: adult T-cell lymphoma/leukemia, HTLV-1, immunomodulatory drug (IMiDs), cereblon modulator (CELMoD), IRF4, IKZF2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1272528/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/c652ad6387c14272840172d06da6e59c

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury

Authors: Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig

Source: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)

Subject Terms: Neuroinflammation, Thalidomide, Cereblon, Immunomodulatory imide drugs (IMiDs), Neurodegeneration, Microglia, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/7c5613a4803945af9101f28f707d2991

Pan-cancer analysis reveals the prognostic and immunologic roles of cereblon and its significance for PROTAC design

Authors: Zhang, Si-Han ¹, Zeng, Na ¹, Sun, Jian-Xuan, Liu, Chen-Qian, Xu, Jin-Zhou, Xu, Meng-Yao, An, Ye, Zhong, Xing-Yu, Ma, Si-Yang, He, Hao-Dong, Xia, Qi-Dong ^{∗, 1}, Hu, Jia ^{∗∗∗, 1}, Wang, Shao-Gang ^{∗∗, 1}

Source: In Heliyon June 2023 9(6)

Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma

Authors: Blaire E. Barton, Matthew K. Collins, Cindy H. Chau, Hyoyoung Choo-Wosoba, David J. Venzon, Christian Steinebach, Kathleen M. Garchitorena, Bhruga Shah, Eric L. Sarin, Michael Gütschow, William D. Figg

Source: Biomolecules, Vol 14, Iss 6, p 725 (2024)

Subject Terms: multiple myeloma, resistance, immunomodulatory drugs, cereblon, angiogenesis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/6/725; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/d74ba37251e44718a94b951da86fbe1b

Replacing the phthalimide core in thalidomide with benzotriazole

Authors: Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 527-530 (2022)

Subject Terms: Cereblon, immunomodulatory drugs, phthalimide, benzotriazole, diazo compounds, carbene N-H insertion, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/05018ca618a34ca08fb973d138964a14