PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

Contributors: Chamcheu, Jean Christopher, Bürger, Claudia, Huang, Shile

Subject Terms: hepatocellular cancer, HCC, LIHC, PDK1, PI3K/AKT/mTOR pathway, BX795, selective inhibitor, radiotherapy, radioresistance, combination therapy, stemness, DNA damage, galectin-1, upper urinary urothelial carcinoma, epithelial–mesenchymal transition, survival, phosphoinositide 3-kinases, focal adhesion kinase, mammalian target of rapamycin, ascorbic acid, oxidative stress, apoptosis, autophagic flux blockage, PI3K/Akt, corneal endothelial cells, PIK3CA, colorectal cancer, EGFR pathway, tumor heterogeneity, RSK, mTORC2, p90 ribosomal s6 kinase, nutrients, AGC kinases, MAPK/ERK, CCTβ, CCT/TRiC, chaperonin, starvation, metabolism, TFEB agonists, autophagy, lysosome, rapamycin, resveratrol, dihydroartemisinin, rhabdomyosarcoma, mTOR, AMPK, PTEN, raptor, muscle protein synthesis, GSI, AKT, SEA complex, GATOR complex, mTORC1 pathway, amino acid signaling, cancer, epilepsy, neurological disorders, JC polyomavirus, PML, astrocytes, SVGA cells, primary cells, PI3K, wortmannin, PI3K/Akt pathway, myocardial infarction, heart failure, left ventricular remodeling, diabetes, necroptosis, ferroptosis, pyroptosis, fibrosis, extracellular vesicles, PI3K/Akt/mTOR pathway, bone marrow mesenchymal stem cells, bone microvascular endothelial cells, breast cancer, AKT1, RNA-sequencing, transcriptome, emerging functions and targets, cancer therapeutics, psoriasis, inflammation, mTORC1, tuberous sclerosis complex, cytokines, cell penetrating peptide, cellular signaling, kinase, protein kinase B (AKT1), phosphoinositide-dependent kinase (PDK1), recombinant protein, trans-activator of transcription (TAT), Research and information: general, Biology, life sciences, Thermodynamics and heat

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Access URL: https://directory.doabooks.org/handle/20.500.12854/153061
https://mdpi.com/books/pdfview/book/10392

Enhancing radiation-induced reactive oxygen species generation through mitochondrial transplantation in human glioblastoma

Authors: Kent L. Marshall, Murugesan Velayutham, Valery V. Khramtsov, Alan Mizener, Christopher P. Cifarelli

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Glioblastoma, Mitochondria, ROS, EPR, Radiation, Cell-penetrating peptide, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c5e35218fabc439f9fd74fb2e2588eb0

Molecular aspects of cell-penetrating peptides: key amino acids, membrane partners, and non-covalent interactions

Authors: Walrant, Astrid, Tazi, Farah, Khemaissa, Sonia, Sagan, Sandrine

Source: Comptes Rendus. Chimie, Vol 28, Iss G1, Pp 37-51 (2025)

Subject Terms: Cell-penetrating peptide, Membrane, Tryptophan, Ion pair–π interactions, Translocation, Biochemistry, QD415-436, Physical and theoretical chemistry, QD450-801, Mathematics, QA1-939

File Description: electronic resource

Relation: https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.359/; https://doaj.org/toc/1878-1543

Access URL: https://doaj.org/article/da47a4aacbb6413bac2074125be0e1d7

Anti-IL-1RAP scFv-mSA-S19-TAT fusion carrier as a multifunctional platform for versatile delivery of biotinylated payloads to myeloid leukemia cells

Authors: Aref Farokhi-Fard, Saman Rahmati, Negin Sadat Hashemi Aval, Farzaneh Barkhordari, Elham Bayat, Samira Komijani, Hooman Aghamirza Moghim Aliabadi, Fatemeh Davami

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)

Subject Terms: Myeloid leukemia, Protein-based delivery vehicle, Bispecific fusion protein, Cell-penetrating peptide, Endosomal escape, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f45f88964e0242f580addbf0aa888e74

Peptide‐Bound Aflibercept Eye Drops for Treatment of Neovascular Age‐Related Macular Degeneration in Nonhuman Primates

Authors: Xingyan Fan, Kuan Jiang, Yongqian Zhao, Benjamin TK Lee, Feiyang Geng, Marten E Brelen, Weiyue Lu, Gang Wei

Source: Advanced Science, Vol 12, Iss 11, Pp n/a-n/a (2025)

Subject Terms: aflibercept, age‐related macular degeneration, cell‐penetrating peptide, eye drops, hydrophobic interaction, Science

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Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/ab023dca03c04e08bf34e9c43e655381

A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion

Authors: Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang

Source: Virus Research, Vol 353, Iss , Pp 199531- (2025)

Subject Terms: Cell-penetrating bispecific antibody, HBcAg, Cell-penetrating peptide, HBV, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216

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Relation: http://www.sciencedirect.com/science/article/pii/S0168170225000073; https://doaj.org/toc/1872-7492

Access URL: https://doaj.org/article/5166cb61916b414cac32690bfecc331f

Evaluation of peptide secondary structure and intracellular uptake by introducing disubstituted amino acids into the amphipathic helical peptide C18AA

Authors: Takuma Kato, Go Ofuka, Ryota Kobayashi, Akiko Asano, Mitsunobu Doi

Source: Results in Chemistry, Vol 14, Iss , Pp 102103- (2025)

Subject Terms: Cell-penetrating peptide, Amphipathic peptide, Non-proteinogenic amino acid, α,α-Disubstituted α-amino acid, Helical structure, Molecular operating environment (MOE), Chemistry, QD1-999

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Relation: http://www.sciencedirect.com/science/article/pii/S2211715625000864; https://doaj.org/toc/2211-7156

Access URL: https://doaj.org/article/b05886520b454661b0f737e3d0c18dfa

Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells

Authors: Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

Source: Molecular Therapy: Nucleic Acids, Vol 36, Iss 1, Pp 102449- (2025)

Subject Terms: MT: Delivery Strategies, mitochondria, mitochondrial DNA, mtDNA, cell-penetrating peptide, nucleic acid delivery, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2162253125000034; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/bf11fef5afea4b50b45b1430cb0bd547

Current State of the Field of Cell-Penetrating Peptides as an Honorific Issue for Professor Ülo Langel

Contributors: Boisguérin, Prisca, Deshayes, Sébastien

Subject Terms: transportan, cell-penetrating peptides, transfection, PepFect, NickFect, blood–brain barrier, penetrating peptides, machine learning techniques, drug delivery, prediction server, hepatocellular carcinoma, tumor-penetrating peptides, interfering peptides, alpha-helix stabilization, secondary structure, lipid–peptide interaction, peptide engineering, cell delivery, glycan recognition, alpha-beta peptide, endocytosis, immunoglobulin, mitochondrial gene therapy, mitochondrial DNA diseases, mitochondria targeting, nanodelivery systems, PEI-based complexes, CFTR-CAL interaction, CFTR stabilizer, cell-penetrating peptide, p.Phe508del mutant, internalization mechanism, cystic fibrosis, protein aggregation, secretion signal peptide, drug design, lactoferrin, intracellular trafficking, lysosomal degradation, solvent, nanoparticle formation, nucleic acid delivery, antimicrobial peptide, antiviral peptide, hepatitis B virus Tachyplesin (Tpl), virion secretion, oligoarginines, aromatic modification, stereoisomers, intracellular uptake, membrane binding, transepithelial permeation, peptide delivery, cell penetrating peptide, bioportide, eyes absent protein, neoblast, planarian, confocal microscopy, stem cell, Technology, Engineering, Agriculture, Industrial processes, Biotechnology

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Access URL: https://directory.doabooks.org/handle/20.500.12854/139359
https://mdpi.com/books/pdfview/book/9357

Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract

Authors: Kang JH, Jeong JH, Kwon YB, Kim YJ, Shin DH, Park YS, Hyun S, Kim DW, Park CW

Source: International Journal of Nanomedicine, Vol Volume 19, Pp 9195-9211 (2024)

Subject Terms: insulin, polyethylene glycol, cell-penetrating peptide, aerodynamic properties, mucus penetration, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/mucosal-penetrative-polymeric-micelle-formulations-for-insulin-deliver-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/f958982a22f0456c9a651005f1c2341c

Targeted mitochondrial therapy for pancreatic cancer

Authors: Xinya Zhao, Guoyu Wu, Xufeng Tao, Deshi Dong, Jing Liu

Source: Translational Oncology, Vol 54, Iss , Pp 102340- (2025)

Subject Terms: Pancreatic cancer, Mitochondria, Mitochondrial dysfunction, Cell-penetrating peptide, Aptamer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523325000713; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/17d83af3acfd4b1b80b763e99344f9b2

Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection

Authors: Wang, Jiang-Hui ^{1, 2, 3, 4, 9}, Cui, Mengtian ^{1, 2, 9}, Liu, Hao ^{1, 2, 9}, Guo, Peiyi ^{1, 2}, McGowan, Jackson ¹, Cheng, Shun-Yun ⁵, Gessler, Dominic J. ^{1, 2, 6, 7}, Xie, Jun ^{1, 2}, Punzo, Claudio ^{1, 5}, Tai, Phillip W.L. ^{1, 2}, Gao, Guangping ^{1, 2, 8, ∗}

Source: In Molecular Therapy - Methods & Clinical Development 13 March 2025 33(1)

Engineered PepFect14 analog for efficient cellular delivery of oligonucleotides

Authors: Biswas, Abhijit ^a, Periyasamy, Kapilraj ^b, Maloverjan, Maria ^a, Porosk, Ly ^a, Arya, Geeta ^a, Mehta, Sudhichan ^b, Andla, Hanna ^b, Raid, Raivo ^c, Kisand, Vambola ^d, Rätsep, Margus ^d, Wengel, Jesper ^e, Rebane, Ana ^b, Pooga, Margus ^{a, ⁎}

Source: In Biomedicine & Pharmacotherapy March 2025 184

Antioxidant PRDX3 gene therapy protects brain cells and prevents neurodegeneration in an animal model of Parkinson's disease

Authors: Villa-Cedillo, Sheila Adela ^a, Acosta-Espinoza, Esrom Jared ^a, Soto-Domínguez, Adolfo ^a, Rodríguez-Rocha, Humberto ^a, Montes-de-Oca-Saucedo, Carlos R. ^a, García-García, Aracely ^a, Loera-Arias, María de Jesús ^a, Ríos-Vazquez, Cristina Sarahi ^a, Sánchez-Torres, Guillermo ^a, Valdés, Jesús ^b, Saucedo-Cárdenas, Odila ^{a, ⁎}

Source: In Neuropeptides March 2025 110

Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles

Authors: Koo, Jain ^{a, b}, Shin, Yuseon ^{a, b}, Jeon, Hyewon ^{a, b}, Cheong, Jaehyun ^{a, b}, Cho, Seongmin ^c, Park, Chanho ^c, Song, Ee Chan ^c, Ramsey, Jacob D. ^d, Lim, Chaemin ^{e, f, ⁎}, Oh, Kyung Taek ^{a, b, ⁎⁎}

Source: In Journal of Controlled Release 10 February 2025 378:997-1012

A human GSDMD protein-derived cell-penetrating peptide enhances the antitumor effects of the proapoptotic peptide KLA

Authors: Kong, Xia ^{a, b}, Li, Na ^c, Ning, Rong-Xuan ^b, Liu, Yu-Ke ^d, Wu, Jing-Heng ^d, Liu, Cun-Yu ^e, Huang, Guo-Liang ^e, Ding, Jie ^e, He, Zhi-Wei ^{a, e, ⁎}

Source: In Journal of Drug Delivery Science and Technology February 2025 104

Intranodal injection of neoantigen-bearing engineered Lactococcus lactis triggers epitope spreading and systemic tumor regressions

Authors: Zhu, Junmeng ^{a, b}, Sun, Yi ^{a, b}, Qian, Xiaoping ^{a, b}, Li, Lin ^{c, d}, Liu, Fangcen ^d, Wang, Xiaonan ^{a, b}, Ke, Yaohua ^{a, b}, Shao, Jie ^{b, c}, Zhu, Lijing ^{a, b}, Wang, Lifeng ^{a, b}, Liu, Qin ^{a, b, ⁎}, Liu, Baorui ^{a, b, c, ⁎}

Source: In Acta Pharmaceutica Sinica B December 2024

Dual cell-penetrating peptide-conjugated polymeric nanocarriers for miRNA-205–5p delivery in gene therapy of cutaneous squamous cell carcinoma

Authors: Lin, Cheng-Yu ^{a, 1}, Fang, Jia-You ^{b, c, d, 1}, Hsiao, Chien-Yu ^{c, e, f}, Lee, Chiang-Wen ^{c, g, h, i}, Alshetaili, Abdullah ^j, Lin, Zih-Chan ^{g, ⁎}

Source: In Acta Biomaterialia February 2025

Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer

Authors: Xingyu Jiang, Muwen Yang, Weijing Zhang, Dongni Shi, Yue Li, Lixin He, Shumei Huang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Yibing Pan, Pinwei Deng, Rui Wang, Ying Ouyang, Xiangfu Chen, Jun Li, Zheng Li, Hequn Zou, Yanna Zhang, Libing Song

Source: Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)

Subject Terms: cancer stem cell, cell‐penetrating peptide, epithelial ovarian cancer, phosphorylation, platinum resistance, protein‐protein interaction, Science

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Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/1503d513de4c4be29beef0a3bde1ed9b

Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy

Authors: Suyang Wang, Michelle Cheng, Chao-Cheng Chen, Chia-Yu Chang, Ya-Chea Tsai, Jr-Ming Yang, TC Wu, Chuan-Hsiang Huang, Chien-Fu Hung

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Bacterial immunotherapy, CD8+ T cell, Cell penetrating peptide, Cervical cancer, Salmonella, Tumor antigen, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/7cfdbd13bc2c4b00a9e47df279922ed5