Neutrophil-Derived Proteases in Lung Inflammation: Old Players and New Prospects.

Authors: Cheetham, Coby J.¹ (AUTHOR) ccheetham01@qub.ac.uk, McKelvey, Michael C.¹ (AUTHOR) m.mckelvey@qub.ac.uk, McAuley, Daniel F.² (AUTHOR) d.f.mcauley@qub.ac.uk, Taggart, Clifford C.¹ (AUTHOR) c.taggart@qub.ac.uk

Source: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 10, p5492. 23p.

Subject Terms: *PNEUMONIA, *CALPAIN, *PROTEOLYTIC enzymes, *SERINE proteinases, *REACTIVE oxygen species, *CATHEPSINS, *LUNG diseases

17β-Estradiol promotes metastasis in triple-negative breast cancer through the Calpain/YAP/β-catenin signaling axis.

Authors: Niu, Xuemei¹ (AUTHOR), Wang, Jianan¹ (AUTHOR), Liu, Jinguang² (AUTHOR), Yu, Qinglong² (AUTHOR) qlyu@yimm.ac.cn, Ci, Mingwei¹ (AUTHOR) qlyu@yimm.ac.cn

Source: PLoS ONE. 3/28/2024, Vol. 19 Issue 3, p1-14. 14p.

Subject Terms: *CALPAIN, *TRIPLE-negative breast cancer, *CATENINS, *WNT signal transduction, *CALPASTATIN, *NUCLEAR proteins, *YAP signaling proteins, *PROTEIN expression

Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke.

Authors: Najjary, Solmaz¹, Mostafavi, Hossein¹, Feizi, Hadi¹, Moradi, Fatemeh¹, Eskandari, Mehdi¹, mehdiesk@zums.ac.ir

Source: Avicenna Journal of Phytomedicine; Nov/Dec2024, Vol. 14 Issue 6, p723-733, 11p

Dysregulated miRNA-375, IL-17, TGF-β, and Microminerals Are Associated with Calpain-10 SNP 19 in Diabetic Patients: Correlation with Diabetic Nephropathy Stages.

Authors: Ezzat, Ghada M.¹ (AUTHOR) ghadaezzat@aun.edu.eg, Azoz, Nashwa Mostafa A.² (AUTHOR), El Zohne, Randa A.³ (AUTHOR) randaz@aun.edu.eg, Abdellatif, HebatAllah³ (AUTHOR) hebatallah.abdellatif@aswu.edu.eg, Saleem, Tahia H.¹ (AUTHOR) tahia.h.saleem@aun.edu.eg, Emam, Wafaa Abdelaziz⁴ (AUTHOR) wafaaabdelaziz.medg@azhar.edu.eg, Mohammed, Amena Rezk⁴ (AUTHOR) amenarezk.medg@azhar.edu.eg, Mohamed, Shimaa Ali⁴ (AUTHOR) shimaaly.medg@azhar.edu.eg, Muhammed, Asmaa A.⁵ (AUTHOR) asmaa.ali@med.aswu.edu.eg, Abd el-Rady, Nessren M.^6,7 (AUTHOR), Hamdy, Marwa⁸ (AUTHOR) marwahamdy@med.asu.edu.eg, Sherkawy, Hoda S.⁹ (AUTHOR), Sabet, Marwa A.¹⁰ (AUTHOR) marwasabet@gmail.com, Seif Eldin, Salwa^11,12 (AUTHOR) salwaseifeldein@aun.edu.eg, Dahpy, Marwa A.^1,13 (AUTHOR) marwadahpy@aun.edu.eg

Source: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 24, p17446. 16p.

Subject Terms: *CALPAIN, *DIABETIC nephropathies, *INTERLEUKIN-17, *PEOPLE with diabetes, *SINGLE nucleotide polymorphisms, *COPPER

Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1.

Authors: Surbek, Marta¹ (AUTHOR), Van de Steene, Tessa^2,3 (AUTHOR), Sachslehner, Attila Placido¹ (AUTHOR), Golabi, Bahar¹ (AUTHOR), Griss, Johannes¹ (AUTHOR), Eyckerman, Sven^2,3 (AUTHOR), Gevaert, Kris^2,3 (AUTHOR), Eckhart, Leopold¹ (AUTHOR) leopold.eckhart@meduniwien.ac.at

Source: Scientific Reports. 12/6/2023, Vol. 13 Issue 1, p1-15. 15p.

Subject Terms: *CATALYTIC activity, *CALPAIN, *KERATINOCYTES, *PROTEIN crosslinking, *CHEMICAL inhibitors, *FC receptors, KERATINOCYTE differentiation

Calpain and Cardiometabolic Diseases.

Authors: Miyazaki, Takuro¹ (AUTHOR) taku@pharm.showa-u.ac.jp

Source: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 23, p16782. 20p.

Subject Terms: *CALPAIN, *HEART metabolism disorders, *VASCULAR endothelial cells, *CYSTEINE proteinases, *NON-alcoholic fatty liver disease, *CELL migration

Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2.

Authors: Ojima, Koichi¹ (AUTHOR) koojima@affrc.go.jp, Hata, Shoji² (AUTHOR), Shinkai-Ouchi, Fumiko² (AUTHOR), Ono, Yasuko² (AUTHOR), Muroya, Susumu¹ (AUTHOR)

Source: Journal of Biochemistry. Nov2023, Vol. 174 Issue 5, p421-431. 11p.

Subject Terms: *CALPAIN, *CELL physiology, *SKELETAL muscle, *PROTEOLYSIS, *CYSTEINE

Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease.

Authors: Mamsa, Rumaiza¹ (AUTHOR), Prabhavalkar, Kedar S.¹ (AUTHOR), Bhatt, Lokesh Kumar¹ (AUTHOR) bhatt.lokesh@gmail.com

Source: European Journal of Neuroscience. Oct2023, Vol. 58 Issue 7, p3719-3731. 13p. 3 Diagrams.

Subject Terms: *ALZHEIMER'S disease, *CALPAIN, *NLRP3 protein, *INFLAMMASOMES, *AMYLOID plaque, *MEMBRANE potential

Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.

Authors: Ma, Jonathan¹, Kummarapurugu, Apparao B.¹, Zheng, Shuo¹, Ghio, Andrew J.², jonathan.ma@vcuhealth.org, Deshpande, Laxmikant S.³, Voynow, Judith A.¹

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jan2025, Vol. 328 Issue 1, pL93-L104, 12p

Calpain Regulation and Dysregulation—Its Effects on the Intercalated Disk.

Authors: Yoder, Micah W.¹ (AUTHOR), Wright, Nathan T.² (AUTHOR) wrightnt@jmu.edu, Borzok, Maegen A.¹ (AUTHOR) wrightnt@jmu.edu

Source: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11726. 17p.

Subject Terms: *CALPAIN, *ADHERENS junctions, *CYSTEINE proteinases, *DESMOSOMES, *HEART diseases, *HEART abnormalities

Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis.

Authors: Liu, Xinpeng^1,2 (AUTHOR), Jiang, Lili^1,3 (AUTHOR), Zhang, Wenxuan¹ (AUTHOR), Zhang, Jiahui^1,4 (AUTHOR), Luan, Xinrui¹ (AUTHOR), Zhan, Yuanbo^1,5 (AUTHOR), Wang, Tuo¹ (AUTHOR), Da, Junlong¹ (AUTHOR), Liu, Lixue¹ (AUTHOR), Zhang, Shujian¹ (AUTHOR), Guo, Yuyao¹ (AUTHOR), Zhang, Kai^1,6 (AUTHOR), Wang, Zhiping² (AUTHOR), Miao, Nan^1,5 (AUTHOR), Xie, Xiaohua^1,7 (AUTHOR), Liu, Peihong⁸ (AUTHOR), Li, Ying¹ (AUTHOR) liying@hrbmu.edu.cn, jin, Han¹ (AUTHOR) jinhan@hrbmu.edu.cn, Zhang, Bin^1,9 (AUTHOR) zhangbin@hrbmu.edu.cn

Source: Journal of Translational Medicine. 6/27/2023, Vol. 21 Issue 1, p1-22. 22p.

Subject Terms: *CALPAIN, *PROTEOLYSIS, *WNT signal transduction, *CASEIN kinase, *CELL migration, *CALPASTATIN, *HOMEOSTASIS

Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation.

Authors: Wette, Stefan G.¹ (AUTHOR) s.wette@latrobe.edu.au, Lamb, Graham D.² (AUTHOR) g.lamb@latrobe.edu.au, Murphy, Robyn M.¹ (AUTHOR) r.murphy@latrobe.edu.au

Source: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9405. 17p.

Subject Terms: *CALPAIN, *RYANODINE receptors, *PEPTIDES, *SKELETAL muscle, *CONNECTIN, *CALCIUM, *SODIUM

Inherited Retinal Degeneration: Towards the Development of a Combination Therapy Targeting Histone Deacetylase, Poly (ADP-Ribose) Polymerase, and Calpain.

Authors: Dong, Yujie^1,2 (AUTHOR), Yan, Jie^1,3,4 (AUTHOR), Yang, Ming⁵ (AUTHOR), Xu, Wenrong¹ (AUTHOR), Hu, Zhulin^1,2 (AUTHOR), Paquet-Durand, François³ (AUTHOR) francois.paquet-durand@klinikum.uni-tuebingen.de, Jiao, Kangwei¹ (AUTHOR) francois.paquet-durand@klinikum.uni-tuebingen.de

Source: Biomolecules (2218-273X). Apr2023, Vol. 13 Issue 4, p581. 21p.

Subject Terms: *CALPAIN, *HISTONE deacetylase, *RETINAL degeneration, *HISTONE deacetylase inhibitors, *POLY(ADP-ribose) polymerase, *CELL death

Lens-specific βA3/A1-conditional knockout mice: Phenotypic characteristics and calpain activation causing protein degradation and insolubilization.

Authors: Joseph, Roy¹ (AUTHOR), Robinson, Michael L.² (AUTHOR), Lambert, Laura³ (AUTHOR), Srivastava, Om P.¹ (AUTHOR) srivasta@uab.edu

Source: PLoS ONE. 3/29/2023, Vol. 18 Issue 3, p1-24. 24p.

Subject Terms: *KNOCKOUT mice, *CALPAIN, *TUBULINS, *CYTOSKELETAL proteins, *PROTEOLYSIS, *CRYSTALLINS, *PHENOTYPIC plasticity

Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain.

Authors: Bai, Yuqiang¹ (AUTHOR), Hou, Chengli¹ (AUTHOR), Huang, Caiyan¹ (AUTHOR), Fang, Fei¹ (AUTHOR), Dong, Yu¹ (AUTHOR), Li, Xin¹ (AUTHOR) xinli.caas@gmail.com, Zhang, Dequan¹ (AUTHOR)

Source: Life (2075-1729). Mar2023, Vol. 13 Issue 3, p854. 12p.

Subject Terms: *CALPAIN, *CALPASTATIN, *PHOSPHORYLATION, *ALKALINE phosphatase, *STRUCTURAL stability, *PROTEIN kinases

Pathogenic CAPN3 Variant Identified in an Iranian Family With Limb-girdle Muscular Dystrophy.

Authors: Sakhaei, Amin¹, Mohammadi-Asl, Javad² dr.mohammadiasl@gmail.com

Source: Basic & Clinical Neuroscience. Nov/Dec2024, Vol. 15 Issue 6, p865-876. 12p.

Subject Terms: *LIMB-girdle muscular dystrophy, *CALPAIN, *MUSCULAR dystrophy, *SHOULDER girdle, *MISSENSE mutation

Hypoxia Tolerance of Two Killifish Species.

Authors: Thomas, Peyton A¹, peyton.thomas@colorado.edu, Kinsey, Stephen T¹

Source: Integrative & Comparative Biology; Oct2024, Vol. 64 Issue 4, p1115-1130, 16p

Calpain Regulates Reactive Oxygen Species Production during Capacitation through the Activation of NOX2 and NOX4.

Authors: Ortiz-García, César I.¹ (AUTHOR), Salgado-Lucio, Monica L.^1,2 (AUTHOR), Roa-Espitia, Ana L.¹ (AUTHOR), Muñoz-Sánchez, Aidé A.¹ (AUTHOR), Cordero-Martínez, Joaquín³ (AUTHOR), Hernández-González, Enrique O.¹ (AUTHOR) enrique.hernandez@cinvestav.mx

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3980. 18p.

Subject Terms: *REACTIVE oxygen species, *CALPAIN, *ACROSOME reaction, *GUINEA pigs, *SPERMATOZOA, *OXIDASES

Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity.

Authors: Yang, Xi-Ming¹ (AUTHOR), Cohen, Michael V.^1,2 (AUTHOR) mcohen@southalabama.edu, Sayner, Sarah¹ (AUTHOR), Audia, Jonathon P.³ (AUTHOR), Downey, James M.¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3801. 16p.

Subject Terms: *CALPAIN, *REPERFUSION, *ADENYLATE cyclase, *ISCHEMIC preconditioning, *REPERFUSION injury, *CASPASES

GCL loss in BRAO.

Authors: Shearer, Thomas R.¹ (AUTHOR) Shearert@ohsu.edu, Steinkamp, Peter N.² (AUTHOR), Parker, Maria² (AUTHOR), Azuma, Mitsuyoshi^1,3 (AUTHOR)

Source: PLoS ONE. 1/5/2023, Vol. 18 Issue 1, p1-9. 9p.

Subject Terms: *CALPAIN, *RETINAL artery occlusion, *RETINAL artery, *MEDICAL record databases, *SAMPLE size (Statistics), *RETINAL ganglion cells