استخدام تقنية التفاعل السلسلي للبوليميراز بالزمن الحقيقي Qrt-PCR لتقدير كمية التعبير الجيني لـــ بروتين C-Flip

Authors: عدنان علي اسبر, رشا مسعود

Source: مجلة جامعة دمشق للعلوم الأساسية, Vol 40, Iss 3 (2024)

Subject Terms: بروتينC-FLIP, التعبير الجينيَّ, تقنية rtPCR, سرطان القولون, Science

File Description: electronic resource

Relation: https://journal.damascusuniversity.edu.sy/index.php/basj/article/view/5181; https://doaj.org/toc/1726-5487; https://doaj.org/toc/2789-6366

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Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death

Authors: Laura K. Hillert-Richter, Corinna König, Nikita V. Ivanisenko, Dirk Reinhold, Inna N. Lavrik

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: cell death, complex II, c-FLIP, FLIPin, caspase-8, SMAC mimetic, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1471216/full; https://doaj.org/toc/2296-634X

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The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

Authors: Katherine Yaacoub, Rémy Pedeux, Pierre Lafite, Ulrich Jarry, Samia Aci-Sèche, Pascal Bonnet, Richard Daniellou, Thierry Guillaudeux

Source: Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 710-728 (2024)

Subject Terms: c-FLIP, TRAIL, apoptosis, protein–protein interaction, drug resistance, cancer treatment, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/1/46; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

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RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in c-Flip Knockdown Mice

Authors: Ting Xie, Qiqi Chen, Nina Li, Shengze Zhang, Lin Zhu, Shaohui Bai, Haolu Zha, Weijian Tian, Chuming Luo, Nan Wu, Xuan Zou, Shisong Fang, Yuelong Shu, Jianhui Yuan, Ying Jiang, Huanle Luo

Source: Viruses, Vol 16, Iss 11, p 1712 (2024)

Subject Terms: c-Flip, knockdown, fetal head, RNA Seq, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/11/1712; https://doaj.org/toc/1999-4915

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Immune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell lung cancer patients

Authors: Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte, Stefano Ugel

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: NSCLC (non-small cell lung cancer), M-MDSCs (monocytic myeloid-derived suppressor cells), c-FLIP (cellular FLICE [FADD-like IL-1β-converting enzyme]- inhibitory protein), ICI (immune checkpoint inhibitor), Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

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Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP

Authors: Christian Holmgren, Ellen Sunström Thörnberg, Victoria Granqvist, Christer Larsson

Source: Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 4803-4821 (2022)

Subject Terms: Smac mimetic, TRAIL, apoptosis, breast cancer, c-FLIP, RIP1, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/44/10/327; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

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Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment

Contributors: Di Meo, Sergio, Venditti, Paola, Napolitano, Gaetana

Subject Terms: CTCL, apoptosis, cell viability, c-FLIP, XIAP, artemisinin, SH-SY5Y cells, hippocampal neurons, H2O2, AMPK pathway, atherosclerosis, sphingomyelin synthase 2, endothelial dysfunction, endoplasmic reticulum stress, β-catenin, insulin resistance, cancer, cardiovascular disease, neurodegenerative disorders, exercise, mitochondria, oxidative stress, PGC-1, Nrf2, UCPs, ROS, light, DNA damage, evolution, D-box, cavefish, Spalax, trimethylamine N-oxide, cardiomyocytes, cardiotoxicity, mitochondrial membrane potential, CORM-2, NADPH oxidase, AP-1, HO-1, Renal cell carcinoma (RCC), reactive oxygen species (ROS), glutathione (GSH) metabolism, cancer therapy, clear cell RCC, papillary RCC, chromophobe RCC, sarcopenia, reactive oxygen species, redox signaling, antioxidant supplementation, protein aggregation, redox, proteinopathy, peroxiredoxins, tumorigenesis, ROS scavengers, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/68973
https://mdpi.com/books/pdfview/book/2741

Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells by Inhibiting the Expression of c-FLIP

Authors: Zhong Chen, Zhiang Zheng, Lan Feng, Zhenqing Huo, Liju Huang, Mingchang Fu, Qiuzan Chen, YanZhuang Ke, Jinjun Yang, Benxin Hou

Source: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 467-475 (2020)

Subject Terms: hepatocellular carcinoma, γδ T cells, miR-382, c-FLIP, caspase 8, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770520301169; https://doaj.org/toc/2372-7705

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Autophagy-mediated degradation of IAPs and c-FLIPL potentiates apoptosis induced by combination of TRAIL and Chal-24

Contributors: Lin, Yong [Lovelace Respiratory Research Institute, Albuquerque, NM (United States)]

Source: Journal of Cellular Biochemistry; 117; 5

File Description: Medium: ED; Size: p. 1136-1144

Access URL: http://www.osti.gov/scitech/servlets/purl/1345225

circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma

Authors: Liu YP, Wan J, Long F, Tian J, Zhang C

Source: Cancer Management and Research, Vol Volume 12, Pp 1229-1240 (2020)

Subject Terms: osteosarcoma, circpvt1, mir-205-5p, c-flip, invasion and metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.dovepress.com/circpvt1-facilitates-invasion-and-metastasis-by-regulating-mir-205-5pc-peer-reviewed-article-CMAR; https://doaj.org/toc/1179-1322

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ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

Authors: Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Carla Sampaio, Christel Larbouret, Romain Lanotte, Marie-Alix Poul, Jean-Marc Barret, Jean-François Prost, André Pèlegrin, Thierry Chardès

Source: Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)

Subject Terms: Cancer, HER3, Antibody, Apoptosis, C-FLIP, ITCH, Medicine, Cytology, QH573-671

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Relation: http://link.springer.com/article/10.1186/s12964-019-0413-8; https://doaj.org/toc/1478-811X

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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Authors: Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa

Source: Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)

Subject Terms: δ-Tocotrienol, Pancreatic cancer, Apoptosis, TRAIL, c-FLIP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12935-019-0876-0; https://doaj.org/toc/1475-2867

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Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics

Authors: Rehmat Jan, Gul-e-Saba Chaudhry

Source: Advanced Pharmaceutical Bulletin, Vol 9, Iss 2, Pp 205-218 (2019)

Subject Terms: Apoptosis, Apoptosis pathways, Cancer, c-FLIP, Caspases, Death receptors, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://apb.tbzmed.ac.ir/PDF/apb-23014; https://doaj.org/toc/2228-5881; https://doaj.org/toc/2251-7308

Access URL: https://doaj.org/article/83e3904c6cc64135af4e8547dc56033e

Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes

Authors: Nikita V. Ivanisenko, Jörn H. Buchbinder, Johannes Espe, Max Richter, Miriam Bollmann, Laura K. Hillert, Vladimir A. Ivanisenko, Inna N. Lavrik

Source: BMC Genomics, Vol 20, Iss S3, Pp 1-12 (2019)

Subject Terms: In silico, Homology modeling, Death receptor network, Evolutionary conservation, C-FLIP, V-FLIP, Biotechnology, TP248.13-248.65, Genetics, QH426-470

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Relation: http://link.springer.com/article/10.1186/s12864-019-5539-y; https://doaj.org/toc/1471-2164

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Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System

Authors: Ah Ram Lee, Yong Kwang Park, Mehrangiz Dezhbord, Kyun-Hwan Kim

Source: Viruses, Vol 14, Iss 2, p 373 (2022)

Subject Terms: hepatitis B virus, cellular FLIP (c-FLIP), viral FLIP (v-FLIP), HBx, innate immune system, Microbiology, QR1-502

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Relation: https://www.mdpi.com/1999-4915/14/2/373; https://doaj.org/toc/1999-4915

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NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin

Authors: Seung Un Seo, Tae Hwan Kim, Dong Eun Kim, Kyoung-jin Min, Taeg Kyu Kwon

Source: Redox Biology, Vol 13, Iss C, Pp 608-622 (2017)

Subject Terms: Thioridazine, Curcumin, c-FLIP, Mcl-1, NOX4, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231717302902; https://doaj.org/toc/2213-2317

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Peptides extracted from edible mushroom: Lentinus squarrosulus induces apoptosis in human lung cancer cells

Authors: Arisara Prateep, Somruethai Sumkhemthong, Maneewan Suksomtip, Pithi Chanvorachote, Chatchai Chaotham

Source: Pharmaceutical Biology, Vol 55, Iss 1, Pp 1792-1799 (2017)

Subject Terms: mushroom extract, selective anticancer activity, human safety, bcl-2, bax, c-flip, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

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Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression

Authors: Seon Min Woo, Kyoung-jin Min, Taeg Kyu Kwon

Source: Molecules, Vol 25, Iss 24, p 5793 (2020)

Subject Terms: Mdivi-1, cisplatin, apoptosis, c-FLIP, Drp1, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/25/24/5793; https://doaj.org/toc/1420-3049

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Hypo-Expression of Flice-Inhibitory Protein and Activation of the Caspase-8 Apoptotic Pathways in the Death-Inducing Signaling Complex Due to Ischemia Induced by the Compression of the Asphyxiogenic Tool on the Skin in Hanging Cases

Authors: Aniello Maiese, Alessandra De Matteis, Giorgio Bolino, Emanuela Turillazzi, Paola Frati, Vittorio Fineschi

Source: Diagnostics, Vol 10, Iss 11, p 938 (2020)

Subject Terms: immunohistochemistry, c-FLIP, vitality, suicide, hanging, Medicine (General), R5-920

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Relation: https://www.mdpi.com/2075-4418/10/11/938; https://doaj.org/toc/2075-4418

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Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells

Authors: Seon Min Woo, Kyoung-jin Min, Taeg Kyu Kwon

Source: Molecules, Vol 25, Iss 19, p 4591 (2020)

Subject Terms: magnolol, TRAIL, DR5, c-FLIP, Mcl-1, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/25/19/4591; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/078910f1de4d47ca9dbff38d63d92aec