Dual targeting of Aurora Kinase A and poly (ADP-ribose) polymerase as a therapeutic option for patients with ovarian cancer: preclinical evaluations

Authors: Soumya M. Turaga, Stacey L. Hembruff, Masha G. Savelieff, Arnab Ghosh, Rajni V. Puri, Harsh B. Pathak, Linda J. Paradiso, Thomas J. Myers, Ao Li, Andrew K. Godwin

Source: Journal of Cancer Research and Clinical Oncology, Vol 151, Iss 3, Pp 1-15 (2025)

Subject Terms: Aurora kinase A, VIC-1911, Olaparib, Poly (ADP-ribose) polymerase, BRCA1, BRCA2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/b9ab1f3fd9f14fb29204ea057a955cb8

Association between single nucleotide polymorphisms of DNA repair genes (BRCA1, BRCA2, and PALB2) and breast cancer incidence in a subset of Iranian population

Authors: Sepideh Jahangiri, Zahra Abdan, Massoud Houshmand, Ali Souroush, Mozaffar Aznab

Source: Hereditary Cancer in Clinical Practice, Vol 23, Iss 1, Pp 1-7 (2025)

Subject Terms: Breast cancer, BRCA1, BRCA2, PALB2, Polymorphism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1897-4287

Access URL: https://doaj.org/article/4bb44e5dd39e4fe7959bcc78d9d858d8

Synthesis and application of diazenyl sulfonamide-based schiff bases as potential BRCA2 active inhibitors against MCF-7 breast cancer cell line

Authors: Olia Rezaeianzadeh, Sakineh Asghari, Mahmood Tajbakhsh, Asieh Khalilpour, Sergey Shityakov

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Subject Terms: Sulfonamides, Sulfonamide-based schiff base, MCF-7 breast cancer cell line, BRCA2, Cytotoxicity, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d60d0d22660e446587281d3c54cb25f4

De novo familial adenomatous polyposis with germline double heterozygosity of APC/BRCA2: a case report and literature review

Authors: Tian-Qi Zhang, Ji-Dong Cai, Cong Li, Yun Xu, Ye Xu

Source: Hereditary Cancer in Clinical Practice, Vol 23, Iss 1, Pp 1-6 (2025)

Subject Terms: Familial adenomatous polyposis, APC, BRCA2, Germline double heterozygosity, Colorectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1897-4287

Access URL: https://doaj.org/article/01019915d2614f168f4ffdb128d6f4df

Primary cutaneous mucinous carcinoma of the scalp in a patient positive for BRCA2 mutation

Authors: Samer Wahood, BA, Megan Tran, BS, Lauryn Orsillo, BS, Christopher DiMarco, MD, Oliver J. Wisco, DO, Elnaz F. Firoz, MD

Source: JAAD Case Reports, Vol 59, Iss , Pp 9-12 (2025)

Subject Terms: BRCA2, breast cancer, cutaneous, mastectomy, Mohs, mucinous carcinoma, Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352512625000396; https://doaj.org/toc/2352-5126

Access URL: https://doaj.org/article/31e6f0af95a34e3e8d97bf7f7c1abd01

Cardiovascular health in breast cancer patients: insight on BRCA1/2 mutations impact

Authors: Panagiotis Mallios, Mehdi Dehghan Manshadi, Laila Hubbert, Tajeri Aydin, Claudia Maes, Johanna Rantala, Annelie Liljegren, Narsis A. Kiani, Elham Hedayati

Source: Cardio-Oncology, Vol 11, Iss 1, Pp 1-18 (2025)

Subject Terms: Breast Neoplasms/ complications, BRCA1 protein, BRCA2 protein, Cardio-oncology, Cardiovascular disease, Risk factors, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2057-3804

Access URL: https://doaj.org/article/6e249ecbf91a4054848626f884a425a8

The known genetic variants of BRCA1, BRCA2 and NOD2 in pancreatitis and pancreatic cancer risk assessment

Authors: Jarosław Matykiewicz, Wioletta Adamus-Białek, Monika Wawszczak-Kasza, Bartosz Molasy, Magdalena Kołomańska, Rusłan Oblap, Łukasz Madej, Dorota Kozieł, Stanisław Głuszek

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Subject Terms: BRCA1, BRCA2, NOD2, Pancreatitis, Pancreatic cancer, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3c1a2c3d0c804ec3b67d6d44a2b2d906

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors

Authors: Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

Source: Breast Cancer Research, Vol 27, Iss 1, Pp 1-15 (2025)

Subject Terms: BRCA1, BRCA2, PARP inhibitor, DNMT inhibitor, Talazoparib, Decitabine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/0fe24e16ab974c51b3dc53369f619926

Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats

Authors: Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-17 (2025)

Subject Terms: BRCA2 exon 11, Pathogenic variant, Heterozygote, Spermatogenesis, Aging, Male subfertility, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a4f8692d33a642efa4439f54bfabf929

BRCA2 germline mutation carrier with five malignancies: a case report

Authors: Elena Su, Yann Christinat, Thomas McKee, Silvia Azzarello-Burri, Wolfram Jochum, Stefanie Fischer, Christian Rothermundt

Source: Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-7 (2024)

Subject Terms: BRCA2 mutation, APC, Genetic testing, Whole-genome sequencing, Breast cancer, Renal cell carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1897-4287

Access URL: https://doaj.org/article/d606246bbfa3464982b8e34fdf1490ce

BRCA1 & BRCA2 methylation as a prognostic and predictive biomarker in cancer: Implementation in liquid biopsy in the era of precision medicine

Authors: Maria Panagopoulou, Theodoros Panou, Anastasios Gkountakos, Gesthimani Tarapatzi, Makrina Karaglani, Ioannis Tsamardinos, Ekaterini Chatzaki

Source: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)

Subject Terms: BRCA1, BRCA2, DNA promoter methylation, Breast cancer, Ovarian, Cancer, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/6860685ecf794e52a09d6cf7b7bdd569

A study on patients’ selection for BRCA1 and BRCA2 mutations testing by different models in Libyan women with breast cancer

Authors: Eanas Saleh Elmaihub, Inas Alhudiri, Adam Elzagheid, Fakria Elfagi, Elham Hassen

Source: Alexandria Journal of Medicine, Vol 60, Iss 1, Pp 120-130 (2024)

Subject Terms: Breast cancer, NCCN criteria, BRCAPRO, BOADICEA, BRCA1, BRCA2, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2090-5068; https://doaj.org/toc/2090-5076

Access URL: https://doaj.org/article/6208629e56a04f36be074103b2729f98

Features and complexity of treatment of BRCA-associated ovarian cancer, chronic disease: literature review

Authors: T. V. Gorodnova, A. P. Sokolenko, Kh. B. Kotiv, I. V. Berlev, E. N. Imyanitov

Source: Опухоли женской репродуктивной системы, Vol 20, Iss 3, Pp 44-51 (2024)

Subject Terms: ovarian cancer, brca1, brca2, chemoresistance, chemotherapy, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://ojrs.abvpress.ru/ojrs/article/view/1275; https://doaj.org/toc/1994-4098; https://doaj.org/toc/1999-8627

Access URL: https://doaj.org/article/472f54d5ebf44779bc60a6be2911a0dd

BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer

Authors: Heidelinde Fiegl, Simon Schnaiter, Daniel U. Reimer, Katharina Leitner, Petra Nardelli, Irina Tsibulak, Verena Wieser, Katharina Wimmer, Esther Schamschula, Christian Marth, Alain G. Zeimet

Source: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)

Subject Terms: Ovarian cancer, BRCA1, BRCA2, DNA-methylation, Homologous recombination deficiency (HRD), Platinum sensitivity, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/0bdf725b0b91401bac844e6c5607a2b3

Pattern Anlysis of Risk-Reducing Strategies in Unaffected Korean BRCA1/2 Mutation Carriers

Authors: Dabin Kim, Jai Min Ryu, Sang-Ah Han, Zisun Kim, Sung-Won Kim

Source: Current Oncology, Vol 31, Iss 11, Pp 6767-6777 (2024)

Subject Terms: hereditary breast and ovarian cancer syndrome, BRCA1 gene, BRCA2 gene, prophylactic mastectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/31/11/499; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/153c231351304580b5ff1462c0c95298

BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview

Authors: Dominika Gedeonová, Claretta Bianchi, Jan Štembírek, Matouš Hrdinka, Zuzana Chyra, Marcela Buchtová, Pavel Hurník, Tomáš Blažek, Jana Režnarová

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: BRCA1, BRCA2, OSCC (oral squamous cell carcinoma), HNSCC (head and neck squamous cell carcinoma), gene alteration, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1528822/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/0fa1d85d46e2433aa4126492f40a2488

Durable response to Olaparib in EGFR and somatic BRCA2-mutated lung adenocarcinoma with leptomeningeal metastases: a case report

Authors: Fang-fang Hou, Li-rong Liu, Wen-jie Zhao, Yan-chun Qu, Rui Zhou, Tian-lin Wang, Yong-song Ye, Xiao-shu Chai, Hai-bo Zhang

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: somatic BRCA2 mutation, Olaparib, leptomeningeal metastases, non-small cell lung cancer, case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1512886/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/22fc8e13d42d40b1b44ce81de8e42418

Case Report: BRCA1 and BRCA2 loss in a young man with primary cutaneous extraskeletal osteosarcoma

Authors: Wen-Feng Luo, Yu-Hang Hou, Yu-Teng Huang, Jun-Dong Lai, Hui-Shan Jiang, Wei-Liang Wang

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: osteosarcoma, primary cutaneous extraskeletal osteosarcoma, soft tissue tumor, BRCA1, BRCA2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1504366/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/5df7cab473224d47bc91d144a1de3e44

HER2-positive breast cancer in patients with BRCA1/2 pathogenic variants: Case series and literature review

Authors: Pujita Munnangi, Polly Ann Niravath, Jenny C Chang, Kai Sun

Source: Current Problems in Cancer: Case Reports, Vol 17, Iss , Pp 100335- (2025)

Subject Terms: HER2-positive, BRCA1, BRCA2, Breast cancer, Case series, Case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666621924000577; https://doaj.org/toc/2666-6219

Access URL: https://doaj.org/article/038b25107d4a4b69ad804e50f992214a

Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer

Authors: Saba Munir, Yasir Nawaz, Fouzia Tanvir, Maria Akram, Muhammad Luqman, Javaria Zafar, Muhammad Zaman

Source: Journal of Liaquat National Hospital, Vol 2, Iss 2, Pp 89-97 (2024)

Subject Terms: breast cancer, single nucleotide polymorphisms, mutations, brca1, brca2, dna, Medicine

File Description: electronic resource

Relation: https://journals.lnh.edu.pk/jlnh/pdf/feda4db7-349d-4032-929c-84ced573f014.pdf; https://doaj.org/toc/2959-1805; https://doaj.org/toc/2960-2963

Access URL: https://doaj.org/article/967a41c8f1024fd2a8abe97e01234b87