Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates

Authors: Aislinn Mayfield, Xin Zhang, Ivan Efremov, Michael G Kauffman, John F Reilly, Bahareh Eftekharzadeh

Source: SLAS Discovery, Vol 32, Iss , Pp 100224- (2025)

Subject Terms: Biomolecular condensates, Phase separation, Corelet™ Technology, high-throughput screening, Drug discovery, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555225000176; https://doaj.org/toc/2472-5552

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Microphase separation produces interfacial environment within diblock biomolecular condensates

Authors: Andrew P Latham, Longchen Zhu, Dina A Sharon, Songtao Ye, Adam P Willard, Xin Zhang, Bin Zhang

Source: eLife, Vol 12 (2025)

Subject Terms: biomolecular condensates, molecular dynamics, multiscale simulations, hydrophobicity, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/90750; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/01b6eb5e652140c29c9883e3e5b9012d

Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

Authors: Jiahe Wang, Yi Fan, Guowen Luo, Liang Xiong, Lijie Wang, Zhuoxuan Wu, Jiayi Wang, Zhengying Peng, Clifford J Rosen, Kefeng Lu, Junjun Jing, Quan Yuan, Zhenwei Zhang, Chenchen Zhou

Source: Advanced Science, Vol 12, Iss 10, Pp n/a-n/a (2025)

Subject Terms: mitophagy, nuclear speckles, phase‐separated biomolecular condensates, pre‐mRNA splicing, snRNP, WAC, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/554b140996c547e79391ecfdabe38bcc

Protein modifications and ionic strength show the difference between protein-mediated and solvent-mediated regulation of biomolecular condensation

Authors: Artur Czajkowski, Abhirami Udayabanu, Manthan Raj, Likhitha Ch. P. Pulibandla, Marija Tursunović, Marcus Jahnel, Ellen M. Adams

Source: Frontiers in Nanotechnology, Vol 7 (2025)

Subject Terms: biomolecular condensates, protein solvation, THz spectroscopy, reentrant phase separation, post-translational modifications, Chemical technology, TP1-1185

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnano.2025.1556384/full; https://doaj.org/toc/2673-3013

Access URL: https://doaj.org/article/711167b4bdef48fa8cf0d400fca9c9a2

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Authors: Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

Source: SLAS Discovery, Vol 31, Iss , Pp 100220- (2025)

Subject Terms: Biomolecular condensates, High content screening, single molecule tracking, Split luciferase, NanoBRET, Dynamics, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555225000139; https://doaj.org/toc/2472-5552

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Emerging roles of liquid-liquid phase separation in liver innate immunity

Authors: Xinying Zhang, Ziyue Yang, Chunmeng Fu, Run Yao, Huan Li, Fang Peng, Ning Li

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: Liquid-liquid phase separation, Biomolecular condensates, Liver innate immunity, Liver disease, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/977fe3c9f115401580f702218fa973a7

Non-equilibrium physics of multi-species assembly applied to fibrils inhibition in biomolecular condensates and growth of online distrust

Authors: Pedro D. Manrique, Frank Yingjie Huo, Sara El Oud, Neil F. Johnson

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Nonequilibrium statistical physics, Amyloid fibrils, Biomolecular condensates, Online distrust networks, Control strategies, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3110a6c3e15c4321affd842af3837d65

Versatility of vimentin assemblies: From filaments to biomolecular condensates and back

Authors: Dolores Pérez-Sala, Silvia Zorrilla

Source: European Journal of Cell Biology, Vol 104, Iss 2, Pp 151487- (2025)

Subject Terms: Vimentin, Oxidative stress, Biomolecular condensates, Filament precursors, Vimentin ULF, Posttranslational modifications, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0171933525000123; https://doaj.org/toc/0171-9335

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Cracking the protein compartmentalization code with ProtGPS

Authors: Ye, Songtao ¹, So, Choon Leng ¹, Cai, Danfeng ^{1, 2, 3, ⁎}

Source: In Trends in Biochemical Sciences May 2025 50(5):369-371

TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma

Authors: So, Choon Leng ^{1, 6}, Lee, Ye Jin ^{1, 6}, Vokshi, Bujamin H. ^{2, 6}, Chen, Wanlu ^{2, 3}, Huang, Binglin ¹, De Sousa, Emily ¹, Gao, Yangzhenyu ³, Portuallo, Marie Elena ¹, Begum, Sumaiya ¹, Jagirdar, Kasturee ¹, Linehan, W. Marston ⁴, Rebecca, Vito W. ^{1, 2}, Ji, Hongkai ³, Toska, Eneda ^{1, 2, ∗}, Cai, Danfeng ^{1, 2, 5, 7, 8, ∗∗}

Source: In Cell Reports 22 April 2025 44(4)

Zinc ions trigger the prion protein liquid-liquid phase separation

Authors: Juliani do Amaral, Mariana ^{⁎, 1}, Soares de Oliveira, Letícia, Cordeiro, Yraima ^⁎⁎

Source: In Biochemical and Biophysical Research Communications 19 March 2025 753

Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function

Authors: Hess, Nathaniel ¹, Joseph, Jerelle A. ^{1, 2, ⁎}

Source: In Trends in Biochemical Sciences March 2025 50(3):206-223

Chaperone-Mediated Heterotypic Phase Separation Prevents the Amyloid Formation of the Pathological Y145Stop Prion Protein Variant

Authors: Arora, Lisha ^{1, 3, †, ⁎}, Bhowmik, Dipankar ^{1, 2, †, ‡}, Sarkar, Snehasis ^{1, 2}, Sarbahi, Anusha ^{1, 2}, Rai, Sandeep K. ^{1, 3, §}, Mukhopadhyay, Samrat ^{1, 2, 3, ⁎}

Source: In Journal of Molecular Biology 1 March 2025 437(5)

Disordered Regions of Condensate-promoting Proteins Have Distinct Molecular Signatures Associated with Cellular Function

Authors: Vashishtha, Shubham, Sabari, Benjamin R. ^⁎

Source: In Journal of Molecular Biology 1 March 2025 437(5)

Liquid-liquid phase separation in microorganisms: Insights into existence, functions, and applications

Authors: Yusuf, Anas ^a, Usman, Abdurrahman ^a, Isah, Murtala Bindawa ^{a, d}, Dang, Mei ^a, Zhang, Xiaoying ^{a, b, c, ⁎}

Source: In Microbiological Research March 2025 292

Decoding phase separation of prion-like domains through data-driven scaling laws

Authors: M Julia Maristany, Anne Aguirre Gonzalez, Jorge R Espinosa, Jan Huertas, Rosana Collepardo-Guevara, Jerelle A Joseph

Source: eLife, Vol 13 (2025)

Subject Terms: phase separation, biomolecular condensates, scaling laws, prion-like low complexity domains, disordered proteins, critical temperature, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/99068; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/cb144abe9d0a448293b24db7f9f284db

Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

Authors: Senem Ntourmas, Martin Sachs, Petra Paclíková, Martina Brückner, Vítězslav Bryja, Jürgen Behrens, Dominic B Bernkopf

Source: eLife, Vol 13 (2024)

Subject Terms: dishevelled, DVL2, Wnt signaling, biomolecular condensates, paralogs, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/96841; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/d5b61e976be743fca0a2384c105e1095

The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain

Authors: Kashif Rahim, Muhammad Umair, Ihtisham Ul Haq

Source: Supramolecular Materials, Vol 3, Iss , Pp 100060- (2024)

Subject Terms: Tiger domain, Tis11b, Membraneless organelles, ER-associated organelles, TIS granule, Biomolecular condensates, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667240523000302; https://doaj.org/toc/2667-2405

Access URL: https://doaj.org/article/07df11d943134359986516f8e882a458

Emergent microenvironments of nucleoli

Authors: Matthew R. King, Kiersten M. Ruff, Rohit V. Pappu

Source: Nucleus, Vol 15, Iss 1 (2024)

Subject Terms: Biomolecular condensates, emergent properties, nucleolus, pH gradients, phase separation, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1949-1034; https://doaj.org/toc/1949-1042

Access URL: https://doaj.org/article/d1a5e3c5f5074299832f797e96ef7638

Liquid-to-gel transitions of phase-separated coacervate microdroplets enabled by endogenous enzymatic catalysis

Authors: Liu, Jian ^a, Li, Junbo ^{a, ⁎}, Huang, Yan ^b, Li, Tong ^b, Xu, Cheng ^a, Tao, Zhengyu ^b, Ji, Wei ^a, Huang, Xin ^{b, ⁎}

Source: In Journal of Colloid And Interface Science 15 August 2025 692