25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition

Authors: Hayoung Choi, Haeng Jun Kim, Sang-Eun Lee, Hyun Ho Song, Jieun Kim, Jihui Han, June-Hyun Jeong, Do Yup Lee, Sunghoe Chang, Inhee Mook-Jung

Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-18 (2025)

Subject Terms: Microglia, Disease-associated microglia, Aβ, Avasimibe, 25HC, Cholesterol, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/7dded7f1cf554411942bdfd5bd9281ec

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Authors: Teng Tu, Hongying Zhang, Huanji Xu

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: sterol-O-acyltransferase 1, cholesterol metabolism, cancer therapy, avasimibe, cholesterol esterification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1197502/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/016c94d625a1460b975c94ee863eebf0

The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer

Authors: Kangping Xiong, Gang Wang, Tianchen Peng, Fenfang Zhou, Siming Chen, Wei Liu, Lingao Ju, Yu Xiao, Kaiyu Qian, Xinghuan Wang

Source: Cancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021)

Subject Terms: Prostate cancer, Avasimibe, E2F-1, Cell cycle, Metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/57bf5138ea8844d188408764f8d0e484

Importance of Mevalonate Pathway Lipids on the Growth and Survival of Primary and Metastatic Gastric Carcinoma Cells

Authors: Ortiz N, Delgado-Carazo JC, Diaz C

Source: Clinical and Experimental Gastroenterology, Vol Volume 14, Pp 217-228 (2021)

Subject Terms: cholesterol, isoprenoids, gastric cancer, metastasis, simvastatin, terbinafine, avasimibe, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://www.dovepress.com/importance-of-mevalonate-pathway-lipids-on-the-growth-and-survival-of--peer-reviewed-fulltext-article-CEG; https://doaj.org/toc/1178-7023

Access URL: https://doaj.org/article/e8ed0fc2729d4b68ae5d89276a7d20b3

Targeting of the Lipid Metabolism Impairs Resistance to BRAF Kinase Inhibitor in Melanoma

Authors: Elisabetta Vergani, Giovanni L. Beretta, Mariachiara Aloisi, Matteo Costantino, Cristina Corno, Simona Frigerio, Stella Tinelli, Matteo Dugo, Felice Maria Accattatis, Agnese Granata, Lorenzo Arnaboldi, Monica Rodolfo, Paola Perego, Laura Gatti

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: melanoma, BRAF inhibitors, drug resistance, lipid metabolism, avasimibe, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.927118/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/753d797eaf4842098f6cfa0e94d7425d

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway

Authors: Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Xiaojing Meng, Fei Zou, Changhui Yu, Shaoxi Cai

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: allergic asthma, avasimibe, basal cell, epithelial barrier, Wnt/β-catenin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.795934/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/156f725c66ab44c69ff2d393637ff17d

Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling

Authors: Yunshu Gao, Dongyun Xu, Hongwei Li, Jiahua Xu, Yating Pan, Xinyi Liao, Jianxin Qian, Yi Hu, Guanzhen Yu

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: cholangiocarcinoma, FoxM1, AKR1C1, avasimibe, progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.677678/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/f8041295a0cf4b93ae6c0de2e39bffd1

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis[S]

Authors: Yuyan Zhu, Chih-Yu Chen, Junjie Li, Ji-Xin Cheng, Miran Jang, Kee-Hong Kim

Source: Journal of Lipid Research, Vol 59, Iss 5, Pp 820-829 (2018)

Subject Terms: adipocytes, avasimibe, cholesterol metabolism, fatty acid synthesis, triglycerides, acyl-CoA:cholesterol acyltransferase, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520331175; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/d798cb3f67a24ca4b05adb07ab431cbd

Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

Authors: Lengyun Wei, Xuyang Lu, Shengmei Weng, Shenglong Zhu, Yongquan Chen

Source: Biomolecules, Vol 11, Iss 6, p 853 (2021)

Subject Terms: breast cancer, cholesteryl ester, SOAT1, avasimibe, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/6/853; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/7706bac4cfb141ca8c5c5188658f89c1

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

Authors: John R. Burnett, Lisa J. Wilcox, Dawn E. Telford, Sandra J. Kleinstiver, P. Hugh R. Barrett, Roger S. Newton, Murray W. Huff

Source: Journal of Lipid Research, Vol 40, Iss 7, Pp 1317-1327 (1999)

Subject Terms: ACAT inhibitor, avasimibe, apolipoprotein B metabolism, kinetics, mRNA, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520334945; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/8db4818fc6fd46e5a7b38427c73ee6f8

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