Artemisinin Stimulates Neuronal Cell Viability and Possess a Neuroprotective Effect In Vitro.

Authors: Pukhov, Sergey A.^1,2 (AUTHOR) lnc@ipac.ac.ru, Semakov, Alexey V.¹ (AUTHOR) l_vok@list.ru, Pukaeva, Nadezhda E.^1,2 (AUTHOR) nadya.pukaeva98@gmail.com, Kukharskaya, Olga A.^1,2 (AUTHOR) loa.ipac@yandex.ru, Ivanova, Tatyana V.² (AUTHOR), Kryshkova, Viktoriya S.^1,2 (AUTHOR) vskryshkova@mail.ru, Bachurin, Sergey O.¹ (AUTHOR) bachurin@ipac.ac.ru, Kukharsky, Michail S.^1,2 (AUTHOR)

Source: Molecules. Jan2025, Vol. 30 Issue 1, p198. 16p.

Subject Terms: *ARTEMISININ derivatives, *ARTEMISININ, *ARTEMISIA annua, *ENDOPLASMIC reticulum, *SODIUM arsenite

Unlocking the Therapeutic Benefits of Artemisia Annua: A Comprehensive Overview of its Medicinal Properties.

Authors: Swamikannu, Bhuminathan¹ (AUTHOR), Umapathy, Vidhya Rekha² (AUTHOR) drvidhyarekha@gmail.com, Natarajan, Prabhu M.³ (AUTHOR), Nandini, MS⁴ (AUTHOR), Queency Stylin, Anin G. S.⁵ (AUTHOR), Vimalarani, V⁶ (AUTHOR), Rajinikanth, Suba⁷ (AUTHOR)

Source: Journal of Pharmacy & Bioallied Sciences. 2024 Suppl 5, Vol. 16, pS4248-S4253. 6p.

Subject Terms: *ARTEMISIA annua, *ARTEMISININ derivatives, *ANIMAL experimentation, *MEDICINAL plants, *WORMWOOD

Artesunate inhibits ROS production and ameliorates mitochondrial damage through the SIRT1/FOXO3a/MnSOD pathway to alleviate heart failure.

Authors: Yaping Li¹, Peng Hu² hup0871@163.com

Source: Signa Vitae. Sep2024, Vol. 20 Issue 9, p103-109. 7p.

Subject Terms: *ARTEMISININ derivatives, *REACTIVE oxygen species, *CELL survival, *HEART failure, *SUPEROXIDE dismutase

Artemisinin and Its Derivatives as Potential Anticancer Agents.

Authors: Wen, Luan¹ (AUTHOR) 1155209219@link.cuhk.edu.hk, Chan, Ben Chung-Lap¹ (AUTHOR) benchan99@cuhk.edu.hk, Qiu, Ming-Hua² (AUTHOR) mhchiu@mail.kib.ac.cn, Leung, Ping-Chung¹ (AUTHOR) ck-wong@cuhk.edu.hk, Wong, Chun-Kwok^1,3,4 (AUTHOR)

Source: Molecules. Aug2024, Vol. 29 Issue 16, p3886. 20p.

Subject Terms: *ARTEMISININ derivatives, *ARTEMISIA annua, *ANTINEOPLASTIC agents, *HERBAL medicine, *ARTEMISININ

Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer's Disease.

Authors: Kiss, Eva^1,2 (AUTHOR) gorgas@ana.uni-heidelberg.de, Kins, Stefan³ (AUTHOR) s.kins@biologie.uni-kl.de, Gorgas, Karin¹ (AUTHOR) joachim.kirsch@urz.uni-heidelberg.de, Venczel Szakács, Kinga Hajnal² (AUTHOR), Kirsch, Joachim¹ (AUTHOR), Kuhse, Jochen¹ (AUTHOR) kiss@ana.uni-heidelberg.de

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4165. 26p.

Subject Terms: *ALZHEIMER'S disease, *ARTEMISININ derivatives, *ANTIMALARIALS, *DONEPEZIL, *DRUG utilization, *HOMEOSTASIS

Assessing fitness costs in malaria parasites: a comprehensive review and implications for drug resistance management.

Authors: Segovia, Xyonane¹ (AUTHOR), Srivastava, Bhavya² (AUTHOR), Serrato-Arroyo, Sergio¹ (AUTHOR), Guerrero, Ashley¹ (AUTHOR), Huijben, Silvie^1,3 (AUTHOR) shuijben@asu.edu

Source: Malaria Journal. 3/1/2025, Vol. 24 Issue 1, p1-18. 18p.

Subject Terms: *ARTEMISININ derivatives, *MEDICAL sciences, *PLASMODIUM, *MEDICAL microbiology, *PLASMODIUM falciparum

Molecular Hybridization as a Strategy for Developing Artemisinin-Derived Anticancer Candidates.

Authors: Marchesi, Elena¹ (AUTHOR) mrclne@unife.it, Perrone, Daniela¹ (AUTHOR) prd@unife.it, Navacchia, Maria Luisa² (AUTHOR) prd@unife.it

Source: Pharmaceutics. Sep2023, Vol. 15 Issue 9, p2185. 40p.

Subject Terms: *MOLECULAR hybridization, *ARTEMISININ derivatives, *ARTEMISININ, *ANTINEOPLASTIC agents, *STRUCTURE-activity relationships

In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues.

Authors: Bege, Miklós^1,2,3 (AUTHOR), Singh, Vigyasa^4,5 (AUTHOR), Sharma, Neha⁶ (AUTHOR), Debreczeni, Nóra¹ (AUTHOR), Bereczki, Ilona^1,7 (AUTHOR), Poonam^8,9 (AUTHOR), Herczegh, Pál¹ (AUTHOR), Rathi, Brijesh^6,9 (AUTHOR) brijeshrathi@hrc.du.ac.in, Singh, Shailja⁴ (AUTHOR) shailja.jnu@gmail.com, Borbás, Anikó^1,7 (AUTHOR) borbas.aniko@pharm.unideb.hu

Source: Scientific Reports. 7/28/2023, Vol. 13 Issue 1, p1-16. 16p.

Subject Terms: *ARTEMISININ derivatives, *THERAPEUTICS, *PLASMODIUM berghei, *ADENOSINE derivatives, *NUCLEOSIDE derivatives, *ADENOSINES

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.

Authors: Basilico, Nicoletta¹ (AUTHOR) nicoletta.basilico@unimi.it, Parapini, Silvia² (AUTHOR) silvia.parapini@unimi.it, D'Alessandro, Sarah³ (AUTHOR) sarah.dalessandro@unimi.it, Misiano, Paola³ (AUTHOR) paola.misiano@guest.unimi.it, Romeo, Sergio⁴ (AUTHOR) sergio.romeo@unimi.it, Dondio, Giulio⁵ (AUTHOR) g.dondio@aphad.eu, Yardley, Vanessa⁶ (AUTHOR) vanessa.yardley@lshtm.ac.uk, Vivas, Livia⁶ (AUTHOR) livia.vivas.net@gmail.com, Nasser, Shereen⁶ (AUTHOR) shereen.nasser84@gmail.com, Rénia, Laurent^7,8 (AUTHOR) lcsrenia@ntu.edu.sg, Russell, Bruce M.⁹ (AUTHOR) b.russell@otago.ac.nz, Suwanarusk, Rossarin⁹ (AUTHOR) noi.suwanarusk@otago.ac.nz, Nosten, François^10,11 (AUTHOR) francois@tropmedres.ac, Sparatore, Anna⁴ (AUTHOR) anna.sparatore@unimi.it, Taramelli, Donatella³ (AUTHOR) anna.sparatore@unimi.it

Source: Biomolecules (2218-273X). May2023, Vol. 13 Issue 5, p836. 23p.

Subject Terms: *ARTEMISININ derivatives, *DRUG discovery, *MALARIA, *CHLOROQUINE, *IN vitro studies

Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells.

Authors: Barman, Madhumanti¹ (AUTHOR), Dandasena, Debabrata^1,2 (AUTHOR), Suresh, Akash¹ (AUTHOR), Bhandari, Vasundhra^1,3 (AUTHOR), Kamble, Sonam^1,2 (AUTHOR), Singh, Sakshi^1,2 (AUTHOR), Subudhi, Madhusmita¹ (AUTHOR), Sharma, Paresh¹ (AUTHOR) paresh@niab.org.in

Source: Cell Communication & Signaling. 4/17/2023, Vol. 21 Issue 1, p1-15. 15p.

Subject Terms: *ARTEMISININ derivatives, *OXIDATIVE stress, *DNA damage, *THEILERIA, *DOUBLE-strand DNA breaks, *P53 antioncogene, *TICK-borne diseases

Integrated Data Analysis Uncovers New COVID-19 Related Genes and Potential Drug Re-Purposing Candidates.

Authors: Xenos, Alexandros^1,2 (AUTHOR), Malod-Dognin, Noël^1,3 (AUTHOR), Zambrana, Carme^1,2 (AUTHOR), Pržulj, Nataša^1,3,4 (AUTHOR) natasha@bsc.es

Source: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 2, p1431. 22p.

Subject Terms: *ARTEMISININ derivatives, *DRUG derivatives, *ANTIMALARIALS, *COVID-19 treatment, *DATA analysis

Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking.

Authors: Ma, Yujie¹ (AUTHOR), Liu, Haixia¹ (AUTHOR), Lu, Xinyue¹ (AUTHOR), Song, Changheng¹ (AUTHOR), Cheng, Yin¹ (AUTHOR), Wang, Yuhan¹ (AUTHOR), Li, Pei¹ (AUTHOR), Chen, Yanjing¹ (AUTHOR), Zhang, Zhiguo¹ (AUTHOR)

Source: Computational & Mathematical Methods in Medicine. 12/22/2022, p1-13. 13p.

Subject Terms: *ARTEMISININ derivatives, *MOLECULAR pharmacology, *MOLECULAR docking, *AMP-activated protein kinases, *OSTEOPOROSIS, *HUMAN reproductive technology

The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.

Authors: Schmidt, Sabine¹, Wichers-Misterek, Jan Stephan¹, Behrens, Hannah Michaela¹, Birnbaum, Jakob¹, Henshall, Isabelle G.¹, Dröge, Jana¹, Jonscher, Ernst¹, Flemming, Sven¹, Castro-Peña, Carolina¹, Mesén-Ramírez, Paolo¹, Spielmann, Tobias¹, spielmann@bnitm.de

Source: PLoS Pathogens; 12/1/2023, Vol. 19 Issue 12, p1-37, 37p

Comparative efficacy and safety of the artemisinin derivatives compared to quinine for treating severe malaria in children and adults: A systematic update of literature and network meta-analysis.

Authors: Nyaaba, Nicholas¹ (AUTHOR) nyabasmail@gmail.com, Andoh, Nana Efua² (AUTHOR), Amoh, Gordon³ (AUTHOR), Amuzu, Dominic Selorm Yao⁴ (AUTHOR), Ansong, Mary⁵ (AUTHOR), Ordóñez-Mena, José M.^6,7 (AUTHOR), Hirst, Jennifer^6,7 (AUTHOR)

Source: PLoS ONE. 7/20/2022, Vol. 17 Issue 7, p1-22. 22p.

Subject Terms: *MALARIA, *ARTEMISININ derivatives, *QUININE, *CEREBRAL malaria, *RANDOM effects model

Geographic Terms: ASIA, AFRICA

Artemisinin derivatives as potential drug candidates against Mycobacterium tuberculosis: insights from molecular docking, MD simulations, PCA, MM/GBSA and ADMET analysis.

Authors: Maharjan, Rajesh¹ (AUTHOR), Gyawali, Kalpana¹ (AUTHOR), Acharya, Arjun¹ (AUTHOR), Khanal, Madan¹ (AUTHOR), Ghimire, Madhav Prasad¹ (AUTHOR), Lamichhane, Tika Ram¹ (AUTHOR) tika.lamichhane@cdp.tu.edu.np

Source: Molecular Simulation. Jul2024, Vol. 50 Issue 11, p717-728. 12p.

Subject Terms: *ARTEMISININ derivatives, *DRUG derivatives, *MOLECULAR docking, *MYCOBACTERIUM tuberculosis, *PRINCIPAL components analysis, *ROOT-mean-squares

Dihydroartemisinin ameliorates skeletal muscle atrophy in the lung cancer cachexia mouse model.

Authors: Li, Xin^1,2 (AUTHOR), Zhu, Zhiying² (AUTHOR), Wen, Keting² (AUTHOR), Ling, Tingting^2,3 (AUTHOR), Huang, Hong² (AUTHOR), Qi, Li⁴ (AUTHOR) ql1104@126.com, Wang, Bei¹ (AUTHOR) wangbei1224 @126.com

Source: Journal of Cancer Research & Therapeutics. Dec2024, Vol. 20 Issue 7, p2004-2012. 9p.

Subject Terms: *MUSCULAR atrophy, *WEIGHT loss, *ARTEMISININ derivatives, *ADIPOSE tissues, *SKELETAL muscle

Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger.

Authors: Luo, Jiaer¹ (AUTHOR), Mobley, Rebecca² (AUTHOR), Woodfine, Sian³ (AUTHOR), Drijfhout, Falko³ (AUTHOR), Horrocks, Paul² (AUTHOR), Ren, Xiao-Dong¹ (AUTHOR) renxiaodong@jlu.edu.cn, Li, Wen-Wu⁴ (AUTHOR) w.li@keele.ac.uk

Source: Applied Microbiology & Biotechnology. Apr2022, Vol. 106 Issue 7, p2433-2444. 12p.

Subject Terms: *ARTEMISININ derivatives, *ASPERGILLUS niger, *BIOCONVERSION, *NORMAL-phase chromatography, *BIOLUMINESCENCE assay, *ARTEMISININ, *PEROXIDES, *SILICA gel

Recent Advances in the Therapeutic Efficacy of Artesunate.

Authors: Ruwizhi, Ngonidzashe¹ (AUTHOR) 201515559@ufh.ac.za, Maseko, Rejoice Bethusile² (AUTHOR) mreemaseko@gmail.com, Aderibigbe, Blessing Atim¹ (AUTHOR) mreemaseko@gmail.com

Source: Pharmaceutics. Mar2022, Vol. 14 Issue 3, p504. 23p.

Subject Terms: *TREATMENT effectiveness, *ARTEMISININ derivatives, *ANTIMALARIALS, *ONCOGENIC viruses, *MALARIA, *LIPOSOMES, *SKIN diseases

New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells.

Authors: Lin, Lixian¹ (AUTHOR), Tang, Zengqi¹ (AUTHOR), Shi, Zhenrui¹ (AUTHOR), Guo, Qing¹ (AUTHOR), Xiong, Hui¹ (AUTHOR)

Source: Journal of Immunology Research. 2/7/2022, p1-7. 7p. 2 Charts.

Subject Terms: *ARTEMISININ derivatives, *ARTEMISININ, *AUTOIMMUNE diseases, *IMMUNE response, *ALLERGIES

A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting.

Authors: Li, Fenglin, Chen, Yao, Zhuang, Haihui, Pei, Renzhi, Lu, Yuyu, chen, Dong, Li, Shuangyue, Ye, Peipei, lian, Jiaying, Lu, Ying

Source: Discover Oncology; 4/9/2025, Vol. 16 Issue 1, p1-10, 10p

Subject Terms: ACUTE myeloid leukemia, VENETOCLAX, BCL-2 proteins, MYC oncogenes, DRUG interactions, APOPTOSIS inhibition, ARTEMISININ derivatives, CANCER chemotherapy