From pre-clinical efficacy to promising clinical trials that delay Type 1 diabetes

Authors: J. Jason Collier, Daniel S. Hsia, Susan J. Burke

Source: Pharmacological Research, Vol 208, Iss , Pp 107342- (2024)

Subject Terms: anti-CD3, autoimmunity, cytokine, NOD mouse, pancreatic islet, teplizumab, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824002871; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/c648dcf52bcb443daacf2a779655f860

Rigid crosslinking of the CD3 complex leads to superior T cell stimulation

Authors: Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Tommi A. White, Adam G. Schrum, John F. Cannon, Diana Gil

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: T cell receptor engagement and triggering, antibody fragment structure, CD3/antibody crosslinking, T cell division and apoptosis, anti-CD3 Fab-based therapies, EAE (experimental autoimmune encephalomyelitis), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1434463/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e0c851df2d934c47ad596fb4db81592c

Antibody‐Conjugated Magnetic Nanoparticle Therapy for Inhibiting T‐Cell Mediated Inflammation

Authors: Mahbub Hasan, Jong‐Gu Choi, Hafeza Akter, Hasung Kang, Meejung Ahn, Sang‐Suk Lee

Source: Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)

Subject Terms: anti‐CD3, immunotherapy, inflammation, magnetic nanoparticles, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/e2776c869cd14b1c8b5c51b9bc321fc9

Microbiota modulates the steroid response to acute immune stress in male mice

Authors: Karla Vagnerová, Taťána Gazárková, Martin Vodička, Peter Ergang, Petra Klusoňová, Tomáš Hudcovic, Dagmar Šrůtková, Petra Petr Hermanová, Lucie Nováková, Jiří Pácha

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: immune stress, gut microbiota, germ-free, mice, anti-CD3, steroids, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330094/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/54bf1724f6044edaa37faf2629886283

Induction of long-term tolerance to a specific antigen using anti-CD3 lipid nanoparticles following gene therapy

Authors: Chun-Yu Chen, Amber Vander Kooi, Alex Cavedon, Xiaohe Cai, Jonathan Hoggatt, Paolo G.V. Martini, Carol H. Miao

Source: Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102043- (2023)

Subject Terms: MT: Delivery Strategies, factor VIII, hemophilia A, lipid nanoparticle, nonviral, anti-CD3 antibody, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123002615; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/c6ff0a3ff3864167a1095fd011125670

Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation

Authors: Sang-Heon Choi, Jong-Gu Choi, Sang-Suk Lee

Source: Journal of Acupuncture & Meridian Studies, Vol 15, Iss 1, Pp 37-42 (2022)

Subject Terms: primo vessel, lipopolysaccharide (lps), anti-cd3, monoclonal antibody, foralumab, lymph vessel, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://www.journal-jams.org/journal/view.html?doi=10.51507/j.jams.2022.15.1.37; https://doaj.org/toc/2005-2901

Access URL: https://doaj.org/article/fa07932544474c83b8b3e3cb3318cb01

Liposomal T cell engager and re-director for tumor cell eradication in cancer immunotherapy

Authors: Fang Xie, Luchen Zhang, Sanyuan Shi, Anjie Zheng, Jiaxing Di, Shanshan Jin, Xuguang Miao, Fenglan Wu, Xiaolong Chen, Yanhong Zhang, Xiaohui Wei, Yuhong Xu

Source: mAbs, Vol 14, Iss 1 (2022)

Subject Terms: T-cell dependent bispecific antibody (TDB), anti-CD3, anti-CD19, liposome, T cell engager, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/55949de4ad0b4a72bd95c8dd421ec7c2

Nasal administration of anti-CD3 monoclonal antibody modulates effector CD8+ T cell function and induces a regulatory response in T cells in human subjects

Authors: Tanuja Chitnis, Belinda J. Kaskow, Junning Case, Katherine Hanus, Zhenhua Li, Johnna F. Varghese, Brian C. Healy, Christian Gauthier, Taylor J. Saraceno, Shrishti Saxena, Hrishikesh Lokhande, Thais G. Moreira, Jonathan Zurawski, Rachel E. Roditi, Regan W. Bergmark, Federico Giovannoni, Maria F. Torti, Zhaorong Li, Francisco Quintana, William A. Clementi, Kunwar Shailubhai, Howard L. Weiner, Clare M. Baecher-Allan

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: Foralumab, nasal anti-CD3, immunomodulation, CD8+ T cells, Tregs, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.956907/full; https://doaj.org/toc/1664-3224

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Evaluation of T Cell Proliferation Using CFSE Dilution Assay: A Comparison between Stimulation with PHA and Anti-CD3/Anti-CD28 Coated Beads

Authors: Sara Kashef, Mozhgan Moghtaderi, Hamid Reza Hatami, Mehdi Kalani, Soheila Alyasin, Hesamodin Nabavizadeh, Shirin Farjadian

Source: Iranian Journal of Allergy, Asthma and Immunology, Vol 21, Iss 4 (2022)

Subject Terms: Anti-CD3, Anti-CD28, Carboxyfluorescein diacetate succinimidyl ester, Lymphocyte transformation, Phytohaemagglutinin, Medicine

File Description: electronic resource

Relation: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3311; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249

Access URL: https://doaj.org/article/cbe67bc7d5874f0d86baffe339826f24

In Vitro Expansion of Vδ1+ T Cells from Cord Blood by Using Artificial Antigen-Presenting Cells and Anti-CD3 Antibody

Authors: Gaeun Hur, Haeyoun Choi, Yunkyeong Lee, Hyun-Jung Sohn, Su-Yeon Kim, Tai-Gyu Kim

Source: Vaccines, Vol 11, Iss 2, p 406 (2023)

Subject Terms: γδ T cells, cord blood, Vδ1+ T cells, PBMC, anti-CD3 antibody, artificial antigen presenting cells, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/11/2/406; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/52ae6c824c734b4cb75f2d4a64cc9dce

Corrigendum: Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study

Authors: Thais G. Moreira, Kimble T. F. Matos, Giovana S. De Paula, Thais M. M. Santana, Raquel G. Da Mata, Fernando C. Pansera, Andre S. Cortina, Marcelle G. Spinola, Clare M. Baecher-Allan, Gerson D. Keppeke, Jules Jacob, Vaseem Palejwala, Karen Chen, Saef Izzy, Brian C. Healey, Rafael M. Rezende, Rogerio A. Dedivitis, Kunwar Shailubhai, Howard L. Weiner

Source: Frontiers in Immunology, Vol 12 (2022)

Subject Terms: foralumab, anti-CD3, COVID-19, SARS-CoV-2, immune responses, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.815812/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ad921884fc424e0688f770608f9a93f2

Characterization and Analysis of the Temporal and Spatial Dynamic of Several Enteritis Modeling Methodologies

Authors: Huangru Xu, Fangfang Cai, Ping Li, Xiaoyang Wang, Yingying Yao, Xiaoyao Chang, Zhiqian Bi, Huisong Sun, Hongqin Zhuang, Zi-Chun Hua

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: enteritis, DSS, anti-CD3 antibody, HFD, inflammatory cytokines, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.727664/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d36d3ecfd0ae4473b45b65da37726e4c

Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodies

Authors: Isabel Garcia Sousa, Kelly Cristina Rodrigues Simi, Manuela Maragno do Almo, Maryani Andressa Gomes Bezerra, Gero Doose, Tainá Raiol, Peter F. Stadler, Steve Hoffmann, Andréa Queiroz Maranhão, Marcelo Macedo Brigido

Source: BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)

Subject Terms: Anti-CD3, RNA-seq, Antibody therapy, Regulatory T cells, Antibody engineering, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12864-019-5967-8; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/ddc89d2e50b348ad8f38428d7c1ae7e5

Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study

Authors: Thais G. Moreira, Kimble T. F. Matos, Giovana S. De Paula, Thais M. M. Santana, Raquel G. Da Mata, Fernando C. Pansera, Andre S. Cortina, Marcelle G. Spinola, Clare M. Baecher-Allan, Gerson D. Keppeke, Jules Jacob, Vaseem Palejwala, Karen Chen, Saef Izzy, Brian C. Healey, Rafael M. Rezende, Rogerio A. Dedivitis, Kunwar Shailubhai, Howard L. Weiner

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: foralumab, anti-CD3, COVID-19, SARS-CoV-2, immune responses, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.709861/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b1a9e151506d41928c312969f7c3db27

Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis

Authors: Dana P. Cook, João Paulo Monteiro Carvalho Mori Cunha, Pieter-Jan Martens, Gabriele Sassi, Francesca Mancarella, Giuliana Ventriglia, Guido Sebastiani, An-Sofie Vanherwegen, Mark A. Atkinson, Karolien Van Huynegem, Lothar Steidler, Silvia Caluwaerts, Pieter Rottiers, Luc Teyton, Francesco Dotta, Conny Gysemans, Chantal Mathieu

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: type 1 diabetes, antigen-specific therapy, anti-CD3, genetically modified Lactococcus lactis, beta cell mass, oral tolerance, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01103/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fac9a292158844b7b13abb31bbfc503b

Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

Authors: Sunao Sugita, Jun Shimizu, Kenichi Makabe, Hiroshi Keino, Takeshi Watanabe, Masayo Takahashi

Source: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)

Subject Terms: Anti-CD3 antibody, T cells, Uveitis, Inhibition, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13075-017-1379-9; https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/dcfa485d59a74eb08544642ada1898d9

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

Authors: Robert A. Benson, Fabien Garcon, Asha Recino, John R. Ferdinand, Menna R. Clatworthy, Herman Waldmann, James M. Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wållberg

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: type 1 diabetes, islets, multiphoton, imaging, immunotherapy, anti-CD3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01006/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/96636762e3204d01b5265dcbd95c7c77

The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering

Authors: Bing-Mae Chen, Mohammad Ameen Al-Aghbar, Chien-Hsin Lee, Tien-Ching Chang, Yu-Cheng Su, Ya-Chen Li, Shih-En Chang, Chin-Chuan Chen, Tsai-Hua Chung, Yuan-Chun Liao, Chau-Hwang Lee, Steve R. Roffler

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: affinity, T cell receptor triggering, artificial antigen-presenting cell, pMHC, anti-CD3 scFv, OKT3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00793/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1a187600c8f249cb8a0694267059942b

The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells

Authors: Chien-Ting Lin, Shang-Ju Wu, Cheng Hao Liao, Reyhung Roc Weng, Chun-Ming Lin

Source: Human Vaccines & Immunotherapeutics, Vol 21, Iss 1 (2025)

Subject Terms: Bifunctional protein, bispecific antibody, CD16, anti-CD3, lymphoma, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/f43305e7624f431d91a55d5143ba724d

HDAC Inhibitor Reduces Cytokine Storm and Facilitates Induction of Chimerism That Reverses Lupus in Anti-CD3 Conditioning Regimen

Authors: Li, Nainong, Zhao, Dongchang, Kirschbaum, Mark, Zhang, Chunyan, Lin, Chia-Lei, Todorov, Ivan, Kandeel, Fouad, Forman, Stephen, Zeng, Defu

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Mar . 105(12), 4796-4801.

Access URL: https://www.jstor.org/stable/25461502