Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy

Authors: Kun Du, He Huang

Source: Translational Oncology, Vol 52, Iss , Pp 102247- (2025)

Subject Terms: Agonist antibody, CD40, Programmed death-ligand 1, Bispecific antibody, Cancer immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324003735; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/7e50d56d818c4c408e91683a635f049c

Advanced Blood-Brain Barrier Drug Delivery

Contributors: Pardridge, William M.

Subject Terms: blood–brain barrier (BBB), brain drug delivery, prodrugs, solute carriers (SLCs), lysosomal storage disease, neuronopathic mucopolysaccharidosis, blood–brain barrier, neurodegeneration, enzyme replacement therapy, receptor-mediated transcytosis, transferrin receptor, insulin receptor, endothelium, receptor-mediated transport, carrier-mediated transport, genetic engineering, IgG fusion proteins, nanoparticles, liposomes, TrkB, agonist antibody, variable new antigen receptor (VNAR), neuroprotection, transferrin receptor 1 (TfR1), blood-brain barrier (BBB), 6-OHDA, Parkinson’s disease, bispecific antibody, alpha-synuclein (αSYN), Parkinson’s disease (PD), immunotherapy, monoclonal antibody, transferrin receptor (TfR), receptor-mediated transcytosis (RMT), single domains antibody, IGF1R, neurotensin, protein-based therapy, lysosomal storage disorders, fusion proteins, Alzheimer’s disease, neurotrophic factors, decoy receptors, ATP-binding cassette transporters, drug delivery, ischemic stroke, SLC transporters, lipid nanoparticle, ssPalm, mRNA transfection, hCMEC/D3 cells, cell toxicity, SWATH-MS, translation, chaperonin-containing TCP-1, proton-coupled organic cation antiporter, photo-affinity labeling, proteomics, SWATH-MS (sequential window acquisition of all theoretical-mass spectra), pharmacokinetics, compartmental models, physiologically based PK models, blood-brain barrier, antibody, cavernous sinus, BBB–peptide shuttle, brain delivery, solute carrier (SLC) transporters, amyotrophic lateral sclerosis (ALS), NSC-34 cell lines, taurine transporter (Taut), large amino acid transporter 1 (LAT1), monocarboxylate transporters (MCTs), organic cation transporters (OCTNs), choline transporter-like protein-1 (CTL1), TNF-α inhibitor, molecular Trojan horse, endosomal, liposome, nanoparticle, targeting, transferrin, Medicine and Nursing, Pharmacology

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/96729
https://mdpi.com/books/pdfview/book/6675

Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia

Authors: Jiwon Shin, Min-Jung Kim, Xingguo Quan, Ji Woong Kim, Sukmook Lee, SaeGwang Park, Jee-Yeong Jeong, Kyungmoo Yea

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)

Subject Terms: Chemotherapy-induced thrombocytopenia, Thrombopoietin receptor, Agonist antibody, Megakaryopoiesis, Platelet production, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/222b3bc5d3984688ac61621c2d8c6081

Recent Advances in Antibody Therapeutics

Contributors: Heo, Yong-Seok

Subject Terms: interleukin 33, ST2 receptor, scFv, C2_2E12, bladder cancer, antibodies, immune checkpoint inhibitors, antibody-drug conjugates, sacituzumab govitecan, enfortumab vedotin, erdafitinib, cost-effectiveness, G protein-coupled receptor, membrane protein, antigen, therapeutic antibody, anti-angiogenesis, delta-like ligand, irinotecan, paclitaxel, VEGF, SARS-CoV-2, spike protein, receptor-binding domain, phage display, monoclonal antibody, cytomegalovirus, peptide/major histocompatibility complex class I complex, T-cell-receptor-like antibody, affinity maturation, yeast surface display, combinatorial antibody library, agonist antibody, cell fate, bispecific antibodies, bioassays, mechanisms of action, binding assays, potency assays, atherosclerosis, inflammation, antibody therapy, blood–brain barrier, antibody, pharmacokinetics, disposition, biochemical and physicochemical properties, Fc binding, receptor-mediated transcytosis, brain shuttle, molecular Trojan horse, transferrin, anti-cancer antibody, antibody engineering, biophysical properties, computational methods, research cell bank, antibody therapeutics, recombinant antibodies, intracellular antibodies, single-chain antibody fragment, nanobody, Human papillomaviruses, HPV oncoproteins, HPV-associated cancer, HPV cancer therapy, asthma, refractory asthma, biomarker, Research and information: general, Chemistry

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Access URL: https://directory.doabooks.org/handle/20.500.12854/87408
https://mdpi.com/books/pdfview/book/5595

Adrenergic receptor signaling regulates the CD40-receptor mediated anti-tumor immunity

Authors: Akansha Singh, Ashish Ranjan

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: immunotherapy, Anti-CD40 agonist antibody, propranalol, adrenergic signaling, anti-tumor immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141712/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c4d574c765cb45b4bf407fe733126eed

OX40‐targeted immune agonist antibodies induce potent antitumor immune responses without inducing liver damage in mice

Authors: Yee C. Tee, Stephen J. Blake, David J. Lynn

Source: FASEB BioAdvances, Vol 3, Iss 10, Pp 829-840 (2021)

Subject Terms: hepatoxicity, immune agonist antibody, immunotherapy, liver, microbiota, natural killer T cells, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2573-9832

Access URL: https://doaj.org/article/509e5b2e3ad24c65b61fa3b52ee3b1d6

Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

Authors: Knorr, David A., Dahan, Rony, Ravetch, Jeffrey V.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct . 115(43), 11048-11053.

Access URL: https://www.jstor.org/stable/26532364

A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson’s Disease

Authors: Emily Clarke, Pawel Stocki, Elizabeth H. Sinclair, Aziz Gauhar, Edward J. R. Fletcher, Alicja Krawczun-Rygmaczewska, Susan Duty, Frank S. Walsh, Patrick Doherty, Julia Lynn Rutkowski

Source: Pharmaceutics, Vol 14, Iss 7, p 1335 (2022)

Subject Terms: TrkB, agonist antibody, variable new antigen receptor (VNAR), neuroprotection, transferrin receptor 1 (TfR1), blood-brain barrier (BBB), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/7/1335; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/7e8201a7d0904e04a5f05e9349a1bc37

FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

Authors: Mark Z. Chen, Joshua C. Chang, Jose Zavala-Solorio, Lance Kates, Minh Thai, Annie Ogasawara, Xiaobo Bai, Sean Flanagan, Victor Nunez, Khanhky Phamluong, James Ziai, Robert Newman, Søren Warming, Ganesh Kolumam, Junichiro Sonoda

Source: Molecular Metabolism, Vol 6, Iss 11, Pp 1454-1467 (2017)

Subject Terms: FGF21, Therapeutic antibody, Agonist antibody, Thermogenesis, Brown adipose tissue, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817304726; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/ce235e57c3334e8584b6bcb64b10b27e

Agonist antibody that induces human malignant cells to kill one another

Authors: Yea, Kyungmoo, Zhang, Hongkai, Xie, Jia, Jones, Teresa M., Lin, Chih-Wei, Francesconi, Walter, Berton, Fulvia, Fallahi, Mohammad, Sauer, Karsten, Lerner, Richard A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Nov 01. 112(45), E6158-E6165.

Access URL: https://www.jstor.org/stable/26466388

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

Authors: Paulo C. M. Urbano, Hans J. P. M. Koenen, Irma Joosten, Xuehui He

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: regulatory T cells, tumor necrosis factor receptor 2, TNFα, rapamycin, tumor necrosis factor receptor 2 agonist antibody, Treg stability, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00573/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/537ef319be574865bd2455c2c2b91be0

Protecting the nerve terminals

Authors: Jonathan D Glass

Source: eLife, Vol 7 (2018)

Subject Terms: amyotrophic lateral sclerosis, neuromuscular disease, neurodegeneration, motor neuron, agonist antibody, MuSK, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/35664; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/95282479a6144039bffdf9fe3019b479

Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

Authors: Sarah Cantor, Wei Zhang, Nicolas Delestrée, Leonor Remédio, George Z Mentis, Steven J Burden

Source: eLife, Vol 7 (2018)

Subject Terms: amyotrophic lateral sclerosis, neuromuscular disease, neurodegeneration, motor neuron, agonist antibody, MuSK, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/34375; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/d3615645dc99482ea7b9f2d156a2a4c8

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