Broadening alloselectivity of T cell receptors by structure guided engineering

Authors: Vijaykumar Karuppiah, Dhaval Sangani, Lorraine Whaley, Robert Pengelly, Pelin Uluocak, Ricardo J. Carreira, Miriam Hock, Pietro Della Cristina, Paulina Bartasun, Paula Dobrinic, Nicola Smith, Keir Barnbrook, Ross A. Robinson, Stephen Harper

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: T cell receptor, HLA, Alloselectivity, Structure-guided engineering, Affinity maturation, PRAME, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d5245e5725e8433484357359ff41b76a

Antigenic drift expands influenza viral escape pathways from recalled humoral immunity

Authors: Maurer, Daniel P. ^{1, 2, 3}, Vu, Mya ^{1, 4}, Schmidt, Aaron G. ^{1, 2, 5, ∗}

Source: In Immunity 11 March 2025 58(3):716-727

Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten

Authors: Rin Yoshizato, Mariko Miura, Kiyomi Shitaoka, Yuri Matsuoka, Akifumi Higashiura, Akima Yamamoto, Yun Guo, Hitoshi Azuma, Yohei Kawano, Shouichi Ohga, Tomoharu Yasuda

Source: Heliyon, Vol 10, Iss 23, Pp e40837- (2024)

Subject Terms: Monoclonal antibody, Memory B cells, B cell receptor, Single cell, Affinity maturation, IgM, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024168685; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/d9668eb981594ab18c46ba8ed36326df

Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies

Authors: Yuye Yin, Shusheng Wu

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: Rheumatoid arthritis, B cells, Autoantibody, Ab affinity maturation, Plasma cells, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/56585b25f9e54319a4c12b6ddb22bf64

Superior Potency of Synthetic Virus-like Structures in Vaccine-Induced Antibody Responses Compared to Qβ Bacteriophage Virus-like Particles

Authors: Alexander R. Meyer, Libo Li, Wei-Yun Wholey, Bryce Chackerian, Wei Cheng

Source: Viruses, Vol 17, Iss 4, p 579 (2025)

Subject Terms: synthetic virus-like structures, Qβ bacteriophage, virus-like particles, antibody, affinity maturation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/17/4/579; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/11f595fd08f94b0c86046674e19e0392

Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant

Authors: Singh, Vishakha ^a, Choudhary, Shweta ^a, Bhutkar, Mandar ^a, Nehul, Sanketkumar ^a, Ali, Sabika ^a, Singla, Jitin ^{a, b}, Kumar, Pravindra ^a, Tomar, Shailly ^{a, ⁎}

Source: In International Journal of Biological Macromolecules February 2025 290

Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Authors: Maryam Oroujeni, Matilda Carlqvist, Eva Ryer, Anna Orlova, Vladimir Tolmachev, Fredrik Y. Frejd

Source: EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-19 (2024)

Subject Terms: B7-H3, Affibody molecule, Dimerization, Affinity maturation, Technetium-99m (99mTc), SKOV-3 xenograft, SPECT/CT imaging, Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/3f8212334a824f1798b022f16777c967

The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task

Authors: Greg A. Kirchenbaum, Graham Pawelec, Paul V. Lehmann

Source: Cells, Vol 14, Iss 3, p 223 (2025)

Subject Terms: ELISPOT, FluoroSpot, immune monitoring, affinity maturation, Ig class, high throughput, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/3/223; https://doaj.org/toc/2073-4409

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Affinity Maturation for Antibody Engineering: The Critical Role of Residues on CDR Loops of Antibodies in Antigen Binding

Authors: Mutsumi Yoshida, Masayuki Oda

Source: Molecules, Vol 30, Iss 3, p 532 (2025)

Subject Terms: affinity maturation, antigen binding, crystal structure, thermal stability, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/30/3/532; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/8e8f3cc3db6849dfac8cf57bf783f733

Homophone Ambiguity Reduction from Word Level Speech Recognition using Artificial Immune System

Authors: Ghosh, Papri, Chinghtham, Tejbanta Singh, Ghose, Mrinal Kanti

Source: 2019 4th International Conference on Recent Trends on Electronics, Information, Communication & Technology (RTEICT) Recent Trends on Electronics, Information, Communication & Technology (RTEICT), 2019 4th International Conference on. :161-166 May, 2019

Relation: 2019 4th International Conference on Recent Trends on Electronics, Information, Communication & Technology (RTEICT)

Non-invasive strategy: Developing a topical IL-4Rα-specific nanobody for the treatment of allergic airway diseases

Authors: Taeyoung Ahn, Dong Hyuk Lee, GeunAh Kim, JiHyun Kim, Joon-Sang Park, Hyung-Ju Cho, Joo Young Kim

Source: Materials Today Bio, Vol 27, Iss , Pp 101148- (2024)

Subject Terms: Allergic rhinitis, Interleukin-4 receptor α, Nanobody, In-silico affinity maturation, Non-invasive treatment, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006424002072; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/f465aa55d3fd4613a27ed8513b7aacb9

A multiscale spatial modeling framework for the germinal center response

Authors: Derek P. Mu, Christopher D. Scharer, Norbert E. Kaminski, Qiang Zhang

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: B cells, germinal center, dark zone, light zone, affinity maturation, proliferative burst, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1377303/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5e589c15bc734046aa4a472526fd8801

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies

Authors: Opeyemi Ernest Oludada, Giulia Costa, Clare Burn Aschner, Anna S Obraztsova, Katherine Prieto, Caterina Canetta, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller, Rajagopal Murugan, Jean‐Philippe Julien, Elena A Levashina, Hedda Wardemann

Source: EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-15 (2023)

Subject Terms: Affinity maturation, Antibodies, Malaria, PfCSP, Plasmodium, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/33752ac8c6164577b956799dc07969a4

A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

Authors: Yang Qin, Gan Wu, Jiayi Jin, Hao Wang, Jiani Zhang, Li Liu, Heping Zhao, Jianguang Wang, Xinyu Yang

Source: BMC Biotechnology, Vol 23, Iss 1, Pp 1-12 (2023)

Subject Terms: CTGF, Phage display, Affinity maturation, Angiogenesis, Arthritis, Human antibody, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6750

Access URL: https://doaj.org/article/4a0a84e26e964c38b6afa0e402c8d31b

Development of Recombinant Antibody by Yeast Surface Display Technology

Authors: Mujahed I. Mustafa, Awad A. Alzebair, Ahmed Mohammed

Source: Current Research in Pharmacology and Drug Discovery, Vol 6, Iss , Pp 100174- (2024)

Subject Terms: Recombinant antibodies, Yeast surface display, Yeast cells, Affinity maturation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590257124000014; https://doaj.org/toc/2590-2571

Access URL: https://doaj.org/article/7a6e19d67d454c038edaa75d97dd21d9

STAT3 signaling in B cells controls germinal center zone organization and recycling

Authors: Fike, Adam J. ^{1, 6}, Chodisetti, Sathi Babu ^{1, 6}, Wright, Nathaniel E. ^{2, 7}, Bricker, Kristen N. ^{1, 7}, Domeier, Phillip P. ³, Maienschein-Cline, Mark ⁴, Rosenfeld, Aaron M. ⁵, Luckenbill, Sara A. ¹, Weber, Julia L. ¹, Choi, Nicholas M. ¹, Luning Prak, Eline T. ⁵, Mandal, Malay ², Clark, Marcus R. ², Rahman, Ziaur S.M. ^{1, 8, ∗}

Source: In Cell Reports 30 May 2023 42(5)

Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations

Authors: Zixuan Bai, Jiewen Wang, Jiaqi Li, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario de Marco, He Huang

Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 601-613 (2023)

Subject Terms: Bispecific construct, Rational affinity maturation, Umbrella sampling simulation, TNF-α, IL-23, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037022005785; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/570a514caad546edb200e78c152b7308

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

Authors: Klara Lenart, Fredrika Hellgren, Sebastian Ols, Xianglei Yan, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Inga Winge, Jakub Hanczak, Stefan O. Mueller, Edith Jasny, Kim Schwendt, Susanne Rauch, Benjamin Petsch, Karin Loré

Source: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 309-323 (2022)

Subject Terms: vaccine, mRNA vaccine, antibody response, affinity maturation, vaccine biodistribution, innate immunity, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122001437; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/7fe635994c564778a82c953e5d6c3cf7

Recent Advances in Antibody Therapeutics

Contributors: Heo, Yong-Seok

Subject Terms: interleukin 33, ST2 receptor, scFv, C2_2E12, bladder cancer, antibodies, immune checkpoint inhibitors, antibody-drug conjugates, sacituzumab govitecan, enfortumab vedotin, erdafitinib, cost-effectiveness, G protein-coupled receptor, membrane protein, antigen, therapeutic antibody, anti-angiogenesis, delta-like ligand, irinotecan, paclitaxel, VEGF, SARS-CoV-2, spike protein, receptor-binding domain, phage display, monoclonal antibody, cytomegalovirus, peptide/major histocompatibility complex class I complex, T-cell-receptor-like antibody, affinity maturation, yeast surface display, combinatorial antibody library, agonist antibody, cell fate, bispecific antibodies, bioassays, mechanisms of action, binding assays, potency assays, atherosclerosis, inflammation, antibody therapy, blood–brain barrier, antibody, pharmacokinetics, disposition, biochemical and physicochemical properties, Fc binding, receptor-mediated transcytosis, brain shuttle, molecular Trojan horse, transferrin, anti-cancer antibody, antibody engineering, biophysical properties, computational methods, research cell bank, antibody therapeutics, recombinant antibodies, intracellular antibodies, single-chain antibody fragment, nanobody, Human papillomaviruses, HPV oncoproteins, HPV-associated cancer, HPV cancer therapy, asthma, refractory asthma, biomarker, Research and information: general, Chemistry

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/87408
https://mdpi.com/books/pdfview/book/5595

Editorial: Does selection against autoreactive B cells limit affinity maturation to pathogens?

Authors: Marilyn Diaz, Laurent Verkoczy

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: somatic hypermutation, B cells, autoreactive, affinity maturation, HIV-1, influenza, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294532/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b0f881139a8a4b81971a3fc28bc8ac0a