FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

Authors: Maheedhar Kodali, Leelavathi N. Madhu, Venkata Sai Vashishta Kolla, Sahithi Attaluri, Charles Huard, Yogish Somayaji, Bing Shuai, Chase Jordan, Xiaolan Rao, Sanath Shetty, Ashok K. Shetty

Source: Military Medical Research, Vol 11, Iss 1, Pp 1-23 (2024)

Subject Terms: Gulf War Illness (GWI), Anhedonia, Activated microglia, Cannabidiol (CBD), Chronic neuroinflammation, Cognition, Medicine (General), R5-920, Military Science

File Description: electronic resource

Relation: https://doaj.org/toc/2054-9369

Access URL: https://doaj.org/article/bdbff770ddb04c3cb3105d2ca65a4300

Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus

Authors: Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar, Ashok K. Shetty

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-26 (2023)

Subject Terms: Activated microglia, Cognitive dysfunction, Extracellular vesicles, Human neural stem cells, Human pluripotent stem cells, NLRP3 inflammasomes, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/babb73ba873d43e5aaae3a4f6631489f

Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease

Authors: Ian A. Clark, Bryce Vissel

Source: Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)

Subject Terms: activated microglia, autocrine feedback loop, endometriosis pain, long COVID, post‐stroke, psychiatric states, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/763eeb788d654238b279b83006fefdff

Exploring the Role of Guanylate-Binding Protein-2 in Activated Microglia-Mediated Neuroinflammation and Neuronal Damage

Authors: Ji-Eun You, Eun-Ji Kim, Ho Won Kim, Jong-Seok Kim, Kyunggon Kim, Pyung-Hwan Kim

Source: Biomedicines, Vol 12, Iss 5, p 1130 (2024)

Subject Terms: neuron damage, guanylate-binding protein 2, immune response, activated microglia, neurodegenerative disease, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/5/1130; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b931d973b6bb4baa86fc6361cf048c98

Promise of metformin for preventing age-related cognitive dysfunction

Authors: Leelavathi N Madhu, Maheedhar Kodali, Ashok K Shetty

Source: Neural Regeneration Research, Vol 17, Iss 3, Pp 503-507 (2022)

Subject Terms: activated microglia, aging, autophagy, cognitive dysfunction, memory, metformin, mtor signaling, neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=503;epage=507;aulast=Madhu; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/840c5f97ce834c64ba0d1e33b827cc31

Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis

Authors: Danica Nheu, Olivia Ellen, Sining Ye, Ezgi Ozturk, Maurice Pagnin, Stephen Kertadjaja, Paschalis Theotokis, Nikolaos Grigoriadis, Catriona McLean, Steven Petratos

Source: Cells, Vol 11, Iss 23, p 3768 (2022)

Subject Terms: multiple sclerosis, microglia, microglial polarization, classically activated microglia, alternatively activated microglia, Nogo-A, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/23/3768; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/30b62862613640308024773349a1d419

Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo

Authors: M.S. Bobola, L. Chen, C.K. Ezeokeke, T.A. Olmstead, C. Nguyen, A. Sahota, R.G. Williams, P.D. Mourad

Source: Brain Stimulation, Vol 13, Iss 4, Pp 1014-1023 (2020)

Subject Terms: Alzheimer’s disease, near diagnostic ultrasound, activated microglia, cleared amyloid beta plaque, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X20300693; https://doaj.org/toc/1935-861X

Access URL: https://doaj.org/article/1fd1baffce2948e3b367c13892425aaf

HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

Authors: Xiao-Yu Sun, Teng Zheng, Xiu Yang, Le Liu, Shen-Shen Gao, Han-Bing Xu, Yu-Tong Song, Kun Tong, Li Yang, Ya Gao, Tong Wu, Jing-Ru Hao, Chen Lu, Tao Ma, Can Gao

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)

Subject Terms: Activated microglia, Cognitive impairment, HDAC2, Isoflurane, Lipopolysaccharide, Neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/edac6ef67a28415cb03534d6a89efc7f

Expression and localization of absent in melanoma 2 in the injured spinal cord

Authors: Sai-Nan Wang, Xue-Yan Guo, Jie Tang, Shu-Qin Ding, Lin Shen, Rui Wang, Shan-Feng Ma, Jian-Guo Hu, He-Zuo Lü

Source: Neural Regeneration Research, Vol 14, Iss 3, Pp 542-552 (2019)

Subject Terms: nerve regeneration, spinal cord injury, absent in melanoma 2, spatio-temporal expression, neurons, astrocytes, oligodendrocytes, infiltrated leukocytes, activated microglia, western blot assay, immunohistochemistry, neural regeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=542;epage=552;aulast=Wang; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/29e2d5ba6b924690b4f7017a6a07c61f

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Authors: Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirths

Source: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)

Subject Terms: Alzheimer’s disease (AD), Glycoprotein nonmetastatic melanoma protein B (GPNMB), Neuroinflammation, Activated microglia, Sporadic AD patients, Transgenic mice, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-018-0612-3; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/f5c9a902a8144fa4878aa4d1c4c44cdb

Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimer’s Disease Model

Authors: Alejandro Lillo, Iu Raïch, Jaume Lillo, Catalina Pérez-Olives, Gemma Navarro, Rafael Franco

Source: Biomedicines, Vol 10, Iss 2, p 214 (2022)

Subject Terms: neuroinflammation, neurodegenerative disease, dementia, G protein-coupled receptor, activated microglia, purinergic signaling, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/214; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/f2551f84dee24d1caf98b7f5feb01129

Inhibiting the kynurenine pathway in spinal cord injury: Multiple therapeutic potentials?

Authors: Kelly R Jacobs, David B Lovejoy

Source: Neural Regeneration Research, Vol 13, Iss 12, Pp 2073-2076 (2018)

Subject Terms: spinal cord injury, neuroinflammation, kynurenine pathway, activated microglia, infiltrating macrophages, quinolinic acid, neuropsychiatry, depression, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2073;epage=2076;aulast=Jacobs; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/93618dbe80e8494d8a1ab4d5f9a60c6a

LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats

Authors: Fang, T., Zhou, D., Lu, L., Tong, X., Wu, J., Yi, L.

Source: Brazilian Journal of Medical and Biological Research. January 2016 49(9)

Subject Terms: Inflammation, Activated microglia, Ischemic stroke, Integrin αvβ3, TNF-α

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000900602

Ganglioside accumulation in activated glia in the developing brain: comparison between WT and GalNAcT KO mice

Authors: Mariko Saito, Gusheng Wu, Maria Hui, Kurt Masiello, Kostantin Dobrenis, Robert W. Ledeen, Mitsuo Saito

Source: Journal of Lipid Research, Vol 56, Iss 8, Pp 1434-1448 (2015)

Subject Terms: brain lipids, ethanol, inflammation, GM2/GD2 synthase knockout mice, activated microglia, astrocyte, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520355218; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/547db53b676e481eb8266ffec9b5cbf4

LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats

Authors: T. Fang, D. Zhou, L. Lu, X. Tong, J. Wu, L. Yi

Source: Brazilian Journal of Medical and Biological Research, Vol 49, Iss 9 (2016)

Subject Terms: Inflammation, Activated microglia, Ischemic stroke, Integrin αvβ3, TNF-α, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000900602&lng=en&tlng=en; https://doaj.org/toc/1414-431X

Access URL: https://doaj.org/article/28c6fb9504b44d4d8dc8d70fa1c7c378

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

Authors: Yossef Alnasser, Siva P. Kambhampati, Elizabeth Nance, Labchan Rajbhandari, Shiva Shrestha, Arun Venkatesan, Rangaramanujam M. Kannan, Sujatha Kannan

Source: Molecules, Vol 23, Iss 5, p 1025 (2018)

Subject Terms: PAMAM hydroxyl dendrimers, activated microglia, mixed primary glial cultures, intracellular trafficking, enhanced cellular uptake, neuroinflammation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/5/1025; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/84b2d843f0c34a0ba8508d4038c1716f

Expression and contributions of the Kir2.1 inward-rectifier K+ channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states

Authors: Doris eLam, Lyanne eSchlichter

Source: Frontiers in Cellular Neuroscience, Vol 9 (2015)

Subject Terms: KCNJ2, CRAC channels, microglial migration, Microglial proliferation, alternative-activated microglia, interleukin-4 stimulation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00185/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/30bcd8a066da4472b5d734c7431439d1

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