Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

Authors: Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

Source: Molecular Neurodegeneration, Vol 20, Iss 1, Pp 1-26 (2025)

Subject Terms: Alzheimer’s disease, Senescence, ABCA1, Caveolin-1, Cholesterol, Lysosome, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/a54f42427b0941998a14c6fa6eba3077

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

Authors: Dan Liu, Jie Wang, Shuangshuang Zhang, Hongfei Jiang, Yudong Wu, Chao Wang, Wujun Chen

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: atherosclerosis, cholesterol efflux, ARL4C, ABCA1, agent development, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1513340/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/c8d800e4e17741cc8b57bd10eb126d1c

Electroacupuncture reduces inflammatory damage following cerebral ischemia–reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia

Authors: Yu-sha Liao, Tie-chun Zhang, Yu-qi Tang, Pei Yu, Ya-ning Liu, Jing Yuan, Ling Zhao

Source: Molecular Brain, Vol 17, Iss 1, Pp 1-13 (2024)

Subject Terms: Electroacupuncture, Cerebral ischemia/reperfusion injury, Efferocytosis, Microglia, Abca1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/769d6931c6be404c9c5c9f9dd43d1d1d

Induction of the intestinal membrane transporters ABCA1 and ABCG8 by 27-hydroxycholesterol through a redox mechanism

Authors: Noemi Iaia, Valerio Leoni, Giuseppe Poli, Fiorella Biasi

Source: Redox Experimental Medicine, Vol 2024, Iss 1, Pp 1-8 (2024)

Subject Terms: 27-hydroxycholesterol, abc transporters, abca1, abcg8, caco-2 cells, oxysterols, plant sterols, Physiology, QP1-981, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://rem.bioscientifica.com/view/journals/rem/2024/1/REM-24-0005.xml; https://doaj.org/toc/2755-158X

Access URL: https://doaj.org/article/7d8b854bdc9c42b8b4ec255345fd2b62

Association between high-density lipoprotein and functional outcome of ischemic stroke patients in a Taiwanese population

Authors: Ting-Chun Lin, Chun-Yao Huang, Yu-Ling Li, Hung-Yi Chiou, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Lung Chan, Li-Ming Lien, Huey-Juan Lin, Chu-Chien Lin, Yi-Chen Hsieh

Source: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-10 (2024)

Subject Terms: Epidemiology, Cholesterol, Prognosis, Restricted cubic spline regression, ABCA1, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1476-511X

Access URL: https://doaj.org/article/528e813c64784412a95a428103a7bef5

TFEB controls sensitivity to chemotherapy and immuno-killing in non-small cell lung cancer

Authors: Muhlis Akman, Ciro Monteleone, Gabriella Doronzo, Martina Godel, Francesca Napoli, Alessandra Merlini, Virginia Campani, Valeria Nele, Elisa Balmas, Tatiana Chontorotzea, Simona Fontana, Sabrina Digiovanni, Francesca Alice Barbu, Elena Astanina, Niloufar Jafari, Iris Chiara Salaroglio, Joanna Kopecka, Giuseppe De Rosa, Thomas Mohr, Alessandro Bertero, Luisella Righi, Silvia Novello, Giorgio Vittorio Scagliotti, Federico Bussolino, Chiara Riganti

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)

Subject Terms: TFEB, Chemo-immuno-resistance, ABCC1, ABCA1, Vγ9Vδ2 T-lymphocytes, Non-small cell lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4a6851a8a8824044acb7cc89ddb408bf

Adipocyte ABCA1 expression analysis using flow cytometry

Authors: Sakshi Shukla, Ashutosh Bansal, Sandeep Aggarwal, Archna Singh

Source: BioTechniques, Vol 76, Iss 8, Pp 405-410 (2024)

Subject Terms: ABCA1, adipocytes, adipose tissue, BMI, flow cytometry, gating, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/5d8e70bd934946f183ff529f878d0721

Calliloboapins A-L, diterpenoids from the branches and leaves of Callicarpa loboapiculata and their biological activities

Authors: Liu, Ting ¹, Wu, Xiao-Lu ¹, Fu, Yu-Xia, Ding, Tao, Ning, De-Sheng, Pan, Zheng-Hong ^⁎

Source: In Bioorganic Chemistry March 2025 156

Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice

Authors: Linhui Zhang, Haixia Wang, Zishan Wang, Jianyi Xu, Mengyuan Wang, Wenxin Wang, Qiongshan He, Yun Yu, Dongping Yuan, Guirong Bu, Runze Qiu, Jun Long

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: atherosclerosis, resveratrol, dendritic cells, T cells, cholesterol efflux, ABCA1, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1450898/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/380e3a7956954bbc87e4cfe009f70f7e

Metabolomics integrated genomics approach: Understanding multidrug resistance phenotype in MCF-7 breast cancer cells exposed to doxorubicin and ABCA1/EGFR/PI3k/PTEN crosstalk

Authors: Kadry, Mai O. ^{a, ⁎}, Abd-Ellatef, Gamal Eldein Fathy ^a, Ammar, Naglaa M. ^a, Hassan, Heba A. ^a, Hussein, Noha S. ^a, Kamel, Nahla N. ^a, Soltan, Maha M. ^b, Abdel-Megeed, Rehab M. ^a, Abdel-Hamid, Abdel-Hamid Z. ^a

Source: In Toxicology Reports June 2025 14

miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1

Authors: Zhilin Ou, Yongquan Cheng, Hao Ma, Kai Chen, Qiong Lin, Jiayu Chen, Ruqin Guo, Zhiping Huang, Qixian Cheng, Nima Alaeiilkhchi, Qingan Zhu, Zucheng Huang, Hui Jiang

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)

Subject Terms: Spinal cord injury (SCI), Microglia, Lipid droplets, miR-223, ATP-binding cassette transporter A1 (ABCA1), Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1ccc7e99bc21401fa5c0b94cd36c8729

Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1

Authors: Shujiang Zhuo, Sufei Song, Chaoyi Wang, Zhe Wang, Ming Zhang, Daobin Lin, Kaili Chen

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Inflammatory corpuscle, Atherosclerosis, AIM2, ABCA1, Cholesterol efflux, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/acb1afe6495246ac945ce74b88e72f82

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1

Authors: Sarkar, Snigdha ¹, Morris, Jamie ², You, Youngki ¹, Sexmith, Hannah ³, Street, Scott E. ², Thibert, Stephanie M. ⁴, Attah, Isaac K. ¹, Hutchinson Bunch, Chelsea M. ¹, Novikova, Irina V. ⁴, Evans, James E. ⁴, Shah, Amy S. ³, Gordon, Scott M. ⁵, Segrest, Jere P. ⁶, Bornfeldt, Karin E. ⁷, Vaisar, Tomas ⁷, Heinecke, Jay W. ⁷, Davidson, W. Sean ^{2, ∗}, Melchior, John T. ^{1, 2, 8, ∗}

Source: In Journal of Lipid Research December 2024 65(12)

miR-3529-3p/ABCA1 axis regulates smooth muscle cell homeostasis by enhancing inflammation via JAK2/STAT3 pathway

Authors: Tingyu Wang, You Yu, Yinglong Ding, Ziying Yang, Shumin Jiang, Faxiong Gao, Shan Liu, Lianbo Shao, Zhenya Shen

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: thoracic aortic dissection, smooth muscle cell, homeostasis, miR-3529-3p, ABCA1, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1441123/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/0054267349e34d8e8893eb1051626dad

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway

Authors: Mingliang Zhong, Zhenyu Wu, Zhixi Chen, Longhuo Wu, Jianguo Zhou

Source: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-12 (2024)

Subject Terms: Osteoporosis, Endoplasmic reticulum stress, Cholesterol, Geniposide, GLP-1R, ABCA1, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/556b5d2df53444e9b662809256fe3a4c

Dapagliflozin improves podocytes injury in diabetic nephropathy via regulating cholesterol balance through KLF5 targeting the ABCA1 signalling pathway

Authors: Jingshu Sun, Xinyu Zhang, Simeng Wang, Dandan Chen, Jianqiang Shu, Nannan Chong, Qinglian Wang, Ying Xu

Source: Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-12 (2024)

Subject Terms: Dapagliflozin, Diabetic Nephropathy, Cholesterol, KLF-5, ABCA1, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/0d90c73a04714e699fb22707e5404dd8

Exosome-Mediated Transfer of X-Motif-Tagged Anti-MiR-33a-5p Antagomirs to the Medial Cells of Transduced Rabbit Carotid Arteries

Authors: Goren Saenz-Pipaon, Bradley K. Wacker, Lianxiang Bi, Alexis Stamatikos, David A. Dichek

Source: Biology, Vol 13, Iss 12, p 965 (2024)

Subject Terms: antagomir, X-motif, exosome, MiR-33a-5p, ABCA1, vascular, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/13/12/965; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/63a4fc4dd4cf4b17b48a0da71fc52305

Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance

Authors: Beibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng

Source: Neural Regeneration Research, Vol 20, Iss 3, Pp 695-714 (2023)

Subject Terms: abca1, alzheimer’s disease, amyloid-beta, apolipoprotein e, cholesterol metabolism, liver, liver x receptor, low-density lipoprotein receptor-related protein 1, peripheral clearance, tauroursodeoxycholic acid, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/1673-5374.391305; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

Access URL: https://doaj.org/article/548fec7ed7264a1f9707fc01ec234d71

Association of ABCA1 gene with Coronary Artery Disease (CAD): an overview

Authors: Tanu Yadav, Arti Yadav, Asif Jafri, Suchit Swaroop

Source: Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-8 (2023)

Subject Terms: Coronary artery disease, ABCA1 gene, Nucleotide binding domain, Polymorphic variants, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2090-2441

Access URL: https://doaj.org/article/04718fabd4254bae94b3745f1b121dda

Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma

Authors: Kaiyu Shen, Shuaiyi Ke, Binyu Chen, Wencang Gao

Source: Discover Oncology, Vol 14, Iss 1, Pp 1-25 (2023)

Subject Terms: ABCA1, Gastric adenocarcinoma, Bioinformatics, Biomarker, Tumor-Associated macrophages, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/305e6cb3e08c4b82a9c1ada8f8f9d1ad