WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome

Authors: Zwi N. Berneman, Maxime De Laere, Paul Germonpré, Manon T. Huizing, Yannick Willemen, Eva Lion, Hans De Reu, Jolien Van den Bossche, Jan Van den Brande, Pol Specenier, Sevilay Altintas, Peter A. van Dam, Nathalie Cools, Griet Nijs, Barbara Stein, Kim Caluwaerts, Annemiek Snoeckx, Bart Op de Beeck, Kirsten Saevels, Lynn Rutsaert, Irma Vandenbosch, Gizem Oner, Martin Lammens, Pierre Van Damme, Sian Llewellyn-Lacey, David A. Price, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Marie M. Couttenye, Ann L. Van de Velde, Viggo F. Van Tendeloo, Marc Peeters, Sébastien Anguille, Evelien L.J.M. Smits

Source: Journal of Hematology & Oncology, Vol 18, Iss 1, Pp 1-6 (2025)

Subject Terms: mRNA, Wilms’ tumor protein, Dendritic cell vaccination, Solid tumors, Cancer immunotherapy, Clinical trial, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/0ae8ea1de1be4c3ba10f3ed38e333bc6

Correction: WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome

Authors: Zwi N. Berneman, Maxime De Laere, Paul Germonpré, Manon T. Huizing, Yannick Willemen, Eva Lion, Hans De Reu, Jolien Van den Bossche, Jan Van den Brande, Pol Specenier, Sevilay Altintas, Peter A. van Dam, Nathalie Cools, Griet Nijs, Barbara Stein, Kim Caluwaerts, Annemiek Snoeckx, Bart Op de Beeck, Kirsten Saevels, Lynn Rutsaert, Irma Vandenbosch, Gizem Oner, Martin Lammens, Pierre Van Damme, Sian Llewellyn-Lacey, David A. Price, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Marie M. Couttenye, Ann L. Van de Velde, Viggo F. Van Tendeloo, Marc Peeters, Sébastien Anguille, Evelien L. J. M. Smits

Source: Journal of Hematology & Oncology, Vol 18, Iss 1, Pp 1-2 (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/717c7570fb634b8ea29fe329fd94ac7a

Effectiveness and Safety of Ibrutinib for Chronic Lymphocytic Leukemia in Routine Clinical Practice: 3-Year Follow-up of the Belgian Ibrutinib Real-World Data (BiRD) Study

Authors: Ann Janssens, Zwi N. Berneman, Fritz Offner, Sylvia Snauwaert, Philippe Mineur, Gaetan Vanstraelen, Stef Meers, Isabelle Spoormans, Dominique Bron, Isabelle Vande Broek, Charlotte Van Bogaert, Birgit De Beleyr, Ann Smet, Lasse Nielsen, Robert Wapenaar, Marc André

Source: Clinical Hematology International, Vol 4, Iss 4, Pp 133-143 (2022)

Subject Terms: Ibrutinib, Chronic lymphocytic leukemia, Belgium, Real-world evidence, Effectiveness, Safety, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2590-0048

Access URL: https://doaj.org/article/246e8f0b6ff948258a81b9155851b6fa

Two for one: targeting BCMA and CD19 in B-cell malignancies with off-the-shelf dual-CAR NK-92 cells

Authors: Gils Roex, Diana Campillo-Davo, Donovan Flumens, Philip Anthony Gilbert Shaw, Laurens Krekelbergh, Hans De Reu, Zwi N. Berneman, Eva Lion, Sébastien Anguille

Source: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)

Subject Terms: Bispecific, Dual, Chimeric antigen receptor, NK-92, Off-the-shelf, Leukemia, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/05c1c30b2722445782796239a7b077f8

In vitro expansion of Wilms’ tumor protein 1 epitope-specific primary T cells from healthy human peripheral blood mononuclear cells

Authors: Sanne van der Heijden, Donovan Flumens, Maarten Versteven, Stefanie Peeters, Hans De Reu, Diana Campillo-Davo, Yannick Willemen, Benson Ogunjimi, Viggo Van Tendeloo, Zwi N. Berneman, Sébastien Anguille, Evelien Smits, Eva Lion

Source: STAR Protocols, Vol 4, Iss 1, Pp 102053- (2023)

Subject Terms: Cell Biology, Cell Culture, Cell Isolation, Flow Cytometry/Mass Cytometry, Cancer, Health Sciences, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723000114; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/00e507c283384e738fce78407e768998

A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy

Authors: Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)

Subject Terms: Poly(I:C), Poly-ICLC (Hiltonol), Glioblastoma, Immunotherapy, Immune checkpoint, Vaccination, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4e74d57df4f94a0fbb9a416bc7ae9cce

Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma

Authors: Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo, Sébastien Anguille

Source: Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)

Subject Terms: BCMA, CAR-T, Multiple myeloma, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/c5abce8e1fbc403397769e67dc74eb91

Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis

Authors: Jessy Elst, Leander P. De Puysseleyr, Didier G. Ebo, Margaretha A. Faber, Athina L. Van Gasse, Marie-Line M. van der Poorten, Ine I. Decuyper, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Luc S. De Clerck, Anke Verlinden, Katrien Vermeulen, Marie-Berthe Maes, Zwi N. Berneman, Peter Valent, Vito Sabato

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: human mast cell, mastocytosis, clonal mast cell disorder, MRGPRX2, FcεRI, flow cytometry, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835618/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/49b22f518563410cb3221eb71e2e21b6

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Authors: Judith Derdelinckx, María José Mansilla, Maxime De Laere, Wai-Ping Lee, Juan Navarro-Barriuso, Inez Wens, Irene Nkansah, Jasmijn Daans, Hans De Reu, Aneta Jolanta Keliris, Johan Van Audekerke, Verdi Vanreusel, Zoë Pieters, Annemie Van der Linden, Marleen Verhoye, Geert Molenberghs, Niel Hens, Herman Goossens, Barbara Willekens, Patrick Cras, Peter Ponsaerts, Zwi N. Berneman, Eva María Martínez-Cáceres, Nathalie Cools

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-20 (2019)

Subject Terms: Messenger RNA electroporation, Tolerogenic dendritic cells, Antigen-specific treatment, Experimental autoimmune encephalomyelitis, Multiple sclerosis, Tolerance induction, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-019-1541-1; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/2366a29bc50643d4a9477ae81546bc64

Antigen-Specific Treatment Modalities in MS: The Past, the Present, and the Future

Authors: Judith Derdelinckx, Patrick Cras, Zwi N. Berneman, Nathalie Cools

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: multiple sclerosis, antigen-specific therapy, tolerance induction, myelin, experimental autoimmune encephalomyelitis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.624685/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/802075c01ae84ab495874bf2c3612acc

Adult acute precursor B-cell lymphoblastic leukemia presenting as hypercalcemia and osteolytic bone lesions

Authors: Nikki Charlotta Paul Granacher, Zwi N. Berneman, Wilfried Schroyens, Ann L. R. Van de Velde, Anke Verlinden, Alain P. A. Gadisseur

Source: Experimental Hematology & Oncology, Vol 6, Iss 1, Pp 1-4 (2017)

Subject Terms: Adult precursor B-cell lymphoblastic leukemia, Case report, Hypercalcemia, Osteolysis, Philadelphia chromosome, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40164-017-0071-8; https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/d532421bfba3440885d27fff29bba382

Chimeric Antigen Receptor-Modified T Cell Therapy in Multiple Myeloma: Beyond B Cell Maturation Antigen

Authors: Marijke Timmers, Gils Roex, Yuedi Wang, Diana Campillo-Davo, Viggo F. I. Van Tendeloo, Yiwei Chu, Zwi N. Berneman, Feifei Luo, Heleen H. Van Acker, Sébastien Anguille

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: chimeric antigen receptor-modified T cells, immunotherapy, multiple myeloma, B cell maturation antigen, CD19, CD138, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01613/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/49a4a6c44b2845dd97520781fda0d3e9

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

Authors: Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Johan M. Van den Bergh, Zwi N. Berneman, Eva Lion, Evelien L. Smits, Viggo F. Van Tendeloo

Source: Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-13 (2016)

Subject Terms: Adoptive transfer, Expansion protocol, Gamma delta T cells, Interleukin-15, Leukemia, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-016-0329-3; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/78513684ceb64217ab35ff0dd5af55bf

The Ins and Outs of Messenger RNA Electroporation for Physical Gene Delivery in Immune Cell-Based Therapy

Authors: Diana Campillo-Davo, Maxime De Laere, Gils Roex, Maarten Versteven, Donovan Flumens, Zwi N. Berneman, Viggo F. I. Van Tendeloo, Sébastien Anguille, Eva Lion

Source: Pharmaceutics, Vol 13, Iss 3, p 396 (2021)

Subject Terms: messenger RNA, gene delivery, electroporation, in vitro transcription, immune cell-based therapy, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/3/396; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/54fd5dcca621443087718cd1a5b2ab14

HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients

Authors: Judith Derdelinckx, Irene Nkansah, Naomi Ooms, Laura Van Bruggen, Marie-Paule Emonds, Liesbeth Daniëls, Tatjana Reynders, Barbara Willekens, Patrick Cras, Zwi N. Berneman, Nathalie Cools

Source: Cells, Vol 9, Iss 12, p 2703 (2020)

Subject Terms: multiple sclerosis, myelin responsiveness, HLA class II genotype, antigen-specific treatment, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/12/2703; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/df725cb8ea9d4360bbda100bfeb77d97

Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing

Authors: Diana Campillo-Davo, Fumihiro Fujiki, Johan M. J. Van den Bergh, Hans De Reu, Evelien L. J. M. Smits, Herman Goossens, Haruo Sugiyama, Eva Lion, Zwi N. Berneman, Viggo Van Tendeloo

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: TCR-gene transfer, electroporation, adoptive cell therapy (ACT), DsiRNA, RNA transfection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.02503/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c139e17698ca4d20b686af4b4ae43c01

Interleukin-15-Cultured Dendritic Cells Enhance Anti-Tumor Gamma Delta T Cell Functions through IL-15 Secretion

Authors: Heleen H. Van Acker, Sébastien Anguille, Hans De Reu, Zwi N. Berneman, Evelien L. Smits, Viggo F. Van Tendeloo

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: acute myeloid leukemia, γδ T cells, dendritic cell vaccination, immunotherapy, interleukin-15, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00658/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ac2662fbd1d4484f89909cd52dfe0ef5

12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

Authors: Nathalie Deckx, Inez Wens, Amber H. Nuyts, Niel Hens, Benedicte Y. De Winter, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

Source: Mediators of Inflammation, Vol 2016 (2016)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/1f55628894894e88aa73c97c55b40107

Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens

Authors: Wai-Ping Lee, Barbara Willekens, Patrick Cras, Herman Goossens, Eva Martínez-Cáceres, Zwi N. Berneman, Nathalie Cools

Source: Journal of Immunology Research, Vol 2016 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156

Access URL: https://doaj.org/article/6264d69ec1d24dbdaa62bd9654ac28ea

Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis

Authors: Nathalie Deckx, Inez Wens, Amber H. Nuyts, Wai-Ping Lee, Niel Hens, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

Source: Mediators of Inflammation, Vol 2015 (2015)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/10dd4fc80e894eec86711b10d6d433c5