New directions in neurosteroid therapeutics in neuropsychiatry

Authors: Zorumski, Charles F. ^{a, d, ⁎}, Covey, Douglas F. ^{a, b, c, d}, Izumi, Yukitoshi ^{a, d}, Evers, Alex S. ^{b, c, d}, Maguire, Jamie L. ^e, Mennerick, Steven J. ^d

Source: In Neuroscience and Biobehavioral Reviews May 2025 172

The Taylor Family Institute at Washington University: Novel Treatments in Psychiatry

Authors: Zorumski, Charles F., Mennerick, Steven J.

Source: Missouri medicine. 120(4):299-305

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633366388&indx=1&recIds=ETOCRN633366388

Persistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation

Authors: Palanca, Ben Julian A., Conway, Charles R., Zeffiro, Thomas, Gott, Britt M., Nguyen, Thomas, Janski, Alvin, Jain, Nisha, Komen, Helga, Burke, Broc A., Zorumski, Charles F., Nagele, Peter

Source: In Biological Psychiatry Global Open Science October 2023 3(4):698-704

Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways

Authors: Jong, Yuh-Jiin I., Izumi, Yukitoshi, Harmon, Steven K., Zorumski, Charles F., ÓMalley, Karen L.

Source: In Journal of Biological Chemistry August 2023 299(8)

Neurosteroid enantiomers as potentially novel neurotherapeutics

Authors: Covey, Douglas F., Evers, Alex S., Izumi, Yukitoshi, Maguire, Jamie L., Mennerick, Steven J., Zorumski, Charles F.

Source: In Neuroscience and Biobehavioral Reviews June 2023 149

Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus

Authors: Izumi, Yukitoshi, Hsu, Fong-Fu, Conway, Charles R., Nagele, Peter, Mennerick, Steven J., Zorumski, Charles F.

Source: In Biological Psychiatry 15 December 2022 92(12):964-972

Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses.

Authors: Izumi, Yukitoshi, O'Dell, Kazuko A., Mennerick, Steven, Zorumski, Charles F.

Source: Scientific Reports; 2/20/2025, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: LONG-term potentiation, INTERLEUKIN-1 receptors, NEUROPLASTICITY, MEDICAL sciences, NLRP3 protein, HEBBIAN memory

Electroconvulsive therapy in treatment resistant depression

Authors: Subramanian, Subha, Lopez, Ruthzaine, Zorumski, Charles F., Cristancho, Pilar

Source: In Journal of the Neurological Sciences 15 March 2022 434

Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity

Authors: Frye, Hannah E., Izumi, Yukitoshi, Harris, Alexis N., Williams, Sidney B., Trousdale, Christopher R., Sun, Min-Yu, Sauerbeck, Andrew D., Kummer, Terrance T., Mennerick, Steven, Zorumski, Charles F., Nelson, Elliot C., Dougherty, Joseph D., Morón, Jose A.

Source: In Biological Psychiatry 1 December 2021 90(11):766-780

Ethanol, neurosteroids and cellular stress responses: Impact on central nervous system toxicity, inflammation and autophagy

Authors: Fujii, Chika, Zorumski, Charles F., Izumi, Yukitoshi ^*

Source: In Neuroscience and Biobehavioral Reviews May 2021 124:168-178

Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-D-Aspartate Receptors, Long-Term Potentiation, and Learning

Authors: Izumi, Yukitoshi, Mennerick, Steven J., Doherty, James J., Zorumski, Charles F. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2021 377(1):181-188

A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors

Authors: Ziolkowski, Luke, Mordukhovich, Isaac, Chen, Daniel M., Chisari, Mariangela, Shu, Hong-Jin, Lambert, Peter M., Qian, Mingxing, Zorumski, Charles F., Covey, Douglas F., Mennerick, Steven

Source: In Neuropharmacology 1 February 2021 183

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

Authors: Ishikawa, Makoto, Takaseki, Sanae, Yoshitomi, Takeshi, Covey, Douglas F., Zorumski, Charles F., Izumi, Yukitoshi

Source: Autophagy. 17(3):743-760

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117854420.0x000001&indx=1&recIds=ETOCvdc_100117854420.0x000001

Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids.

Authors: Izumi, Yukitoshi, Reiersen, Angela M., Lenze, Eric J., Mennerick, Steven J., Zorumski, Charles F.

Source: Translational Psychiatry; 11/21/2024, Vol. 14 Issue 1, p1-11, 11p

Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment.

Authors: Yukitoshi Izumi, O’Dell, Kazuko A., Zorumski, Charles F.

Source: Neural Regeneration Research; Oct2024, Vol. 19 Issue 10, p2212-2218, 7p

Endoplasmic reticulum stress, autophagy, neuroinflammation, and sigma 1 receptors as contributors to depression and its treatment.

Authors: Chika Fujii, Zorumski, Charles F., Yukitoshi Izumi

Source: Neural Regeneration Research; Oct2024, Vol. 19 Issue 10, p2202-2211, 10p

Inhibitors of cellular stress overcome acute effects of ethanol on hippocampal plasticity and learning

Authors: Izumi, Yukitoshi, Zorumski, Charles F.

Source: In Neurobiology of Disease July 2020 141

Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents

Authors: Kalmoe, Molly C., Janski, Alvin M., Zorumski, Charles F., Nagele, Peter, Palanca, Ben J., Conway, Charles R.

Source: In Journal of the Neurological Sciences 15 May 2020 412

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Authors: Zorumski, Charles F., Paul, Steven M., Covey, Douglas F., Mennerick, Steven

Source: In Neurobiology of Stress November 2019 11

Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment

Authors: Maloney, Susan E., Creeley, Catherine E., Hartman, Richard E., Yuede, Carla M., Zorumski, Charles F., Jevtovic-Todorovic, Vesna, Dikranian, Krikor, Noguchi, Kevin K., Farber, Nuri B., Wozniak, David F.

Source: In Neurobiology of Learning and Memory November 2019 165