Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

Authors: Gerrick, Elias R., Zlitni, Soumaya, West, Patrick T., Carter, Matthew M., Mechler, Claire M., Olm, Matthew R., Caffrey, Elisa B., Li, Jessica A., Higginbottom, Steven K., Severyn, Christopher J., Kracke, Frauke, Spormann, Alfred M., Sonnenburg, Justin L., Bhatt, Ami S., Howitt, Michael R.

Source: In Cell 4 January 2024 187(1):62-78

Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection

Authors: Natarajan, Aravind, Zlitni, Soumaya, Brooks, Erin F., Vance, Summer E., Dahlen, Alex, Hedlin, Haley, Park, Ryan M., Han, Alvin, Schmidtke, Danica T., Verma, Renu, Jacobson, Karen B., Parsonnet, Julie, Bonilla, Hector F., Singh, Upinder, Pinsky, Benjamin A., Andrews, Jason R., Jagannathan, Prasanna, Bhatt, Ami S.

Source: In Med 10 June 2022 3(6):371-387

Gut microbiota impairs insulin clearance in obese mice

Authors: Foley, Kevin P., Zlitni, Soumaya, Duggan, Brittany M., Barra, Nicole G., Anhê, Fernando F., Cavallari, Joseph F., Henriksbo, Brandyn D., Chen, Cassandra Y., Huang, Michael, Lau, Trevor C., Plante, Roxanne, Schwab, Michael, Marette, André, Schertzer, Jonathan D.

Source: In Molecular Metabolism December 2020 42

Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes

Authors: Sberro, Hila, Fremin, Brayon J., Zlitni, Soumaya, Edfors, Fredrik, Greenfield, Nicholas, Snyder, Michael P., Pavlopoulos, Georgios A., Kyrpides, Nikos C., Bhatt, Ami S.

Source: In Cell 22 August 2019 178(5):1245-1259

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

Authors: Carfrae, Lindsey A., MacNair, Craig R., Brown, Christopher M., Tsai, Caressa N., Weber, Brent S., Zlitni, Soumaya, Rao, Vishwas N., Chun, Joshua, Junop, Murray S., Coombes, Brian K., Brown, Eric D.

Source: Nature microbiology. 5(1):93-101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193509465.0x000001&indx=1&recIds=ETOCvdc_100193509465.0x000001

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

Authors: Carfrae, Lindsey A., MacNair, Craig R., Brown, Christopher M., Tsai, Caressa N., Weber, Brent S., Zlitni, Soumaya, Rao, Vishwas N., Chun, Joshua, Junop, Murray S., Coombes, Brian K., Brown, Eric D.

Source: Nature microbiology. 5(1):93-101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130016302.0x000001&indx=1&recIds=ETOCvdc_100130016302.0x000001

Life‐long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents

Authors: Anhê, Fernando F., Zlitni, Soumaya, Barra, Nicole G., Foley, Kevin P., Nilsson, Mats I., Nederveen, Joshua P., Koch, Lauren G., Britton, Steven L., Tarnopolsky, Mark A., Schertzer, Jonathan D.

Source: Physiological reports. 10(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163880967.0x000001&indx=1&recIds=ETOCvdc_100163880967.0x000001

Strain-resolved microbiome sequencing reveals mobile elements that drive bacterial competition on a clinical timescale.

Authors: Zlitni, Soumaya^1,2 (AUTHOR), Bishara, Alex^1,3 (AUTHOR), Moss, Eli L.^1,2 (AUTHOR), Tkachenko, Ekaterina^1,2 (AUTHOR), Kang, Joyce B.⁴ (AUTHOR), Culver, Rebecca N.¹ (AUTHOR), Andermann, Tessa M.⁵ (AUTHOR), Weng, Ziming⁶ (AUTHOR), Wood, Christina⁷ (AUTHOR), Handy, Christine⁷ (AUTHOR), Ji, Hanlee P.⁷ (AUTHOR), Batzoglou, Serafim³ (AUTHOR), Bhatt, Ami S.^1,2 (AUTHOR) asbhatt@stanford.edu

Source: Genome Medicine. 5/29/2020, Vol. 12 Issue 1, p1-17. 17p.

Subject Terms: *COMPARATIVE genomics, *DRUG resistance in bacteria, *HUMAN microbiota, *GUT microbiome, *MICROBIAL genomes, *NUCLEOTIDE sequence, *BACTEROIDES, *FECAL analysis

Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity.

Authors: Anhê, Fernando F., Zlitni, Soumaya, Song-Yang Zhang, Choi, Béatrice So-Yun, Chen, Cassandra Y., Foley, Kevin P., Barra, Nicole G., Surette, Michael G., Biertho, Laurent, Richard, Denis, Tchernof, André, Lam, Tony K. T., Marette, Andre, Schertzer, Jonathan

Source: Gut; Mar2023, Vol. 72 Issue 3, p460-471, 12p

Subject Terms: GASTRIC bypass, FECAL microbiota transplantation, GUT microbiome, BARIATRIC surgery, HUMAN microbiota, WEIGHT loss, GLUCOSE

Mutations in C2orf37, Encoding a Nucleolar Protein, Cause Hypogonadism, Alopecia, Diabetes Mellitus, Mental Retardation, and Extrapyramidal Syndrome

Authors: Alazami, Anas M., Al-Saif, Amr, Al-Semari, Abdulaziz, Bohlega, Saeed, Zlitni, Soumaya, Alzahrani, Fatema, Bavi, Prashant, Kaya, Namik, Colak, Dilek, Khalak, Hanif, Baltus, Andy, Peterlin, Borut, Danda, Sumita, Bhatia, Kailash P., Schneider, Susanne A., Sakati, Nadia, Walsh, Christopher A., Al-Mohanna, Futwan, Meyer, Brian, Alkuraya, Fowzan S.

Source: In The American Journal of Human Genetics 12 December 2008 83(6):684-691

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

Authors: Foley, Kevin P., Zlitni, Soumaya, Denou, Emmanuel, Duggan, Brittany M., Chan, Rebecca W., Stearns, Jennifer C., Schertzer, Jonathan D.

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129872326.0x000001&indx=1&recIds=ETOCvdc_100129872326.0x000001

Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.

Authors: Natarajan, Aravind, Han, Alvin, Zlitni, Soumaya, Brooks, Erin F., Vance, Summer E., Wolfe, Marlene, Singh, Upinder, Jagannathan, Prasanna, Pinsky, Benjamin A., Boehm, Alexandria, Bhatt, Ami S.

Source: Nature Communications; 10/1/2021, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: SARS-CoV-2, EXTRACTION techniques, RNA, COVID-19, RESPIRATORY infections, RNA analysis, FECES

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.

Authors: Zlitni, Soumaya¹, Ferruccio, Lauren F², Brown, Eric D¹

Source: Nature Chemical Biology. Dec2013, Vol. 9 Issue 12, p796-804. 9p.

Subject Terms: *ANTIBACTERIAL agents, *DRUG metabolism, *DRUG development, *BIOCHEMICAL mechanism of action, *ESCHERICHIA coli, *BACTERIAL metabolites

NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice.

Authors: Cavallari, Joseph F., Pokrajac, Nenad T., Zlitni, Soumaya, Foley, Kevin P., Henriksbo, Brandyn D., Schertzer, Jonathan D.

Source: American Journal of Physiology: Endocrinology & Metabolism; Aug2020, Vol. 319 Issue 2, pE305-E314, 10p

Subject Terms: FATTY liver, GUT microbiome, MOUSE diseases, LIVER histology, BACTERIAL cell walls, LIVER cells, HEPATITIS

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

Authors: Pathania, Ranjana^1,2,3, Zlitni, Soumaya^1,2, Barker, Courtney^1,2, Das, Rahul⁴, Gerritsma, David A.^2,4, Lebert, Julie^2,4, Awuah, Emilia^2,4, Melacini, Giuseppe^1,4, Capretta, Fred A.^2,4, Brown, Eric D.^1,2 ebrown@mcmaster.ca

Source: Nature Chemical Biology. Nov2009, Vol. 5 Issue 11, p849-856. 8p. 1 Color Photograph, 2 Diagrams, 2 Charts, 1 Graph.

Subject Terms: *ANTIBACTERIAL agents, *MOLECULAR genetics, *BACTERIAL genetics, *ESCHERICHIA coli, *PSEUDOMONAS aeruginosa, *BACTERIAL growth, *MICROBIAL metabolites, *LIPOPROTEIN drug carriers

Weaponized metabolites? Salmonella versus macrophage-produced succinate
Meeting on Microbial Pathogenesis & Host Response

Authors: Hersch, Steven J., Zlitni, Soumaya, Radan, Bojana, Ilyas, Bushra, Caudy, Amy A., Rosebrock, Adam P., Navarre, William W.

Source: Abstracts of papers presented at the ... meeting on microbial pathogenesis & host response. 1000004:125-125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN603300929&indx=1&recIds=ETOCCN603300929

Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA

Authors: Barker, Courtney A., Allison, Sarah E., Zlitni, Soumaya, Nguyen, Nick Duc, Das, Rahul, Melacini, Giuseppe, Capretta, Alfredo A., Brown, Eric D.

Source: In Bioorganic & Medicinal Chemistry Letters 15 April 2013 23(8):2426-2431

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Bugs as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease.

Authors: Zlitni, Soumaya¹, Bhatt, Ami S.¹ asbhatt@stanford.edu

Source: Emerging Infectious Diseases. Jul2019, Vol. 25 Issue 7, p1439-1439. 1p.

Subject Terms: *THERAPEUTICS, *PREVENTIVE medicine, *MICROORGANISMS, *EMERGING infectious diseases, *FECAL microbiota transplantation

Not as fab as we thought.

Authors: Zlitni, Soumaya, Brown, Eric D.

Source: Nature; March 5 2009, Vol. 458, p39-40, 2p