Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

Authors: Yan, Shixian, Schöpe, Paul Curtis, Lewis, Joe, Putzker, Kerstin, Uhrig, Ulrike, Specker, Edgar, von Kries, Jens Peter, Lindemann, Peter, Omran, Anahid, Sanchez-Ibarra, Hector E., Unger, Anke, Zischinsky, Mia-Lisa, Klebl, Bert, Walther, Wolfgang, Nazaré, Marc, Kobelt, Dennis, Stein, Ulrike

Source: In Biomedicine & Pharmacotherapy December 2023 168

A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation

Authors: Aarhus, Thomas Ihle, Eickhoff, Jan, Klebl, Bert, Unger, Anke, Boros, Joanna, Choidas, Axel, Zischinsky, Mia-Lisa, Wolowczyk, Camilla, Bjørkøy, Geir, Sundby, Eirik, Hoff, Bård Helge

Source: In European Journal of Medicinal Chemistry 5 July 2023 255

The Pseudo‐Natural Product Rhonin Targets RHOGDI

Authors: Akbarzadeh, Mohammad, Flegel, Jana, Patil, Sumersing, Shang, Erchang, Narayan, Rishikesh, Buchholzer, Marcel, Kazemein Jasemi, Neda S., Grigalunas, Michael, Krzyzanowski, Adrian, Abegg, Daniel, Shuster, Anton, Potowski, Marco, Karatas, Hacer, Karageorgis, George, Mosaddeghzadeh, Niloufar, Zischinsky, Mia‐Lisa, Merten, Christian, Golz, Christopher, Brieger, Lucas, Strohmann, Carsten, Antonchick, Andrey P., Janning, Petra, Adibekian, Alexander, Goody, Roger S., Ahmadian, Mohammad Reza, Ziegler, Slava, Waldmann, Herbert

Source: Angewandte Chemie. 134(18)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170797923.0x000001&indx=1&recIds=ETOCvdc_100170797923.0x000001

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein

Authors: Höing, Susanne, Yeh, Ting-Yu, Baumann, Matthias, Martinez, Nancy E., Habenberger, Peter, Kremer, Lea, Drexler, Hannes C.A., Küchler, Philipp, Reinhardt, Peter, Choidas, Axel, Zischinsky, Mia-Lisa, Zischinsky, Gunther, Nandini, Swaran, Ledray, Aaron P., Ketcham, Stephanie A., Reinhardt, Lydia, Abo-Rady, Masin, Glatza, Michael, King, Stephen J., Nussbaumer, Peter, Ziegler, Slava, Klebl, Bert, Schroer, Trina A., Schöler, Hans R., Waldmann, Herbert, Sterneckert, Jared

Source: Cell chemical biology. 25(4):357-369.e6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077946034.0x000001&indx=1&recIds=ETOCvdc_100077946034.0x000001

Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth.

Authors: Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina

Source: Journal of Experimental & Clinical Cancer Research (17569966); 1/20/2023, Vol. 42 Issue 1, p1-18, 18p

Subject Terms: HER2 positive breast cancer, CHOLINE, BREAST cancer, CANCER cells, SMALL molecules, GENE expression

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