Guiding ATR and PARP inhibitor combinations with chemogenomic screens

Authors: Zimmermann, Michal, Bernier, Cynthia, Kaiser, Beatrice, Fournier, Sara, Li, Li, Desjardins, Jessica, Skeldon, Alexander, Rimkunas, Victoria, Veloso, Artur, Young, Jordan T.F., Roulston, Anne, Zinda, Michael

Source: In Cell Reports 12 July 2022 40(2)

ATM Germline-Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics, and Potential Therapeutic Implications

Authors: El Jabbour, Tony, Misyura, Maksym, Cowzer, Darren, Zimmermann, Michal, Rimkunas, Victoria, Marra, Antonio, Derakhshan, Fatemeh, Selenica, Pier, Parilla, Megan, Setton, Jeremy S, Ceyhan-Birsoy, Ozge, Kemel, Yelena, Catchings, Amanda, Ranganathan, Megha, Ku, Geoffrey Y, Janjigian, Yelena Y, Zinda, Michael, Koehler, Maria, Stadler, Zsofia, Shia, Jinru, Reis-Filho, Jorge S, Mandelker, Diana

Source: Journal of the National Cancer Institute. 114(5):761-770

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152529139.0x000001&indx=1&recIds=ETOCvdc_100152529139.0x000001

A Genetic Map of the Response to DNA Damage in Human Cells

Authors: Olivieri, Michele, Cho, Tiffany, Álvarez-Quilón, Alejandro, Li, Kejiao, Schellenberg, Matthew J., Zimmermann, Michal, Hustedt, Nicole, Rossi, Silvia Emma, Adam, Salomé, Melo, Henrique, Heijink, Anne Margriet, Sastre-Moreno, Guillermo, Moatti, Nathalie, Szilard, Rachel K., McEwan, Andrea, Ling, Alexanda K., Serrano-Benitez, Almudena, Ubhi, Tajinder, Feng, Sumin, Pawling, Judy, Delgado-Sainz, Irene, Ferguson, Michael W., Dennis, James W., Brown, Grant W., Cortés-Ledesma, Felipe, Williams, R. Scott, Martin, Alberto, Xu, Dongyi, Durocher, Daniel

Source: In Cell 23 July 2020 182(2):481-496

Control of homologous recombination by the HROB—MCM8—MCM9 pathway

Authors: Hustedt, Nicole, Saito, Yuichiro, Zimmermann, Michal, Álvarez-Quilón, Alejandro, Setiaputra, Dheva, Adam, Salomé, McEwan, Andrea, Yuan, Jing Yi, Olivieri, Michele, Zhao, Yichao

Source: Genes & development. 33(19/20):1397-1415

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621927527&indx=1&recIds=ETOCRN621927527

Identifying chemogenetic interactions from CRISPR screens with drugZ

Authors: Colic, Medina, Wang, Gang, Zimmermann, Michal, Mascall, Keith, McLaughlin, Megan, Bertolet, Lori, Lenoir, W., Moffat, Jason, Angers, Stephane, Durocher, Daniel, Hart, Traver

Source: Genome medicine. 11(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189863774.0x000001&indx=1&recIds=ETOCvdc_100189863774.0x000001

Guiding ATR and PARP inhibitor combinationswith chemogenomic screens

Authors: Zimmermann, Michal, Bernier, Cynthia, Kaiser, Beatrice, Fournier, Sara, Li, Li, Desjardins, Jessica, Skeldon, Alexander, Rimkunas, Victoria, Veloso, Artur, Young, Jordan T.F., Roulston, Anne, Zinda, Michael

Source: Cell reports. 40(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168337046.0x000001&indx=1&recIds=ETOCvdc_100168337046.0x000001

The shieldin complex mediates 53BP1-dependent DNA repair

Authors: Noordermeer, Sylvie, Adam, Salomé, Setiaputra, Dheva, Barazas, Marco, Pettitt, Stephen, Ling, Alexanda, Olivieri, Michele, Álvarez-Quilón, Alejandro, Moatti, Nathalie, Zimmermann, Michal, Annunziato, Stefano, Krastev, Dragomir, Song, Feifei, Brandsma, Inger, Frankum, Jessica, Brough, Rachel, Sherker, Alana, Landry, Sébastien, Szilard, Rachel, Munro, Meagan, McEwan, Andrea, Goullet de Rugy, Théo, Lin, Zhen-Yuan, Hart, Traver, Moffat, Jason, Gingras, Anne-Claude, Martin, Alberto, Attikum, Haico, Jonkers, Jos, Lord, Christopher, Rottenberg, Sven, Durocher, Daniel

Source: Nature. 560(7716):117-121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174812332.0x000001&indx=1&recIds=ETOCvdc_100174812332.0x000001

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

Authors: Mirman, Zachary, Lottersberger, Francisca, Takai, Hiroyuki, Kibe, Tatsuya, Gong, Yi, Takai, Kaori, Bianchi, Alessandro, Zimmermann, Michal, Durocher, Daniel, Lange, Titia

Source: Nature. 560(7716):112-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174812423.0x000001&indx=1&recIds=ETOCvdc_100174812423.0x000001

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Authors: Zimmermann, Michal, Murina, Olga, Reijns, Martin, Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou, Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie, Hart, Traver, Bono, Johann, Stankovic, Tatjana, Jackson, Andrew, Durocher, Daniel

Source: Nature. 559(7713):285-289

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171353587.0x000001&indx=1&recIds=ETOCvdc_100171353587.0x000001

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres

Authors: Kibe, Tatsuya, Zimmermann, Michal, de Lange, Titia

Source: In Molecular Cell 21 January 2016 61(2):236-246

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Authors: Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R., MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P., Rissland, Olivia S., Durocher, Daniel, Angers, Stephane, Moffat, Jason

Source: In Cell 3 December 2015 163(6):1515-1526

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

Authors: Canny, Marella D, Moatti, Nathalie, Wan, Leo C K, Fradet-Turcotte, Amélie, Krasner, Danielle, Mateos-Gomez, Pedro A, Zimmermann, Michal, Orthwein, Alexandre, Juang, Yu-Chi, Zhang, Wei, Noordermeer, Sylvie M, Seclen, Eduardo, Wilson, Marcus D, Vorobyov, Andrew, Munro, Meagan, Ernst, Andreas, Ng, Timothy F, Cho, Tiffany, Cannon, Paula M, Sidhu, Sachdev S, Sicheri, Frank, Durocher, Daniel

Source: Nature biotechnology. 36(1):95-102

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132383648.0x000001&indx=1&recIds=ETOCvdc_100132383648.0x000001

53BP1: pro choice in DNA repair

Authors: Zimmermann, Michal, de Lange, Titia

Source: In Trends in Cell Biology February 2014 24(2):108-117

Targeting ATR in patients with cancer

Authors: Ngoi, Natalie Y. L., Pilié, Patrick G., McGrail, Daniel J., Zimmermann, Michal, Schlacher, Katharina, Yap, Timothy A.

Source: Nature Reviews Clinical Oncology; April 2024, Vol. 21 Issue: 4 p278-293, 16p

Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)

Authors: Black, W. Cameron, Abdoli, Abbas, An, Xiuli, Auger, Anick, Beaulieu, Patrick, Bernatchez, Michel, Caron, Cathy, Chefson, Amandine, Crane, Sheldon, Diallo, Mohamed, Dorich, Stéphane, Fader, Lee D., Ferraro, Gino B., Fournier, Sara, Gao, Qi, Ginzburg, Yelena, Hamel, Martine, Han, Yongshuai, Jones, Paul, Lanoix, Stéphanie, Lacbay, Cyrus M., Leclaire, Marie-Eve, Levy, Maayan, Mamane, Yael, Mulani, Amina, Papp, Robert, Pellerin, Charles, Picard, Audrey, Skeldon, Alexander, Skorey, Kathryn, Stocco, Rino, St.-Onge, Miguel, Truchon, Jean-François, Truong, Vouy Linh, Zimmermann, Michal, Zinda, Michael, Roulston, Anne

Source: Journal of Medicinal Chemistry; February 2024, Vol. 67 Issue: 4 p2349-2368, 20p

53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Authors: Zimmermann, Michal, Lottersberger, Francisca, Buonomo, Sara B., Sfeir, Agnel, de Lange, Titia

Source: Science, 2013 Feb 01. 339(6120), 700-704.

Access URL: http://dx.doi.org/10.1126/science.1231573

Recognition of Transcription Termination Signal by the Nuclear Polyadenylated RNA-binding (NAB) 3 Protein

Authors: Hobor, Fruzsina, Pergoli, Roberto, Kubicek, Karel, Hrossova, Dominika, Bacikova, Veronika, Zimmermann, Michal, Pasulka, Josef, Hofr, Ctirad, Vanacova, Stepanka, Stefl, Richard

Source: In Journal of Biological Chemistry 4 February 2011 286(5):3645-3657

The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove

Authors: Stefl, Richard, Oberstrass, Florian C., Hood, Jennifer L., Jourdan, Muriel, Zimmermann, Michal, Skrisovska, Lenka, Maris, Christophe, Peng, Li, Hofr, Ctirad, Emeson, Ronald B., Allain, Frédéric H.-T.

Source: In Cell 15 October 2010 143(2):225-237

ATM Germline-Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics, and Potential Therapeutic Implications.

Authors: Jabbour, Tony El, Misyura, Maksym, Cowzer, Darren, Zimmermann, Michal, Rimkunas, Victoria, Marra, Antonio, Derakhshan, Fatemeh, Selenica, Pier, Parilla, Megan, Setton, Jeremy S, Ceyhan-Birsoy, Ozge, Kemel, Yelena, Catchings, Amanda, Ranganathan, Megha, Ku, Geoffrey Y, Janjigian, Yelena Y, Zinda, Michael, Koehler, Maria, Stadler, Zsofia, Shia, Jinru

Source: JNCI: Journal of the National Cancer Institute; May2022, Vol. 114 Issue 5, p761-770, 10p

Subject Terms: STOMACH tumors, ADENOCARCINOMA, ESOPHAGUS, PROTEIN kinases, GERM cells, RESEARCH funding, ESOPHAGEAL tumors

Prediction of localization and interactions of apoptotic proteins

Authors: Matula Pavel, Ulman Vladimír, Amrichová Jana, Zimmermann Michal, Vařecha Miroslav, Kozubek Michal

Source: Journal of Biomedical Science, Vol 16, Iss 1, p 59 (2009)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://www.jbiomedsci.com/content/16/1/59; https://doaj.org/toc/1021-7770; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/1e15189eae9849f2bc4d860cca281fb1