Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators

Authors: Mu, Xu-Yang ^{a, d}, Gao, Li-Xin ^b, Zhang, Zhen-Xuan ^{a, c}, Cao, Zi-Tong ^{b, e}, Cao, Qing ^a, Zhang, Chun ^a, Li, Jia ^c, Xiang, Da-Jun ^{f, ⁎}, Zhou, Yu-Bo ^{c, ⁎⁎}, Wang, Wen-Long ^{a, d, ⁎⁎⁎}

Source: In European Journal of Medicinal Chemistry 15 April 2025 288

Insights into the fluorescence and bio-activity of 2-quinolone derivatives against SHP2 from simulated and experimental aspects

Authors: Zhang, Chun ^{a, 1}, Yang, Yuting ^{a, 1}, Gao, Li-Xin ^a, Gan, Suya ^a, Zhao, Tian-Tian ^a, Gao, Wenran ^b, Li, Jia ^{c, d}, Zhu, Yun-Long ^{e, ⁎}, Zhou, Yu-Bo ^{c, d, ⁎}, Wang, Wen-Long ^{a, ⁎}

Source: In Journal of Molecular Structure 15 April 2025 1327

Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+ and cell imaging

Authors: Yan, Xue ^{a, d}, Zhang, Chun ^a, Gao, Li-Xin ^c, Cao, Zi-Tong ^{c, f}, Gan, Su-Ya ^a, Li, Jia ^c, Xiang, Da-Jun ^{e, ⁎}, Zhou, Yu-Bo ^{b, ⁎}, Wang, Wen-Long ^{a, d, ⁎}

Source: In Journal of Molecular Structure 5 March 2025 1324

Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1

Authors: Yan, Xue ^{a, c}, Zhang, Chun ^a, Gao, Li-Xin ^{a, b}, Liu, Min-Min ^a, Yang, Yu-Ting ^a, Yu, Li-Jie ^a, Zhou, Yu-Bo ^b, Milaneh, Slieman ^{a, d}, Zhu, Yun-Long ^{e, ∗∗}, Li, Jia ^{b, ∗∗∗}, Wang, Wen-Long ^{a, c, ∗}

Source: In European Journal of Medicinal Chemistry 5 February 2024 265

Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study

Authors: Zhao, Tian-Tian, Hu, Hao-Jie, Gao, Li-Xin, Zhou, Yu-Bo, Zhu, Yun-Long, Zhang, Chun, Li, Jia, Wang, Wen-Long

Source: In Journal of Molecular Graphics and Modelling December 2023 125

A study on optical properties of various hot drug molecules by 2020Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3nj00973d

Authors: Zhang, Chun, Yang, Yuting, Yan, Xue, Sun, Yi-Tao, Shao, Andong, Gao, Sinuo, Zhou, Yu-Bo, Ren, Ai-Min, Li, Jia, Wang, Wen-Long

Source: New journal of chemistry. 47(21):10046-10060

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184386316.0x000001&indx=1&recIds=ETOCvdc_100184386316.0x000001

Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3Kα inhibitors via virtual screening and docking-based structure optimization

Authors: Gu, Dongyan, Zhang, Mengmeng, Cai, Lvtao, Wang, Chang, Zhou, Yu-Bo, Li, Jia, Sheng, Rong

Source: In Bioorganic & Medicinal Chemistry 15 May 2023 86

Effects of vaginal seeding on gut microbiota, body mass index, and allergy risks in infants born through cesarean delivery: a randomized clinical trial

Authors: Liu, Yang, Li, Hong-tian, Zhou, Shu-jin, Zhou, Hui-huang, Xiong, Ying, Yang, Jing, Zhou, Yu-bo, Chen, Dun-jin, Liu, Jian-meng

Source: In American Journal of Obstetrics & Gynecology MFM January 2023 5(1)

Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications.

Authors: Yan, Xue, Gao, Li-Xin, Cao, Zi-Tong, Gan, Su-Ya, Fu, Yi-Qiu, Li, Jia, Xiang, Da-Jun, Zhou, Yu-Bo, Wang, Wen-Long

Source: Journal of Materials Chemistry B; 3/21/2025, Vol. 13 Issue 11, p3633-3643, 11p

6H-Indolo-[2,3-b]-quinoxaline derivatives as promising bifunctional SHP1 inhibitors.

Authors: Zhang, Chun, Dong, Yi-Xin, Gao, Li-Xin, Gan, Suya, Gao, Wenran, Li, Jia, Xiang, Da-Jun, Wang, Xin, Zhou, Yu-Bo, Wang, Wen-Long

Source: Organic & Biomolecular Chemistry; 2/14/2025, Vol. 23 Issue 6, p1394-1405, 12p

Theoretical study and application of 2-phenyl-1, 3, 4-thiadiazole derivatives with optical and inhibitory activity against SHP1Electronic supplementary information (ESI) available. See DOI: 10.1039/d1cp04268h

Authors: Zhang, Chun, Sun, Yi-Tao, Gao, Li-Xin, Feng, Bo, Yan, Xue, Guo, Xue-Hui, Ren, Ai-Min, Zhou, Yu-Bo, Li, Jia, Wang, Wen-Long

Source: Physical chemistry chemical physics. 24(2):861-874

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140019538.0x000001&indx=1&recIds=ETOCvdc_100140019538.0x000001

Enantiomeric pairs of meroterpenoids with 11/5/6 spiro-heterocyclic systems from Hypericum kouytchenseElectronic supplementary information (ESI) available: 1D and 2D NMR, HRESIMS, UV, IR spectra for compounds 1–6. CCDC 2160217–2160220 and 2204875. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d2qo01485h

Authors: Huang, Jin-Chang, Sheng, Li, Zong, Jian-Fa, Zhou, Yu-Bo, Li, Jia, Hou, Ai-Jun

Source: Organic chemistry frontiers. 9(23):6475-6483

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165411302.0x000001&indx=1&recIds=ETOCvdc_100165411302.0x000001

Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors

Authors: Meng, Xiang-Dong, Gao, Li-Xin, Wang, Zhi-Jia, Feng, Bo, Zhang, Chun, Satheeshkumar, Rajendran, Li, Jia, Zhu, Yun-Long, Zhou, Yu-Bo, Wang, Wen-Long

Source: In Bioorganic Chemistry November 2021 116

Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening

Authors: Gu, Dongyan, Cheng, Gang, Zhang, Mengmeng, Zhou, Yu-Bo, Li, Jia, Sheng, Rong

Source: In Bioorganic & Medicinal Chemistry 1 January 2021 29

Synthesis of 2-ethoxycarbonylthieno[2, 3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1BElectronic supplementary information (ESI) available. See DOI: 10.1039/d0ra09247a

Authors: Mu, Xu-Yang, Wang, Zhi-Jia, Feng, Bo, Xu, Lei, Gao, Li-Xin, Satheeshkumar, Rajendran, Li, Jia, Zhou, Yu-Bo, Wang, Wen-Long

Source: RSC advances. 11(6):3216-3220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116416256.0x000001&indx=1&recIds=ETOCvdc_100116416256.0x000001

Optimization and Biological Evaluation of Novel 1H‑Pyrrolo[2,3‑c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia.

Authors: Jiang, Hong, Li, Cong, Li, Na, Sheng, Li, Wang, Jingkai, Kan, Wei-Juan, Chen, Yuelei, Zhao, Dongmei, Guo, Dong, Zhou, Yu-Bo, Xiong, Bing, Li, Jia, Liu, Tongchao

Source: Journal of Medicinal Chemistry; 12/26/2024, Vol. 67 Issue 24, p22080-22103, 24p

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

Authors: Jiang, Wei, Xiong, Juan, Zang, Yi, Li, Junmin, Osman, Ezzat E.A., Li, Jing-Ya, Zhou, Yu-Bo, Li, Jia, Hu, Jin-Feng

Source: In Phytochemistry January 2020 169

Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives

Authors: Sun, Yi‐Tao, Zhang, Chun, Gao, Li‐Xin, Liu, Min‐Min, Yang, Yuting, Shao, Andong, Zhou, Yu‐Bo, Zhu, Yun‐Long, Li, Jia, Wang, Wen‐Long

Source: Chemphyschem. 24(17)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191755960.0x000001&indx=1&recIds=ETOCvdc_100191755960.0x000001

Discovery of 4-oxo-4, 5-dihydropyrazolo[1, 5-a]quinoxaline-7-carboxamide derivatives as PI3Kα inhibitors via virtual screening and docking-based structure optimization

Authors: Gu, Dongyan, Zhang, Mengmeng, Cai, Lvtao, Wang, Chang, Zhou, Yu-Bo, Li, Jia, Sheng, Rong

Source: Bioorganic & medicinal chemistry. 86

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190025418.0x000001&indx=1&recIds=ETOCvdc_100190025418.0x000001

Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities

Authors: Xiao, Donghuai, Wang, Yu-jie, Hu, Xiao-bei, Kan, Wei-juan, Zhang, Qiumeng, Jiang, Xuefeng, Zhou, Yu-bo, Li, Jia, Lu, Wei

Source: In European Journal of Medicinal Chemistry 15 August 2019 176:419-430