Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.

Authors: Ashton, Trent D., Calic, Petar P. S., Dans, Madeline G., Kang Ooi, Zi, Zhou, Qingmiao, Loi, Katie, Jarman, Kate E., Palandri, Josephine, Qiu, Deyun, Lehane, Adele M., Maity, Bikash, De, Nirupam, Famodimu, Mufuliat T., Delves, Michael J., Mao, Emma Y., Gancheva, Maria R., Wilson, Danny W., Chowdury, Mrittika, de Koning‐Ward, Tania F., Baud, Delphine

Source: ChemMedChem; 12/16/2024, Vol. 19 Issue 24, p1-16, 16p

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Authors: Ashton, Trent D., Calic, Petar P. S., Dans, Madeline G., Ooi, Zi Kang, Zhou, Qingmiao, Palandri, Josephine, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Maity, Bikash Chandra, De, Nirupam, Giannangelo, Carlo, MacRaild, Christopher A., Creek, Darren J., Mao, Emma Y., Gancheva, Maria R., Wilson, Danny W., Chowdury, Mrittika, de Koning-Ward, Tania F.

Source: Journal of Medicinal Chemistry; 8/22/2024, Vol. 671 Issue 6, p14493-14523, 31p