The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

Authors: Vind, Anna Constance ^{1, 2, 12, ∗}, Wu, Zhenzhen ^{1, 2, 12}, Firdaus, Muhammad Jasrie ^{3, 12}, Snieckute, Goda ^{1, 2}, Toh, Gee Ann ³, Jessen, Malin ⁴, Martínez, José Francisco ^{1, 2}, Haahr, Peter ², Andersen, Thomas Levin ^{5, 6}, Blasius, Melanie ^{1, 2}, Koh, Li Fang ⁷, Maartensson, Nina Loeth ^{8, 10}, Common, John E.A. ^{7, 9}, Gyrd-Hansen, Mads ⁴, Zhong, Franklin L. ^{3, 11, ∗∗}, Bekker-Jensen, Simon ^{1, 2, 13, ∗∗∗}

Source: In Molecular Cell 19 December 2024 84(24):4774-4789

Structural Basis of High-Precision Protein Ligation and Its Application.

Authors: Chong, Kelvin Han Chung, Liu, Lichao, Chua, Rae, Chai, Yoke Tin, Lu, Zhuojian, Liu, Renming, Tan, Eddie Yong Jun, Dong, Jinxi, Khoh, Yek How, Lin, Jianqing, Zhong, Franklin L., Lescar, Julien, Zheng, Peng, Wu, Bin

Source: Journal of the American Chemical Society; 1/15/2025, Vol. 147 Issue 2, p1604-1611, 8p

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Authors: Drutman, Scott B., Haerynck, Filomeen, Zhong, Franklin L., Hum, David, Hernandez, Nicholas J., Belkaya, Serkan, Rapaport, Franck, de Jong, Sarah Jill, Creytens, David, Tavernier, Simon J., Bonte, Katrien, De Schepper, Sofie, van der Werff ten Bosch, Jutte, Lorenzo-Diaz, Lazaro, Wullaert, Andy, Bossuyt, Xavier, Orth, Gérard, Bonagura, Vincent R., Béziat, Vivien, Abel, Laurent, Jouanguy, Emmanuelle, Reversade, Bruno, Casanova, Jean-Laurent

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep . 116(38), 19055-19063.

Access URL: https://www.jstor.org/stable/26851667

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Authors: Zhong, Franklin L., Robinson, Kim, Teo, Daniel Eng Thiam, Tan, Kiat-Yi, Lim, Chrissie, Harapas, Cassandra R., Yu, Chien-Hsiung, Xie, William H., Sobota, Radoslaw M., Au, Veonice Bijin, Hopkins, Richard, D'Osualdo, Andrea, Reed, John C., Connolly, John E., Masters, Seth L., Reversade, Bruno

Source: In Journal of Biological Chemistry 7 December 2018 293(49):18864-18878

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

Authors: Gong, Qin, Robinson, Kim, Xu, Chenrui, Huynh, Phuong Thao, Chong, Kelvin Han Chung, Tan, Eddie Yong Jun, Zhang, Jiawen, Boo, Zhao Zhi, Teo, Daniel Eng Thiam, Lay, Kenneth, Zhang, Yaming, Lim, John Soon Yew, Goh, Wah Ing, Wright, Graham, Zhong, Franklin L., Reversade, Bruno, Wu, Bin

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191091830.0x000001&indx=1&recIds=ETOCvdc_100191091830.0x000001

Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1

Authors: Freund, Adam, Zhong, Franklin L., Venteicher, Andrew S., Meng, Zhaojing, Veenstra, Timothy D., Frydman, Judith, Artandi, Steven E.

Source: In Cell 4 December 2014 159(6):1389-1403

Chapter 3 - The NLRP1 and CARD8 inflammasomes

Authors: Sandstrom, Andrew, Robinson, Kim S., Zhong, Franklin L., Shan, Liang

Source: In Inflammasome Biology 2023:33-50

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

Authors: Zhong, Franklin L., Batista, Luis F.Z., Freund, Adam, Pech, Matthew F., Venteicher, Andrew S., Artandi, Steven E.

Source: In Cell 3 August 2012 150(3):481-494

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

Authors: Chu, Ci, Qu, Kun, Zhong, Franklin L., Artandi, Steven E., Chang, Howard Y.

Source: In Molecular Cell 18 November 2011 44(4):667-678

Physical Plasticity of the Nucleus in Stem Cell Differentiation

Authors: Pajerowski, J. David, Dahl, Kris Noel, Zhong, Franklin L., Sammak, Paul J., Discher, Dennis E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Oct 01. 104(40), 15619-15624.

Access URL: https://www.jstor.org/stable/25449188

Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

Authors: Zeng, Ruizhu, Sidik, Harwin, Robinson, Kim S., Zhong, Franklin L., Reversade, Bruno, Pouladi, Mahmoud A.

Source: Stem cell research. 40

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098032330.0x000001&indx=1&recIds=ETOCvdc_100098032330.0x000001

Structural basis of RIP2 activation and signaling

Authors: Gong, Qin, Long, Ziqi, Zhong, Franklin L., Teo, Daniel Eng Thiam, Jin, Yibo, Yin, Zhan, Boo, Zhao Zhi, Zhang, Yaming, Zhang, Jiawen, Yang, Renliang, Bhushan, Shashi, Reversade, Bruno, Li, Zongli, Wu, Bin

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129868638.0x000001&indx=1&recIds=ETOCvdc_100129868638.0x000001

Mitochondrial damage activates the NLRP10 inflammasome

Authors: Próchnicki, Tomasz, Vasconcelos, Matilde B., Robinson, Kim S., Mangan, Matthew S. J., De Graaf, Dennis, Shkarina, Kateryna, Lovotti, Marta, Standke, Lena, Kaiser, Romina, Stahl, Rainer, Duthie, Fraser G., Rothe, Maximilian, Antonova, Kateryna, Jenster, Lea-Marie, Lau, Zhi Heng, Rösing, Sarah, Mirza, Nora, Gottschild, Clarissa, Wachten, Dagmar, Günther, Claudia, Kufer, Thomas A., Schmidt, Florian I., Zhong, Franklin L., Latz, Eicke

Source: Nature Immunology; April 2023, Vol. 24 Issue: 4 p595-603, 9p

Contributors

Authors: Abbate, Antonio, Aksentijevich, Ivona, Amaral, Marcelo Pires, Andrade-Silva, Magaiver, Angosto-Bazarra, Diego, Antonioli, Luca, Aral, Kübra, Aróstegui, Juan I., Barlow, Jillian, Benvenuti, Laura, Bernardini, Nunzia, Bertinaria, Massimo, Biasizzo, Monika, Bortoluci, Karina Ramalho, Boucher, Dave, Branco, Laura Migliari, Brough, David, Broz, Petr, Bryant, Clare E., Cahill, Mark, Campbell, Matthew, Cho, Soo Jung, Christgen, Shelbi, Coll, Rebecca C., Couillin, Isabelle, Cyr, Brianna, Dalmon, Sarah, de Rivero Vaccari, Juan Pablo, Di Virgilio, Francesco, Dorfleutner, Andrea, Doyle, Sarah L., D'Antongiovanni, Vanessa, Feldstein, Ariel E., Fornai, Matteo, García-Palenciano, Carlos, Gastaldi, Simone, Geyer, Matthias, Ghiringhelli, François, Giuliani, Anna Lisa, González-Navajas, José Manuel, Hafner-Bratkovič, Iva, Hamarsheh, Shaima'a, Heneka, Michael T., Henry, Thomas, Hikima, Jun-ichi, Hochheiser, Inga V., Hogg, Alexander, Hooftman, Alexander, Hoyle, Christopher, Huang, Yin, Huot-Marchand, Sarah, Hurtado-Navarro, Laura, Jha, Sushmita, Kanneganti, Thirumala-Devi, Kaufmann, Benedikt, Kim, Andrea D., Kopitar-Jerala, Nataša, Kron, Jordana, Lage, Silvia Lucena, Lozano-Ruiz, Beatriz, Marini, Elisabetta, Matchett, Billie, Mauro, Adolfo G., Mezzaroma, Eleonora, Milward, Michael R., Mizuno Watanabe, Ingrid Kazue, Morimoto, Natsuki, Mukherjee, Sandip, Orzáez, Mar, O'Neill, Luke A.J., Pelegrín, Pablo, Pellegrini, Carolina, Perrichet, Anaïs, Picó, Joanna, Potere, Nicola, Pronko, Alexander, Ravichandran, Kishore Aravind, Riteau, Nicolas, Robinson, Kim S., Rébé, Cédric, Salloum, Fadi N., Sancho, Mónica, Sandstrom, Andrew, Saraiva Câmara, Niels Olsen, Schmidt, Florian I., Shan, Liang, Silke, Eoin, Soriano-Teruel, Paula M., Stehlik, Christian, Stout-Delgado, Heather, Theiss, Arianne L., Ting, Jenny P.-Y., Toldo, Stefano, Tsakem, Elviche L., Tweedell, Rebecca E., Tzoumpa, Amalia, Venuprasad, K., Wellens, Rose, Zeiser, Robert, Zhong, Franklin L., Zotta, Alessia

Source: In Inflammasome Biology 2023:xxi-xxviii

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Authors: Zhong, Franklin L., Mamaï, Ons, Sborgi, Lorenzo, Boussofara, Lobna, Hopkins, Richard, Robinson, Kim, Szeverényi, Ildikó, Takeichi, Takuya, Balaji, Reshmaa, Lau, Aristotle, Tye, Hazel, Roy, Keya, Bonnard, Carine, Ahl, Patricia J., Jones, Leigh Ann, Baker, Paul J., Lacina, Lukas, Otsuka, Atsushi, Fournie, Pierre R., Malecaze, François, Lane, E. Birgitte, Akiyama, Masashi, Kabashima, Kenji, Connolly, John E., Masters, Seth L., Soler, Vincent J., Omar, Salma Samir, McGrath, John A., Nedelcu, Roxana, Gribaa, Moez, Denguezli, Mohamed, Saad, Ali, Hiller, Sebastian, Reversade, Bruno

Source: Cell. 167(1):187-202.e17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061588166.0x000001&indx=1&recIds=ETOCvdc_100061588166.0x000001

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.

Authors: Lee, Cheryl Q. E., Kerouanton, Baptiste, Chothani, Sonia, Zhang, Shan, Chen, Ying, Mantri, Chinmay Kumar, Hock, Daniella Helena, Lim, Radiance, Nadkarni, Rhea, Huynh, Vinh Thang, Lim, Daryl, Chew, Wei Leong, Zhong, Franklin L., Stroud, David Arthur, Schafer, Sebastian, Tergaonkar, Vinay, St John, Ashley L., Rackham, Owen J. L., Ho, Lena

Source: Nature Communications; 4/9/2021, Vol. 12 Issue 1, p1-22, 22p

Subject Terms: CYTOCHROME oxidase, INFLAMMATION, MEMBRANE potential, MITOCHONDRIAL membranes, OPEN reading frames (Genetics), IMMUNITY, IMMUNE response

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Authors: Batista, Luis F. Z., Pech, Matthew F., Zhong, Franklin L., Nguyen, Ha Nam, Xie, Kathleen T., Zaug, Arthur J., Crary, Sharon M., Choi, Jinkuk, Sebastiano, Vittorio, Cherry, Athena, Giri, Neelam, Wernig, Marius, Alter, Blanche P., Cech, Thomas R., Savage, Sharon A., Reijo Pera, Renee A., Artandi, Steven E.

Source: Nature. 6/16/2011, Vol. 474 Issue 7351, p399-402. 4p. 1 Color Photograph, 1 Black and White Photograph, 2 Graphs.

Subjects: PLURIPOTENT stem cells, TELOMERES, GENETIC mutation, KERATOSIS, TELOMERASE, PLANT diseases, CELL culture

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

Authors: Robinson, Kim Samirah, Toh, Gee Ann, Firdaus, Muhammad Jasrie, Tham, Khek Chian, Rozario, Pritisha, Lim, Chrissie K., Toh, Ying Xiu, Lau, Zhi Heng, Binder, Sophie Charlotte, Mayer, Jacob, Bonnard, Carine, Schmidt, Florian I., Common, John E.A., Zhong, Franklin L.

Source: The Journal of Experimental Medicine; October 2023, Vol. 220 Issue: 10 pe20230105-e20230105, 1p

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

Authors: Pinilla, Miriam, Mazars, Raoul, Vergé, Romain, Gorse, Leana, Paradis, Margaux, Suire, Bastien, Santoni, Karin, Robinson, Kim Samirah, Toh, Gee Ann, Prouvensier, Laure, Leon-Icaza, Stephen Adonai, Hessel, Audrey, Péricat, David, Murris, Marlène, Guet-Revillet, Hélène, Henras, Anthony, Buyck, Julien, Ravet, Emmanuel, Zhong, Franklin L., Cougoule, Céline, Planès, Rémi, Meunier, Etienne

Source: The Journal of Experimental Medicine; October 2023, Vol. 220 Issue: 10 pe20230104-e20230104, 1p

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.

Authors: Robinson, Kim S., Teo, Daniel Eng Thiam, Tan, Kai Sen, Toh, Gee Ann, Ong, Hsiao Hui, Lim, Chrissie Kaishi, Lay, Kenneth, Au, Bijin Veonice, Lew, Tian Sheng, Chu, Justin Jang Hann, Chow, Vincent Tak Kwong, Wang, De Yun, Zhong, Franklin L., franklin.zhong@ntu.edu.sg, Reversade, Bruno, bruno@reversade.com

Source: Science; 12/4/2020, Vol. 370 Issue 6521, p1182-1182, 1p, 1 Diagram